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Neuroscientist, Stem Cell Biology, Drug Discovery - Stem Pharm - Madison, WI

Indeed.com - Bioinformatics - Tue, 2023-07-18 10:21
Demonstrated skills in project planning, organization, analysis and communication. Working knowledge of confocal microscopy and image analysis. $70,000 - $125,000 a year
From Indeed - Tue, 18 Jul 2023 14:21:58 GMT - View all Madison, WI jobs
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The Francis Crick Institute: Postdoctoral Fellow

New Scientist - Bioinformatics - Tue, 2023-07-18 07:02
From £41,935 with benefits, subject to skills and experience: The Francis Crick Institute: Dr Li’s laboratory investigates the molecular regulation of intestinal stem cell and cancer. London (Central), London (Greater)
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Providence Service: Bioinformatics Scientist

New Scientist - Bioinformatics - Mon, 2023-07-17 20:00
Providence Service: The Bioinformatics Scientist is responsible for providing bioinformatics support to the Providence Oregon Regional Molecular Genomics laboratory in... Portland, Oregon
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E-talentnetwork: Bioinformatics

New Scientist - Bioinformatics - Mon, 2023-07-17 20:00
E-talentnetwork: Overall Position Summary and Objectives Under this task order, the contractor will provide support services to satisfy the overall operational obj... Bethesda, Maryland
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Oxford Nanopore Technologies: Field Applications Scientist - Genomics (UK)

New Scientist - Bioinformatics - Mon, 2023-07-17 08:32
Negotiable: Oxford Nanopore Technologies: Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and a commercial presence in many England
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AstraZeneca : Associate Director, Translational Data Science, Oncology R&D

New Scientist - Bioinformatics - Mon, 2023-07-17 04:40
Negotiable: AstraZeneca : Translational Data Science Munich, Germany
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Next Generation Chemistry Centers for Fusion Oncoproteins (UM1 Clinical Trial Not Allowed)

Funding Opportunity RFA-CA-23-037 from the NIH Guide for Grants and Contracts. NCI is forming the Targeting Fusion Oncoproteins in Childhood Cancers (TFCC) Network to advance our understanding of the mechanisms of action of fusion oncoproteins in pediatric cancers and to apply novel chemical strategies for developing targeted therapeutic approaches. This RFA will use the UM1 mechanism to fund Next Generation Chemistry Centers (NGC) for Fusion Oncoproteins that have independent research projects using innovative chemical biology technologies and chemoproteomic approaches to target fusion-driven cancers. The goal of these discovery efforts will be to identify and develop small molecules that effectively disrupt fusion oncoproteins through mechanisms including, but not limited to, inhibiting activities of individual fusion oncoproteins, blocking critical fusion protein interactions, interacting with coding and/or noncoding RNAs required for fusion protein oncogenesis, and selectively inducing fusion protein degradation or degradation of proteins representing critical fusion oncoprotein dependencies. Compounds envisaged to be derived from these efforts may be either at the level of chemical probes and tools to delineate underlying biology, advanced leads to support further optimization to a candidate, or potential drug candidates themselves. In addition to the research proposed in their applications, each NGC Center will be expected to participate in collaborative projects with the U01s and potentially other members of the fusion oncoprotein community. Funding priority will be given to applications that focus on fusion oncoproteins found in tumors that have high risk of treatment failure and for which there has been little progress in identifying targeted agents. Applications focused on high-risk pediatric solid tumors and brain cancers are particularly encouraged. UM1 recipients will meet regularly with U01 grantees funded through the Mechanisms of Fusion-Driven Oncogenesis in Childhood Cancers FOA.

Mechanisms of Fusion-Driven Oncogenesis in Childhood Cancers (U01 Clinical Trial Not Allowed)

Funding Opportunity RFA-CA-23-036 from the NIH Guide for Grants and Contracts. NCI is forming the Targeting Fusion Oncoproteins in Childhood Cancers (TFCC) Network to advance our understanding of the mechanisms of action of fusion oncoproteins in pediatric cancers and to apply novel chemical strategies for developing targeted therapeutic approaches. This RFA will use the U01 mechanism to solicit applications focused on molecular mechanisms by which fusion oncoproteins drive pediatric cancers with the goals of better understanding the biology of these cancers and identifying potential drug targets or critical dependencies. Examples of relevant research activities include, but are not limited to, dissecting pathways by which these fusion oncoproteins cause cancer, characterizing the composition and structure of fusion oncoprotein complexes, and delineating the roles of ncRNAs and post-translational modifications in fusion oncoprotein function. Funding priority will be given to applications that focus on fusion oncoproteins found in tumors that have high risk of treatment failure and for which there has been little progress in identifying targeted agents. Applications focused on pediatric solid tumors and brain tumors are particularly encouraged. U01 recipients will meet regularly with UM1 grantees funded through the Next Generation Chemistry Centers for Fusion Oncoproteins FOA.

