Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Source: https://grants.nih.gov/grants/guide/newsfeed/fundingopps.xml

Notice of Early Expiration of RFA-EB-22-002, "HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed)"

Notice of Early Termination of NOT-OD-24-117 "Notice of Information: Research Opportunities Centering the Health of Women Across the HIV Research Continuum"

Notice of Information to Revise the Scheduling Details for PA-25-212 "Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed)"

Guidance on Salary Limitation for Grants and Cooperative Agreements FY 2025

NIH Operates Under a Continuing Resolution

Notice to Extend the Expiration Date of PAR-23-220 SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1 Clinical Trial Required)

Notice to Extend the Expiration Date of PAR-23-219 SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)

Implementation Update: Enhancing Security Measures for NIH Controlled-Access Data

Notice to Extend the Expiration Date of PA-24-248 PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)

Notice to Extend the Expiration Date of PA-24-247 PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

A new target for drug repositioning: CEBPalpha elicits LL-37 expression in a vitamin D-independent manner promoting Mtb clearance

The drug discovery candidate for targeting PARP1 with Onosma. Dichroantha compounds in triple-negative breast cancer: A virtual screening and molecular dynamic simulation

DrugGen enhances drug discovery with large language models and reinforcement learning

Decoding potential host protein targets against Flaviviridae using protein-protein interaction network

High-throughput screening of FDA-approved drugs identifies colchicine as a potential therapeutic agent for atypical teratoid/rhabdoid tumors (AT/RTs)

A Deep Subgrouping Framework for Precision Drug Repurposing via Emulating Clinical Trials on Real-world Patient Data

Pharmacological strategies for targeting biofilms in otorhinolaryngologic infections and overcoming antimicrobial resistance (Review)

Mechanisms of action of repurposed Ebola virus antivirals - the roles of phospholipidosis and cholesterol homeostasis

ASS1 is a hub gene and possible therapeutic target for regulating metabolic dysfunction-associated steatotic liver disease modulated by a carbohydrate-restricted diet

Virtual Screening and Molecular Dynamics of Cytokine-Drug Complexes for Atherosclerosis Therapy

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

Characteristics, clinical findings, and treatment of idiopathic pulmonary fibrosis in Japanese patients registered with a medical subsidy system for intractable diseases

PI3K/Akt in IPF: untangling fibrosis and charting therapies

Polygenic risk of idiopathic pulmonary fibrosis and COVID-19 severity

Formononetin-Loaded PLGA Large Porous Microparticles via Intratracheal Instillation for Bleomycin-Induced Pulmonary Fibrosis Treatment

Lung Microbiome in Autoimmune-Associated Interstitial Lung Disease

Studying the efficacy of JBOL volatile components in idiopathic pulmonary fibrosis (IPF) using GC-MS and network pharmacology

AnxA2-EGFR pro-inflammatory signaling potentiates EMT-induced fibrotic stress and its modulation by short-chain fatty acid butyrate in idiopathic pulmonary fibrosis

Insights Into the Cellular and Molecular Mechanisms Behind the Antifibrotic Effects of Nerandomilast

Pirfenidone Mitigates TGF-β-induced Inflammation Following Virus Infection

Analysis of treatment efficacy, tolerability, and survival of patients receiving antifibrotic therapy for progressive nonidiopathic pulmonary fibrosis

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

A host-pathogen metabolic synchrony that facilitates disease tolerance

Remote monitoring of cystic fibrosis lung disease in children and young adults

Early life inflammation in CF: can it be reversed by CFTR modulators?

Experimental investigation of hematological toxicity after radiation therapy combined with immune checkpoint inhibitors

From geroscience to precision geromedicine: Understanding and managing aging

Intraluminal causes of mechanical small bowel obstruction: CT findings and diagnostic approach

Phosphatidylinositol 5-Phosphate-Loaded Apoptotic Body-Like Liposomes for Mycobacterium abscessus Infection Management in Patients With Cystic Fibrosis

Prevalence of CFTR Pathogenic Variants in Pancreatitis: A Systematic Review and Meta-Analysis

A narrative review of digital health literacy within cystic fibrosis telehealth: are we considering it?

