Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Source: https://grants.nih.gov/grants/guide/newsfeed/fundingopps.xml

Request for Information (RFI) on the Need to Expand Epidemiological Research at NIAMS

Notice of Announcement of the NCATS Rare Diseases Are Not Rare! 2025 Challenge Prize Competition

Request for Information: Extending the Response Date for Inviting Feedback on the Proposed NIH Research Plan on Rehabilitation Scientific Themes FY26-FY30

Reminder: Unauthorized Use of Credentials is Prohibited

Request for Information on Maximizing Research Funds by Limiting Allowable Publishing Costs

Notice of NICHD Participation in PAR-25-442, "Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)"

The NIH RECOVER Program Announces Plan to Request Ancillary Studies

Request for Information: Inviting Feedback on the Proposed NIH Research Plan on Rehabilitation Scientific Themes FY26-FY30

Findings of Research Misconduct - Liping Zhang

Extension of Deadline for Submitting a Response to NOT-CA-25-037, Request for Information (RFI): Benchmarks for Artificial Intelligence in Cancer Research and Care

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

Low-dose methotrexate as a potential treatment for schizophrenia via astrocytic and neuroimmune modulation

Identify new pseudogene RPL7P1-oriented network as a drug target against infections pre-existing diabetes

Insights into Caspase-6 Mutations and Neuropathology in Huntington's Disease and Psychiatric Disorders: A Structural Genomics and Drug Repurposing Approach

Construction of the Veterinary DrugBank and Drug Repurposing

Antibacterial activity of diazepam against planktonic and biofilm strains of methicillin-resistant Staphylococcus aureus

Predicting disease-overarching therapeutic approaches for congenital disorders of glycosylation using multi-OMICS

Shifting Paradigms: Imidocarb dipropionate as an alternative chemotherapeutic strategy for Trypanosoma evansi infection in animals

A controlled comparative study of the effects of methotrexate and pharmacogenetic factors on arterial blood pressure and arterial stiffness in patients with rheumatoid arthritis

Trigeminal nerve-driven neurogenic inflammation linking migraine to glioblastoma invasion: a literature review

Integrated multi-omics and machine learning reveal an immunogenic cell death-related signature for prognostic stratification and therapeutic optimization in colorectal cancer

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

Ability of patient-reported outcomes to predict progression-free survival in patients with mild to moderate fibrosing interstitial lung disease

LPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities

The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications

The mechanism of plasma exosome miR-15a-5p targeting the CF-modified protein IGF1R to regulate alveolar epithelial autophagy and influence pulmonary interstitial fibrosis

Radiation-induced Lung Injury (RILI) in Non-human Primates (NHPs) Induces Cellular Senescence and Upregulation of Tyrosine Kinase Fgr, which is Detectable in Bronchoalveolar Lavage

Prognostication in patients with idiopathic pulmonary fibrosis using quantitative airway analysis from HRCT: a retrospective study

Comprehensive analysis of molecular characteristic and clinical prognosis of CD8+ T cell related genes in idiopathic pulmonary fibrosis

Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions

Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis

Rational design and identification of potent imidazole-fused Autotaxin inhibitors for treatment of idiopathic pulmonary fibrosis

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Patients With Cystic Fibrosis Undergoing Posterior Lumbar Fusion Are at an Increased Odds of Perioperative Complications

The cystic fibrosis pathogen Achromobacter xylosoxidans inhibits biofilm formation of Pseudomonas aeruginosa

From pancreatitis to Puestow: The winding path of cystic fibrosis

Nontuberculous mycobacteria remodel lung microbiota in cystic fibrosis-associated respiratory infections

Clinical Practice Guideline: Adult Sinusitis Update

Executive Summary of the Clinical Practice Guideline on Adult Sinusitis Update

Isolation and Culture of Ferret Airway Stem Cells

Mapping the oxidative landscape in cystic fibrosis: methodological frontiers and application

Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions

Shallow metagenomic shotgun sequencing improves detection of pathogenic species in cystic fibrosis respiratory samples

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

Differential Expression and Microsystem Physiology Reveal Predominant and Drug Reversible CFTR-Related Defects in Idiopathic Pancreatitis

Wilms' tumor 1 impairs apoptotic clearance of fibroblasts in distal fibrotic lung lesions

Brain Transcriptome Changes Associated With an Acute Increase of Protein O-GlcNAcylation and Implications for Neurodegenerative Disease

Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease

The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice

Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia

Application of artificial intelligence and machine learning in drug repurposing

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score

Multiomics analysis reveals the genetic and epigenetic features of high-risk NK cell-type chronic active EBV infection

Correction: Szebeni, J. Expanded Spectrum and Increased Incidence of Adverse Events Linked to COVID-19 Genetic Vaccines: New Concepts on Prophylactic Immuno-Gene Therapy, Iatrogenic Orphan Disease, and Platform-Inherent Challenges. Pharmaceutics 2025,...

