Funding Opportunity PAR-25-058 from the NIH Guide for Grants and Contracts. Reissue PAR-21-122. This NOFO provides funding to conduct pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to demonstrate that proposed therapeutic agent(s) have sufficient biological activity to warrant further development to treat neurological or neuromuscular disorders that fall under the NINDS mission. Therapeutic agents include small molecules, biologics or biotechnology-derived products. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for the Blueprint Neurotherapeutics Network or other translational programs.

Funding Opportunity PAR-25-060 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) encourages the development and validation of animal models and human/animal tissue ex vivo systems that recapitulate the phenotypic and physiologic characteristics of a defined neurological or neuromuscular disorder. The goal of this FOA is to promote a significant improvement in the translational relevance of animal models or ex vivo systems that will be utilized to facilitate future development of neurotherapeutics. Ideally, models proposed for this FOA would have the potential to provide feasible and meaningful assessments of efficacy following therapeutic intervention that would be applicable in both preclinical and clinical settings. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) Program focused on enabling the exploratory and early stages of drug discovery.

Notice NOT-OD-25-013 from the NIH Guide for Grants and Contracts

Notice NOT-AG-24-068 from the NIH Guide for Grants and Contracts

Notice NOT-CA-24-115 from the NIH Guide for Grants and Contracts

Notice NOT-CA-24-114 from the NIH Guide for Grants and Contracts

Notice NOT-CA-24-113 from the NIH Guide for Grants and Contracts

Notice NOT-CA-24-112 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-MD-24-010 from the NIH Guide for Grants and Contracts. The Environmental Health Disparities Centers seeks to solicit multidisciplinary research, research capacity building, and community-engaged research activities on environmental health disparities and environmental justice research for populations and communities experiencing health disparities within the US and its territories.

Notice NOT-HD-24-035 from the NIH Guide for Grants and Contracts

Notice NOT-DE-25-042 from the NIH Guide for Grants and Contracts

Notice NOT-HD-24-042 from the NIH Guide for Grants and Contracts

Notice NOT-AI-24-083 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DE-25-003 from the NIH Guide for Grants and Contracts. To develop a national, interdisciplinary, patient-centered research consortium to advance Temporomandibular Disorders (TMDs) basic and clinical research, research training, and translation to evidence-based treatments and improved clinical care.

Funding Opportunity PAR-25-082 from the NIH Guide for Grants and Contracts. This initiative seeks to enhance our mechanistic and epidemiologic understanding of infection-related cancers, with a focus on the etiologic roles of co-infection in cancer. Preference will be given to co-infections (excluding co-infection with human immunodeficiency virus [HIV]) that engendered novel opportunities for prevention and treatment and focus on understudied populations. Coinfection is defined as the occurrence of infections by two or more infectious (pathogenic or nonpathogenic) agents either concurrently or sequentially and includes both acute and chronic infections by viruses, bacteria, parasites, and/or other microorganisms.

Notice NOT-ES-25-001 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-120 from the NIH Guide for Grants and Contracts. The NIDCD Early Career Research (ECR) Award (R21) is intended to support both basic and clinical research from scientists who are beginning to establish an independent research career. It cannot be used for thesis or dissertation research. The research must be focused on one or more of the areas within the biomedical and behavioral scientific mission of the NIDCD: hearing, balance, smell, taste, voice, speech, or language. The NIDCD ECR Award R21 grant mechanism supports different types of projects including secondary analysis of existing data; small, self-contained research projects; development of research methodology; translational research; outcomes research; and development of new research technology. Irrespective of the type of project, the intent of the NIDCD ECR Award R21 is for the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) to obtain sufficient preliminary data for a subsequent R01 application.

Funding Opportunity PAR-25-078 from the NIH Guide for Grants and Contracts. This notice of funding opportunity (NOFO) supports small research projects on cancer that can be carried out in a short period of time with limited resources. The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.

Notice NOT-AI-25-003 from the NIH Guide for Grants and Contracts

Notice NOT-HD-24-038 from the NIH Guide for Grants and Contracts