Notice NOT-OD-18-107 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-MD-18-003 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support community-based and healthcare setting-based research to understand the individual, interpersonal, community and societal factors that influence patterns of PrEP attitudes, access, availability, and adherence among health disparity populations in the US. Projects may involve primary quantitative/qualitative data collection and/or secondary analysis of existing data.

Funding Opportunity RFA-AI-17-042 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications from single institutions or consortia of institutions to participate in the Centers for Excellence in Translational Research (CETR) program. The purpose of this program is to support multidisciplinary translational research centers focused on generating, validating and advancing medical countermeasures to select NIAID Emerging Infectious Diseases/Pathogens.

Notice NOT-CA-18-024 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-TR-18-001 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to promote the development of in vitro microphysiological systems in modeling human diseases and conditions that mimic the pathology in major organs and tissues in the human body, when exposed to the extreme environments of space, and the use of these models at the International Space Station-U.S. National Laboratory (ISS-NL) to facilitate the assessment of biomarkers, bioavailability, efficacy, and toxicity of therapeutic agents prior to entry into clinical trials. Funds from the NIH will be made available through the UG3/UH3 cooperative agreement mechanism. During the initial two-year UG3 phase, support will be provided to develop robust models that recapitulate the progression and pathology of human diseases and conditions exposed to prolonged microgravity environment. Following administrative review, the two-year UH3 phase will build upon successful UG3 models to demonstrate the functional utility of the models for more defined experiments at the ISS-NL. It is anticipated that these studies will lead to identification of novel treatment mechanisms through better understanding of disease biology, drug screening, assessment of candidate therapies for efficacy and safety assessments, and establishing the pre-clinical foundation that will inform clinical trial design on Earth.

Notice NOT-CA-18-023 from the NIH Guide for Grants and Contracts

Notice NOT-MH-18-010 from the NIH Guide for Grants and Contracts

Funding Opportunity PA-18-418 from the NIH Guide for Grants and Contracts. The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This NIBIB Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of the NIBIB.

Funding Opportunity PAR-18-419 from the NIH Guide for Grants and Contracts. The purpose of the NIDDK Mentored Research Scientist Development Award (K01) is to provide support and protected time (three, four, or five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. The NIDDK invites K01 applications from experienced postdoctoral (two years minimum) and/or recently appointed junior faculty (usually with a Ph.D. degree) in biomedical or behavioral sciences who are pursuing careers in research areas supported by the NIDDK. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial that is itself comprised of a clinical trial intervention(s). Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor . Applicants proposing a clinical trial or an ancillary study (that is itself a clinical trial) to an ongoing clinical trial as lead investigator, should apply to the companion FOA (PAR-DK-18-NNN).

Funding Opportunity PAR-18-418 from the NIH Guide for Grants and Contracts. The purpose of the NIDDK Mentored Research Scientist Development Award (K01) is to provide support and protected time for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. The NIDDK invites K01 applications from experienced postdoctoral (two years minimum) and/or recently appointed junior faculty (usually with a Ph.D. degree) in biomedical, behavioral, or clinical sciences who are pursuing careers in research areas supported by the NIDDK. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development. The ancillary study must also meet the NIH clinical trial definition. Applicants not planning an independent clinical trial, or proposing to gain research experience in a clinical trial led by another investigator, must apply to companion FOA (PAR-18-NNN).

Notice NOT-AG-17-023 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-18-287 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage innovative exploratory and developmental health services research to improve minority health and/or reduce health disparities at the health care system-level as well as within clinical settings.

Funding Opportunity PAR-18-286 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage innovative health services research that can directly and demonstrably contribute to the improvement of minority health and/or the reduction of health disparities at the health care system-level as well as within clinical settings.

Funding Opportunity PAR-18-263 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to transition the core resources and biomedical research activities of Centers of Biomedical Research Excellence (COBRE) into independence and sustainability.

Funding Opportunity PAR-18-249 from the NIH Guide for Grants and Contracts. This purpose of this Funding Opportunity Announcement (FOA) is to provide a mechanism of support to research organizations interested in clinically translating already optimized quantitative imaging software tools capable of measuring or predicting the response of cancer to clinical therapies, or in translating imaging tools for planning and validating radiation therapy treatment strategies in clinical trials. The quantitative tools must have been developed and optimized during a performance period in the Quantitative Imaging Network (QIN) or under other separate funding. The proposed research effort should be an extension of the research that successfully completed the tasks of developing and optimizing the chosen software tools or data collection methods intended to facilitate clinical decision making during clinical trials. This FOA is intended to support the efforts of validating those tools in prospective multisite clinical trials in order to test tool performance and to demonstrate that the tool can be integrated into clinical workflow with a minimum of disruption.

Funding Opportunity PAR-18-248 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages research project applications under the cooperative agreement (UG3/UH3) mechanism to address the development, optimization and validation of quantitative imaging (QI) software tools and methods for prediction and/or measurement of response to cancer therapies or for planning and validating radiation therapy treatment strategies in clinical trials.

Funding Opportunity PA-18-281 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits behavioral, social, and implementation science research designed to (a) identify gaps in the HIV pre-exposure prophylaxis (PrEP) care continuum and associated determinants; (b) develop and test interventions to strengthen PrEP delivery, use, and outcomes; and (c) reduce racial/ethnic and age-related disparities in PrEP uptake and use.

Funding Opportunity PA-18-280 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages implementation research projects designed in partnership with global and domestic service providers, to target the particular needs in the selected community, to achieve the 90/90/90 HIV prevention and treatment targets identified by HIV/AIDS global leadership. The targets for HIV testing are that 90% of all persons living with HIV know their status, for treatment initiation that 90% of those diagnosed receive timely and effective antiretroviral treatment (ART), and for optimal treatment and preventive benefit that 90% of those on treatment achieve sustained viral suppression.

Funding Opportunity PA-18-279 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages implementation research projects designed in partnership with global and domestic service providers, to target the particular needs in the selected community, to achieve the 90/90/90 HIV prevention and treatment targets identified by HIV/AIDS global leadership. The targets for HIV testing are that 90% of all persons living with HIV know their status, for treatment initiation that 90% of those diagnosed receive timely and effective antiretroviral treatment (ART), and for optimal treatment and preventive benefit that 90% of those on treatment achieve sustained viral suppression.

Notice NOT-AG-17-019 from the NIH Guide for Grants and Contracts