John Wiley & Sons , Inc.: Bioinformatics Scientist

New Scientist - Bioinformatics - Sat, 2023-07-15 20:00
John Wiley & Sons , Inc.: Bioinformatics Scientist will be responsible for assisting research and development team in a collaborative and multi-disciplinary effort in develo... Tulsa, Oklahoma
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Limited Competition for the Continuation of Cure Glomerulonephropathy (CureGN) Participating Clinical Centers (U01 Clinical Trial Not Allowed)

Funding Opportunity RFA-DK-22-512 from the NIH Guide for Grants and Contracts. The purpose of this Limited Competition is to extend the Cure Glomerulonephropathy (CureGN) Network by continuing to support the Participating Clinical Centers (PCCs). The CureGN Network is a multicenter observational cohort study of glomerular disease patients with the goal of improving care for all glomerular disease patients. The CureGN PCCs will continue to follow-up previously enrolled participants and enroll a limited number of new participants. The primary objective of the PCCs will be to optimize retention strategies, and methods for "remote" or "virtual" study participation; ensure complete and accurate data and biosample collection with a focus on clinical assessment of disease activity and outcomes. The DCC, under a separate NOFO, provides key leadership functions for this study in the areas of study organization, study design and implementation, and biosample management.

Update - NIH Response to Registration Issues in SAM.gov

Notice NOT-OD-23-153 from the NIH Guide for Grants and Contracts

Imperial College London: Imperial College Fellowships

New Scientist - Bioinformatics - Fri, 2023-07-14 06:43
A competitive salary : Imperial College London: It is anticipated that applicants will be at the early stages of their research career and be able to demonstrate..... London
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Molecular Atlas of Lung Development Program (LungMAP) Phase 3 - Research Centers (U01 Clinical Trial Not Allowed)

Funding Opportunity RFA-HL-24-006 from the NIH Guide for Grants and Contracts. The purpose of this NOFO is to support the Molecular Atlas of Lung Development Program (LungMAP) Phase 3 Research Centers (RCs). The overall goal of LungMAP is to build a comprehensive molecular and cellular atlas of the human lung to serve as a reference platform to better understand both normal biology and disease pathobiology, and to identify critical cellular components, molecular pathways, and novel therapeutic targets in lung disease. RCs will be expected to obtain and analyze pediatric and adult lung tissues in order to generate high-resolution molecular profiling data of the diseased lung. RCs will perform integrated data analysis, explore mechanisms of disease pathogenesis, collaborate closely with other LungMAP teams and to disseminate this resource to the broader research community. Applicants are not required to have been funded in LungMAP Phase 2 (RFA-HL-19-020) in order to submit applications to this NOFO.

Single Source: Molecular Atlas of Lung Development Program (LungMAP) Phase 3 - Data Coordinating Center (U24- Clinical Trial Not Allowed)

Funding Opportunity RFA-HL-24-007 from the NIH Guide for Grants and Contracts. The objective of the Molecular Atlas of Lung Development (LungMAP) program is to build a comprehensive molecular and cellular atlas of the human lung to serve as a reference platform to better understand both normal biology and disease pathobiology, and to identify critical cellular components, molecular pathways, and novel therapeutic targets in lung disease. LungMAP is an open access resource integrating multi-scale, high-content, high-resolution information to define lung cells with gene expression, physiological states, 3-dimensional locations, as well as developmental and pathological trajectories.

Single Source: Molecular Atlas of Lung Development Program (LungMAP) Phase 3 - Human Tissue Core (U01- Clinical Trial Not Allowed)

Funding Opportunity RFA-HL-24-012 from the NIH Guide for Grants and Contracts. The objective of the Molecular Atlas of Lung Development (LungMAP) program is to build a comprehensive molecular and cellular atlas of the human lung to serve as a reference platform to better understand both normal biology and disease pathobiology, and to identify critical cellular components, molecular pathways, and novel therapeutic targets in lung disease. LungMAP is an open access resource integrating multi-scale, high-content, high-resolution information to define lung cells with gene expression, physiological states, 3-dimensional locations, as well as developmental and pathological trajectories.

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