Pharmacogenomics
Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects
Arch Pharm Res. 2022 Dec 23. doi: 10.1007/s12272-022-01423-0. Online ahead of print.
ABSTRACT
Tolperisone hydrochloride is a centrally-acting muscle relaxant used for relieving spasticities of neurological origin and muscle spasms associated with painful locomotor diseases. It is metabolized to the inactive metabolite mainly by CYP2D6 and, to a lesser extent, by CYP2C19 and CYP1A2. In our previous study, the pharmacokinetics of tolperisone was significantly affected by the genetic polymorphism of CYP2D6, but the wide interindividual variation of tolperisone pharmacokinetics was not explained by genetic polymorphism of CYP2D6 alone. Thus, we studied the effects of CYP2C19 genetic polymorphism on tolperisone pharmacokinetics. Eighty-one subjects with different CYP2C19 genotypes received a single oral dose of 150 mg tolperisone with 240 mL of water, and blood samples were collected up to 12 h after dosing. The plasma concentration of tolperisone was measured by a liquid chromatography-tandem mass spectrometry system. The CYP2C19PM group had significantly higher Cmax and lower CL/F values than the CYP2C19EM and CYP2C19IM groups. The AUCinf of the CYP2C19PM group was 2.86-fold and 3.00-fold higher than the CYP2C19EM and CYP2C19IM groups, respectively. In conclusion, the genetic polymorphism of CYP2C19 significantly affected tolperisone pharmacokinetics.
PMID:36564599 | DOI:10.1007/s12272-022-01423-0
circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer
Genes Chromosomes Cancer. 2022 Dec 22. doi: 10.1002/gcc.23121. Online ahead of print.
NO ABSTRACT
PMID:36562080 | DOI:10.1002/gcc.23121
MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta-analysis
Cancer Rep (Hoboken). 2022 Dec 22:e1773. doi: 10.1002/cnr2.1773. Online ahead of print.
NO ABSTRACT
PMID:36560873 | DOI:10.1002/cnr2.1773
Pharmacogenetic Dose Modeling Based on CYP2C19 Allelic Phenotypes
Pharmaceutics. 2022 Dec 16;14(12):2833. doi: 10.3390/pharmaceutics14122833.
NO ABSTRACT
PMID:36559326 | DOI:10.3390/pharmaceutics14122833
In Vitro Cytopathogenic Activities of <em>Acanthamoeba</em> T3 and T4 Genotypes on HeLa Cell Monolayer
Pathogens. 2022 Dec 5;11(12):1474. doi: 10.3390/pathogens11121474.
NO ABSTRACT
PMID:36558808 | DOI:10.3390/pathogens11121474
Evaluation of the Association between Single Nucleotide Polymorphisms of Metabolizing Enzymes with the Serum Concentration of Paracetamol and Its Metabolites
Metabolites. 2022 Dec 9;12(12):1235. doi: 10.3390/metabo12121235.
NO ABSTRACT
PMID:36557273 | DOI:10.3390/metabo12121235
Dolutegravir Discontinuation for Neuropsychiatric Symptoms in People Living with HIV and Their Outcomes after Treatment Change: A Pharmacogenetic Study
Metabolites. 2022 Dec 1;12(12):1202. doi: 10.3390/metabo12121202.
NO ABSTRACT
PMID:36557240 | DOI:10.3390/metabo12121202
Impact of COVID-19 Pandemic on Disease Control Status and Quality of Life of Patients with Acromegaly
Medicina (Kaunas). 2022 Nov 23;58(12):1711. doi: 10.3390/medicina58121711.
NO ABSTRACT
PMID:36556914 | DOI:10.3390/medicina58121711
The Transition from Cancer "omics" to "epi-omics" through Next- and Third-Generation Sequencing
Life (Basel). 2022 Dec 2;12(12):2010. doi: 10.3390/life12122010.
NO ABSTRACT
PMID:36556377 | DOI:10.3390/life12122010
Patients' Perspectives of Factors That Influence Pharmacogenetic Testing Uptake: Enhancing Patient Counseling and Results Dissemination
J Pers Med. 2022 Dec 11;12(12):2046. doi: 10.3390/jpm12122046.
NO ABSTRACT
PMID:36556266 | DOI:10.3390/jpm12122046
Physicians' Knowledge, Attitude, and Experience of Pharmacogenomic Testing in China
J Pers Med. 2022 Dec 7;12(12):2021. doi: 10.3390/jpm12122021.
NO ABSTRACT
PMID:36556242 | DOI:10.3390/jpm12122021
Pharmacogenetics of <em>CYP2A6</em>, <em>CYP2B6</em>, and <em>UGT2B7</em> in the Context of HIV Treatments in African Populations
J Pers Med. 2022 Dec 5;12(12):2013. doi: 10.3390/jpm12122013.
NO ABSTRACT
PMID:36556234 | DOI:10.3390/jpm12122013
Validation of Pharmacogenomic Interaction Probability (PIP) Scores in Predicting Drug-Gene, Drug-Drug-Gene, and Drug-Gene-Gene Interaction Risks in a Large Patient Population
J Pers Med. 2022 Nov 29;12(12):1972. doi: 10.3390/jpm12121972.
NO ABSTRACT
PMID:36556194 | DOI:10.3390/jpm12121972
Genetic Biomarkers of Antipsychotic-Induced Prolongation of the QT Interval in Patients with Schizophrenia
Int J Mol Sci. 2022 Dec 13;23(24):15786. doi: 10.3390/ijms232415786.
NO ABSTRACT
PMID:36555428 | DOI:10.3390/ijms232415786
Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives
Int J Mol Sci. 2022 Dec 10;23(24):15694. doi: 10.3390/ijms232415694.
NO ABSTRACT
PMID:36555333 | DOI:10.3390/ijms232415694
Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update
Genes (Basel). 2022 Dec 16;13(12):2388. doi: 10.3390/genes13122388.
NO ABSTRACT
PMID:36553655 | DOI:10.3390/genes13122388
A Patient with Corticobasal Syndrome and Progressive Non-Fluent Aphasia (CBS-PNFA), with Variants in <em>ATP7B</em>, <em>SETX</em>, <em>SORL1</em>, and <em>FOXP1</em> Genes
Genes (Basel). 2022 Dec 14;13(12):2361. doi: 10.3390/genes13122361.
NO ABSTRACT
PMID:36553628 | DOI:10.3390/genes13122361
The Influence of Structural Variants of the <em>CES1</em> Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613
Genes (Basel). 2022 Nov 27;13(12):2225. doi: 10.3390/genes13122225.
NO ABSTRACT
PMID:36553492 | DOI:10.3390/genes13122225
Proteomics and Phospho-Proteomics Profiling of the Co-Formulation of Type I and II Interferons, HeberFERON, in the Glioblastoma-Derived Cell Line U-87 MG
Cells. 2022 Dec 15;11(24):4068. doi: 10.3390/cells11244068.
NO ABSTRACT
PMID:36552831 | DOI:10.3390/cells11244068
Converging Evidence Points to BDNF as Biomarker of Depressive Symptoms in Schizophrenia-Spectrum Disorders
Brain Sci. 2022 Dec 4;12(12):1666. doi: 10.3390/brainsci12121666.
NO ABSTRACT
PMID:36552127 | DOI:10.3390/brainsci12121666