Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Source: https://grants.nih.gov/grants/guide/newsfeed/fundingopps.xml

NINDS Policy for applications requesting $500,000 or more in direct costs in any year (excluding consortium F and A)on NIH Parent R01 Notices of Funding Opportunities

NHLBI Outstanding Investigator Award (OIA) (R35 Clinical Trial Optional)

NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)

Coordinating Center for Type 1 Diabetes TrialNet (U01 Clinical Trial Required)

NIDCD Individual Fellowship Pre-Application Information Session

Notice of Special Interest (NOSI): Administrative Supplement to Support the NCI Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Research

Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Required)

Independent Scientist Award (Parent K02 Independent Basic Experimental Studies with Humans Required)

Independent Scientist Award (Parent K02 - Independent Clinical Trial Required)

Notice of Budget Change in RFA-AI-24-006 Centers for Research in Emerging Infectious Diseases (CREID) Network (U01 Clinical Trial Not Allowed)

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

Cryptosporidium life cycle small molecule probing implicates translational repression and an Apetala 2 transcription factor in macrogamont differentiation

Fusobacterium nucleatum: An Overview of Evidence, Demi-Decadal Trends, and Its Role in Adverse Pregnancy Outcomes and Various Gynecological Diseases, including Cancers

Modular Hub Genes in DNA Microarray Suggest Potential Signaling Pathway Interconnectivity in Various Glioma Grades

Cancer nutritional-immunotherapy with NIR-II laser-controlled ATP release based on material repurposing strategy

Erratum: Publisher Correction: Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis

LIFU/MMP-2 dual-responsive release of repurposed drug disulfiram from nanodroplets for inhibiting vasculogenic mimicry and lung metastasis in triple-negative breast cancer

Minocycline and photodynamic priming significantly improve chemotherapy efficacy in heterotypic spheroids of pancreatic ductal adenocarcinoma

An Extensive Review on Lung Cancer Therapeutics Using Machine Learning Techniques: State-of-the-art and Perspectives

Montelukast as a repurposable additive drug for standard-efficacy multiple sclerosis treatment: Emulating clinical trials with retrospective administrative health claims data

Mendelian randomization analysis identifies druggable genes and drugs repurposing for chronic obstructive pulmonary disease

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

lncRNA-mRNA Co-Expression and Regulation Analysis in Lung Fibroblasts from Idiopathic Pulmonary Fibrosis

A Machine Learning System to Indicate Diagnosis of Idiopathic Pulmonary Fibrosis Non-Invasively in Challenging Cases

Smoking and idiopathic pulmonary fibrosis: A meta-analysis

A preoperative use of manual therapy in a patient with idiopathic pulmonary fibrosis awaiting lung transplant: a case report

Protection of Qingfei Xieding prescription from idiopathic pulmonary fibrosis by regulating renin-angiotensin and ferroptosis in MLE-12 cells

O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis

A Rare Case of Idiopathic Pleuro-Parenchymal Fibroelastosis Presenting With Bilateral Spontaneous Pneumothoraces

Antifibrotic treatment adherence, efficacy and outcomes for patients with idiopathic pulmonary fibrosis in Spain: a real-world evidence study

Body weight loss is a simple and useful indicator of prognosis and predictive tolerability in the first year of nintedanib therapy in patients with interstitial lung disease

A protective role for B-1 cells and oxidation-specific epitope IgM in lung fibrosis

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Five-Year Outcomes Among U.S. Bronchiectasis and Nontuberculous Mycobacterial Registry Patients

Evolution of Resistance against Ciprofloxacin, Tobramycin, and Trimethoprim/Sulfamethoxazole in the Environmental Opportunistic Pathogen Stenotrophomonas maltophilia

Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transporters

Presentation, characteristics and management of obstructive intestinal conditions in cystic fibrosis

Pancreatic enzymes digest obstructive meconium from cystic fibrosis pig intestines

Evolution of nutritional management in children with cystic fibrosis - a narrative review

In vitro platform to model the function of ionocytes in the human airway epithelium

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules

Mutational spectrum of CFTR in cystic fibrosis patients with gastrointestinal and hepatobiliary manifestations

