Funding Opportunity RFA-DK-22-019 from the NIH Guide for Grants and Contracts. This U2C funding opportunity announcement (FOA) is a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative to establish a novel national Stakeholder Engagement Innovation Center for advancing equity in type 1 diabetes research (SEIC-T1D). A primary goal of the SEIC-T1D is to accelerate equitable engagement of diverse stakeholders in T1D research, particularly those from diverse communities that experience diabetes-related health disparities, as well as the healthcare and social systems that impact community members and patients health. The SEIC-T1D will provide highly specialized research resources to support investigators by fully embedding communities, people living with T1D, and other stakeholders into the full spectrum of research activities through expert consultations and education in principles and methods of community-engaged research. The SEIC-T1D will also establish a network consisting of diverse, multidisciplinary research investigators with expertise in T1D and community-engaged methods, community experts with lived experiences, and representatives of various health and other organizations deemed essential for addressing disparities and advancing health equity in T1D early detection and treatment.

Notice NOT-CA-22-108 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DK-22-503 from the NIH Guide for Grants and Contracts. The purpose of this Limited Competition is to extend the Chronic Renal Insufficiency Cohort (CRIC) Study by continuing to support the Scientific and Data Coordinating Center (SDCC). The CRIC Study is a multi-center, prospective, observational cohort study of men and women with chronic kidney disease (CKD). The CRIC Clinical Centers will complete follow-up previously enrolled participants under a separate FOA with a focus on completing enrollment into ongoing sub-studies that utilize at-home assessments of kidney and cardiovascular function. The primary objective of this FOA is to support the SDCC to lead the study group to achieve the scientific goals of the next project period and develop a sustainable strategy to disseminate the CRIC data and samples to the larger research community, as well as ensure that all study samples and data are archived into the NIDDK Central Repository.

Funding Opportunity RFA-NS-22-055 from the NIH Guide for Grants and Contracts. This FOA invites applications that propose the comprehensive functional validation of newly identified therapeutic target candidates for Alzheimer's Disease-Related Dementias (ADRDs). This FOA seeks to promote critical target validation approaches to help de-risk subsequent translational research and accelerate the advancement of novel therapies for ADRD. Target(s) or molecular pathway(s) to be considered for validation must have been already identified using tissue expression or genetic data generated in human samples. In its initial phase, this FOA provided support for up to two years (R61 stage) for the development of customized technologies, models, and protocols to modulate the expression or activity of target candidate(s) in cells or tissues and monitor their functional biological consequences in in vitro or in vivo disease models. Upon demonstration of technical feasibilities, a second phase (R33 stage) will carefully and reproducibly measure and cross-validate the impact of the target modulation in different modalities across collaborating laboratories using the NIH rigor and reproducibility guidelines. Applicants responding to this FOA must address objectives for both the UG3 and UH3 phases and are expected to have a substantial collaborative effort between independents laboratories. This FOA is not specific for any one or group within the ADRD spectrum of disorders. Disorders covered in these applications are frontotemporal degeneration (FTD), Lewy body dementias (LBD) (including dementia with Lewy bodies (DLB)), Parkinson disease dementia (PDD), vascular contributions to cognitive impairment and dementia (VCID), mixed dementias including the associated diagnostic challenges of multiples etiology dementias (MED).

Funding Opportunity RFA-NS-22-053 from the NIH Guide for Grants and Contracts. Emergency Award: This Funding Opportunity Announcement (FOA) solicits research applications that propose implementation science methodology to embed existing evidence-based coordinated pain care models into a variety of public and private health care systems (HCS) where this type of care does not exist. Applications that combine comparative effectiveness studies of innovative coordinated care models with strong implementation science methodology to embed effective approaches into HCSs also are encouraged. This FOA requires that the coordinated care model under study be embedded into the health care delivery system of the applicant institutions. Coordinated pain care approaches proposed for study should include interventions from multiple disciplines as described below and should aim to improve pain management based on the biopsychosocial model of pain. Emphasis should be on populations of patients with greatest need. This FOA solicits applications from HCS who have resources and infrastructure to support research and implementation of study approaches in partnership with those HCS who lack research resources or experience and would benefit most from implementation of cost-effective coordinated pain care. HCS partners who serve populations that are under-represented in research are encouraged to apply. Models of coordinated care proposed by the study team should be aligned with health care resources of the participating HCS and should be informed through engagement of stakeholders including patients, providers, healthcare system executives, policy makers, and payors. The study teams must include health care providers from multiple disciplines and implementation scientists.

