Funding Opportunity RFA-AG-19-001 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for P30 Alzheimer's Disease Research Centers. NIA-designated Alzheimer's Disease Research Centers (ADRCs) serve as major sources of discovery into the nature of Alzheimers disease (AD) and related dementias and into the development of more effective approaches to prevention, diagnosis, care, and therapy. They contribute significantly to the development of shared resources that support dementia-relevant research, and they collaborate and coordinate their research efforts with other NIH-funded programs and investigators.

Funding Opportunity RFA-RM-18-001 from the NIH Guide for Grants and Contracts. The purpose of this Research Opportunity Announcement (ROA) is to establish the HuBMAP Integration, Visualization and Engagement (HIVE) Collaboratory that will 1) manage the data generated by the Consortium, 2) coordinate internal and external Consortium activities, 3) develop novel tools for visualizing, searching and modelling data and 4) build an atlas of tissue maps. The HIVE will be composed of four Components all of which are expected to work closely together to act as the unified backbone for HuBMAP. The HIVE is expected to work closely with the other funded projects as part of the HuBMAP Consortium to catalyze development of a framework for mapping the human body with high spatial resolution. An application may propose only one Component. However, a coordinated set of separate applications, each describing a separate Component but with a common vision, can be proposed.

Notice NOT-OD-18-129 from the NIH Guide for Grants and Contracts

Funding Opportunity PA-18-592 from the NIH Guide for Grants and Contracts. The Office of Research on Women's Health (ORWH) and participating Institutes and Centers (ICs) of the National Institutes of Health (NIH) announce the continuation of the program for administrative supplements to research grants to support individuals with high potential to re-enter an active research career after an interruption for family responsibilities or other qualifying circumstances. The purpose of these supplements is to encourage such individuals to re-enter research careers within the missions of all the program areas of NIH. This program will provide administrative supplements to existing NIH research grants for the purpose of supporting full-time or part-time research by these individuals to update their existing research skills and knowledge.

Funding Opportunity PA-18-591 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH) hereby notify Program Directors/Principal Investigators (PD(s)/PI(s)) holding specific types of NIH research grants listed in the full Funding Opportunity Announcement (FOA) that funds may be available for administrative supplements to meet increased costs that are within the scope of the approved award, but were unforeseen when the new or renewal application or grant progress report for non-competing continuation support was submitted. Applications for administrative supplements are considered prior approval requests (as described in Section 8.1.2.11 of the NIH Grants Policy Statement) and will be routed directly to the Grants Management Officer of the parent award. Although requests for administrative supplements may be submitted through this FOA, there is no guarantee that funds are available from the awarding IC or for any specific grant. All applicants are encouraged to discuss potential requests with the awarding IC. Additionally, prior to submission, applicants must review the awarding IC's web site to ensure they meet the IC's requirements. A list of those web sites is available at https://grants.nih.gov/grants/guide/admin_supp/index.htm.

Funding Opportunity RFA-RM-18-018 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support the establishment of a Dissemination and Coordination Center (DCC) for the NIH Somatic Cell Genome Editing (SCGE) Consortium. In addition to this DCC, the Consortium will include four components (genome editing tools, delivery systems, animal models and biological assays) to produce validated techniques and knowledge through exchange of expertise, information and research tools. The DCC is expected to interact with other components of the SCGE Consortium to facilitate collaborative activities within the entire Consortium. The DCC will develop an online platform to facilitate information sharing within the Consortium, assemble resources (tools, methods, data and best practices) generated from all Consortium components into a genome editing toolkit, and disseminate the genome editing toolkit and other appropriate resources to researchers across the biomedical research community.

Funding Opportunity RFA-RM-18-017 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications proposing research on the development of novel and optimized alternatives to existing in vivo genome editing complexes.

Funding Opportunity RFA-RM-18-016 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support the development and evaluation of innovative approaches to deliver genome editing machinery into somatic cells, with the ultimate goal of accelerating the development of genome editing therapeutics to treat human disease.

Funding Opportunity RFA-RM-18-015 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications that propose to develop and validate cell- and tissue-based platforms for assessing potential adverse biological consequences of somatic cell genome editing.

Funding Opportunity RFA-RM-18-013 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to create novel large animal reporter models for testing in vivo genome editing technologies. The deliverables from the initiative will be a set of large animal models (pigs and non-human primates), containing one or more reporter genes expressed in all cell types, that will allow facile and quantitative evaluation of genome editing in any cell type of interest. Within the Consortium, these models will be used to test new delivery systems and genome editing tools developed by accompanying components in planned Large Animal Testing Centers. The large animal models will allow investigators to optimize scale up of delivery systems and editing tools, which will be necessary for clinical trials in humans.

Funding Opportunity RFA-RM-18-012 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to create rodent reporter models for testing in vivo genome editing technologies, and to use these animal models to test genome editing delivery technologies and new genome editors developed under RFA-RM-18-016 and RFA-RM-18-017. The deliverables from the initiative will be a set of animal models (mice and rat), containing one or more reporter genes expressed in all cell types, that will allow facile and quantitative evaluation of genome editing in any cell type of interest. The Testing Centers will use these models to validate new delivery systems and genome editing tools developed by other investigators in the Somatic Cell Genome Editing Program. The creation and testing of these rodent models will accelerate the translation of genome editing technologies into treatments for human diseases.

Negotiable: Paramount Recruitment: *Contribute to in-house pipeline to analyse WGS data of patients and aid in the interpretation of findings using clinical bioinformatics capabilities *Perform quality assurance of the analysis and interpretation made by third parties and by our in-house London, England

GBP35000 - GBP45000 per annum: Paramount Recruitment: Full Stack Web Developer Cambridge A great opportunity is available for a full stack web developer working with a world-leading Bioinformatics organisation in Cambridge. The role focuses on back and front-end web application development in the context of Cambridge, England

Funding Opportunity PAR-18-585 from the NIH Guide for Grants and Contracts. This FOA invites applications for pragmatic trials for dementia care in Long-term Services and Support (LTSS) settings which will: (1) be designed to address practical comparative questions faced by Alzheimers disease (AD) and Alzheimers disease and related dementia (ADRD) patients, clinicians, and caregivers (both paid and unpaid); (2) include broad and diverse populations; and (3) be conducted in real-world settings. These trials are intended to produce results that can be directly adopted by healthcare providers, patients or caregivers for rapid translation. Successful applications will: (1) improve quality of care of persons with dementia; (2) improve quality of life for persons with dementia and their informal caregivers; (3) deliver more patient-focused, cost- effective care in LTSS; and/or (4) reduce disparities in LTSS care. This FOA will support pilot research to test the feasibility of implementing and integrating LTSS interventions (R21 phase) that, if successful, can transition to an R33 phase for implementation of large pragmatic trials. The transition from the R21 to the R33 phase of the award will be administratively reviewed and determined by successful completion of the Go/No-Go Criteria that are specified for the R21 phase.

Notice NOT-AI-18-013 from the NIH Guide for Grants and Contracts

Notice NOT-AI-18-012 from the NIH Guide for Grants and Contracts

Notice NOT-AI-18-014 from the NIH Guide for Grants and Contracts

Notice NOT-CA-18-040 from the NIH Guide for Grants and Contracts

Notice NOT-CA-18-035 from the NIH Guide for Grants and Contracts

Notice NOT-HL-18-584 from the NIH Guide for Grants and Contracts