Funding Opportunity PAR-24-083 from the NIH Guide for Grants and Contracts. This notice of funding opportunity (NOFO) invites applications for investigator-initiated clinical trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) in NCCIH-designated areas of high research priority. Applications submitted under this NOFO are expected to propose a multisite feasibility clinical trial that will provide new information that is scientifically necessary for the planning and conduct of a subsequent clinical efficacy or effectiveness study, pragmatic trial, or dissemination and implementation trial within NCCIHs mission. NCCIH expects that applications to this NOFO will describe the planned future clinical trial and in so doing demonstrate that the proposed (R01) research is scientifically necessary to design or plan the subsequent fully powered, full-scale clinical trial. Under this R01, the data collected should be used to fill gaps in scientific knowledge, including, but not limited to the following: assessing whether the intervention can be delivered with fidelity across sites; demonstrating feasibility of recruitment, accrual, and randomization of participants across sites; demonstrating participant adherence to the intervention, as well as retention of participants throughout the study across sites; refining and assessing the feasibility of protocolized multimodal interventions, and/or demonstrating feasibility of data collection across sites in preparation for a future fully powered, multisite efficacy or effectiveness trial. The need for multisite feasibility trials is expected to be justified by sufficient preliminary data from previous single site feasibility or acceptability trial(s) or the published literature. The data collected should be used to fill gaps in scientific knowledge and be necessary to develop a competitive fully powered multisite clinical trial that has the potential to make a significant impact on public health.

Notice NOT-CA-24-023 from the NIH Guide for Grants and Contracts

Notice NOT-DK-24-007 from the NIH Guide for Grants and Contracts

Notice NOT-CA-24-022 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-048 from the NIH Guide for Grants and Contracts

Notice NOT-HG-24-012 from the NIH Guide for Grants and Contracts

Notice NOT-MH-24-140 from the NIH Guide for Grants and Contracts

Notice NOT-AR-23-024 from the NIH Guide for Grants and Contracts

Notice NOT-EB-23-024 from the NIH Guide for Grants and Contracts

Notice NOT-DE-24-007 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-23-315 from the NIH Guide for Grants and Contracts. The overarching goal of this PAR is to support educational activities that complement and/or enhance the training of the clinical and research workforce, and bring awareness of Geroscience to members of the public, by supporting creative educational activities with a primary focus on the development and integration of basic, applied, translational, and clinical topics in Geroscience including: Curriculum or Methods Development, Courses for Skills Development, Research Experiences and Networking, Development of a Repository of Important Reviews and Opinion Pieces and Clinical Trials in Progress, Outreach and Creation of Lay Public Documents on Geroscience.

Notice NOT-HL-23-125 from the NIH Guide for Grants and Contracts

Notice NOT-DK-24-005 from the NIH Guide for Grants and Contracts

Notice NOT-DK-24-004 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-033 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-034 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-035 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-036 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DA-25-028 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to support the development of Clinical Outcome Assessments (COA) for Substance Use Disorders (SUD). The COA development plan is expected to progress into the FDA drug development tool qualification program. This notice of funding opportunity (NOFO) utilizes the UG3/UH3Phased Innovation Awards Cooperative Agreement grant mechanism that includes two phases. The applications responding to this NOFO should contain a COA development plan that will cover both UG3 and UH3 phases. In the first 2-year UG3 phasethe project must have a set of operational milestones to be completed by the end of this period. Once NIDA program has evaluated the progress of the UG3 phase and determined that the UG3 phase has been successfully completed, it transitions to the UH3 phase to be funded for three additional years.The goal of this NOFO is to expand the armamentarium of COA that are FDA qualified as drug development tool (DDT) in the context of use (COI) of a SUD. Achieving this goal will greatly facilitate the development of treatments for SUDs. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Funding Opportunity RFA-NR-24-003 from the NIH Guide for Grants and Contracts. Care delivery has traditionally approached a patients health as separate and distinct from their social context. This practice must be reimagined to make meaningful improvements in health, eliminate health disparities, and advance health equity. The purpose of the Bridge-to-Care Initiative is to advance research that leverages healthcare-community partnerships to address unmet health-related social needs among individuals and families and adverse social determinants of health (SDOH) within communities.