The Impact of Transmissible Microbes: How the Cystic Fibrosis Community Mobilized Against Cepacia

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells

Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn disease, and celiac disease

Relationships between gene expression and behavior in mice in response to systemic modulation of the O-GlcNAcylation pathway

A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

Real-world evidence on tagraxofusp for blastic plasmacytoid dendritic cell neoplasm - collected cases from a single center and case reports

Cannabidiol attenuates seizure susceptibility and behavioural deficits in adult CDKL5R59X knock-in mice

Between hope and reality: treatment of genetic diseases through nucleic acid-based drugs

De novo variants in the non-coding spliceosomal snRNA gene RNU4-2 are a frequent cause of syndromic neurodevelopmental disorders

The value of knowing: preferences for genetic testing to diagnose rare muscle diseases

Is Glaucoma a Two-Pressure-Related Optic Neuropathy? A Systematic Review and Meta-Analysis

Patient preferences in genetic newborn screening for rare diseases: study protocol

A quantitative and qualitative analysis of patient group narratives suggests common biopsychosocial red flags of undiagnosed rare disease

Improving access to gene therapy for rare diseases

Bioinformatics pipeline for the systematic mining genomic and proteomic variation linked to rare diseases: The example of monogenic diabetes

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths

Standard Operating Procedure to Optimize Resazurin-Based Viability Assays

Pharmacogenetic variability of tuberculosis biomarkers in native and mestizo Peruvian populations

Do future healthcare professionals advocate for pharmacogenomics? A study on medical and health sciences undergraduate students

Common P-glycoprotein (ABCB1) polymorphisms do not seem to be associated with the risk of rivaroxaban-related bleeding events: Preliminary data

Improving olaparib exposure to optimize adverse effects management

Abemaciclib pharmacology and interactions in the treatment of HR+/HER2- breast cancer: a critical review

Tumour organoids and assembloids: Patient-derived cancer avatars for immunotherapy

PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug-drug interactions with clarithromycin and paroxetine

Mitochondrial calcium uniporter as biomarker and therapeutic target for breast cancer: Prognostication, immune microenvironment, epigenetic regulation and precision medicine

Deep learning for biomedical sciences and genomics

Deep learning for low-data drug discovery: Hurdles and opportunities

Brain tumor detection using proper orthogonal decomposition integrated with deep learning networks

Dense Sample Deep Learning

Feature shared multi-decoder network using complementary learning for Photon counting CT ring artifact suppression

Deep learning-based anatomical position recognition for gastroscopic examination

Clinical VMAT machine parameter optimization for localized prostate cancer using deep reinforcement learning

Real-time 3D tracking of swimming microbes using digital holographic microscopy and deep learning

Understanding Double Descent Using VC-Theoretical Framework

Classification of the quality of canine and feline ventrodorsal and dorsoventral thoracic radiographs through machine learning

3D auto-segmentation of biliary structure of living liver donors using magnetic resonance cholangiopancreatography for enhanced preoperative planning

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

Medication safety in the perioperative setting: A comparison of methods for detecting medication errors and adverse medication events: Erratum

A qualitative study on determinants of the use of malaria rapid diagnostic test and anti-malarial drug prescription practices by primary healthcare workers in Ebonyi state, Nigeria

Bimekizumab in psoriasis: a monocentric study evaluating short- and mid-term effectiveness and safety profile in a real-world setting

Glomerulonephritis after Alemtuzumab Treatment for Multiple Sclerosis: A Report of Two Cases

Efficacy and safety of pelvic floor magnetic stimulation combined with mirabegron in female patients with refractory overactive bladder: a prospective study

A multicenter, open-label long-term safety study of rimegepant for the acute treatment of migraine

Safety, Tolerability, and Pharmacokinetics of Oral BI 1358894 in Healthy Japanese Male Volunteers

Phase 1 study of safety and tolerability of an oral contraceptive containing low-dose ethinyl oestradiol combined with glecaprevir/pibrentasvir treatment in healthy premenopausal women

Pharmacotherapy considerations for patients who develop acute kidney injury during cancer therapy

Case report: A rare immune-related adverse effect: hepatic cavernous hemangioma induced by camrelizumab

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events