MethodsX. 2024 Jan 11;12:102542. doi: 10.1016/j.mex.2023.102542. eCollection 2024 Jun.

ABSTRACT

Data-driven solutions offer great promise for improving healthcare. However, standard clinical neuroimaging data is subject to real-world imaging artefacts that can render the data unusable for computational research and quantitative neuroradiology. T1 weighted structural MRI is used in dementia research to obtain volumetric measurements from cortical and subcortical brain regions. However, clinical radiologists often prioritise T2 weighted or FLAIR scans for visual assessment. As such, T1 weighted scans are often acquired but may not be a priority, resulting in artefacts such as partial brain coverage being systematically present in memory clinic data. Here we present "MRI Crop Filling", a pipeline to replace the missing T1 data with synthetic data generated from the T2 scan, making real-world clinical T1 data usable for computational research including the latest AI innovations. Our method consists of the following steps:•Register scans: T2 and (cropped) T1.•Synthesise a new T1 using an open source deep learning tool.•Replace missing (cropped) T1 data in original T1 scan and super-resolve to improve image quality.

PMID:38313693 | PMC:PMC10837087 | DOI:10.1016/j.mex.2023.102542

Front Neurorobot. 2024 Jan 19;17:1301785. doi: 10.3389/fnbot.2023.1301785. eCollection 2023.

ABSTRACT

Loop closure detection is an important module for simultaneous localization and mapping (SLAM). Correct detection of loops can reduce the cumulative drift in positioning. Because traditional detection methods rely on handicraft features, false positive detections can occur when the environment changes, resulting in incorrect estimates and an inability to obtain accurate maps. In this research paper, a loop closure detection method based on a variational autoencoder (VAE) is proposed. It is intended to be used as a feature extractor to extract image features through neural networks to replace the handicraft features used in traditional methods. This method extracts a low-dimensional vector as the representation of the image. At the same time, the attention mechanism is added to the network and constraints are added to improve the loss function for better image representation. In the back-end feature matching process, geometric checking is used to filter out the wrong matching for the false positive problem. Finally, through numerical experiments, the proposed method is demonstrated to have a better precision-recall curve than the traditional method of the bag-of-words model and other deep learning methods and is highly robust to environmental changes. In addition, experiments on datasets from three different scenarios also demonstrate that the method can be applied in real-world scenarios and that it has a good performance.

PMID:38313328 | PMC:PMC10837850 | DOI:10.3389/fnbot.2023.1301785

ArXiv. 2024 Jan 17:arXiv:2401.07825v2. Preprint.

ABSTRACT

Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into clinical risk assessment tools. Even the commonly used calcium score for coronary arteries, which assumes risk scales positively with total calcification, has important inconsistencies. Fundamental studies are needed to determine how risk is influenced by the diverse calcification phenotypes. However, studies of these kinds are hindered by the lack of high-throughput, objective, and non-destructive tools for classifying calcification in imaging data sets. Here, we introduce a new classification system for phenotyping calcification along with a semi-automated, non-destructive pipeline that can distinguish these phenotypes in even atherosclerotic tissues. The pipeline includes a deep-learning-based framework for segmenting lipid pools in noisy micro-CT images and an unsupervised clustering framework for categorizing calcification based on size, clustering, and topology. This approach is illustrated for five vascular specimens, providing phenotyping for thousands of calcification particles across as many as 3200 images in less than seven hours. Average Dice Similarity Coefficients of 0.96 and 0.87 could be achieved for tissue and lipid pool, respectively, with training and validation needed on only 13 images despite the high heterogeneity in these tissues. By introducing an efficient and comprehensive approach to phenotyping calcification, this work enables large-scale studies to identify a more reliable indicator of the risk of cardiovascular events, a leading cause of global mortality and morbidity.

PMID:38313202 | PMC:PMC10836085

ArXiv. 2024 Jan 15:arXiv:2401.00232v2. Preprint.

