Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Source: https://grants.nih.gov/grants/guide/newsfeed/fundingopps.xml

Request for Information (RFI) on the Need to Expand Epidemiological Research at NIAMS

Notice of Announcement of the NCATS Rare Diseases Are Not Rare! 2025 Challenge Prize Competition

Request for Information: Extending the Response Date for Inviting Feedback on the Proposed NIH Research Plan on Rehabilitation Scientific Themes FY26-FY30

Reminder: Unauthorized Use of Credentials is Prohibited

Request for Information on Maximizing Research Funds by Limiting Allowable Publishing Costs

Notice of NICHD Participation in PAR-25-442, "Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)"

The NIH RECOVER Program Announces Plan to Request Ancillary Studies

Request for Information: Inviting Feedback on the Proposed NIH Research Plan on Rehabilitation Scientific Themes FY26-FY30

Findings of Research Misconduct - Liping Zhang

Extension of Deadline for Submitting a Response to NOT-CA-25-037, Request for Information (RFI): Benchmarks for Artificial Intelligence in Cancer Research and Care

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1

New insights on Drug's design against candidiasis on the fructose biphosphate aldolase (Fba1) and the pyruvate kinase (Pk) of <em>Candida glabrata</em>

Multi-dimensional data-driven computational drug repurposing strategy for screening novel neuroprotective agents in ischemic stroke

Kinase Inhibitors for Targeted Cancer Therapy

Exploring therapeutic strategies for candidiasis: From current treatments to future perspectives

Integration of Genetics Into the Design and Conduct of Clinical Trials in Nephrology

Drug repurposing for osteoarthritis disease modification in the Early 21(st) Century

The unexplored mechanism of antitumoral effect of pirfenidone in melanoma cells

Repurposing Etalocib suppresses multidrug-resistant Staphylococcus aureus by disrupting the bacterial membrane

Literature data-based de novo candidates for drug repurposing

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis

Hypereosinophilic Syndrome in a Patient With Cystic Fibrosis: A Rare Case of Cardiac Involvement and Response to Mepolizumab

Clinical efficacy and safety evaluation of drug therapies for the treatment of progressive fibrotic-interstitial lung diseases (PF-ILDs): a network meta-analysis of randomized controlled trials

Incidence and risk factors of unilateral upper-lung field pulmonary fibrosis radiologically consistent with pleuroparenchymal fibroelastosis after lung cancer surgery in interstitial lung disease patients

DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases

Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models

Beyond Cancer: The Role of Radiolabeled Fibroblast Activation Protein Inhibitors (FAPI) in Non-Oncological Molecular Imaging

Inhalable Nucleic Acid Therapeutics for Chronic Pulmonary Disease: Progress, Challenges, and Prospects

Peripheral and pulmonary telomere lengths in patients with non-idiopathic pulmonary fibrosis interstitial lung diseases

The unexplored mechanism of antitumoral effect of pirfenidone in melanoma cells

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Using delafloxacin, a 4th generation fluoroquinolone, in combination with nebulised tobramycin to eradicate Pseudomonas aeruginosa in cystic fibrosis

Respiratory infections after elexacaftor/tezacaftor/ivacaftor treatment in people with cystic fibrosis: analysis of the European Cystic Fibrosis Society Patient Registry

Cystic fibrosis transmembrane conductance regulator therapy with elexacaftor/tezacaftor/ivacaftor reduces detection of hallmark cystic fibrosis pathogens in Europe: progress made but no time to slow down

Arthritis in Cystic Fibrosis-Comparison of a Single-Center Cohort and Published Case Reports/Series and a Review of the Literature

Catalytic region mimetics in Na+ /H+ exchanger regulatory factor 4 suppress Guanylate Cyclase 2C activity to regulate enterotoxin triggered diarrhea

Non-Coding DNA Variants Increase the Genetic Diagnostic Yield in Primary Ciliary Dyskinesia

First results from the international paediatric bronchiectasis registry (Child-BEAR-Net Registry) describing multicountry variations in childhood bronchiectasis and its management: a multicentre, cross-sectional study

A Rare Case of Familial Hypocalciuric Hypercalcemia in Patient With Pancreatitis

Clinical efficacy of elexacaftor-tezacaftor-ivacaftor in two siblings with homozygous I1234V mutation cystic fibrosis: A prospective case series

Hypereosinophilic Syndrome in a Patient With Cystic Fibrosis: A Rare Case of Cardiac Involvement and Response to Mepolizumab

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

Differential Expression and Microsystem Physiology Reveal Predominant and Drug Reversible CFTR-Related Defects in Idiopathic Pancreatitis

Wilms' tumor 1 impairs apoptotic clearance of fibroblasts in distal fibrotic lung lesions

