Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Source: https://grants.nih.gov/grants/guide/newsfeed/fundingopps.xml

Notice of Special Interest (NOSI): AI/ML in Pre-Clinical Drug Development for Psychiatric Disorders

Notice of Special Interest (NOSI): Molecular and Cellular Computational Tools Supporting Fundamental Neuroscience Research in Health, Mental Illness and Developmental Processes

Notice of Informational Webinar on the NIH Advancing Research Careers (ARC) Program Notices of Funding Opportunity (F99/K00 and UE5)

Notice of Virtual Question and Answer Office Hour for the NIGMS Postbaccalaureate Research Education Program (PREP) Program

Notice of Intent to Publish a Funding Opportunity Announcement - Alcohol-HIV/AIDS Program Project Comorbidities, Coinfections, and Complications Research: Intervention and Cross-Cutting Foundational Research (P01 Clinical Trial Optional)

Notice of Special Interest: Cardiorespiratory and Sleep Complications of the Muscular Dystrophies

Special Emphasis Notice: AHRQ Announces Interest in Health Services Research to Reduce Emergency Department Boarding and Hospital Crowding

2026 NIAID Omnibus Broad Agency Announcement HHS-NIH-NIAID-BAA2025-1 Now Available

Notice of Special Interest (NOSI): NCI's Interest in Research on Interprofessional Teamwork and Coordination During Cancer Diagnosis and Treatment

Notice of NIDCD Participation in PA-25-301 "NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)"

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases

Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery

Ytterbium Doping-Retooled Prussian Blue for Tumor Metabolism Interference Therapy

Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in charcot-marie-tooth type 2 neuropathies

Harnessing Drug Repurposing to Combat Breast Cancer by Targeting Altered Metabolism and Epithelial-to-Mesenchymal Transition Pathways

Repurposing Drugs and Synergistic Combinations as Potential Therapies for Inhibiting SARS-CoV-2 and Coronavirus Replication

Novel artificial intelligence-based identification of drug-gene-disease interaction using protein-protein interaction

Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes

Nucleotide analogues and Mpox : Repurposing the repurposable

Identification of the atypical antipsychotic Asenapine as a direct survivin inhibitor with anticancer properties and sensitizing effects to conventional therapies

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

Semimechanistic Population PK/PD Modeling of Axatilimab in Healthy Participants and Patients With Solid Tumors or Chronic Graft-Versus-Host Disease

Diagnostic and predictive values of m5C-associated genes in idiopathic pulmonary fibrosis

Cell Membrane Hybrid Liposome-Targeted Delivery of the Heat Shock Protein 90 C-Terminal Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis

Rectus femoris cross sectional area and timed up and go test potential useful of as a predictor of sarcopenia and mortality in idiopathic pulmonary fibrosis

Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis

Computational deconvolution of cell type-specific gene expression in COPD and IPF lungs reveals disease severity associations

Diagnostic and prognostic implications of family history of fibrotic interstitial lung diseases

Idiopathic pleuroparenchymal fibroelastosis: A review of the previous literature and current knowledge

Association between the HAL score and the development of progressive pulmonary fibrosis in idiopathic interstitial pneumonia: A prospective observational study

Predictive factors of progression in mild fibrosing interstitial lung disease patients with gender-age-physiology score of 3 or less

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Right ventricle free wall longitudinal strain screening of lung transplant candidates

Heme alters biofilm formation in Mycobacterium abscessus

Virome assembly reveals draft genomes of native Pseudomonas phages isolated from a paediatric bronchoalveolar lavage sample

Facilitators and Barriers to Increasing Equity in Cystic Fibrosis Newborn Screening Algorithms

Papilledema in Children With Cystic Fibrosis Receiving Elexacaftor/Tezacaftor/Ivacaftor: A Multicenter Case Series

Postnatal Outcome After Ultrasound Findings of an Abnormal Fetal Gallbladder: A Systematic Review and Meta-Analysis

Gene Therapy: Towards a New Era of Medicine

The in vitro synergistic and antibiofilm activity of Ceftazidime/avibactam against Achromobacter species recovered from respiratory samples of cystic fibrosis patients

The F508del-CFTR trafficking correctors elexacaftor and tezacaftor are CFTR-independent Ca2+-mobilizing agonists normalizing abnormal Ca2+ levels in human airway epithelial cells

AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

Acute increase of protein O-GlcNAcylation in mice leads to transcriptome changes in the brain opposite to what is observed in Alzheimer's Disease

The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling

Roles of cMyBP-C phosphorylation on cardiac contractile dysfunction in db/db mice

Specific binding sites on Rhesus rotavirus capsid protein dictates the method of endocytosis inducing the murine model of biliary atresia