Cholesterol and triglyceride concentrations following 12-18 months of clinically prescribed elexacaftor-tezacaftor-ivacaftor-PROMISE sub-study

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

Brain Transcriptome Changes Associated With an Acute Increase of Protein O-GlcNAcylation and Implications for Neurodegenerative Disease

Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease

The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice

Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia

Application of artificial intelligence and machine learning in drug repurposing

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

BioStruct-Africa's capacity building workshops as a model for advancing the emerging community of structural biologists in Africa

Therapeutic target prediction for orphan diseases integrating genome-wide and transcriptome-wide association studies

Rare Adrenal Tumors and Adrenal Metastasis

Advancing Precision Medicine: The Role of Genetic Testing and Sequencing Technologies in Identifying Biological Markers for Rare Cancers

A Genomic Analysis of Usher Syndrome: Population-Scale Prevalence and Therapeutic Targets

Applying artificial intelligence to rare diseases: a literature review highlighting lessons from Fabry disease

A retrospective study of insurance coverage status and economic cost of rare diseases in Hainan Province

Pediatric Pulmonology 2024 Year in Review: Rare and Diffuse Lung Disease

Exploring the path for patient organizations to participate in medical security for rare diseases

Effects of continuing medical education on emergency trainees' rare disease knowledge and attitude: a single-center study

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

Decoding Allosteric Effects of Missense Variations in Drug Metabolism: Afrocentric CYP3A4 Alleles Explored

Efficacy and compliance of carbohydrate-restricted diets for treating drug-resistant epilepsy: A network meta-analysis of randomized controlled trials

Personalized Prophylactic Antiemetic Regimens for Control of Chemotherapy-Induced Nausea and Vomiting by Pharmacogenetic Analysis of Three Receptor Genes: HTR3A, HTR3B, TACR1

A Comprehensive 4-Layered In Silico Pharmacogenomics Analysis of the Genetic Addiction Risk Severity (GARS) Test: Strong Genetic Evidence Supporting GARS as a Novel Personalized Pre-Addiction Assessment Tool in the Opioid Crisis

Application of dihydropyrimidine dehydrogenase deficiency testing for the prevention of fluoropyrimidine toxicity: a real-world experience in a Southern Italy cancer center

ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

Pharmacogenomic analysis and clinical annotation of 635 patients

Similarity of drug targets to human microbiome metaproteome promotes pharmacological promiscuity

Efficacy of interventions for the treatment of irritable bowel syndrome, functional abdominal pain-not otherwise specified, and abdominal migraine in children: a systematic review and network meta-analysis

Therapeutic Reference Range for Clozapine Plasma Levels in Parkinson's Disease or Dementia: A Systematic Review and Individual Participant Data Meta-analysis

Deep learning for biomedical sciences and genomics

EffiCOVID-Net: A Highly Efficient Convolutional Neural Network for COVID-19 Diagnosis Using Chest X-ray Imaging

Tailored self-supervised pretraining improves brain MRI diagnostic models

EBMGP: a deep learning model for genomic prediction based on Elastic Net feature selection and bidirectional encoder representations from transformer's embedding and multi-head attention pooling

A hybrid approach combining deep learning and signal processing for bearing fault diagnosis under imbalanced samples and multiple operating conditions

Automated assessment of simulated laparoscopic surgical skill performance using deep learning

Diagnosis of early glaucoma likely combined with high myopia by integrating OCT thickness map and standard automated and Pulsar perimetries

Efficient hybrid heuristic adopted deep learning framework for diagnosing breast cancer using thermography images

Deep learning unlocks the true potential of organ donation after circulatory death with accurate prediction of time-to-death

Habitat Radiomics and Deep Learning Features Based on CT for Predicting Lymphovascular Invasion in T1-stage Lung Adenocarcinoma: A Multicenter Study

Progress in machine learning-supported electronic nose and hyperspectral imaging technologies for food safety assessment: A review

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

Prediction models for severe treatment-related toxicities in older adults with cancer: a systematic review

Intranasal insulin for improving cognitive function in multiple sclerosis

Association between drug-related cutaneous adverse events and survival outcomes in patients treated with enfortumab vedotin

The Adverse Impact of Tyrosine Kinase Inhibitors on Wound Healing and Repair

Real-World pharmacovigilance analysis of drug-related conjunctivitis using the FDA adverse event reporting system database

Severe coagulation dysfunction and active bleeding induced by cefoperazone/sulbactam in a patient with severe renal insufficiency: a case report

Protective Effects of Ginsenosides on Drug-induced Cardiotoxicity: A New Therapeutic Approach with Focus on Molecular Mechanisms in Cardio-oncology Field

Efficacy and safety of ziresovir in hospitalised infants aged 6 months or younger with respiratory syncytial virus infection in China: findings from a phase 3 randomised trial with 24-month follow-up

Re-assessing the risk-benefit profile of Thiazolidinediones: Cardiovascular Risks and Stroke Prevention Through Real-World Data

Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1): a phase 3 randomised, open-label, non-inferiority, multicentre study

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events