NIH Funding Opportunities (Notices, PA, RFA)

Weekly Funding Opportunities and Policy Notices from the National Institutes of Health.
Updated: 1 hour 57 min ago
Notice of NIMHD Participation in PA-25-306, NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)
Notice NOT-MD-25-009 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
Notice of NIMHD Participation in PA-25-304, NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)
Notice NOT-MD-25-010 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
Single Source: National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-26-002 from the NIH Guide for Grants and Contracts. This is a non-competitive funding opportunity intended to fund a single award. The National Institute on Aging is announcing its intent to issue a single source cooperative agreement award to Indiana University Indianapolis for the National Centralized Repository for Alzheimer's Disease and Related Dementias.
Categories: Job Watch, Literature Watch
Notice of Correction to Key Dates in PAR-25-416 "NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed)"
Notice NOT-GM-25-020 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional)
Funding Opportunity RFA-OD-25-008 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) aims to support new biomedical, behavioral, and social science investigators who are in the early stages of establishing independent careers in tobacco regulatory research. The R03 grant mechanism supports different types of projects, including pilot and feasibility studies, secondary analysis of existing data, small, self-contained research projects, development of research methodology, and development of new research technology. Applicants are encouraged to conduct projects that ultimately have the potential to inform regulations on tobacco product manufacturing, distribution, and marketing. Research projects must address one or more High-Priority Research Topic(s) related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as mandated by the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31. The awards under this NOFO will be administered by NIH using funds made available through FDA CTP and the FSPTCA. Research results from this NOFO are expected to generate findings and data directly relevant to informing the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.
Categories: Job Watch, Literature Watch
Notice of Participation of the National Institute of Dental and Craniofacial Research (NIDCR) in PA-23-317, Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)
Notice NOT-DE-26-002 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
NIH Announces the Open Period of FY 2026 Helium-3 Requests for Medical Research
Notice NOT-HL-25-028 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
Environmental influences on Child Health Outcomes (ECHO) Cohort Data and Biospecimen Access (X01 Clinical Trial Not Allowed)
Funding Opportunity PAR-25-437 from the NIH Guide for Grants and Contracts. The purpose of this Program Announcement with Special Receipt, Referral, and/or Review Considerations (PAR) is to solicit applications to access limited identifiable data or biospecimens from the ECHO Cohort to study high-priority areas of maternal and child health.
Categories: Job Watch, Literature Watch
Implementation Update: Terminating or Suspending Dangerous Gain-of-Function Research in Accordance with the Executive Order on Improving the Safety and Security of Biological Research
Notice NOT-OD-25-127 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
Notice of Research Opportunity Announcement (ROA) Publication for the East Palestine, Ohio Train Derailment Study
Notice NOT-ES-25-005 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
Notice of NIMH Participation in PA-25-422, Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)
Notice NOT-MH-25-215 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
Notice of Change to the Instructions for Purpose and Scope in PAR-24-167 "Utilizing Equipment to Study Environmental Extrinsic Factors and Enhance Rigor and Reproducibility of Animal Research (R24, Clinical Trials Not-Allowed)"
Notice NOT-OD-25-125 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)
Funding Opportunity PAR-25-383 from the NIH Guide for Grants and Contracts. The purpose of this announcement is to encourage investigators to pursue translational activities and clinical feasibility studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent clinical feasibility study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress. Participants in Blueprint MedTech receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants to receive assistance with specialty areas including regulatory, reimbursement, intellectual property, commercialization, and strategic partnerships. Participants can also augment their project with NIH contract research organizations that specialize in large animal testing, sterilization testing, biocompatibility assessment, manufacturing, and medical monitoring. Individuals, institutions, or businesses developing their own devices or that already have established collaborations with device manufacturers are welcome to apply directly to this NOFO or any of the companion opportunities. For more information see BP MedTech website.
Categories: Job Watch, Literature Watch
Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)
Funding Opportunity PAR-25-442 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes.
Categories: Job Watch, Literature Watch
NOTICE OF CORRECTION: Eligible Individuals, Ruth L. Kirschstein Research Service Award (NRSA) Fellowships
Notice NOT-OD-25-126 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
Notice of Change to Application Due Dates for PAR-25-438, "Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)"
Notice NOT-TR-25-010 from the NIH Guide for Grants and Contracts
Categories: Job Watch, Literature Watch
National Alzheimers Coordinating Center (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-26-003 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for a National Alzheimer's Coordinating Center (NACC) whose purpose is to serve NIA and the Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) field as: 1) A national data resource, collecting data from the Alzheimer's Disease Research Centers (ADRCs), affiliated data, and sample repositories; 2) A facilitator of current and future AD/ADRD research; and 3) The central hub for organizing and enabling communication within and outside the ADRC program, including annual meetings and steering committees.
Categories: Job Watch, Literature Watch
NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)
Funding Opportunity PAR-25-333 from the NIH Guide for Grants and Contracts. The purpose of the NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00) program is to develop and maintain a strong cohort of independently funded dentist scientists dedicated to improving dental, oral and craniofacial health. This program is designed to facilitate a timely transition of outstanding dual degree dentist scientists from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions by providing support for two years of mentored training and three to five years of independent research. An option for five years of independent (R00) support is available to accommodate clinical training in a dental specialty program at no more than 3 person-months effort (25% full-time professional effort) in any year of the R00 phase.
Categories: Job Watch, Literature Watch
Limited Competition: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UH3 Clinical Trial Optional)
Funding Opportunity RFA-AR-25-014 from the NIH Guide for Grants and Contracts. Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UH3 Clinical Trial Required)
Categories: Job Watch, Literature Watch
Limited Competition: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Studies (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-AR-25-013 from the NIH Guide for Grants and Contracts. Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Studies (U01 Clinical Trial Not Allowed)
Categories: Job Watch, Literature Watch