Funding Opportunity RFA-HL-19-005 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement is to identify and then prospectively evaluate the effectiveness of current practices used by primary healthcare providers to manage patients with asthma. Investigators will identify management strategies in current use for primary care of asthma by analyzing electronic health records (EHRs) from a nationally representative sample of patients and then prospectively evaluate the paradigms for management that appear to be most effective through EHR-enabled clinical trials. The Cooperative Agreement awarded through this FOA will support a Clinical Center, comprised of a primary care network (PCN), a data management core (DMC), and a clinical consultation center (CCC).

Funding Opportunity RFA-NS-18-041 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support the discovery of promising candidate biomarkers that will facilitate the development of non-opioid therapeutic options for the treatment of pain conditions. The goal of this FOA is to encourage a biomarker discovery process that will result in the development of pain biomarkers that can withstand rigorous clinical and analytical validation. It is hoped that an increased availability of rigorous biomarkers for pain will facilitate the discovery and development of transformational non-opioid therapeutics for pain.

Funding Opportunity PAR-18-886 from the NIH Guide for Grants and Contracts. NIDDK utilizes High Impact, Interdisciplinary Science (RC2) grants to support projects that will lay the foundation for new fields of investigation within the mission of NIDDK. The RC2 is envisioned to use an interdisciplinary approach to generate a research resource and/or foster discovery-based or hypothesis-generating science that can have a significant impact on the broader scientific community. This targeted FOA specifically seeks to generate scientific advancements that are focused on identifying new signals and regulatory networks that mediate metabolic cross talks within and between organs that play a role in the development of diabetes and obesity. The interdisciplinary approaches proposed should be designed to foster novel synergies that will accelerate conceptual and technical breakthroughs in science related to metabolic tissue communication.

Notice NOT-HL-18-644 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-MD-18-009 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) grant applications that propose to develop a product, process or service for commercialization with the aim of improving minority health and/or reducing health disparities in one or more NIH-defined health disparity population groups. Appropriate technologies should be effective, affordable, and culturally acceptable.

Funding Opportunity RFA-MD-18-010 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) grant applications that propose to develop a product, process or service for commercialization with the aim of improving minority health and/or reducing health disparities in one or more NIH-defined health disparity population groups. Appropriate technologies should be effective, affordable, and culturally acceptable.

Funding Opportunity PAR-18-885 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications that use novel approaches for the development of safe, real-time, non-invasive (or minimally invasive), in vivo methods to assess the development and function of the human placenta across pregnancy.

Funding Opportunity PAR-18-884 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications that use novel approaches for the development of safe, real-time, non-invasive (or minimally invasive), in vivo methods to assess the development and function of the human placenta across pregnancy.

Notice NOT-RM-18-020 from the NIH Guide for Grants and Contracts

Notice NOT-DC-18-008 from the NIH Guide for Grants and Contracts

Notice NOT-DK-18-021 from the NIH Guide for Grants and Contracts

Notice NOT-NR-18-017 from the NIH Guide for Grants and Contracts

Notice NOT-NR-18-016 from the NIH Guide for Grants and Contracts

Notice NOT-OD-18-215 from the NIH Guide for Grants and Contracts

Notice NOT-GM-18-041 from the NIH Guide for Grants and Contracts

Notice NOT-AI-18-050 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HL-18-035 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH), participating NIH Institutes and Centers, in coordination with the U.S. Food and Drug Administration, invite cooperative agreement (U44) applications to support small business research studies aimed at furthering the field of regenerative medicine (RM) using adult stem cells. These applications are expected to focus on innovative projects that propose solutions to widely recognized issues in the development of safe and effective RM therapies. Emphasis will be given to projects that address critical issues in product development relevant for regulatory submissions. Areas of focus may include improved tools, methods, standards, or applied science that support a better understanding and improved evaluation of in-depth product characterization, manufacturing, potency, identity, quality, safety, in vivo function and integration, or effectiveness. Toward these ends, the NIH will consider applications for late stage preclinical research studies involving adult stem cells in the context of generating or supplementing the necessary evidence for clinical development, including, but not limited to, the submission of an Investigational New Drug (IND) or Investigational New Device Exemption (IDE) package; or to support such research conducted under an authorized IND or IDE.

Funding Opportunity RFA-HL-18-033 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH), participating NIH Institutes and Centers, in coordination with the U.S. Food and Drug Administration, invite cooperative agreement (UT2) applications to support small business research studies aimed at furthering the field of regenerative medicine (RM) using adult stem cells. These applications are expected to focus on innovative projects that propose solutions to widely recognized issues in the development of safe and effective RM therapies. Emphasis will be given to projects that address critical issues in product development relevant for regulatory submissions. Areas of focus may include improved tools, methods, standards, or applied science that support a better understanding and improved evaluation of in-depth product characterization, manufacturing, potency, identity, quality, safety, in vivo function and integration, or effectiveness. Toward these ends, the NIH will consider applications for late stage preclinical research studies involving adult stem cells in the context of generating or supplementing the necessary evidence for clinical development, including, but not limited to, the submission of an Investigational New Drug (IND) or Investigational New Device Exemption (IDE) package; or to support such research conducted under an authorized IND or IDE.

Funding Opportunity RFA-HL-18-031 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH), participating NIH Institutes and Centers, in coordination with the U.S. Food and Drug Administration, invite exploratory/developmental phased award cooperative agreement (UG3/UH3) applications to support investigator-initiated clinical trials (Phase I or later phase) aimed at furthering the field of regenerative medicine (RM) using adult stem cells. These applications are expected to focus on innovative projects that propose solutions to widely recognized issues in the development of safe and effective RM therapies. Emphasis will be given to projects that use RM products with demonstrated readiness to be advanced into clinical trials through appropriate product development and pre-clinical studies. Trials for which this FOA applies must be relevant to the research mission of one or more participating NIH Institutes and Centers and meet the NIH definition of a clinical trial (see NOT-OD-15-015). This FOA utilizes a bi-phasic, milestone-driven cooperative agreement mechanism of award. This FOA seeks applications that present a strong scientific rationale for the clinical trial and a comprehensive scientific and operational plan. It is anticipated that applications will consist of plans for project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, data sharing, and dissemination of results. Before the time of award and if applicable, successful applicants must obtain an Investigational New Drug (IND) or Investigational New Device Exemption (IDE) application authorization or approval, respectively, to administer the product to humans. Due to the complex nature of conducting a clinical trial, applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application. Staff will be able to assist applicants in meeting the objectives of this FOA.

Funding Opportunity RFA-HL-18-030 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH) participating Institutes and Centers, in coordination with the U.S. Food and Drug Administration, invite cooperative agreement (U01) applications to support investigator-initiated clinical research studies aimed at furthering the field of regenerative medicine (RM) using adult stem cells. These applications are expected to focus on innovative projects that propose solutions to widely recognized issues in the development of safe and effective RM therapies. Emphasis will be given to projects that address critical issues in product development relevant for regulatory submissions. Areas of focus may include improved tools, methods, standards, or applied science that support a better understanding and improved evaluation of in-depth product characterization, manufacturing, potency, identity, quality, safety, in vivo function and integration, or effectiveness. Toward these ends, the NIH will consider applications for late-stage preclinical research studies involving adult stem cells in the context of generating or supplementing the necessary evidence for clinical development, including, but not limited to, the submission of an Investigational New Drug (IND) or Investigational New Device Exemption (IDE) package; or to support such research conducted under an authorized IND or IDE.