Funding Opportunity RFA-AG-25-013 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity Announcement (NOFO) invites applications to develop and maintain a (NSC3). The goal of the NSC3 is to provide logistical and organization support of the NSC. Applicants should be familiar with Nathan Shock Centers (NSC) activities, but they do not need to be part of an NSC. Major activities of the proposed NSC3 will include improving visibility of the NSC nationally and internationally, improving collaboration and coordination among NSC, enhancing NSC training activities, facilitating the sharing of resources, and interacting with NIA and NSC to develop strategies and plans for further development. The successful application will include a plan to improve transparency and the interactions of NSC with the research community. It should also leverage existing bioinformatics resources. The NSC3 director will be a participant in the NIA's Research Centers Collaborative Network.

Funding Opportunity RFA-AG-25-012 from the NIH Guide for Grants and Contracts. This NOFO invites applications for the Nathan Shock Centers of Excellence in Basic Biology of Aging (NSC). These Center grants will provide funding for leadership, training, research, and outreach activities that will increase and disseminate scientific knowledge in areas supported by the NIA's Division of Aging Biology.

Funding Opportunity PAR-24-162 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for innovative basic and translational pilot research projects within the mission of the NIDDK that are aligned with NIH HIV/AIDS research priorities. These priorities were most recently outlined by the NIH Office of AIDS Research (OAR) in NOT-20-018, UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding, scientific priorities. Potential topics could address multiple overarching priorities. These include elucidation of unique pathophysiological mechanisms contributing to HIV comorbidities, coinfections, and complications (CCCs) affecting organs, tissues, and processes within the mission of the NIDDK. Likewise, interrogations into biological mechanisms underlying HIV reservoirs in NIDDK-relevant tissues are important for developing strategies for long-term viral suppression or eradication. Finally, health-impeding social determinants of health may affect CCCs or viral reservoirs within NIDDK's mission through multiple pathways.

Funding Opportunity RFA-MH-25-120 from the NIH Guide for Grants and Contracts. NIMH seeks applications to evaluate the preliminary effectiveness of therapeutic and service delivery interventions that utilize lethal means safety strategies to reduce suicide risk in healthcare and community settings. Behavioral health clinics that incorporate lethal means counseling into their programming have been associated with significant reductions in suicide attempts and death. Yet, the field is lacking strong evidence on the effectiveness of these strategies tested in healthcare and community settings. Pilot effectiveness research will advance knowledge regarding optimization strategies, therapeutic change mechanisms, and inform decisions about whether further effectiveness testing is warranted. The research will provide preliminary evidence on the extent to which lethal means safety interventions more optimally lead to improved safety (e.g., number/percent of firearms safely stored, overdose injury codes for an individual) and lower suicide risk. In this pilot phase of effectiveness research, the trial should be designed to evaluate the feasibility, tolerability, acceptability, safety, and potential effectiveness of the approach; to address whether the intervention engages the target(s)/mechanisms(s) that is/are presumed to underlie the intervention effects; and to obtain preliminary data needed as a pre-requisite to a larger-scale effectiveness trial (e.g., comparative effectiveness study, practical trial) designed to definitively test the effectiveness of the intervention.

Notice NOT-HD-24-016 from the NIH Guide for Grants and Contracts

£45,585 to £54,395 with potential progression once in post to £61,198. : University of Birmingham: Three Post-doctoral Research Fellows are sought to work on the Wellcome Trust funded research programme.. University of Birmingham, Edgbaston, Birmingham UK

Notice NOT-RM-24-008 from the NIH Guide for Grants and Contracts

Notice NOT-RM-24-007 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-25-014 from the NIH Guide for Grants and Contracts. "Fluctuating cognition can occur in many types of dementia and is a core clinical feature of Dementia with Lewy Bodies. Cognitive fluctuations can last from seconds to days, are unpredictable (e.g., do not just occur in the evenings, as with sun-downing), and are associated with poor daily functioning for the patient. A number of small studies have suggested that cognitive fluctuations in subjects with dementia may be related to epileptiform discharges and impaired oscillatory activity on EEG, but it is not clear that these are the only factors involved in patient populations that often experience dysautonomia, orthostasis, and sleep disturbances. The etiology of cognitive fluctuations may be multi-factorial and may vary in different dementia populations. Understanding the physiology related to cognitive fluctuations is a critical next step to the development of treatment approaches and improving quality of life for these patients. This initiate would encourage research that will better characterize the physiology responsible for cognitive fluctuations in ADRD populations. Given their variable appearance and time course, it is anticipated that wearable digital devices will be important for capturing fluctuations in a timely fashion, and applicants should consider incorporating those device(s) capable of acquiring the relevant data to support the hypothesized mechanism(s). Applicants may focus on assessing multiple mechanisms in a specific ADRD population, or may chose to compare mechanisms across multiple types of ADRDs. "

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From £41,935, subject to skills and experience: The Francis Crick Institute: The lab works on the regulation of human normal haematopoietic stem cell biology and leukemia. London (Central), London (Greater)

Notice NOT-CA-24-035 from the NIH Guide for Grants and Contracts

Notice NOT-HD-24-010 from the NIH Guide for Grants and Contracts