Application of artificial intelligence and machine learning in drug repurposing

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

Genetic diseases of epigenetic machinery

Multi-stakeholder sessions on major innovation topics in rare disease clinical trials

Benign phyllodes tumor of the distal end of the ureter: an extremely rare case and literature review

Exome and Genome Sequencing to Diagnose the Genetic Basis of Neonatal Hypotonia: An International Consortium Study

National virtual tumor boards to inform the management of children with rare cancers

Assessing the effectiveness of measurement scales in evaluating the health-related quality of life in rare disease patients after treatment: a systematic review

Case series of kidney transplantation in two pediatric recipients with rare genetic diseases and intellectual disability

An Automatic and End-to-End System for Rare Disease Knowledge Graph Construction Based on Ontology-Enhanced Large Language Models: Development Study

Statistical design and application of clinical trials with small sample sizes for rare diseases

De novo variants disrupt an LDB1-regulated transcriptional network in congenital ventriculomegaly

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

A Study Of the effect of Sex on drug dosing, concentrations, and pharmacogenomics in the Montreal Heart Institute Hospital Cohort (SOS-PGx): methodology and research progress

Genetic profiling of multidrug-resistant Acinetobacter baumannii from a tertiary care center in Malaysia

Polymorphisms within genes encoding Ikaros family proteins IKZF1 and IKZF3 in multiple myeloma patients treated with thalidomide

Clinical and genetic features of AGel amyloidosis caused by novel gelsolin variant and its impact on cardiac function and conduction disorders

Association of NOTCH4 and CYP2E1 Genetic Variants With Schizophrenia in the Bangladeshi Population: A Case-Control Study

Genetic variation on dolutegravir pharmacokinetics and relation to safety and efficacy outcomes: a systematic review

Associations between (pharmaco-)genetic markers and postoperative pain after inguinal hernia repair - a prospective study protocol

A genotype-guided prediction model for the incidence of persistent acute kidney injury following lung transplantation

Prognostic, oncogenic roles, and pharmacogenomic features of AMD1 in hepatocellular carcinoma

Rapamycin Abrogates Aggregation of Human α-Synuclein Expressed in Fission Yeast via an Autophagy-Independent Mechanism

Deep learning for biomedical sciences and genomics

A Variational Network for Biomedical Images Denoising using Bayesian model and Auto-Encoder

HeatGSNs: Integrating Eigenfilters and Low-Pass Graph Heat Kernels into Graph Spectral Convolutional Networks for Brain Tumor Segmentation and Classification

Correction to: Toward molecular diagnosis of major depressive disorder by plasma peptides using a deep learning approach

Large Language Models in Gastroenterology: Systematic Review

Assessing the prognostic impact of body composition phenotypes on surgical outcomes and survival in patients with spinal metastasis: a deep learning approach to preoperative CT analysis

Automated Identification of Breast Cancer Relapse in Computed Tomography Reports Using Natural Language Processing

Insights into AI advances in immunohistochemistry for effective breast cancer treatment: a literature review of ER, PR, and HER2 scoring

Survival analysis of clear cell renal cell carcinoma based on radiomics and deep learning features from CT images

Quantifying interpretation reproducibility in Vision Transformer models with TAVAC

Accelerating antimicrobial peptide design: Leveraging deep learning for rapid discovery

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

Application of a Language Model Tool for COVID-19 Vaccine Adverse Event Monitoring Using Web and Social Media Content: Algorithm Development and Validation Study

A study of N-acetyltransferase 2 gene polymorphisms in the Indian population and its relationship with serum isoniazid concentrations in a cohort of tuberculosis patients

Consumer views on the use of digital tools for reporting adverse drug reactions: a cross-sectional study

Cannabigerol Mitigates Haloperidol-Induced Vacuous Chewing Movements in Mice

Restructuring of the COVID-19 Vaccine Safety Committee 2020-2023 in MexicoReestruturação do Comitê para Segurança das Vacinas contra a COVID-19, 2020-2023, México

The knowledge and skills required for the onco-rheumatologist: Study of four-year consultation records of a high-volume cancer centre

Barriers and Facilitators on Pharmacovigilance Practice Among Pharmacists in Metro Manila, Philippines

A real-world disproportionality analysis of the US Food and Drug Administration (FDA) adverse event reporting system (FAERS) events for Durvalumab

Immune-related adverse events correlate with the clinical efficacy in advanced Non-Small-Cell Lung Cancer patients treated with PD-1 inhibitors combination therapy

Evaluation of comparative efficacy of Umeclidinium/Vilanterol versus other bronchodilators in the management of chronic obstructive pulmonary disease: a systematic review and meta-analysis of RCTs

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events