Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

Crystal structure of N-terminally hexahistidine-tagged Onchocerca volvulus macrophage migration inhibitory factor-1

BioKGrapher: Initial evaluation of automated knowledge graph construction from biomedical literature

Network medicine informed multiomics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral Sclerosis

Network Medicine-Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD-L1 Expression via Targeting SPOP in Cancer

Pimozide-loaded nanostructured lipid carriers: Repurposing strategy against lung cancer

Multi-bioinformatics revealed potential biomarkers and repurposed drugs for gastric adenocarcinoma-related gastric intestinal metaplasia

Exploring non-hormonal therapies and drug repositioning for endometriosis: insights from mouse model studies

Antifungal Associations with a Polyelectrolyte Promote Significant Reduction of Minimum Inhibitory Concentrations against Opportunistic Candida spp. Strains

Striatal Cholinergic Interneurons Control Physical Nicotine Withdrawal via Muscarinic Receptor Signaling

Transcriptomic imputation identifies tissue-specific genes associated with cervical myelopathy

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

Bexotegrast Shows Dose-dependent Integrin alpha(v)beta(6) Receptor Occupancy in Lungs of Participants with Idiopathic Pulmonary Fibrosis: A Phase 2, Open-Label Clinical Trial

Identification, course, and management of progressive pulmonary fibrosis

Real-world data on the course of idiopathic pulmonary fibrosis

Spatially resolved gene expression profiles of fibrosing interstitial lung diseases

Rare variants and survival of patients with idiopathic pulmonary fibrosis

Gene polymorphisms and risk of idiopathic pulmonary fibrosis: a systematic review and meta-analysis

Revisiting the role of MicroRNAs in the pathogenesis of idiopathic pulmonary fibrosis

Pirfenidone as a Cornerstone in the Management of Fibrotic Interstitial Lung Diseases and Its Emerging Applications: A Comprehensive Review

Corrigendum: Identification of oxidative stress-related diagnostic markers and immune infiltration features for idiopathic pulmonary fibrosis by bibliometrics and bioinformatics

Quantitative micro-CT-derived biomarkers elucidate age-related lung fibrosis in elder mice

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Have CFTR modulators changed the need for liver and lung transplantation among patients with cystic fibrosis? An analysis of the UNOS database

Heterogeneity in Reported Side Effects Following Initiation of Elexacaftor-Tezacaftor-Ivacaftor: Experiences at a Quaternary CF Care Center

Plasma Microbial Cell-Free DNA Metagenomic Next-Generation Sequencing in People With Cystic Fibrosis

Genetic and clinical factors influencing CF-associated liver disease: the impact of SERPINA1 variants and CFTR genotypes in Romanian pediatric cystic fibrosis patients

Complicated meconium ileus in a male neonate with cystic fibrosis: Case report

Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells

Aging with CF: Characteristics of people with CF aged 40 and older in the United States

A phase I study assessing the safety and tolerability of SPL84, an inhaled antisense oligonucleotide for treatment of cystic fibrosis patients with the 3849 +10kb C->T

A comparative study and trace- level detection of volatile organic biomarkers using UV-IR-THz sources based high -Q helmholtz photoacoustic sensor

Asthma and COVID-19: Unveiling Outcome Disparities and Treatment Impact Based on Distinct Endotypes

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease

The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in <em>db/db</em> mice

Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia

Application of artificial intelligence and machine learning in drug repurposing

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

Rare connective tissue diseases in patients with C1-inhibitor deficiency hereditary angioedema: first evidence on prevalence and distribution from a large Italian cohort study

Nature-based interventions for individuals with rare skeletal disorders: evaluation of a 5-day sailing program on health-related quality of life

Latin America sets out to end neglect of rare diseases

Elucidating the roles of SOD3 correlated genes and reactive oxygen species in rare human diseases using a bioinformatic-ontology approach

Epidemiological characterization of rare diseases in Brazil: A retrospective study of the Brazilian Rare Diseases Network

MECP2 Variants in Males: More Common than Previously Appreciated

Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay

Measuring the impact of rare diseases in Tasmania, Australia

Genotype‒phenotype correlation in recessive DNAJB4 myopathy

Preferences of parents from diverse backgrounds on genomic screening of apparently healthy newborns

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

miRNAs, dd-cf-DNA, and Chemokines as Potential Noninvasive Biomarkers for the Assessment of Clinical Graft Evolution and Personalized Immunosuppression Requirement in Solid Organ Transplantation

Pediatric pharmacogenetics: profiling CYP2C8 polymorphisms at King Abdulaziz University Dental Clinic

Genomic variations associated with risk and protection against vincristine-induced peripheral neuropathy in pediatric cancer patients

The ZNF263/CPT1B axis regulates fatty acid β-oxidation to affect cisplatin resistance in lung adenocarcinoma

Scoping review of enablers and challenges of implementing pharmacogenomics testing in the primary care settings

Impact of Genetic Polymorphisms and Drug-Drug Interactions Mediated by Carboxylesterase1 on Remimazolam Deactivation

Revolutionized attitude toward recurrent pregnancy loss and recurrent implantation failure based on precision regenerative medicine

Contemporary and prospective use of azathioprine (AZA) in viral, rheumatic, and dermatological disorders: a review of pharmacogenomic and nanotechnology applications

Pharmacogenomic Study of Selected Genes Affecting Amlodipine Blood Pressure Response in Patients with Hypertension

Targeting uridine diphosphate glucuronosyltransferase 1A1 in liver disease: Current research and future directions

Deep learning for biomedical sciences and genomics

Predicting disease-associated microbes based on similarity fusion and deep learning

IMGT/RobustpMHC: robust training for class-I MHC peptide binding prediction

scDTL: enhancing single-cell RNA-seq imputation through deep transfer learning with bulk cell information

Memprot.GPCR-ModSim: Modelling and simulation of membrane proteins in a nutshell

Using Artificial Intelligence to Diagnose Lacrimal Passage Obstructions Based on Dacryocystography Images

Non-small cell lung cancer detection through knowledge distillation approach with teaching assistant

Few-shot learning for inference in medical imaging with subspace feature representations

How deep is your art: An experimental study on the limits of artistic understanding in a single-task, single-modality neural network

A Feature Fusion Model Based on Temporal Convolutional Network for Automatic Sleep Staging Using Single-Channel EEG

A Survey of Few-Shot Learning for Biomedical Time Series

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

New perspectives of drug related kidney diseases and disorders

Heterogeneity in Reported Side Effects Following Initiation of Elexacaftor-Tezacaftor-Ivacaftor: Experiences at a Quaternary CF Care Center

Irish College of GPs to phase out pharma sponsorship

Adverse events associated with herbal medicine products reported in the Korea Adverse Event Reporting System from 2012 to 2021

Checkpoint inhibitor therapy: Immune-related adverse event management

Efficacy of rechallenge after first-line immunotherapy for advanced gastric cancer: A retrospective real-world study

A Case of Clozapine-Induced Hepatotoxicity: Management Considerations and Future Direction

A Case of Statin-Induced Necrotizing Autoimmune Myopathy

A phase 3 randomized trial of sulopenem vs. ertapenem in patients with complicated intraabdominal infections

Leukocytes telomere length as a biomarker of adverse drug reactions induced by Osimertinib in advanced non-small cell lung cancer

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events