ABSTRACT

Low-dose emission tomography (ET) plays a crucial role in medical imaging, enabling the acquisition of functional information for various biological processes while minimizing the patient dose. However, the inherent randomness in the photon counting process is a source of noise which is amplified in low-dose ET. This review article provides an overview of existing post-processing techniques, with an emphasis on deep neural network (NN) approaches. Furthermore, we explore future directions in the field of NN-based low-dose ET. This comprehensive examination sheds light on the potential of deep learning in enhancing the quality and resolution of low-dose ET images, ultimately advancing the field of medical imaging.

PMID:38313194 | PMC:PMC10836084

PeerJ. 2024 Jan 30;12:e16773. doi: 10.7717/peerj.16773. eCollection 2024.

ABSTRACT

BACKGROUND: Human opisthorchiasis is a dangerous infectious chronic disease distributed in many Asian areas in the water-basins of large rivers, Siberia, and Europe. The gold standard for human opisthorchiasis laboratory diagnosis is the routine examination of Opisthorchis spp. eggs under a microscope. Manual detection is laborious, time-consuming, and dependent on the microscopist's abilities and expertise. Automatic screening of Opisthorchis spp. eggs with deep learning techniques is a useful diagnostic aid.

METHODS: Herein, we propose a convolutional neural network (CNN) for classifying and automatically detecting O. viverrini eggs from digitized images. The image data acquisition was acquired from infected human feces and was processed using the gold standard formalin ethyl acetate concentration technique, and then captured under the microscope digital camera at 400x. Microscopic images containing artifacts and O.viverrini egg were augmented using image rotation, filtering, noising, and sharpening techniques. This augmentation increased the image dataset from 1 time to 36 times in preparation for the training and validation step. Furthermore, the overall dataset was subdivided into a training-validation and test set at an 80:20 ratio, trained with a five-fold cross-validation to test model stability. For model training, we customized a CNN for image classification. An object detection method was proposed using a patch search algorithm to detect eggs and their locations. A performance matrix was used to evaluate model efficiency after training and IoU analysis for object detection.

RESULTS: The proposed model, initially trained on non-augmented data of artifacts (class 0) and O. viverrini eggs (class 1), showed limited performance with 50.0% accuracy, 25.0% precision, 50.0% recall, and a 33.0% F1-score. After implementing data augmentation, the model significantly improved, reaching 100% accuracy, precision, recall, and F1-score. Stability assessments using 5-fold cross-validation indicated better stability with augmented data, evidenced by an ROC-AUC metric improvement from 0.5 to 1.00. Compared to other models such as ResNet50, InceptionV3, VGG16, DenseNet121, and Xception, the proposed model, with a smaller file size of 2.7 MB, showed comparable perfect performance. In object detection, the augmented data-trained model achieved an IoU score over 0.5 in 139 out of 148 images, with an average IoU of 0.6947.

CONCLUSION: This study demonstrated the successful application of CNN in classifying and automating the detection of O. viverrini eggs in human stool samples. Our CNN model's performance metrics and true positive detection rates were outstanding. This innovative application of deep learning can automate and improve diagnostic precision, speed, and efficiency, particularly in regions where O. viverrini infections are prevalent, thereby possibly improving infection sustainable control and treatment program.

PMID:38313031 | PMC:PMC10836206 | DOI:10.7717/peerj.16773

Front Neurosci. 2024 Jan 19;18:1361055. doi: 10.3389/fnins.2024.1361055. eCollection 2024.

NO ABSTRACT

PMID:38312932 | PMC:PMC10834769 | DOI:10.3389/fnins.2024.1361055

Front Toxicol. 2024 Jan 19;5:1340860. doi: 10.3389/ftox.2023.1340860. eCollection 2023.

