Drug Repositioning

Emerging Therapeutics Agents and Recent Advances in Drug Repurposing for Alzheimer's Disease

Sun, 2022-12-18 06:00

Ageing Res Rev. 2022 Dec 15:101815. doi: 10.1016/j.arr.2022.101815. Online ahead of print.

NO ABSTRACT

PMID:36529440 | DOI:10.1016/j.arr.2022.101815

Categories: Literature Watch

Drug repurposing based novel anti-leishmanial drug screening using <em>in-silico</em> and <em>in-vitro</em> approaches

Sun, 2022-12-18 06:00

J Biomol Struct Dyn. 2022;40(21):10812-10820. doi: 10.1080/07391102.2021.1950574. Epub 2021 Jul 11.

NO ABSTRACT

PMID:36529188 | DOI:10.1080/07391102.2021.1950574

Categories: Literature Watch

Drug repurposing: From the discovery of a useful pharmacological effect to making the treatment available to the patient

Sat, 2022-12-17 06:00

Therapie. 2022 Dec 5:S0040-5957(22)00273-6. doi: 10.1016/j.therap.2022.11.009. Online ahead of print.

NO ABSTRACT

PMID:36528417 | DOI:10.1016/j.therap.2022.11.009

Categories: Literature Watch

Uncovering the gene regulatory network of type 2 diabetes through multi-omic data integration

Fri, 2022-12-16 06:00

J Transl Med. 2022 Dec 16;20(1):604. doi: 10.1186/s12967-022-03826-5.

NO ABSTRACT

PMID:36527108 | DOI:10.1186/s12967-022-03826-5

Categories: Literature Watch

Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair

Fri, 2022-12-16 06:00

Adv Sci (Weinh). 2022 Dec 16:e2203053. doi: 10.1002/advs.202203053. Online ahead of print.

NO ABSTRACT

PMID:36526599 | DOI:10.1002/advs.202203053

Categories: Literature Watch

Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing

Thu, 2022-12-15 06:00

BMC Pharmacol Toxicol. 2022 Dec 15;23(1):93. doi: 10.1186/s40360-022-00634-x.

NO ABSTRACT

PMID:36522756 | DOI:10.1186/s40360-022-00634-x

Categories: Literature Watch

Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch

Thu, 2022-12-15 06:00

J Immunother Cancer. 2022 Dec;10(12):e005002. doi: 10.1136/jitc-2022-005002.

NO ABSTRACT

PMID:36521927 | DOI:10.1136/jitc-2022-005002

Categories: Literature Watch

Synergistic Combinations of FDA-Approved Drugs with Ceftobiprole against Methicillin-Resistant Staphylococcus aureus

Thu, 2022-12-15 06:00

Microbiol Spectr. 2022 Dec 15:e0372622. doi: 10.1128/spectrum.03726-22. Online ahead of print.

NO ABSTRACT

PMID:36519895 | DOI:10.1128/spectrum.03726-22

Categories: Literature Watch

Molecular dynamics simulation and docking analysis of NF-κB protein binding with sulindac acid

Thu, 2022-12-15 06:00

Bioinformation. 2022 Mar 31;18(3):170-179. doi: 10.6026/97320630018170. eCollection 2022.

NO ABSTRACT

PMID:36518123 | PMC:PMC9722428 | DOI:10.6026/97320630018170

Categories: Literature Watch

Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors

Wed, 2022-12-14 06:00

Eur J Med Chem. 2022 Dec 6;246:115011. doi: 10.1016/j.ejmech.2022.115011. Online ahead of print.

NO ABSTRACT

PMID:36516582 | DOI:10.1016/j.ejmech.2022.115011

Categories: Literature Watch

A network medicine approach for identifying diagnostic and prognostic biomarkers and exploring drug repurposing in human cancer

Wed, 2022-12-14 06:00

Comput Struct Biotechnol J. 2022 Nov 29;21:34-45. doi: 10.1016/j.csbj.2022.11.037. eCollection 2023.

NO ABSTRACT

PMID:36514340 | PMC:PMC9732137 | DOI:10.1016/j.csbj.2022.11.037

Categories: Literature Watch

Vir2Drug: a drug repurposing framework based on protein similarities between pathogens

Tue, 2022-12-13 06:00

Brief Bioinform. 2022 Dec 13:bbac536. doi: 10.1093/bib/bbac536. Online ahead of print.

NO ABSTRACT

PMID:36513376 | DOI:10.1093/bib/bbac536

Categories: Literature Watch

Potential target identification for osteosarcoma treatment: Gene expression re-analysis and drug repurposing

Tue, 2022-12-13 06:00

Gene. 2022 Dec 10:147106. doi: 10.1016/j.gene.2022.147106. Online ahead of print.

NO ABSTRACT

PMID:36513192 | DOI:10.1016/j.gene.2022.147106

Categories: Literature Watch

Drug repurposing in skeletal muscle ion channelopathies

Tue, 2022-12-13 06:00

Curr Opin Pharmacol. 2022 Dec 10;68:102329. doi: 10.1016/j.coph.2022.102329. Online ahead of print.

NO ABSTRACT

PMID:36512979 | DOI:10.1016/j.coph.2022.102329

Categories: Literature Watch

Age, gender and degree of inclusion are predictors of timing for spontaneous repositioning of intruded primary teeth in pre-school children

Tue, 2022-12-13 06:00

Eur J Paediatr Dent. 2022 Dec;23(4):269-274. doi: 10.23804/ejpd.2022.23.04.03.

NO ABSTRACT

PMID:36511905 | DOI:10.23804/ejpd.2022.23.04.03

Categories: Literature Watch

Phenotypic screening of 1,953 FDA-approved drugs reveals 26 hits with potential for repurposing for Peyronie's disease

Mon, 2022-12-12 06:00

PLoS One. 2022 Dec 12;17(12):e0277646. doi: 10.1371/journal.pone.0277646. eCollection 2022.

NO ABSTRACT

PMID:36508413 | DOI:10.1371/journal.pone.0277646

Categories: Literature Watch

Cellular Genome-Scale Metabolic Modeling Identifies New Potential Drug Targets Against Hepatocellular Carcinoma

Mon, 2022-12-12 06:00

OMICS. 2022 Dec;26(12):671-682. doi: 10.1089/omi.2022.0122.

NO ABSTRACT

PMID:36508280 | DOI:10.1089/omi.2022.0122

Categories: Literature Watch

Montelukast Inhibits Lung Cancer Cell Migration by Suppressing Cysteinyl Leukotriene Receptor 1 Expression In Vitro

Mon, 2022-12-12 06:00

Curr Pharm Biotechnol. 2022 Dec 7. doi: 10.2174/1389201024666221207143513. Online ahead of print.

NO ABSTRACT

PMID:36503460 | DOI:10.2174/1389201024666221207143513

Categories: Literature Watch

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