Drug-induced Adverse Events
Safety warning: combination products containing codeine and ibuprofen
Drug Ther Bull. 2022 Dec 23:dtb-2022-000075. doi: 10.1136/dtb.2022.000075. Online ahead of print.
ABSTRACT
Overview of: European Medicines Agency Pharmacovigilance Risk Assessment Committee. Codeine with ibuprofen: PRAC adds warning for serious renal and gastrointestinal harms. September 2022.
PMID:36564156 | DOI:10.1136/dtb.2022.000075
Polymorphisms in drug metabolism genes as a risk factor for first-line anti-tuberculosis drug-induced liver injury
Mol Biol Rep. 2022 Dec 23. doi: 10.1007/s11033-022-08158-7. Online ahead of print.
ABSTRACT
BACKGROUND: Anti-tuberculosis drug-induced liver injury (AT-DILI) is one of the most common side effects in TB patients during treatment. The prime cause of liver injury during TB treatment is reported to be isoniazid and its metabolites. Different factors influenced the development of AT-DILI, and genetic factors are one of the major factors.
METHODS AND RESULTS: Polymorphisms in drug metabolism genes like NAT2, CYP2E1, PXR, and GST have been reported to be associated with AT-DILI, and they are one of the major areas of focus at present. Attempts are met in this review to analyse the different markers in these drug metabolism genes for their association with AT-DILI.
CONCLUSION: A better understanding of the polymorphisms in these genes and their functional effects will give better insights into the development of AT-DILI, and it could facilitate in designing and developing more effective personalized treatment for TB.
PMID:36562936 | DOI:10.1007/s11033-022-08158-7
Side Effects of COVID-19 Vaccines Primer Doses: Experience of Saudi Healthcare Workers Participating in CoVaST-SA
Vaccines (Basel). 2022 Dec 13;10(12):2137. doi: 10.3390/vaccines10122137.
NO ABSTRACT
PMID:36560547 | DOI:10.3390/vaccines10122137
Doxorubicin-Induced Platelet Activation and Clearance Relieved by Salvianolic Acid Compound: Novel Mechanism and Potential Therapy for Chemotherapy-Associated Thrombosis and Thrombocytopenia
Pharmaceuticals (Basel). 2022 Nov 22;15(12):1444. doi: 10.3390/ph15121444.
NO ABSTRACT
PMID:36558895 | DOI:10.3390/ph15121444
Drug-Induced Liver Injury in Hospitalized Patients during SARS-CoV-2 Infection
Medicina (Kaunas). 2022 Dec 15;58(12):1848. doi: 10.3390/medicina58121848.
NO ABSTRACT
PMID:36557050 | DOI:10.3390/medicina58121848
Ileal Bile Acid Transporter Blockers for Cholestatic Liver Disease in Pediatric Patients with Alagille Syndrome: A Systematic Review and Meta-Analysis
J Clin Med. 2022 Dec 19;11(24):7526. doi: 10.3390/jcm11247526.
NO ABSTRACT
PMID:36556142 | DOI:10.3390/jcm11247526
Local Tranexamic Acid for Preventing Hemorrhage in Anticoagulated Patients Undergoing Dental and Minor Oral Procedures: A Systematic Review and Meta-Analysis
Healthcare (Basel). 2022 Dec 13;10(12):2523. doi: 10.3390/healthcare10122523.
NO ABSTRACT
PMID:36554047 | DOI:10.3390/healthcare10122523
Renal manifestations of recreational drugs: A narrative review of the literature
Medicine (Baltimore). 2022 Dec 16;101(50):e31888. doi: 10.1097/MD.0000000000031888.
NO ABSTRACT
PMID:36550840 | DOI:10.1097/MD.0000000000031888
LiSA: an assisted literature search pipeline for detecting serious adverse drug events with deep learning
BMC Med Inform Decis Mak. 2022 Dec 22;22(1):338. doi: 10.1186/s12911-022-02085-0.