ABSTRACT

Drug-induced liver injury (DILI) is a severe adverse reaction caused by drugs and may result in acute liver failure and even death. Many efforts have centered on mitigating risks associated with potential DILI in humans. Among these, quantitative structure-activity relationship (QSAR) was proven to be a valuable tool for early-stage hepatotoxicity screening. Its advantages include no requirement for physical substances and rapid delivery of results. Deep learning (DL) made rapid advancements recently and has been used for developing QSAR models. This review discusses the use of DL in predicting DILI, focusing on the development of QSAR models employing extensive chemical structure datasets alongside their corresponding DILI outcomes. We undertake a comprehensive evaluation of various DL methods, comparing with those of traditional machine learning (ML) approaches, and explore the strengths and limitations of DL techniques regarding their interpretability, scalability, and generalization. Overall, our review underscores the potential of DL methodologies to enhance DILI prediction and provides insights into future avenues for developing predictive models to mitigate DILI risk in humans.

PMID:38312894 | PMC:PMC10834666 | DOI:10.3389/ftox.2023.1340860

Front Neurosci. 2024 Jan 19;17:1333725. doi: 10.3389/fnins.2023.1333725. eCollection 2023.

ABSTRACT

Mild traumatic brain injury (mTBI) is a public health concern. The present study aimed to develop an automatic classifier to distinguish between patients with chronic mTBI (n = 83) and healthy controls (HCs) (n = 40). Resting-state functional MRI (rs-fMRI) and positron emission tomography (PET) imaging were acquired from the subjects. We proposed a novel deep-learning-based framework, including an autoencoder (AE), to extract high-level latent and rectified linear unit (ReLU) and sigmoid activation functions. Single and multimodality algorithms integrating multiple rs-fMRI metrics and PET data were developed. We hypothesized that combining different imaging modalities provides complementary information and improves classification performance. Additionally, a novel data interpretation approach was utilized to identify top-performing features learned by the AEs. Our method delivered a classification accuracy within the range of 79-91.67% for single neuroimaging modalities. However, the performance of classification improved to 95.83%, thereby employing the multimodality model. The models have identified several brain regions located in the default mode network, sensorimotor network, visual cortex, cerebellum, and limbic system as the most discriminative features. We suggest that this approach could be extended to the objective biomarkers predicting mTBI in clinical settings.

PMID:38312737 | PMC:PMC10837852 | DOI:10.3389/fnins.2023.1333725

RSC Adv. 2024 Feb 2;14(7):4492-4502. doi: 10.1039/d3ra08650j. eCollection 2024 Jan 31.

ABSTRACT

Rational structure-based drug design relies on accurate predictions of protein-ligand binding affinity from structural molecular information. Although deep learning-based methods for predicting binding affinity have shown promise in computational drug design, certain approaches have faced criticism for their potential to inadequately capture the fundamental physical interactions between ligands and their macromolecular targets or for being susceptible to dataset biases. Herein, we propose to include bond-critical points based on the electron density of a protein-ligand complex as a fundamental physical representation of protein-ligand interactions. Employing a geometric deep learning model, we explore the usefulness of these bond-critical points to predict absolute binding affinities of protein-ligand complexes, benchmark model performance against existing methods, and provide a critical analysis of this new approach. The models achieved root-mean-squared errors of 1.4-1.8 log units on the PDBbind dataset, and 1.0-1.7 log units on the PDE10A dataset, not indicating significant advantages over benchmark methods, and thus rendering the utility of electron density for deep learning models context-dependent. The relationship between intermolecular electron density and corresponding binding affinity was analyzed, and Pearson correlation coefficients r > 0.7 were obtained for several macromolecular targets.

PMID:38312732 | PMC:PMC10835705 | DOI:10.1039/d3ra08650j

Plant Methods. 2024 Feb 4;20(1):24. doi: 10.1186/s13007-024-01140-3.

NO ABSTRACT

PMID:38311760 | DOI:10.1186/s13007-024-01140-3

Environ Monit Assess. 2024 Feb 5;196(3):233. doi: 10.1007/s10661-024-12394-8.

