Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Source: https://grants.nih.gov/grants/guide/newsfeed/fundingopps.xml

Redesigned NIH Grants and Funding Website to Launch on September 24, 2024

Notice to Extend Expiration Dates for PA-22-175 Competitive Revision Supplements to Existing AHRQ Grants and Cooperative Agreements to Enhance Workforce Diversity in Health Services Research

Notice of Intent to Publish a Notice of Funding Opportunity for Social Determinants of Health (SDoH) and Quality of Care Contributors to Cancer Disparities in People with HIV (U01; Clinical Trial Optional)

Notice of Pre-Application Webinar for Ethical, Legal, and Social Implications (ELSI) Congress (U13, Clinical Trials Not Allowed)

Notice of Intent to Publish a Funding Opportunity Announcement for NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)

Notice of Intent to Publish a Funding Opportunity Announcement for NHLBI SBIR Phase IIB Small Market Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)

Coordinating Center to Support Consortium for Neuroscience Alzheimers Disease (AD) and AD-Related Dementias (ADRD) Research in Low- and Middle-Income Countries (LMICs) (U24 Clinical Trial Not Allowed)

Notice of Intent to Publish a Funding Opportunity Announcement for Precision Medicine for Type 1 Diabetic Nephropathy (U01 Clinical Trial Not Allowed)

Urology Centers Program Interactions Core (U24 Clinical Trial Not Allowed)

Notice of Special Interest (NOSI): Career Development Opportunities for Research on Cancer in Global Settings at the Center for Global Health at the National Cancer Institute

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

Identification of macrophage driver genes in fibrosis caused by different heart diseases based on omics integration

Identification of novel anti-leishmanials targeting glutathione synthetase of the parasite: a drug repurposing approach

Unlocking the potential of signature-based drug repurposing for anticancer drug discovery

An exploration into CTEPH medications: Combining natural language processing, embedding learning, in vitro models, and real-world evidence for drug repurposing

Antivirals for monkeypox virus: Proposing an effective machine/deep learning framework

Identifying genetically-supported drug repurposing targets for non-small cell lung cancer through mendelian randomization of the druggable genome

Understanding innate and adaptive responses during radiation combined burn injuries

Developing neuro-oncology clinical trials in low- and middle-income countries: a scoping review of the current literature

Calculating the similarity between prescriptions to find their new indications based on graph neural network

In silico comparative analysis of cestode and human NPC1 provides insights for ezetimibe repurposing to visceral cestodiases treatment

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

Causal relationship between serum metabolites and idiopathic pulmonary fibrosis: Insights from a two-sample Mendelian randomization study

IL6 receptor inhibitors: exploring the therapeutic potential across multiple diseases through drug target Mendelian randomization

The association between testosterone, estradiol, estrogen sulfotransferase and idiopathic pulmonary fibrosis: a bidirectional mendelian randomization study

Pathological features of connective tissue disease-associated interstitial lung disease in transbronchial cryobiopsies

Targeting AnxA2-EGFR signaling: hydroxychloroquine as a therapeutic strategy for bleomycin-induced pulmonary fibrosis

Inhalable drug-loaded silk fibroin carriers for pulmonary drug delivery

Impact of the coronavirus disease 2019 pandemic on hospital admissions for idiopathic pulmonary fibrosis: a nationwide population-based study

"Lipid Nanoparticles for Pulmonary Fibrosis: A Comprehensive Review"

Potential of phosphodiesterase 4B inhibitors in the treatment of interstitial lung disease associated with autoimmune diseases

The transcriptome of CD14 (+) CD163 (-) HLA-DR (low) monocytes predicts mortality in Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Correction: Trends in hospitalizations of children with respiratory syncytial virus aged less than 1 year in Italy, from 2015 to 2019

Impact of the expanded label for elexacaftor-tezacaftor-ivacaftor in people with cystic fibrosis with no F508del variant in the United States

Chaperoning system: Intriguing target to modulate the expression of CFTR in cystic fibrosis

Recent Advances in Therapeutics and Manufacturing Processes of Recombinant Adeno-Associated Virus for the Treatment of Lung Diseases

Activity of antibiotics against Burkholderia cepacia complex in artificial sputum medium

Phosphatidylserine liposomes induce a phagosome acidification-dependent and ROS-mediated intracellular killing of Mycobacterium abscessus in human macrophages

Assessment of patients' baseline cystic fibrosis knowledge levels following translation and adaptation of the CF R.I.S.E translation program into Turkish

Lung ultrasound in children with primary ciliary dyskinesia or cystic fibrosis

Longitudinal Changes in Bone Mineral Density in Adults with Cystic Fibrosis

Evaluating precision medicine tools in cystic fibrosis for racial and ethnic fairness

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice

Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia

Application of artificial intelligence and machine learning in drug repurposing

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

Commentary: Which Principles Should Apply for a National Strategy on Rare Diseases?

