Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)

Occupational Safety and Health Training Project Grants [T03]

Notice of Special Interest (NOSI): Leveraging Microbial Exposure for Improving Mouse Models of Human Immunity

Notice of Early Expiration of "Notice of Special Interest (NOSI): Leveraging Microbial Exposure for Improving Mouse Models of Human Immunity", NOT-AI-21-072

NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)

Notice of Early Expiration of "Notice of Special Interest (NOSI): Accelerating Malaria Vaccine Discovery", NOT-AI-22-014

Notice of Participation of OBSSR in RFA-MH-26-140 "BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)"

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

Drug modifications: graphene oxide-chitosan loading enhanced anti-amoebic effects of pentamidine and doxycycline

Predictive Modeling and Drug Repurposing for Type-II Diabetes

DrugRepPT: a deep pre-training and fine-tuning framework for drug repositioning based on drug's expression perturbation and treatment effectiveness

Drug-target interaction prediction by integrating heterogeneous information with mutual attention network

Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas

Imatinib Impedes EMT and Notch Signalling by Inhibiting p300 Acetyltransferase in Breast Cancer Cells

IRON METABOLISM DYSFUNCTION IN NEUROPSYCHIATRIC DISORDERS: IMPLICATIONS FOR THERAPEUTIC INTERVENTION

Predicting the effects of drugs and unveiling their mechanisms of action using an interpretable pharmacodynamic mechanism knowledge graph (IPM-KG)

BT-11 repurposing potential for Alzheimer's disease and insights into its mode of actions

Unlocking the secrets of trace amine-associated receptor 1 agonists: new horizon in neuropsychiatric treatment

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

A Ramped Treadmlll Protocol Exercise Test Identifies Higher Ambulatory Oxygen Needs in IPF and COPD

Quantification of Interstitial Lung Diseases, From the AJR Special Series on Quantitative Imaging

Novel Substituted Benzimidazole Compounds as TLR9 Inhibitors for Treating Fibrotic Diseases, Particularly Idiopathic Pulmonary Fibrosis

Allium sativum nanovesicles exhibit anti-inflammatory and antifibrotic activity in a bleomycin-induced lung fibrosis model

MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease

Protocol and research program of the European registry and biobank for interstitial lung diseases (eurILDreg)

Cough Reflex Hypersensitivity as a Key Treatable Trait

Timing impact on the initiation of pirfenidone therapy on idiopathic pulmonary fibrosis disease progression

Mendelian randomization study on the causal relationship between chronic hepatitis B/C virus infection and idiopathic pulmonary fibrosis

Axatilimab: First Approval

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Delayed Diagnosis of Primary Ciliary Dyskinesia in Low-Middle-Income Countries: The Clinical Value of Nasal Nitric Oxide

Exploring Therapeutic Strategies for Pediatric Cystic Fibrosis: An In-Depth Comparative Review

The TIPping point: Inflammation and Ionocyte loss

Optimisation of a novel series of ENaC inhibitors, leading to the selection of the long-acting inhaled clinical candidate ETD001, a potential new treatment for cystic fibrosis

Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab

Mission and Future Plans for the ADPKD Centers of Excellence Program

AAAAI-EAACI PRACTALL: Standardizing oral food challenges-2024 Update

Characterization and Comparative Genomic Analysis of vB_BceM_CEP1: A Novel Temperate Bacteriophage Infecting Burkholderia cepacia Complex

Qualitative understanding of experiences of people with cystic fibrosis in a treatment discontinuation trial: The QUEST study

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and emerging treatment

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease

The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice

Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia

Application of artificial intelligence and machine learning in drug repurposing

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

Clinical Reasoning: A 65-Year-Old Woman With Isolated Macroglossia as the Initial Presentation of a Rare Disease

Diagnostic trajectories of patients with rare cancer in the Netherlands: results from a nationwide cross-sectional survey

The clinical actionability of genes: A concept for rare diseases and the first objective assessment for myopathies

