Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Source: https://grants.nih.gov/grants/guide/newsfeed/fundingopps.xml

Notice to Extend the Expiration Date for PA-22-051 AHRQ Mentored Career Enhancement Awards for Established Investigators in Patient-Centered Outcome Research (K18)

Notice to Extend Expiration dates for AHRQ PA-22-049 and PA-22-050

Notice of NIAMS-specific language in RFA-NR-25-003 Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional)

Notice of Intent to Publish a Notice of Funding Opportunity for the Re-issue of RFA-AG-23-016 Transition to Aging Research for Predoctoral Students (F99/K00 - Clinical Trial Not Allowed)

Notice of Special Interest (NOSI): Digital Technology for Early Detection and Monitoring of Alzheimers Disease (AD) and AD-Related Dementias (ADRD)

NIA Postdoctoral Fellowship Award to Promote Broad Participation in Translational Research for AD/ADRD (F32 Clinical Trial Not Allowed)

Notice of Information: Administrative Supplements to Increase the Number of Training Slots in NIA-funded T32 Awards to Support Within-Scope Training of Music-Science Research

Notice of Information: Re-issue of Longstanding NHLBI T32 Program

Notice of Early Expiration and Reissue of PAR-24-062, "Phased Research to Support Substance Use Epidemiology, Prevention, and Services Studies (R61/R33 Clinical Trials Optional)"

Notice of Early Expiration and Reissue of PAR-24-060, "Pilot and Feasibility Studies in Preparation for Substance Use Prevention Trials (R34 Clinical Trial Optional)"

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment

Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation

Alopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug

Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy

Mapping the cellular etiology of schizophrenia and complex brain phenotypes

Identification of dequalinium as a potent inhibitor of human organic cation transporter 2 by machine learning based QSAR model

Repurposing the familiar: Future treatment options against chronic kidney disease

Multi-Omics Analysis for Identifying Cell-Type-Specific Druggable Targets in Alzheimer's Disease

Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription

Metronomic Chemotherapy and Drug Repurposing: Two Sides of an Oncology Coin To Reduce Host and Financial Toxicity

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

Comparison of nanoLC-MALDI-MS/MS with nanoLC-TIMS-MS/MS in the proteomic analysis of extracellular vesicles of bronchoalveolar lavage fluid

Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF

Human epididymis protein 4-annexin II binding promotes aberrant epithelial-fibroblast crosstalk in pulmonary fibrosis

Role of IPF genetic risk loci in post-COVID-19 lung abnormalities: a cohort study

Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model

Current status of pulmonary rehabilitation and impact on prognosis of patients with idiopathic pulmonary fibrosis in South Korea

Impact of antifibrotic therapy on lung cancer incidence and mortality in patients with idiopathic pulmonary fibrosis

Mortality-related risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analysis

TWEAK-Fn14 signaling protects mice from pulmonary fibrosis by inhibiting fibroblast activation and recruiting pro-regenerative macrophages

Discovery of novel capsaicin analogs as TRPV1 inhibitors for the treatment of idiopathic pulmonary fibrosis

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Secondhand vape exposure regulation of CFTR and immune function in cystic fibrosis

C-Reactive Protein Changes in Adult and Pediatric People With Cystic Fibrosis During Treatment of Pulmonary Exacerbations

Induced Sputum: A Valuable Tool for Assessing Cellular and Microbiological Characteristics in Cystic Fibrosis Expectorating Teenagers

Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity

Connecting the Past and Present: An Updated Literature Review of Aquagenic Syringeal Acrokeratoderma

Acute fibrinous and organizing pneumonia after lung transplantation: A case report of treatment with infliximab and tocilizumab and literature review

Successful Treatment of a Patient With Chronic Bronchiectasis Using an Induced Native Phage Cocktail: A Case Report

Epigenetic regulation of HOXA2 expression affects tumor progression and predicts breast cancer patient survival

Protease-activated receptor 1 in the pathogenesis of cystic fibrosis

Unlocking the potential of CRISPR-Cas9 for cystic fibrosis: A detailed review

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

Brain Transcriptome Changes Associated With an Acute Increase of Protein O-GlcNAcylation and Implications for Neurodegenerative Disease

Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease

The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in <em>db/db</em> mice

Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia

Application of artificial intelligence and machine learning in drug repurposing

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice

Current progress in CRISPR-Cas systems for rare diseases

Assessment of Rare Cancers and Sarcoma Policy and Sarcoma Drug Approvals in Latin America: A Report From the LACOG Sarcoma Group

Pulmonary alveolar proteinosis: Clinical and morphological overview of a rare disease associated with macrophage dysfunction

Structural variation in nebulin and its implications on phenotype and inheritance: establishing a dominant distal phenotype caused by large deletions

Fucosidosis: A Review of a Rare Disease

Expanding Upon Genomics in Rare Diseases: Epigenomic Insights

Primary malignant melanoma of the vagina: A case report of a rare disease that is difficult to diagnose

The Population-Based Incidence and Prevalence of Catatonia

Clinical and genetic characteristics analysis of two children with comorbidity of two rare genetic diseases

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

The impact of genetic variability on Alzheimer's therapies: obstacles for pharmacogenetic progress

Corrigendum: Review of adult gender transition medications: mechanisms, efficacy measures, and pharmacogenomic considerations

Managing Arrhythmias in Cardiogenic Shock: Insights Into Milrinone and Dobutamine Therapy

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery

Pharmacogenetic associations of GATA4 and KCNQ1 with ibrutinib cardiovascular toxicity

Validating the accuracy of mathematical model-based pharmacogenomics dose prediction with real-world data

Editorial: Insights in pharmacogenetics and pharmacogenomics: 2023

Exploring perceived barriers and attitudes in young adults towards antidepressant pharmacotherapy, including the implementation of pharmacogenetic testing to optimize prescription practices

Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub-Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases

Pharmacogenetic markers and macrolide safety in influenza patients: insights from a prospective study

Deep learning for biomedical sciences and genomics

Volume and quality of the gluteal muscles are associated with early physical function after total hip arthroplasty

Highly accurate real-space electron densities with neural networks

Deep learning and generative artificial intelligence in aging research and healthy longevity medicine

Automated Deep Learning-Based Detection and Segmentation of Lung Tumors at CT

Comparative Analysis of Recurrent Neural Networks with Conjoint Fingerprints for Skin Corrosion Prediction

Advancing forecasting capabilities: A contrastive learning model for forecasting tropical cyclone rapid intensification

Coati optimization algorithm for brain tumor identification based on MRI with utilizing phase-aware composite deep neural network

End-to-end underwater acoustic transmission loss prediction with adaptive multi-scale dilated network

χ-sepnet: Deep Neural Network for Magnetic Susceptibility Source Separation

Lesion classification and diabetic retinopathy grading by integrating softmax and pooling operators into vision transformer

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

A Randomized, Comparative Trial of a Potassium-Competitive Acid Blocker (X842) and Lansoprazole for the Treatment of Patients with Erosive Esophagitis

Efficacy of Contezolid in the Treatment of Catheter-Related Bloodstream Infections Caused by Methicillin-Resistant <em>Staphylococcus aureus</em> in a Patient with Hepatorenal Syndrome and Acute Kidney Injury: A Case Report

Acute Pancreatitis Caused by Tirzepatide

Drug-induced urinary retention: a real-world pharmacovigilance study using FDA and Canada vigilance databases

Safety of brigatinib following alectinib-induced-pneumonitis: Case report

Molecular mechanisms of mTOR-mediated cisplatin response in tumor cells

Second-generation antipsychotic-induced dystonia: Analysis using the Japanese Adverse Drug Event Report (JADER) database

A multidimensional assessment of adverse events associated with paliperidone palmitate: a real-world pharmacovigilance study using the FAERS and JADER databases

D(1) dopamine / mu opioid receptor interactions in operant conditioning assays of pain-depressed responding and drug-induced rate suppression, and a conditioned place preference procedure: assessment of therapeutic index in male Sprague Dawley rats

Prevalence of prescription medication use that can exacerbate heart failure among US adults with heart failure

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events