Federal Funding for Expensive Drugs for Rare Diseases: How Do We Pick and Choose?

If You Build It, Patients with Rare Cancers Will Come: A Successful Clinical Trial in Relapsed and Refractory JMML

Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication

Experiences of quality of life and access to health services among rare disease caregivers: a scoping review

Rare diseases: a challenge in paediatric dentistry

A Genotype/Phenotype Study of KDM5B-Associated Disorders Suggests a Pathogenic Effect of Dominantly Inherited Missense Variants

Wolfram Syndrome 1: A Neuropsychiatric Perspective on a Rare Disease

Bacterial Production of CDKL5 Catalytic Domain: Insights in Aggregation, Internal Translation and Phosphorylation Patterns

Patterns of the Health and Economic Burden of 33 Rare Diseases in China: Nationwide Web-Based Study

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

Review of pharmacogenetics of antiseizure medications: focusing on genetic variants of mechanistic targets

In vitro assessment of the risk of ABCB1-mediated drug-drug interaction between rivaroxaban and tacrolimus in human embryonic kidney 293 recombinant cell lines

Editorial: Utilization of pharmacogenomics in clinical practice

Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency

Implementation of a pharmacist-guided pharmacogenomics dosing service at a rural NCI-designated comprehensive cancer center

An inherited genetic variant of the CEP72 gene is associated with the development of vincristine-induced peripheral neuropathy in female patients with aggressive B-cell lymphoma

Pharmacogenomics Clinical Decision Support Systems

Pharmacogenomic Analysis of Response to Topical Tumor Necrosis Factor alpha Antagonist Licaminlimab (OCS-02) in Dry Eye Disease: Retraction

Challenging pharmacotherapy management of a psychotic disorder due to a delicate pharmacogenetic profile and drug-drug interactions: a case report and literature review

Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals

Deep learning for biomedical sciences and genomics

GRABSEEDS: extraction of plant organ traits through image analysis

Mild cognitive impairment prediction based on multi-stream convolutional neural networks

Deep Learning for Automated Classification of Hip Hardware on Radiographs

Convolutional Neural Networks for Segmentation of Pleural Mesothelioma: Analysis of Probability Map Thresholds (CALGB 30901, Alliance)

Training and validation of a deep learning U-net architecture general model for automated segmentation of inner ear from CT

Predicting multiple sclerosis disease progression and outcomes with machine learning and MRI-based biomarkers: a review

An open-source framework for end-to-end analysis of electronic health record data

Inferring gene regulatory networks with graph convolutional network based on causal feature reconstruction

Heat wave attribution assessment using deep learning

An attentional mechanism model for segmenting multiple lesion regions in the diabetic retina

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

Clinical guidance for cannabidiol-associated hepatotoxicity: A narrative review

Reimagining the ADR Alert Card: a novel approach to recurrence prevention in low-cost settings for adverse drug reactions

Clozapine may consistently protect from suicidal behaviors while other antipsychotics may lack a specific protective effect: a comprehensive VigiBase study interpreted in the context of the prior literature

A Case of Severe Thrombocytopenia, Aseptic Meningitis, and Hepatitis Caused by Trimethoprim-Sulfamethoxazole: A Triple Threat

Long-term efficacy, safety, and tolerability, including behavior and executive functioning, during adjunctive lacosamide treatment in pediatric patients with uncontrolled epilepsy

Public perspective on potential treatment intervention harm in clinical trials-terminology and communication

Efficacy and safety analysis of AKT inhibitor in triple-negative breast cancer: A meta-analysis and systematic review

Quantitative Measurement of the Direct Public Health Impact of Medicines Withdrawals in Europe: Development of a Modelling Method and Proof-of-Concept Study to Estimate the Morbidity and Mortality Prevented by Regulatory Action

Estimating Adverse Events Associated With Herbal Medicines Using Pharmacovigilance Databases: Systematic Review and Meta-Analysis

Insights into hospitalization pattern for drug, medicament, and biological substance poisoning, adverse effect, and underdosing in Australia: An ecological study between 1998 and 2019

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events