ABSTRACT

Remote sensing is one of the most important methods for analysing the multitemporal changes over a certain period. As a cost-effective way, remote sensing allows the long-term analysis of agricultural land by collecting satellite imagery from different satellite missions. Landsat is one of the longest-running world missions which offers a moderate-resolution earth observation dataset. Land surface mapping and monitoring are generally performed by incorporating classification and change detection models. In this work, a deep learning-based change detection (DCD) algorithm has been proposed to detect long-term agricultural changes using the Landsat series datasets (i.e., Landsat-7, Landsat-8, and Landsat-9) during the period 2012 to 2023. The proposed algorithm extracts the features from satellite data according to their spectral and geographic characteristics and identifies seasonal variability. The DCD integrates the deep learning-based (Environment for visualizing images) ENVI Net-5 classification model and posterior probability-based post-classification comparison-based change detection model (PCD). The DCD is capable of providing seasonal variations accurately with distinct Landsat series dataset and promises to use higher resolution dataset with accurate results. The experimental result concludes that vegetation has decreased from 2012 to 2023, while build-up land has increased up to 88.22% (2012-2023) for Landsat-7 and Landsat-8 datasets. On the other side, degraded area includes water (3.20-0.05%) and fallow land (1-0.59%). This study allows the identification of crop growth, crop yield prediction, precision farming, and crop mapping.

PMID:38311668 | DOI:10.1007/s10661-024-12394-8

Med Biol Eng Comput. 2024 Feb 5. doi: 10.1007/s11517-024-03021-2. Online ahead of print.

ABSTRACT

This study introduces an electroencephalography (EEG)-based dataset to analyze lie detection. Various analyses or detections can be performed using EEG signals. Lie detection using EEG data has recently become a significant topic. In every aspect of life, people find the need to tell lies to each other. While lies told daily may not have significant societal impacts, lie detection becomes crucial in legal, security, job interviews, or situations that could affect the community. This study aims to obtain EEG signals for lie detection, create a dataset, and analyze this dataset using signal processing techniques and deep learning methods. EEG signals were acquired from 27 individuals using a wearable EEG device called Emotiv Insight with 5 channels (AF3, T7, Pz, T8, AF4). Each person took part in two trials: one where they were honest and another where they were deceitful. During each experiment, participants evaluated beads they saw before the experiment and stole from them in front of a video clip. This study consisted of four stages. In the first stage, the LieWaves dataset was created with the EEG data obtained during these experiments. In the second stage, preprocessing was carried out. In this stage, the automatic and tunable artifact removal (ATAR) algorithm was applied to remove the artifacts from the EEG signals. Later, the overlapping sliding window (OSW) method was used for data augmentation. In the third stage, feature extraction was performed. To achieve this, EEG signals were analyzed by combining discrete wavelet transform (DWT) and fast Fourier transform (FFT) including statistical methods (SM). In the last stage, each obtained feature vector was classified separately using Convolutional Neural Network (CNN), Long Short-Term Memory (LSTM), and CNNLSTM hybrid algorithms. At the study's conclusion, the most accurate result, achieving a 99.88% accuracy score, was produced using the LSTM and DWT techniques. With this study, a new data set was introduced to the literature, and it was aimed to eliminate the deficiencies in this field with this data set. Evaluation results obtained from the data set have shown that this data set can be effective in this field.

PMID:38311647 | DOI:10.1007/s11517-024-03021-2

Sci Rep. 2024 Feb 5;14(1):2888. doi: 10.1038/s41598-024-52592-5.