Brain Transcriptome Changes Associated With an Acute Increase of Protein O-GlcNAcylation and Implications for Neurodegenerative Disease

Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease

The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in <em>db/db</em> mice

Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia

Application of artificial intelligence and machine learning in drug repurposing

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

Academic Learning Profiles Across Disorders of KMT2 Gene Family: Superimposed and Distinct Features Across Kabuki, Wiedemann-Steiner and ODLURO Syndromes

Single large-scale mitochondrial DNA deletion syndromes: scientific and family conference optimizes the collection of rare disease research outcomes

Modeling rare genetic disease with patient-derived induced pluripotent stem cells: reassessment of the minimum numbers of lines needed

Bridging psychiatry and rare genetic diseases: a scoping review of therapeutic strategies and diagnostic delay paired with healthcare economic burden analysis

Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score

Multiomics analysis reveals the genetic and epigenetic features of high-risk NK cell-type chronic active EBV infection

Correction: Szebeni, J. Expanded Spectrum and Increased Incidence of Adverse Events Linked to COVID-19 Genetic Vaccines: New Concepts on Prophylactic Immuno-Gene Therapy, Iatrogenic Orphan Disease, and Platform-Inherent Challenges. Pharmaceutics 2025,...

Quality of life among children and young adults with rare diseases. A parental perspective

The rare disease burden: a multidimensional challenge

Proactive identification of rare diseases: lessons from hereditary angioedema diagnosis using electronic medical records

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

The prevalence of pharmacogenetic testing in the United States

Exploration of JAK/STAT pathway activation in ulcerative colitis reveals sex-dependent activation of JAK2/STAT3 in the inflammatory response

Pharmacogenetic exploration of buprenorphine and related metabolites in umbilical cord blood

Pharmacogenetics association with long-term clinical evolution in a kidney transplant patients cohort

Pharmacogenetics or predictive genetics? APOE testing blurs the lines

Clinical significance and gene prediction of a novel classification system based on tacrolimus concentration-to-dose ratio in the early post-liver transplant period

Concerning BPC-157, a natural pentadecapeptide, that acts as a cytoprotectant and is believed to protect the gastro-intestinal tract (GIT)

The history and future of pharmacogenetics in Aotearoa/New Zealand

Implementing genomic medicine in New Zealand

Implementation of genetic testing for heritable cardiac conditions: A scoping review

Deep learning for biomedical sciences and genomics

Bridging technology and medicine: artificial intelligence in targeted anticancer drug delivery

Cardio-rheumatology: integrated care and the opportunities for personalized medicine

NeSyDPP-4: discovering DPP-4 inhibitors for diabetes treatment with a neuro-symbolic AI approach

Detection of microplastics stress on rice seedling by visible/near-infrared hyperspectral imaging and synchrotron radiation Fourier transform infrared microspectroscopy

Dynamic gating-enhanced deep learning model with multi-source remote sensing synergy for optimizing wheat yield estimation

DLML-PC: an automated deep learning and metric learning approach for precise soybean pod classification and counting in intact plants

Updating "BePLi Dataset v1: Beach Plastic Litter Dataset version 1, for instance segmentation of beach plastic litter" with 13 object classes

Hybrid deep learning models for text-based identification of gene-disease associations

A multi-model deep learning approach for human emotion recognition

SMoFFI-SegFormer: a novel approach for ovarian tumor segmentation based on an improved SegFormer architecture

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

Interstitial Nephritis Induced by Repeated Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Use for Persistent Fever: A Case Report

A Case of Drug-Induced Pancytopenia due to Tamoxifen

Safety of esaxerenone (CS-3150) and its impacts on blood pressure and renal function: A systematic review and meta-analysis

Acute neurological dysfunction in critically ill patients with solid tumors: A 14-year retrospective study

Active drug-safety monitoring and management in the treatment of rifampicin-resistant tuberculosis: a nationwide multicenter prospective study

Efficacy and Safety of Mirabegron and Tamsulosin Combination Therapy Compared to Tamsulosin Monotherapy for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: Results of a Multicenter, Randomized, Double-Blind, Phase III Clinical Trial

To evaluate the short and long term outcomes of renal transplant recipients with low dose Everolimus, Tacrolimus - based minimal quadruple immunosuppressive regimen

Vestibulopathies and adult cancers: A literature review

Medication Safety in Acute Care Settings

Effect of Acid Suppressants on Adverse Events of Immune Checkpoint Inhibitors Using Real-world Databases

Anil Jegga

What's hot and what's current:

Click on the PubMed link for a complete list of all the articles published pertaining to the respective subjects (using the query!). In case you encounter any errors, please refresh the page.

NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events