Pharmacogenomics

PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia

Wed, 2022-12-14 06:00

Sci Adv. 2022 Dec 14;8(50):eadd6403. doi: 10.1126/sciadv.add6403. Epub 2022 Dec 14.

NO ABSTRACT

PMID:36516256 | DOI:10.1126/sciadv.add6403

Categories: Literature Watch

Deep Intronic <em>FGF14</em> GAA Repeat Expansion in Late-Onset Cerebellar Ataxia

Wed, 2022-12-14 06:00

N Engl J Med. 2022 Dec 14. doi: 10.1056/NEJMoa2207406. Online ahead of print.

NO ABSTRACT

PMID:36516086 | DOI:10.1056/NEJMoa2207406

Categories: Literature Watch

LncRNA weighted gene co-expression network analysis reveals novel biomarkers related to prostate cancer metastasis

Tue, 2022-12-13 06:00

BMC Med Genomics. 2022 Dec 13;15(1):256. doi: 10.1186/s12920-022-01410-w.

NO ABSTRACT

PMID:36514044 | DOI:10.1186/s12920-022-01410-w

Categories: Literature Watch

Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania

Tue, 2022-12-13 06:00

Mol Psychiatry. 2022 Dec 13. doi: 10.1038/s41380-022-01888-x. Online ahead of print.

NO ABSTRACT

PMID:36513812 | DOI:10.1038/s41380-022-01888-x

Categories: Literature Watch

Semaglutide delays 4-hour gastric emptying in women with PCOS and obesity

Tue, 2022-12-13 06:00

Diabetes Obes Metab. 2022 Dec 13. doi: 10.1111/dom.14944. Online ahead of print.

NO ABSTRACT

PMID:36511825 | DOI:10.1111/dom.14944

Categories: Literature Watch

Identifying the prevalence of clinically actionable drug-gene interactions in a health system biorepository to guide pharmacogenetics implementation services

Tue, 2022-12-13 06:00

Clin Transl Sci. 2022 Dec 12. doi: 10.1111/cts.13449. Online ahead of print.

NO ABSTRACT

PMID:36510710 | DOI:10.1111/cts.13449

Categories: Literature Watch

Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate

Mon, 2022-12-12 06:00

Eur J Hum Genet. 2022 Dec 12. doi: 10.1038/s41431-022-01262-z. Online ahead of print.

NO ABSTRACT

PMID:36509836 | DOI:10.1038/s41431-022-01262-z

Categories: Literature Watch

Genome-Wide Association Study Identifies Copy Number Variants Associated with Warfarin Dose Response and Risk of Venous Thromboembolism in African Americans

Mon, 2022-12-12 06:00

Clin Pharmacol Ther. 2022 Dec 12. doi: 10.1002/cpt.2820. Online ahead of print.

NO ABSTRACT

PMID:36507737 | DOI:10.1002/cpt.2820

Categories: Literature Watch

Correlation between assessment of cytochrome P450 1A2 activity and enzyme activity scores, and their relation with clozapine exposure

Mon, 2022-12-12 06:00

Br J Clin Pharmacol. 2022 Dec 12. doi: 10.1111/bcp.15636. Online ahead of print.

NO ABSTRACT

PMID:36507652 | DOI:10.1111/bcp.15636

Categories: Literature Watch

Eight pharmacokinetic genetic variants are not associated with the risk of bleeding from direct oral anticoagulants in non-valvular atrial fibrillation patients

Mon, 2022-12-12 06:00

Front Pharmacol. 2022 Nov 24;13:1007113. doi: 10.3389/fphar.2022.1007113. eCollection 2022.

NO ABSTRACT

PMID:36506510 | PMC:PMC9730333 | DOI:10.3389/fphar.2022.1007113

Categories: Literature Watch

Predictive genomic tools in disease stratification and targeted prevention: a recent update in personalized therapy advancements

Mon, 2022-12-12 06:00

EPMA J. 2022 Nov 12;13(4):561-580. doi: 10.1007/s13167-022-00304-2. eCollection 2022 Dec.

NO ABSTRACT

PMID:36505888 | PMC:PMC9727029 | DOI:10.1007/s13167-022-00304-2

Categories: Literature Watch

Integrated profiling uncovers prognostic, immunological, and pharmacogenomic features of ferroptosis in triple-negative breast cancer

Mon, 2022-12-12 06:00

Front Immunol. 2022 Nov 25;13:985861. doi: 10.3389/fimmu.2022.985861. eCollection 2022.

NO ABSTRACT

PMID:36505498 | PMC:PMC9732280 | DOI:10.3389/fimmu.2022.985861

Categories: Literature Watch

Corrigendum to "Quantitative and structural characteristics of mitochondrial DNA in varicose veins" [Vascular Pharmacology 145 (2022) 107021]

Mon, 2022-12-12 06:00

Vascul Pharmacol. 2022 Dec 8:107138. doi: 10.1016/j.vph.2022.107138. Online ahead of print.

NO ABSTRACT

PMID:36503632 | DOI:10.1016/j.vph.2022.107138

Categories: Literature Watch

CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway

Mon, 2022-12-12 06:00

Int J Biochem Cell Biol. 2022 Dec 8:106344. doi: 10.1016/j.biocel.2022.106344. Online ahead of print.

NO ABSTRACT

PMID:36503048 | DOI:10.1016/j.biocel.2022.106344

Categories: Literature Watch

Quantitative Analysis of Isoniazid and Its Four Primary Metabolites in Plasma of Tuberculosis Patients Using LC-MS/MS

Sun, 2022-12-11 06:00

Molecules. 2022 Dec 6;27(23):8607. doi: 10.3390/molecules27238607.

NO ABSTRACT

PMID:36500699 | DOI:10.3390/molecules27238607

Categories: Literature Watch

Potential Role of Host Microbiome in Areca Nut-Associated Carcinogenesis and Addiction

Sun, 2022-12-11 06:00

Molecules. 2022 Nov 24;27(23):8171. doi: 10.3390/molecules27238171.

NO ABSTRACT

PMID:36500264 | DOI:10.3390/molecules27238171

Categories: Literature Watch

Pharmacological Mechanism of NRICM101 for COVID-19 Treatments by Combined Network Pharmacology and Pharmacodynamics

Sun, 2022-12-11 06:00

Int J Mol Sci. 2022 Dec 6;23(23):15385. doi: 10.3390/ijms232315385.

NO ABSTRACT

PMID:36499711 | DOI:10.3390/ijms232315385

Categories: Literature Watch

Modern Advances in CARs Therapy and Creating a New Approach to Future Treatment

Sun, 2022-12-11 06:00

Int J Mol Sci. 2022 Nov 30;23(23):15006. doi: 10.3390/ijms232315006.

NO ABSTRACT

PMID:36499331 | DOI:10.3390/ijms232315006

Categories: Literature Watch

Adults with Intellectual Disability and Autism Spectrum Disorder: What Is the Evidence around the Use of Polypharmacy

Sun, 2022-12-11 06:00

Int J Environ Res Public Health. 2022 Nov 30;19(23):15974. doi: 10.3390/ijerph192315974.

NO ABSTRACT

PMID:36498043 | DOI:10.3390/ijerph192315974

Categories: Literature Watch

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