Quality of life among children and young adults with rare diseases. A parental perspective

The rare disease burden: a multidimensional challenge

Proactive identification of rare diseases: lessons from hereditary angioedema diagnosis using electronic medical records

"I can't enjoy my full sex life": Understanding the sexual experiences of women with interstitial cystitis

Supporting Participant Engagement in Cancer Genomics Research in Rare Cancers: A Qualitative Study of Patients, Caregivers, and Advocates

Global partnerships in rare disease research

Nanovesicular Drug Delivery Systems for Rare Ocular Diseases: Advances, Challenges, and Future Directions

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

Pharmacogenomic insights into amlodipine response: the role of CACNA1D, CACNA1C, and TRIB3 variants in hypertensive patients

Predicting nifedipine responses in preterm labor: a risk score incorporating ABCG2 polymorphisms and clinical factors

Nationwide Phenotypic and Genotypic Characterisation of 103 Patients With SH3TC2 Gene-Related Demyelinating Peripheral Neuropathy

Mitochondrial targeting and anticancer cell killing by arylurea-fatty acids containing in-chain sulfur atoms

A GWAS Meta-meta-analysis and In-depth Silico Pharmacogenomic Investigations in Identification of APOE and Other Genes Associated with Pain, Anti-inflammatory, and Immunomodulating Agents in Opioid Use Disorder (OUD) Derived from 14.91 M Subjects

A controlled comparative study of the effects of methotrexate and pharmacogenetic factors on arterial blood pressure and arterial stiffness in patients with rheumatoid arthritis

Clinical and cost-effectiveness of pharmacogenomic testing for anthracycline-induced cardiotoxicity in childhood cancer: a systematic review and meta-analysis

Optimizing perimenopausal mental health by integrating precision biomarkers, digital health interventions, and psychosocial care

Potential causal link between antiseizure medication targets and cognitive function: A mendelian randomization study

Population pharmacokinetics of levofloxacin in drug-susceptible and drug-resistant tuberculosis patients: Optimal dose suggestion based on renal function

Deep learning for biomedical sciences and genomics

Accelerating cardiac radial-MRI: Fully polar based technique using compressed sensing and deep learning

Multi-Faceted Consistency learning with active cross-labeling for barely-supervised 3D medical image segmentation

A dual-view deep learning-driven discovery of cinnamoyl anthranilic acid derivatives against orthopoxvirus through targeting host ITGB3

A comparative study of machine learning models for automated detection and classification of retinal diseases in Ghana

Combinatorial Tuning of 5'UTR and N-Terminal Coding Sequences for Enhanced Recombinant Protein Expression in Corynebacterium glutamicum

LTR-Net: A deep learning-based approach for financial data prediction and risk evaluation in enterprises

Temporal and Heterogeneous Graph Neural Network for Remaining Useful Life Prediction

Leveraging Large Language Models for Personalized Parkinson's Disease Treatment

Geometric Deep Learning for Protein-Ligand Affinity Prediction with Hybrid Message Passing Strategies

ChemFixer: Correcting Invalid Molecules to Unlock Previously Unseen Chemical Space

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

Visualization of FDA Adverse Drug Reaction Reports: Development and Usability Study of the VisDrugs Web Server

Tibremciclib or Placebo Plus Fulvestrant in Hormone Receptor-Positive and ERBB2-Negative Advanced Breast Cancer After Endocrine Therapy: A Randomized Clinical Trial

A Case Report of Clozapine-Induced Cardiomyopathy

The impact of rifampin on the efficacy of implant retention and prosthesis removal in staphylococcal periprosthetic joint infection

The need for guardrails with large language models in pharmacovigilance and other medical safety critical settings

Drug-Induced Retinal Toxicity

Artificial intelligence in pharmacovigilance: a narrative review and practical experience with an expert-defined Bayesian network tool

The role of lenvatinib in different types of thyroid cancer

Rapid intravenous symptom-inhibiting fentanyl induction (SIFI) to optimize rotation onto oral opioid agonist therapy among individuals who use unregulated fentanyl: protocol for an open-label, single arm clinical trial

Assessing the Impact of Pharmacists' Interventions on Preventing and Resolving Drug-Related Problems in Cancer Pain Management

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events