Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Notice of Informational Webinar for RFA-EY-25-002 Advancing Vision Health Equity through Multi-level Interventions and Community-Engaged Research (R01 - Clinical Trial Optional)

Notice of Information: Reissuance of Notices of Funding Opportunity (NOFO) Global Brain and Nervous System Disorders Research Across the Lifespan (R01, R21)

New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed)

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

VP3.15, a dual GSK-3β/PDE7 inhibitor, reduces glioblastoma tumor growth though changes in the tumor microenvironment in a PTEN wild-type context

Stearyl amine tailored spanlastics embedded within tetronic® nanogel for boosting the repurposed anticancer potential of mebendazole: formulation, in vitro profiling, cytotoxicity assessment, and in vivo permeation analysis

Network-based multi-omics integrative analysis methods in drug discovery: a systematic review

Synergistic potential of CDH3 in targeting CRC metastasis and enhancing immunotherapy

(2R,6R)-hydroxynorketamine prevents opioid abstinence-related negative affect and stress-induced reinstatement in mice

The Intersections between Neuroscience and Medulloblastoma

Formulation of repurposed celecoxib-loaded nanostructured lipid carriers using Box Behnken design, its characterization, and anticancer evaluation

An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment

Exploring therapeutic paradigm focusing on genes, proteins, and pathways to combat leprosy and tuberculosis: A network medicine and drug repurposing approach

UBC4: A Repurposed Drug Regimen for Adjunctive Use During Bladder Cancer Treatment

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

Pirfenidone in post-COVID19 pulmonary fibrosis (FIBRO-COVID): a phase 2 randomized clinical trial

Dual alphavbeta6 and alphavbeta1 Inhibition Over 12 Weeks Reduces Active Type 1 Collagen Deposition in Individuals with Idiopathic Pulmonary Fibrosis: A Phase 2, Double-Blind, Placebo-controlled Clinical Trial

Bioinformatics-based identification of mirdametinib as a potential therapeutic target for idiopathic pulmonary fibrosis associated with endoplasmic reticulum stress

Developing an IPF Prognostic Model and Screening for Key Genes Based on Cold Exposure-Related Genes Using Bioinformatics Approaches

Listening to the Patient: Holistic Assessment to Reveal and Manage Breathlessness

Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis

Telomeropathy: pretransplant and posttransplant considerations for clinicians

Lung transplantation during acute exacerbations of interstitial lung disease and post-transplant survival

Chimeric antigen receptor T-cell therapy for refractory post-transplant lymphoproliferative disorder after lung transplantation

Differential effects of donor factors on post-transplant survival in lung transplantation

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Mechanism-based approach in designing patient-specific combination therapies for nonsense mutation diseases

Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis

Contribution of post-infectious bronchiolitis obliterans to non-cystic fibrosis bronchiectasis in children

Fatty Acid Metabolism Provides an Essential Survival Signal in OxPhos and BCR DLBCL Cells

A cluster of inhibitory residues in the regulatory domain prevents activation of the cystic fibrosis transmembrane conductance regulator

Dynamic 11C-PABA PET/CT for Visualizing Pulmonary Mycobacteroides abscessus Infections

Microvesicles Derived from Human Bronchial Epithelial Cells Regulate Macrophage Activation During Mycobacterium abscessus Infection

The Role of Triple CFTR Modulator Therapy in Reducing Systemic Inflammation in Cystic Fibrosis

Correction

Mucolytics for children with chronic suppurative lung disease

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

Brain Transcriptome Changes Associated With an Acute Increase of Protein O-GlcNAcylation and Implications for Neurodegenerative Disease

Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease

The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice

Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia

Application of artificial intelligence and machine learning in drug repurposing

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

Rare subtypes of lung cancer

Application of observational research methods to real-world studies for rare disease drugs: A scoping review protocol

A single centre experience of patients with rare cancers referred for early phase clinical trials

Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes

Large Osteolipoma of the Posterior Ankle: A Rare Tumor in an Unusual Location

Tracing a Rare Genetic Disease: Familial Congenital CD59 Deficiency and Carrier Cases Identified Through Village Screening

Experience of illness with chronic singultus: a qualitative interview study

Towards a standard benchmark for phenotype-driven variant and gene prioritisation algorithms: PhEval - Phenotypic inference Evaluation framework

Trajectories of depression and anxiety in adults with rare disorders across 13 months during the COVID-19 pandemic

Zhu-Tokita-Takenouchi-Kim syndrome in a neonate

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

Authors' reply to "Comment on Chaparro-Solano et al.: 'Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease - What is missing? A systematic review'"

Single subanesthetic dose of ketamine exerts antioxidant and antidepressive-like effect in ACTH-induced preclinical model of depression

In Vitro Characterization of SLCO2B1 Genetic Variants

The Relationship of the Microbiome, Associated Metabolites and the Gut Barrier with Pancreatic Cancer

Pharmacogenomic Study of SARS-CoV-2 Treatments: Identifying Polymorphisms Associated with Treatment Response in COVID-19 Patients

Circulating microRNAs as Potential Biomarkers of Overweight and Obesity in Adults: A Narrative Review

Pharmacogenetic Factors Shaping Treatment Outcomes in Chronic Obstructive Pulmonary Disease

Oncological Treatment Adverse Reaction Prediction: Development and Initial Validation of a Pharmacogenetic Model in Non-Small-Cell Lung Cancer Patients

Translational Advances in Oncogene and Tumor-Suppressor Gene Research

Pharmacogenomics in Solid Tumors: A Comprehensive Review of Genetic Variability and Its Clinical Implications

Deep learning for biomedical sciences and genomics

A novel deep learning-based model for automated tooth detection and numbering in mixed and permanent dentition in occlusal photographs

N6-methyladenine identification using deep learning and discriminative feature integration

An integration of ensemble deep learning with hybrid optimization approaches for effective underwater object detection and classification model

Impact of optimized and conventional facility designs on outpatient abdominal MRI workflow efficiency

An ESG-ConvNeXt network for steel surface defect classification based on hybrid attention mechanism

Multimodal Deep Learning for Grading Carpal Tunnel Syndrome: A Multicenter Study in China

GPT4LFS (generative pre-trained transformer 4 omni for lumbar foramina stenosis): enhancing lumbar foraminal stenosis image classification through large multimodal models

Near-term prediction of sustained ventricular arrhythmias applying artificial intelligence to single-lead ambulatory electrocardiogram

Enhancing visual speech perception through deep automatic lipreading: A systematic review

ResTransUNet: A hybrid CNN-transformer approach for liver and tumor segmentation in CT images

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

Comparing immunopathogenesis of non-human immunodeficiency virus immune reconstitution inflammatory syndrome and immune-related adverse events: A prospective multicenter cohort study

Ketorolac in the perioperative management of acute type A aortic dissection: a randomized double-blind placebo-controlled trial

Management of fall-risk-increasing drugs in Australian aged care residents: a retrospective cross-sectional study

Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events

Advanced Cardiovascular Toxicity Screening: Integrating Human iPSC-Derived Cardiomyocytes with 2D In Silico Models

Oncological Treatment Adverse Reaction Prediction: Development and Initial Validation of a Pharmacogenetic Model in Non-Small-Cell Lung Cancer Patients

Pharmacogenetics and adverse drug reports: Insights from a United Kingdom national pharmacovigilance database

Late-Onset Immune-Related Adverse Events After Immune Checkpoint Inhibitor Therapy

Transarterial Chemoembolization with BioPearls for the Treatment of Hepatocellular Carcinoma: A Preliminary Experience

A phase Ia study of the MEK1/2 inhibitor PD-0325901 with the c-MET inhibitor crizotinib in patients with advanced solid cancers

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events