Funding Opportunity RFA-DA-18-018 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement [FOA] submitted through the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to stimulate the development and validation of novel tools and analytical methods to target, identify and characterize non-neuronal cells in the brain. This FOA complements previous and ongoing cell-census and tool development efforts initiated under BRAIN, RFA-MH-14-215 and RFA-MH-14-216, that have focused almost exclusively on neuronal cells. The cutting-edge tools and methods developed under this opportunity should focus specifically on providing improved points of entry into non-neuronal cell-types (glial and vascular) to enable their inventory and characterization within the CNS and help define how these cells interact among each other and with neuronal cells to impact functional circuitries. Plans for validating the utility of the tool/technology/method and demonstrating its advantage over currently available approaches will be an essential feature of a successful application. Tools that can be used in several species or model organisms rather than in a single species are especially desirable.

Funding Opportunity RFA-AG-18-018 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to develop valid markers to assess the activity of fundamental aging mechanisms in humans that may influence the risk and progression of multiple aging conditions. Projects are encouraged that focus on selected mechanism(s) that may regulate aging changes, assess multiple possible markers for these mechanisms, test methods to improve their measurement properties, characterize their variability among individuals of differing ages and within the same age cohort, and assess their relationships in humans to in vivo functions influenced by the mechanism(s) under study. It is strongly encouraged that each project includes an interdisciplinary research team with expertise, as needed, in the biology of their selected mechanism(s), biomedical aging research, clinical pathology including laboratory assays, imaging methods, human cohort studies, tissue banking, biorepository resources, and statistics. Though the principal focus of the initiative is on development of markers in humans, studies in laboratory animals may also be conducted when necessary for the development of human markers, and potential development of parallel laboratory animal markers of a given mechanism.

Notice NOT-DK-17-020 from the NIH Guide for Grants and Contracts

Notice NOT-AI-17-043 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-ES-17-009 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) will support research using population-based model organism resources for environmental health science and toxicology questions. This FOA is particularly interested in the interplay between environment, genetics, and epigenetics and the identification and understanding of host susceptibility to environmental exposures, relevant to human disease outcomes.

Notice NOT-OD-17-118 from the NIH Guide for Grants and Contracts

Notice NOT-OD-17-114 from the NIH Guide for Grants and Contracts

Notice NOT-OD-17-110 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-18-006 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) supports high impact efforts to make resources available to neuroscience researchers. Projects should engage in one or more of the following activities: facilitating access to cutting edge reagents or techniques, dissemination of resources to new user groups, or innovative approaches to increase the scale/efficiency of resource production and delivery. Applications focused primarily on technology or software development are not responsive to this FOA, as the focus is on dissemination or provision of resources. Use of existing technologies to develop new reagents or genetic lines of significant value to the research community may be appropriate. Projects should address compelling needs of broad communities of neuroscience researchers or should offer unique services that otherwise would be unavailable. Projects must support the NINDS mission.

Notice NOT-HL-17-543 from the NIH Guide for Grants and Contracts

Notice NOT-OD-17-115 from the NIH Guide for Grants and Contracts

Notice NOT-GM-17-021 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-18-002 from the NIH Guide for Grants and Contracts. December 15, 2017, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on this date. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Funding Opportunity RFA-NS-18-005 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) supports efforts to disseminate resources and to integrate them into neuroscience research practice. Projects should be highly relevant to specific goals of the BRAIN Initiative, goals that are described in the planning document "BRAIN 2025: A Scientific Vision." They should engage in one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community. Applications strictly focused on technology or software development, rather than dissemination of an existing resource, are not responsive to this FOA. Refinements to microscopes or tools necessary to customize them to the experimental needs of the end users are allowed. Projects should address compelling needs of neuroscience researchers working toward the goals of the BRAIN 2025 report that are otherwise unavailable or impractical in their current form.

Funding Opportunity PA-17-488 from the NIH Guide for Grants and Contracts. The purpose of the funding opportunity announcement (FOA) is to encourage research on the etiology of depressive symptoms that occur in the context of a sudden onset acute illness. Although it is known that depressive symptoms may linger and affect functional recovery long after physical recovery from an acute insult, there is a gap in knowledge about the pathobiology that may underlie these incident depressive symptoms. A greater understanding of the etiological factors that contribute to and/or mitigate a trajectory of depressive symptoms may inform a personalized, holistic approach to managing recovery from acute illness.

Funding Opportunity PA-17-487 from the NIH Guide for Grants and Contracts. The purpose of the funding opportunity announcement (FOA) is to encourage research on the etiology of depressive symptoms that occur in the context of a sudden onset acute illness. Although it is known that depressive symptoms may linger and affect functional recovery long after physical recovery from an acute insult, there is a gap in knowledge about the pathobiology that may underlie these incident depressive symptoms. A greater understanding of the etiological factors that contribute to and/or mitigate a trajectory of depressive symptoms may inform a personalized, holistic approach to managing recovery from acute illness.

Notice NOT-HL-17-536 from the NIH Guide for Grants and Contracts

Notice NOT-NS-18-009 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-RM-17-020 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to establish Collaborative Centers to study ethical, legal and societal issues (ELSI) of human genome and environmental health research across the African continent. Of particular interest are projects that propose bioethical, legal, and social science analyses of new or emerging issues that affect multiple communities across the continent of Africa. These awards will support 3-5 collaborating research projects at three or more African institutions working together as a partnership to accomplish more than each project could accomplish on its own.

Funding Opportunity RFA-RM-17-021 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to study the ethical, legal and societal issues (ELSI) of human genome research in African populations. Of particular interest are projects that propose focused bioethical, legal, and social science analyses of new or emerging issues.