Targeted Next-Generation Sequencing in Rare Diseases

Cystinosis metabolic bone disease: inflammatory profile in human peripheral blood mononuclear cells and derived osteoclasts

Global burden associated with rare infectious diseases of poverty in 2021: findings from the Global Burden of Disease Study 2021

The economic burden of diagnostic uncertainty on rare disease patients

Rare diseases in a medical genetics service of population with social security

Un/Diagnosed: Family Experience of Genomic Diagnoses and the Re-Making of (Rare) Disease in the UK

Management Strategy for Patients With Idiopathic Recurrent Pericarditis. Position Statement of the Experts of the Russian Society оf Cardiology and Eurasian Association of Therapists

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

PGxDB: an interactive web-platform for pharmacogenomics research

Effect of UGT1A6 and UGT2B7 polymorphisms on the valproic acid serum concentration and drug-induced liver injury

Advancing pharmacogenomics research: automated extraction of insights from PubMed using SpaCy NLP framework

Impact of genetic variants on fentanyl metabolism in major breast surgery patients: a candidate gene association study

Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy

Implementation of pharmacogenetic testing in pediatric oncology: barriers and facilitators assessment at eight Canadian academic health centres

Pharmacogenomics in 2023: Big studies, big results, big implications, big responsibilities: Editorial

NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency

Genomics and pharmacogenomics of cluster headache: implications for personalized management? A systematic review

Rifampin-like Red-brown Bronchial Secretions Staining in a Patient Treated with Cefiderocol

Deep learning for biomedical sciences and genomics

Digital image processing to detect adaptive evolution

Enhancing Gout Diagnosis with Deep Learning in Dual-energy Computed Tomography: A Retrospective Analysis of Crystal and Artifact Differentiation

Comparative Genomics and Epigenomics of Transcriptional Regulation

Bidirectional Long Short-Term Memory-Based Detection of Adverse Drug Reaction Posts Using Korean Social Networking Services Data: Deep Learning Approaches

An AI deep learning algorithm for detecting pulmonary nodules on ultra-low-dose CT in an emergency setting: a reader study

A Physically Constrained Deep-Learning Fusion Method for Estimating Surface NO(2) Concentration from Satellite and Ground Monitors

Deep Learning Applied to Diffusion-weighted Imaging for Differentiating Malignant from Benign Breast Tumors without Lesion Segmentation

Leveraging laryngograph data for robust voicing detection in speech

Deep learning enabled integration of tumor microenvironment microbial profiles and host gene expressions for interpretable survival subtyping in diverse types of cancers

Tractography-Based Automated Identification of Retinogeniculate Visual Pathway With Novel Microstructure-Informed Supervised Contrastive Learning

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

Bidirectional Long Short-Term Memory-Based Detection of Adverse Drug Reaction Posts Using Korean Social Networking Services Data: Deep Learning Approaches

Adverse Drug Reactions Among Hospitalized Psychiatric Patients, Prevalence, Severity, Preventability, and Opportunities for Intervention

Comparative efficacy and safety of eribulin versus paclitaxel in breast cancer: a systematic review and meta-analysis

First-in-human study of 99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin

Efficacy and safety of antistaphylococcal penicilin or cephazolin-based combinations versus monotherapy for methicillin-susceptible Staphylococcus aureus infective endocarditis. A propensity score analysis of nationwide prospective cohort

Characteristics of the current situation of drug use in elderly patients with chronic diseases in Chongqing: A cross-sectional survey

Unveiling the Hidden Risks: An Update Decade-Long Analysis of Abraxane-Related Adverse Events from the FAERS Database

Real-World Pharmacovigilance Study Identifies Drugs Linked to Hepatitis B Virus Reactivation

Can the integration of new rules into a clinical decision support system reduce the incidence of acute kidney injury and hyperkalemia among hospitalized older adults: a protocol for a stepped-wedge, cluster-randomized trial (DETECT-IP)

Psychotropic drug-induced adverse drug reactions in 462,661 psychiatric inpatients in relation to age: results from a German drug surveillance program from 1993-2016

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events