Funding Opportunity PAR-25-374 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications that propose to use mouse models to conduct rigorous preclinical testing of drugs or drug combinations currently used for other conditions, as well as investigational drugs at various stages of clinical development, predicted to be efficacious in AD/ADRD. This initiative will also support preclinical testing of repurposable or investigational drug candidates in combination with non-pharmacologic interventions leading to robust translational outcomes. The central goal is to establish robust proof of concept that will enable rational drug repurposing and combination therapy development for the treatment and prevention of AD/ADRD.

Funding Opportunity RFA-EY-25-002 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to request applications that aim to implement and evaluate multi-level interventions and community engaged research in advancing vision equity. This Notice of Funding Opportunity (NOFO) supports research directed at preventing, reducing, or eliminating disparities in eye and vision health. Applications responding to this NOFO must involve multilevel interventions that simultaneously address vision health conditions and social determinants of health (SDOH) at one or more levels of influence, such as individual, interpersonal, organizational, and community. Research must include a focus on improving vision health in one or more NIH-designated Populations with Health Disparities. Additionally, research must demonstrate meaningful community engagement in the research process.

Funding Opportunity PAR-25-101 from the NIH Guide for Grants and Contracts. The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is underrepresented or not included in NIDA's current portfolio that has the potential to transform SUD research. The proposed research should: 1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or 2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

Notice NOT-AG-24-086 from the NIH Guide for Grants and Contracts

Notice NOT-MH-25-050 from the NIH Guide for Grants and Contracts

Notice NOT-MH-25-045 from the NIH Guide for Grants and Contracts

Notice NOT-GM-25-017 from the NIH Guide for Grants and Contracts

Notice NOT-GM-25-016 from the NIH Guide for Grants and Contracts

Notice NOT-AA-25-002 from the NIH Guide for Grants and Contracts

Notice NOT-HL-24-036 from the NIH Guide for Grants and Contracts

Notice NOT-HS-25-012 from the NIH Guide for Grants and Contracts

Notice NOT-AI-25-017 from the NIH Guide for Grants and Contracts

Notice NOT-CA-25-007 from the NIH Guide for Grants and Contracts

Notice NOT-DC-25-022 from the NIH Guide for Grants and Contracts

Notice NOT-GM-25-012 from the NIH Guide for Grants and Contracts

Notice NOT-EY-25-003 from the NIH Guide for Grants and Contracts

Funding Opportunity PA-25-303 from the NIH Guide for Grants and Contracts. The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this NOFO include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the appropriate Clinical Trials Required or Clinical Trial Optional NOFO. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

Funding Opportunity PA-25-305 from the NIH Guide for Grants and Contracts. The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity Announcement requires that at lease 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

Funding Opportunity RFA-OH-25-183 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity Announcement (NOFO) is to solicit meritorious applications from universities with graduate programs in mining and explosives engineering to develop and conduct research specifically focused on aspects of underground mine evacuation technologies and human factors related to mine emergencies.

Funding Opportunity PA-25-301 from the NIH Guide for Grants and Contracts. The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. This Notice of Funding Opportunity does not accept applications proposing clinical trial(s).