ABSTRACT

This work aims to investigate the application of advanced deep learning algorithms and image recognition technologies to enhance language analysis tools in secondary education, with the goal of providing educators with more effective resources and support. Based on artificial intelligence, this work integrates data mining techniques related to deep learning to analyze and study language behavior in secondary school education. Initially, a framework for analyzing language behavior in secondary school education is constructed. This involves evaluating the current state of language behavior, establishing a framework based on evaluation comments, and defining indicators for analyzing language behavior in online secondary school education. Subsequently, data mining technology and image and character recognition technology are employed to conduct data mining for online courses in secondary schools, encompassing the processing of teaching video images and character recognition. Finally, an experiment is designed to validate the proposed framework for analyzing language behavior in secondary school education. The results indicate specific differences among the grouped evaluation scores for each analysis indicator. The significance p values for the online classroom discourse's speaking rate, speech intelligibility, average sentence length, and content similarity are -0.56, -0.71, -0.71, and -0.74, respectively. The aim is to identify the most effective teaching behaviors for learners and enhance the support for online course instruction.

PMID:38311606 | DOI:10.1038/s41598-024-52592-5

Neuroimage. 2024 Feb 2:120530. doi: 10.1016/j.neuroimage.2024.120530. Online ahead of print.

ABSTRACT

With the arrival of disease-modifying drugs, neurodegenerative diseases will require an accurate diagnosis for optimal treatment. Convolutional neural networks are powerful deep learning techniques that can provide great help to physicians in image analysis. The purpose of this study is to introduce and validate a 3D neural network for classification of Alzheimer's disease (AD), frontotemporal dementia (FTD) or cognitively normal (CN) subjects based on brain glucose metabolism. Retrospective [18F]-FDG-PET scans of 199 AD, 192 FTD and 200 CN subjects were collected from our local database, Alzheimer's disease and frontotemporal lobar degeneration neuroimaging initiatives. Training and test sets were created using randomization on a 90%-10% basis, and training of a 3D VGG16-like neural network was performed using data augmentation and cross-validation. Performance was compared to clinical interpretation by three specialists in the independent test set. Regions determining classification were identified in an occlusion experiment and Gradient-weighted Class Activation Mapping. Test set subjects were age- and sex-matched across categories. The model achieved an overall 89.8% accuracy in predicting the class of test scans. Areas under the ROC curves were 93.3% for AD, 95.3% for FTD, and 99.9% for CN. The physicians' consensus showed a 69.5% accuracy, and there was substantial agreement between them (kappa = 0.61, 95% CI: 0.49-0.73). To our knowledge, this is the first study to introduce a deep learning model able to discriminate AD and FTD based on [18F]-FDG PET scans, and to isolate CN subjects with excellent accuracy. These initial results are promising and hint at the potential for generalization to data from other centers.

PMID:38311126 | DOI:10.1016/j.neuroimage.2024.120530

Neuroimage. 2024 Feb 2:120528. doi: 10.1016/j.neuroimage.2024.120528. Online ahead of print.

ABSTRACT

Quantitative Susceptibility Mapping (QSM) is frequently employed in investigating brain iron related to brain development and diseases within deep gray matter (DGM). Nonetheless, the acquisition of whole-brain QSM data is time-intensive. An alternative approach, focusing the QSM specifically on areas of interest such as the DGM by reducing the field-of-view (FOV), can significantly decrease scan times. However, severe susceptibility value underestimations have been reported during QSM reconstruction with a limited FOV, largely attributable to artifacts from incorrect background field removal in the boundary region. This presents a considerable barrier to the clinical use of QSM with small spatial coverages using conventional methods alone. To mitigate the propagation of these errors, we proposed a harmonic field extension method based on a physics-informed generative adversarial network. Both quantitative and qualitative results demonstrate that our method outperforms conventional methods and delivers results comparable to those obtained with full FOV. Furthermore, we demonstrate the versatility of our method by applying it to data acquired prospectively with limited FOV and to data from patients with Parkinson's disease. The method has shown significant improvements in local field results, with QSM outcomes. In a clear illustration of its feasibility and effectiveness in real clinical environments, our proposed method addresses the prevalent issue of susceptibility underestimation in QSM with small spatial coverage.

