Literature Watch

NIH Funding Opportunities (Notices, PA, RFA)

Source: https://grants.nih.gov/grants/guide/newsfeed/fundingopps.xml

NIAID T32 Training Grants Maximum Number of Trainee Slots

Notice of Change: Termination of RFA-MH-22-145, BRAIN Initiative: Standards to Define Experiments Related to the BRAIN Initiative (R01 Clinical Trial Not Allowed)

Notice of Intent to Publish a Funding Opportunity Announcement for Limited Competition: NIMHD Initiative for Improving American Indian and Alaska Native Cancer Outcomes (U01- Clinical Trial Optional)

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)

Notice of Change in the NIAID K24 Allowable Application Types and Eligibility Requirements

Notice of Information: NIAID to Increase K99, K25, and K01 Salary and Research Support and R00 Years of Support

Notice of NIAID Withdrawal of Participation from PA-23-080 "Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)"

Notice of Change to Increase K99 Salary Support, Research Support, and R00 Years of Support in PAR-23-070, NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required)

Notice of Change to Increase K99 Salary Support, Research Support, and R00 Years of Support in PAR-23-071, NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Independent Clinical Trial Not Allowed)

Drug Repositioning

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug+repositioning"+OR+"drug+repurposing"

Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma

Atorvastatin attenuates intestinal mucositis induced by 5-fluorouracil in mice by modulating the epithelial barrier and inflammatory response

Statins as anti-tumor agents: A paradigm for repurposed drugs

Current Pharmacotherapies for Smoking Cessation and Promising Emerging Drugs

Repurposing of anti-malarial drugs for the treatment of tuberculosis: realistic strategy or fanciful dead end?

Metabolic models predict fotemustine and the combination of eflornithine/rifamycin and adapalene/cannabidiol for the treatment of gliomas

AI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data

Biomarkers of Alzheimer's Disease Associated with Programmed Cell Death Reveal Four Repurposed Drugs

Shared etiology of Mendelian and complex disease supports drug discovery

Computational Screening of Some Phytochemicals to Identify Best Modulators for Ligand Binding Domain of Estrogen Receptor Alpha

Idiopathic Pulmonary Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="idiopathic+pulmonary+fibrosis"

Bilateral orthotopic lung transplant via a clamshell thoracosternotomy from a donor with extended cold static lung preservation

Pre-clinical proof-of-concept of anti-fibrotic activity of caveolin-1 scaffolding domain peptide LTI-03 in ex vivo precision cut lung slices from patients with Idiopathic Pulmonary Fibrosis

Shenqi Chongcao Formula ameliorates inflammatory response in rats with pulmonary fibrosis by activating the ASS1/src/STAT3 signaling pathway

Lipocalin-2 as a prognostic marker in patients with acute exacerbation of idiopathic pulmonary fibrosis

Issue 3-The occupational burden of respiratory diseases, an update

Combination of co-amorphization with SNEDDS outperforms Ofev® in the oral absorption of nintedanib

Urea cycle promotion via ammonia-upregulated CPS1 is involved in arsenite-induced pulmonary fibrosis through enhancing collagen synthesis

Shared biomarkers and mechanisms in idiopathic pulmonary fibrosis and non-small cell lung cancer

Acute exacerbation predicting poor outcomes in idiopathic interstitial pneumonia and advanced lung cancer patients undergoing cytotoxic chemotherapy

Lung Transplantation in Patients With Systemic Scleroderma-Description of the First Consecutive Cases in Poland: Case Series Report and a Short Literature Review

Cystic Fibrosis

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="Cystic+Fibrosis"

Cystic fibrosis in childhood and adulthood

Elexacaftor/Tezacaftor/Ivacaftor Effectiveness in N1303K Variant in Adult People With Cystic Fibrosis

The Impact of Tobacco Smoking in Bronchiectasis: Data from the United States Bronchiectasis and NTM Research Registry

Challenges with drug efficacy prediction of in vitro models of biofilms infecting cystic fibrosis airway

Clinical and anthropometric evolution of individuals with cystic fibrosis during COVID-19 pandemic: A 24-month cohort study

Codevelopment of a model of care for adults living with cystic fibrosis-related diabetes

Levelling the playing field through the London Network of the UK clinical trials accelerator platform

Glycoproteomic and proteomic analysis of <em>Burkholderia cenocepacia</em> reveals glycosylation events within FliF and MotB are dispensable for motility

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

In vitro activity of cefiderocol in Pseudomonas aeruginosa isolates from people with cystic fibrosis recovered during three multicentre studies in Spain