ABSTRACT
INTRODUCTION: Detecting safety signals attributed to a drug in scientific literature is a fundamental issue in pharmacovigilance. The constant increase in the volume of publications requires the automation of this tedious task, in order to find and extract relevant articles from the pack. This task is critical, as serious Adverse Drug Reactions (ADRs) still account for a large number of hospital admissions each year.
OBJECTIVES: The aim of this study is to develop an augmented intelligence methodology for automatically identifying relevant publications mentioning an established link between a Drug and a Serious Adverse Event, according to the European Medicines Agency (EMA) definition of seriousness.
METHODS: The proposed pipeline, called LiSA (for Literature Search Application), is based on three independent deep learning models supporting a precise detection of safety signals in the biomedical literature. By combining a Bidirectional Encoder Representations from Transformers (BERT) algorithms and a modular architecture, the pipeline achieves a precision of 0.81 and a recall of 0.89 at sentences level in articles extracted from PubMed (either abstract or full-text). We also measured that by using LiSA, a medical reviewer increases by a factor of 2.5 the number of relevant documents it can collect and evaluate compared to a simple keyword search. In the interest of re-usability, emphasis was placed on building a modular pipeline allowing the insertion of other NLP modules to enrich the results provided by the system, and extend it to other use cases. In addition, a lightweight visualization tool was developed to analyze and monitor safety signal results.
CONCLUSIONS: Overall, the generic pipeline and the visualization tool proposed in this article allows for efficient and accurate monitoring of serious adverse drug reactions from the literature and can easily be adapted to similar pharmacovigilance use cases. To facilitate reproducibility and benefit other research studies, we also shared a first benchmark dataset for Serious Adverse Drug Events detection.
PMID:36550485 | PMC:PMC9773506 | DOI:10.1186/s12911-022-02085-0
Levofloxacin-associated transient mixed sensorimotor lacunar syndrome
BMJ Case Rep. 2022 Dec 22;15(12):e252052. doi: 10.1136/bcr-2022-252052.
ABSTRACT
Fluoroquinolones are commonly used antimicrobials with multiple known adverse effects, yet overdose events are rarely reported. Here, we report a case of a previously healthy middle-aged woman who unintentionally ingested 7 g of levofloxacin in one dose. Thereafter, she presented to the emergency department with hemiparesis concerning for ischaemic stroke and was administered tissue plasminogen activator. Her brain imaging showed no ischaemic injury and her symptoms resolved within 24 hours; this is consistent with a transient ischaemic attack. Our case highlights potential adverse effects of an acute overdose of levofloxacin that has not previously been well described.
PMID:36549757 | DOI:10.1136/bcr-2022-252052
Metabolic adverse events associated with systemic corticosteroid therapy-a systematic review and meta-analysis
BMJ Open. 2022 Dec 22;12(12):e061476. doi: 10.1136/bmjopen-2022-061476.
ABSTRACT
OBJECTIVES: To assess the risk of new-onset or worsening hyperglycaemia, hypertension, weight gain and hyperlipidaemia with systemic corticosteroid therapy (CST) as reported in published randomised control trial (RCT) studies.
DATA SOURCES: Literature search using MEDLINE, EMBASE, Cochrane library, Web of Science and Scopus STUDY ELIGIBILITY CRITERIA: Published articles on results of RCT with a systemic CST arm with numerical data presented on adverse effect (AE).
PARTICIPANTS AND INTERVENTIONS: Reports of hyperglycaemia, hypertension, weight gain and hyperlipidaemia associated with systemic CST in patients or healthy volunteer's ≥17 years of age.
STUDY APPRAISAL METHODS: Risk of bias tool, assessment at the level of AE and key study characteristics.