PMID:38311125 | DOI:10.1016/j.neuroimage.2024.120528

J Shoulder Elbow Surg. 2024 Feb 2:S1058-2746(24)00076-4. doi: 10.1016/j.jse.2023.12.009. Online ahead of print.

ABSTRACT

BACKGROUND: The diagnosis of rotator cuff tears using radiographs alone is clinically challenging; thus, the utility of deep learning algorithms based on convolutional neural networks has been remarkable in the field of medical imaging recognition. We aimed to evaluate the diagnostic performance of artificial intelligence (a deep learning algorithm; a convolutional neural network) to detect and classify rotator cuff tears using shoulder radiographs, and compare its diagnostic performance with that of orthopedic surgeons.

METHODS: A total of 1,169 plain shoulder anteroposterior radiographs (one image per shoulder) were included in the total dataset and divided into four groups: intact, small, medium, and large to massive tear groups. The sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the receiver operating curve were measured for the detection of rotator cuff tears through binary classification. The average accuracy, recall, precision, and F1-score were divided into four groups by cuff tear size for multiclass classification.

RESULTS: The convolutional neural network demonstrated a high performance, with 92% sensitivity, 69% specificity, 86% accuracy, and an AUC of 0.88 for the detection of rotator cuff tears. The average accuracy, recall, precision, and F1-score of the convolutional neural network for classification were 60%, 0.42, 0.49, and 0.45, respectively. The accuracy of the convolutional neural network for the detection and classification of rotator cuff tears was significantly better than that of orthopedic surgeons.

CONCLUSION: The convolutional neural network demonstrated the diagnostic ability to detect and classify rotator cuff tears using plain shoulder radiographs, and the diagnostic performance exhibited equal to superior accuracy when compared with those of shoulder experts.

PMID:38311106 | DOI:10.1016/j.jse.2023.12.009

Comput Biol Med. 2024 Feb 1;170:108032. doi: 10.1016/j.compbiomed.2024.108032. Online ahead of print.

ABSTRACT

COVID-19, known as Coronavirus Disease 2019 primarily targets the respiratory system and can impact the cardiovascular system, leading to a range of cardiorespiratory complications. The current forefront in analyzing the dynamical characteristics of physiological systems and aiding clinical decision-making involves the integration of entropy-based complexity techniques with artificial intelligence. Entropy-based measures offer promising prospects for identifying disturbances in cardiorespiratory control system (CRCS) among COVID-19 patients by assessing the oxygen saturation variability (OSV) signals. In this investigation, we employ scale-based entropy (SBE) methods, including multiscale entropy (MSE), multiscale permutation entropy (MPE), and multiscale fuzzy entropy (MFE), to characterize the dynamical characteristics of OSV signals. These measurements serve as features for the application of traditional machine learning (ML) and deep learning (DL) approaches in the context of classifying OSV signals from COVID-19 patients during their illness and subsequent recovery. We use the Beurer PO-80 pulse oximeter which non-invasively acquired OSV and pulse rate data from COVID-19 infected patients during the active infection phase and after a two-month recovery period. The dataset comprises of 88 recordings collected from 44 subjects(26 men and 18 women), both during their COVID-19 illness and two months post-recovery. Prior to analysis, data preprocessing is performed to remove artifacts and outliers. The application of SBE measures to OSV signals unveils a reduction in signal complexity during the course of COVID-19. Leveraging these SBE measures as feature sets, we employ two DL techniques, namely the radial basis function network (RBFN) and RBFN with dynamic delay algorithm (RBFNDDA), for the classification of OSV data collected during and after COVID-19 recovery. To evaluate the classification performance, we employ standard metrics such as sensitivity, specificity, false positive rate (FPR), and the area under the receiver operator characteristic curve (AUC). Among the three scale-based entropy measures, MFE outperformed MSE and MPE by achieving the highest classification performance using RBFN with 13 best features having sensitivity (0.84), FPR (0.30), specificity (0.70) and AUC (0.77). The outcomes of our study demonstrate that SBE measures combined with DL methods offer a valuable approach for categorizing OSV signals obtained during and after COVID-19, ultimately aiding in the detection of CRCS dysfunction.

