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Notice to Extend PA-18-793

Notice NOT-HS-22-021 from the NIH Guide for Grants and Contracts

NCI Outstanding Investigator Award (R35 Clinical Trial Optional)

Funding Opportunity RFA-CA-22-045 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications for the Outstanding Investigator Award (R35) in any area of cancer research.The objective of the National Cancer Institute (NCI) Outstanding Investigator Award (OIA) is to provide long-term support to accomplished investigators with outstanding records of cancer research productivity who propose to conduct exceptional research. The OIA is intended to allow investigators the opportunity to take greater risks, be more adventurous in their lines of inquiry, or take the time to develop new techniques. The OIA would allow an Institution to submit applications nominating established Program Directors/Principal Investigators (PDs/PIs) for the NCI OIA.It is expected that the OIA would provide extended funding stability and encourage investigators to embark on projects of unusual potential in cancer research. The research projects should break new ground or extend previous discoveries toward new directions or applications that may lead to a breakthrough that will advance biomedical, behavioral, or clinical cancer research.

Senior Data Scientist - Gregor Diagnostics - Madison, WI

Indeed.com - Bioinformatics - Tue, 2022-07-26 01:46
The Senior Data Scientist will be involved in Research and Development projects serving as a lead and subject matter expert in the analysis of Gregor’s high…
From Gregor Diagnostics - Tue, 26 Jul 2022 05:46:47 GMT - View all Madison, WI jobs
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Cellular and Molecular Mechanisms of Prion-Like Aggregate Seeding, Propagation, and Neurotoxicity in AD/ADRD (R01 Clinical Trial Not Allowed)

Funding Opportunity PAR-23-023 from the NIH Guide for Grants and Contracts. The accumulation of misfolded proteins in the brain is a key pathological feature shared by many neurodegenerative diseases that can result in dementia such as Alzheimers Disease, Lewy Body Diseases, Frontotemporal Degeneration, and cerebral amyloid angiopathy. Classical prion diseases such as Creutzfeldt-Jakob Disease are a rare family of neurodegenerative disorders that occur when the cellular prion protein (PrPC) undergoes structural conversion to a pathological form (PrPSc), which is usually triggered by its interaction with an infectious variant of the protein that forces the conformational change. Once this process is initiated, it becomes self-propagating until toxic aggregates accumulate within the CNS, leading to neuronal death. Because misfolded proteins of AD/ADRD have been reported to share some features with pathological prion protein at the structural level, it has thus been proposed that ADRD-relevant proteins such as Alpha, tau, beta-synuclein, and TDP-43 (among others) may exhibit prion-like behaviors that lead to toxic aggregate and tangle formation. The goal of this initiative is to promote studies that increase our understanding of the cellular and molecular mechanisms by which such prion-like conversion events occur and are propagated in AD/ADRD, as well as the downstream mechanisms that trigger neurotoxicity, pathological and circuit changes in the brain.

F. Hoffmann-La Roche AG: Senior (Principal) Scientist, Computational Biologist / Bioinformatics - AIDD

New Scientist - Bioinformatics - Fri, 2022-07-22 13:57
Competitive Salary: F. Hoffmann-La Roche AG: The PositionPrimary Purpose of JobAs a member of the AI, Data and Digital (AIDD) team, you will partner with research scientists and data experts at C Shanghai (CN)
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F. Hoffmann-La Roche AG: Principal Bioinformatics Software Engineer, Java Development

New Scientist - Bioinformatics - Fri, 2022-07-22 13:55
Competitive Salary: F. Hoffmann-La Roche AG: This position may be based out of Santa Clara, California, USA, with remote work locations possible in The United States.Impact HealthcareRoche Sequen Santa Clara, California (US)
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F. Hoffmann-La Roche AG: Senior Bioinformatics Scientist

New Scientist - Bioinformatics - Fri, 2022-07-22 13:55
Competitive Salary: F. Hoffmann-La Roche AG: The PositionImpact HealthcareRoche Diagnostics Cape Town is a dynamic and rapidly growing biotechnology company employing cutting edge technologies to South Africa (ZA)
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F. Hoffmann-La Roche AG: Senior Software Bioinformatics Engineer

New Scientist - Bioinformatics - Fri, 2022-07-22 13:54
Competitive Salary: F. Hoffmann-La Roche AG: The PositionImpact HealthcareRoche Sequencing is not only changing science, but we are changing lives. Our software teams are laying the groundwork fo Ottawa (Region), Ontario (CA)
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F. Hoffmann-La Roche AG: Principal Computational Researcher, Immunology

New Scientist - Bioinformatics - Fri, 2022-07-22 13:53
Competitive Salary: F. Hoffmann-La Roche AG: The PositionThe Immunology Bioinformatics group is seeking a highly motivated computational scientist to engage in therapeutic discovery efforts withi San Francisco, California (US)
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F. Hoffmann-La Roche AG: Principal Bioinformatics Software Engineer, NGS Data Pipeline

New Scientist - Bioinformatics - Fri, 2022-07-22 13:53
Competitive Salary: F. Hoffmann-La Roche AG: Roche Sequencing is not only changing science, but we are changing lives. Our software teams are laying the groundwork for the future by developing po Santa Clara, California (US)
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