Jegga - Recent Publications

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=jegga

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell disease

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma

Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells

Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn disease, and celiac disease

Relationships between gene expression and behavior in mice in response to systemic modulation of the O-GlcNAcylation pathway

A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases

Orphan or Rare Diseases

Source: http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term="orphan+disease+OR+"rare+diseases"

Innovative methodologies for rare diseases clinical trials

'High hopes for treatment': Australian stakeholder perspectives of the clinical translation of advanced neurotherapeutics for rare neurological diseases

Scoping review of the recommendations and guidance for improving the quality of rare disease registries

Efficacy and safety of atezolizumab and bevacizumab in appendiceal adenocarcinoma

A resident with an orphan disease: trial and error

IgG4-related disease-rare but you should not forget it

Bronchiectasis in Türkiye: Data from a Multicenter Registry (Turkish Adult Bronchiectasis Database)

An algorithm to identify patients aged 0-3 with rare genetic disorders

Project SATURN- a real-world evidence data collaboration with existing European datasets in Osteogenesis Imperfecta to support future therapies

WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production

Pharmacogenomics

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term=pharmacogenomics

Rcn1, the fission yeast homolog of human DSCR1, regulates arsenite tolerance independently from calcineurin

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study

Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis

Ethics of artificial intelligence in supportive care in cancer

Pharmacogenetics of tenofovir drug transporters in the context of HBV: Is there an impact?

Cannabinoid levels description in a cohort of patients with chronic and neuropathic pain treated with Cannabis decoction: A possible role of TDM

First-in-man use of a cardiovascular cell-derived secretome in heart failure. Case report

Topical Steroid Withdrawal is a Targetable Excess of Mitochondrial NAD

Editorial: The impact of the human genome on interindividual variability in drug response

Multiple extreme overdose of antipsychotics with minimal side effects: A case report

Deep learning for biomedical sciences and genomics

Trends in artificial intelligence, machine learning, and chemometrics applied to chemical data

Brain MRI sequence and view plane identification using deep learning

ContourTL-Net: Contour-Based Transfer Learning Algorithm for Early-Stage Brain Tumor Detection

MAN-C: A masked autoencoder neural cryptography based encryption scheme for CT scan images

A practical guide to the implementation of artificial intelligence in orthopaedic research-Part 2: A technical introduction

Advances in artificial intelligence in thyroid-associated ophthalmopathy

Synthesizing 3D Multi-Contrast Brain Tumor MRIs Using Tumor Mask Conditioning

Audio-Based Emotion Recognition Using Self-Supervised Learning on an Engineered Feature Space

The new paradigm in machine learning - foundation models, large language models and beyond: a primer for physicians

DenseNet model incorporating hybrid attention mechanisms and clinical features for pancreatic cystic tumor classification

Drug-induced Adverse Events

Source: https://www.ncbi.nlm.nih.gov/pubmed/?term="drug-induced adverse events"

Atorvastatin-induced Myositis and Drug-induced Liver Injury

BERT-based language model for accurate drug adverse event extraction from social media: implementation, evaluation, and contributions to pharmacovigilance practices

Influence of medications on fall risk assessment in maintenance hemodialysis patients: A cross-sectional study

Adverse event profiles of drug-induced liver injury caused by antidepressant drugs: a disproportionality analysis

Prospective manipulation of the gut microbiome with microbial ecosystem therapeutic 4 (MET4) in HPV-related locoregionally-advanced oropharyngeal cancer squamous cell carcinoma (LA-OPSCC) undergoing primary chemoradiation: ROMA2 study

Gallstone Dissolution Effects of Combination Therapy with n-3 Polyunsaturated Fatty Acids and Ursodeoxycholic Acid: A Randomized, Prospective, Preliminary Clinical Trial

Urticarial Vasculitis Induced by Adalimumab Biosimilar in an Elderly Female With Hidradenitis Suppurativa: A Case Report

Efficacy of Tegoprazan in Patients With Functional Dyspepsia: A Prospective, Multicenter, Single-arm Study

ATR inhibitor, camonsertib, dose optimization in patients with biomarker-selected advanced solid tumors (TRESR study)

Trastuzumab deruxtecan in patients with solid tumours harbouring specific activating HER2 mutations (DESTINY-PanTumor01): an international, phase 2 study

Anil Jegga

What's hot and what's current:

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NIH Funding Opportunities (Notices, PA, RFA)

Drug Repositioning

Idiopathic Pulmonary Fibrosis

Cystic Fibrosis

Jegga - Recent Publications

Orphan or Rare Diseases

Pharmacogenomics

Deep learning for biomedical sciences and genomics

Drug-induced Adverse Events