RESULTS: A total of 5446 articles were screened to include 118 studies with 152 systemic CST arms (total participants=17 113 among which 8569 participants treated with CST). Pooled prevalence of hyperglycaemia in the CST arms within the studies was 10% (95% CI 7% to 14%), with the highest prevalence in respiratory illnesses at 22% (95% CI 9% to 35%). Pooled prevalence of severe hyperglycaemia, hypertension, weight gain and hyperlipidaemia within the corticosteroid arms was 5% (95% CI 2% to 9%), 6% (95% CI 4% to 8%), 13% (95% CI 8% to 18%), 8% (95% CI 4% to 17%), respectively. CST was significantly associated hyperglycaemia, hypertension and weight gain as noted in double-blinded placebo-controlled parallel-arms studies: OR of 2.13 (95% CI 1.66 to 2.72), 1.68 (95% CI 0.96 to 2.95) and 5.20 (95% CI 2.10 to 12.90), respectively. Intravenous therapy posed higher risk than oral therapy: OR of 2.39 (95% CI 1.16 to 4.91).
LIMITATIONS: There was significant heterogeneity in the AE definitions and quality of AE reporting in the primary studies and patient populations in the studies. The impact of cumulative dose effect on incidental AE could not be calculated.
CONCLUSIONS AND IMPLICATIONS OF KEY FINDINGS: Systemic CST use is associated with increased risk of metabolic AEs, which differs for each disease group and route of administration.
PROSPERO REGISTRATION NUMBER: CRD42020161270.
PMID:36549729 | PMC:PMC9772659 | DOI:10.1136/bmjopen-2022-061476
Chinese herbal compound prescriptions combined with Chinese medicine powder based on traditional Chinese medicine syndrome differentiation for treatment of chronic atrophic gastritis with erosion: a multi-center, randomized, positive-controlled...
Chin Med. 2022 Dec 22;17(1):142. doi: 10.1186/s13020-022-00692-7.
NO ABSTRACT
PMID:36550503 | DOI:10.1186/s13020-022-00692-7
Effectiveness, Toxicity, and Survival Predictors of Regorafenib in Metastatic Colorectal Cancer: A Multicenter Study of Routinely Collected Data
Oncology (Williston Park). 2022 Dec 20;36(12):732-738. doi: 10.46883/2022.25920981.
NO ABSTRACT
PMID:36548097 | DOI:10.46883/2022.25920981
Safety of triazole antifungals: a pharmacovigilance study from 2004 to 2021 based on FAERS
Ther Adv Drug Saf. 2022 Dec 16;13:20420986221143266. doi: 10.1177/20420986221143266. eCollection 2022.
NO ABSTRACT
PMID:36545565 | PMC:PMC9761248 | DOI:10.1177/20420986221143266
Drug-related Death low Registration in Iran: A Mixed Method Approach for Causes, Recommendations to Solve This Problem and Geographical Evaluation of an Intervention
Addict Health. 2022 Apr;14(2):138-151. doi: 10.22122/AHJ.2022.196156.1266.
NO ABSTRACT
PMID:36544515 | PMC:PMC9743819 | DOI:10.22122/AHJ.2022.196156.1266
Toxocarosis: a One Health issue
Drug Ther Bull. 2023 Jan;61(1):3. doi: 10.1136/dtb.2022.000072.
NO ABSTRACT
PMID:36543344 | DOI:10.1136/dtb.2022.000072
Safety update: dupilumab and ocular adverse reactions
Drug Ther Bull. 2023 Jan;61(1):6. doi: 10.1136/dtb.2022.000073.
NO ABSTRACT
PMID:36543342 | DOI:10.1136/dtb.2022.000073
Escitalopram Induced Angioedema
Cureus. 2022 Nov 17;14(11):e31600. doi: 10.7759/cureus.31600. eCollection 2022 Nov.
NO ABSTRACT
PMID:36540519 | PMC:PMC9758958 | DOI:10.7759/cureus.31600
Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects
Nat Commun. 2022 Dec 20;13(1):7838. doi: 10.1038/s41467-022-35470-4.
NO ABSTRACT
PMID:36539421 | PMC:PMC9767940 | DOI:10.1038/s41467-022-35470-4
Determination and comparison of potential drug-drug interactions using three different databases in northern cyprus community pharmacies
Niger J Clin Pract. 2022 Dec;25(12):2005-2009. doi: 10.4103/njcp.njcp_448_22.
NO ABSTRACT
PMID:36537458 | DOI:10.4103/njcp.njcp_448_22