PMID:38310805 | DOI:10.1016/j.compbiomed.2024.108032

Curr Opin Struct Biol. 2024 Feb 3;85:102777. doi: 10.1016/j.sbi.2024.102777. Online ahead of print.

ABSTRACT

The development of anti-aging interventions requires quantitative measurement of biological age. Machine learning models, known as "aging clocks," are built by leveraging diverse aging biomarkers that vary across lifespan to predict biological age. In addition to traditional aging clocks harnessing epigenetic signatures derived from bulk samples, emerging technologies allow the biological age estimating at single-cell level to dissect cellular diversity in aging tissues. Moreover, imaging-based aging clocks are increasingly employed with the advantage of non-invasive measurement, making it suitable for large-scale human cohort studies. To fully capture the features in the ever-growing multi-modal and high-dimensional aging-related data and uncover disease associations, deep-learning based approaches, which are effective to learn complex and non-linear relationships without relying on pre-defined features, are increasingly applied. The use of big data and AI-based aging clocks has achieved high accuracy, interpretability and generalizability, guiding clinical applications to delay age-related diseases and extend healthy lifespans.

PMID:38310737 | DOI:10.1016/j.sbi.2024.102777

Ultramicroscopy. 2024 Jan 24;259:113926. doi: 10.1016/j.ultramic.2024.113926. Online ahead of print.

ABSTRACT

Selected area electron diffraction (SAED) is a widely used technique for characterizing the structure and measuring lattice parameters of materials. An autonomous analytic method has become an urgent demand for the large-scale SAED data produced from in-situ experiments. In this work, we realize the automatic processing for center identification with a proposed deep segmentation model named the multi-scale Transformer (MS-Trans) network. This algorithm enables robust segmentation of the central spots by combining a novel gated axial-attention module and multi-scale feature fusion. The proposed MS-Trans model shows high precision and robustness, enabling autonomous processing of SAED patterns without any prior knowledge. The application on in-situ SAED data of the oxidation process of FeNi alloy demonstrates its capability of implementing autonomous quantitative processing. © 2017 Elsevier Inc. All rights reserved.

PMID:38310650 | DOI:10.1016/j.ultramic.2024.113926

Mayo Clin Proc. 2024 Feb 2:S0025-6196(23)00469-X. doi: 10.1016/j.mayocp.2023.09.021. Online ahead of print.

ABSTRACT

OBJECTIVE: To determine whether body composition derived from medical imaging may be useful for assessing biologic age at the tissue level because people of the same chronologic age may vary with respect to their biologic age.

METHODS: We identified an age- and sex-stratified cohort of 4900 persons with an abdominal computed tomography scan from January 1, 2010, to December 31, 2020, who were 20 to 89 years old and representative of the general population in Southeast Minnesota and West Central Wisconsin. We constructed a model for estimating tissue age that included 6 body composition biomarkers calculated from abdominal computed tomography using a previously validated deep learning model.

RESULTS: Older tissue age associated with intermediate subcutaneous fat area, higher visceral fat area, lower muscle area, lower muscle density, higher bone area, and lower bone density. A tissue age older than chronologic age was associated with chronic conditions that result in reduced physical fitness (including chronic obstructive pulmonary disease, arthritis, cardiovascular disease, and behavioral disorders). Furthermore, a tissue age older than chronologic age was associated with an increased risk of death (hazard ratio, 1.56; 95% CI, 1.33 to 1.84) that was independent of demographic characteristics, county of residency, education, body mass index, and baseline chronic conditions.

CONCLUSION: Imaging-based body composition measures may be useful in understanding the biologic processes underlying accelerated aging.

PMID:38310501 | DOI:10.1016/j.mayocp.2023.09.021