Funding Opportunity RFA-NS-22-065 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to solicit applications for a Coordinating Center to provide leadership for the HEAL Coordinated Approaches to Pain Care in Health Care Systems Program. The Coordinating Center will 1) work collaboratively with each Project team supported through the Collaboratory program, including their partnering health care system (HCS), to develop, test, and implement the proposed Projects while providing technical, design, and coordination support; 2) provide centralized resources (e.g., electronic health records expertise, study design and statistical expertise for implementation trials, bioethics and regulatory expertise) for coordination and integration of the research effort across all projects; and 3) centralize the engagement of patients, care providers, health care systems, payors, and policy makers to inform the activities of the program of research, with a particular focus on HCS with less historical involvement in research studies. The Coordinating Center also will serve as the central administrative resource for the activities of the Coordinated Approaches to Pain Care Program.

Notice NOT-AI-22-061 from the NIH Guide for Grants and Contracts

Notice NOT-AI-22-062 from the NIH Guide for Grants and Contracts

Notice NOT-AI-22-063 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-MH-22-190 from the NIH Guide for Grants and Contracts. This NIMH funding opportunity announcement (FOA) seeks to strengthen the evidence for effective interventions and implementation strategies that address SDoH for HIV, and ultimately improve HIV outcomes and reduce health inequities. The FOA will solicit and fund a set of implementation research projects that aim to reduce HIV inequities, with the goal to support high-impact implementation research in HIV health inequity reduction and develop a generalizable knowledge base to guide implementation of innovative strategies, inform policy, shape guidelines, and provide a model for other jurisdictions. Research projects or collaboratives will employ efficient hybrid implementation-effectiveness research designs to simultaneously advance the evidence base for effective SSDoH-encompassing interventions and test implementation strategies to accompany these interventions.

Funding Opportunity RFA-MH-22-191 from the NIH Guide for Grants and Contracts. This NIMH funding opportunity announcement (FOA) seeks to strengthen the evidence for effective interventions and implementation strategies that address SDoH for HIV, and ultimately improve HIV outcomes and reduce health inequities. The FOA will solicit and fund a set of implementation research projects that aim to reduce HIV inequities, with the goal to support high-impact implementation research in HIV health inequity reduction and develop a generalizable knowledge base to guide implementation of innovative strategies, inform policy, shape guidelines, and provide a model for other jurisdictions. Research projects or collaboratives will employ efficient hybrid implementation-effectiveness research designs to simultaneously advance the evidence base for effective SSDoH-encompassing interventions and test implementation strategies to accompany these interventions.

Notice NOT-TR-22-033 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AI-22-046 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support research on the underlying cause(s) of signs and symptoms that may persist following a Lyme disease diagnosis and antibiotic treatment.

Notice NOT-NS-23-010 from the NIH Guide for Grants and Contracts

Notice NOT-RM-22-016 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DK-22-502 from the NIH Guide for Grants and Contracts. The purpose of this Limited Competition is to extend the Chronic Renal Insufficiency Cohort (CRIC) Study by continuing to support Clinical Centers that have previously enrolled and followed study participants. The CRIC Study is a multi-center, prospective, observational cohort study of men and women with chronic kidney disease (CKD). The primary objective of this FOA is to complete follow-up of the entire cohort. Under this FOA, the Clinical Centers will complete all data collection on enrolled participants and arrange to transfer these data and all collected biosamples to the Scientific and Data Coordinating Center (SDCC) for ultimate deposition into the NIDDK Central Biorepository.

Notice NOT-PM-22-004 from the NIH Guide for Grants and Contracts

Notice NOT-HD-22-034 from the NIH Guide for Grants and Contracts

Notice NOT-HD-22-033 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-CA-22-040 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for Biomarker Characterization Centers (BCCs), one of the three scientific units of the Early Detection Research Network (EDRN). The EDRN is a national infrastructure to discover, develop, and validate biomarkers and imaging methods for early cancer detection and risk assessment. BCCs will (1) discover, develop, characterize and test new biomarkers or refine existing biomarkers, (2) develop, refine and/or standardize biomarker assays, (3) provide resources and support for the validation of biomarkers developed by the EDRN, and (4) participate in collaborative projects with other laboratories and centers.The other two scientific units of the continuing EDRN program are the Clinical Validation Centers (CVCs), which will conduct clinical research on the validation of biomarkers and will serve as resource centers for the Network by participating in collaborative biomarker validation studies with EDRN BCCs; and the Data Management and Coordinating Center (DMCC), which will support statistical and computational analyses, informatics infrastructure, study design, coordination and management of EDRN-sponsored biomarker validation studies, and the coordination of Network-wide meetings and workshops.