£38000 - £45000 per annum: Hyper Recruitment Solutions (HRS): We are currently looking for a Senior Software Engineer to join a world-leading research organisation based in the Hertfordshire area. Conducting ground breaking research that... Hertfordshire

Funding Opportunity RFA-AI-22-010 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit research applications for projects focused on development and/or production of medical diagnostics that permit rapid differential species identification, and corresponding phenotypic antibacterial susceptibility profiles for bacteremia or hospital acquired pneumonia. The primary goal of such diagnostics is to facilitate antibacterial stewardship, thereby reducing selective pressure and improving patient outcomes.

From £48,000 per annum, subject to skills and experience: The Francis Crick Institute: We are recruiting for a Project Manager- Advanced Sequencing Facility London (Central), London (Greater) (GB)

Notice NOT-NS-22-083 from the NIH Guide for Grants and Contracts

Notice NOT-DA-22-004 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HL-23-018 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) will support meritorious exploratory research relevant to the NHLBI mission (http://www.nhlbi.nih.gov/about/org/mission) using the existing biospecimen collections that are stored in the NHLBI Biologic Specimen Repository (Biorepository), thereby maximizing the scientific value of the stored collections and providing researchers with an opportunity to generate preliminary data for subsequent research proposals.

Funding Opportunity PAR-22-089 from the NIH Guide for Grants and Contracts. The overarching purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and/or early evaluation of strong candidate biomarkers and biomarker signatures that can be used as tools to facilitate the clinical development of neurotherapeutics and their use in clinical practice. Specifically, the focus of this FOA is on the identification and initial biological, analytical and clinical evaluation of biomarkers and biomarker signatures for neurological and neuromuscular disorders. Although research supported by this FOA can include animal studies, it must also include preliminary human evaluation using carefully standardized human samples or datasets. The goal of this initiative is to deliver candidate biomarkers or biomarker signatures that are ready for definitive analytical and clinical validation studies.

Funding Opportunity RFA-AG-23-007 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites research to develop, validate, and disseminate measurement tools that could be used to screen for deficits related to decision-making, planning, and other important higher order functional outcomes in older adults. In particular, we are interested in instruments that can track changes in decision-making capacity that could be useful in the context of future screening for cognitive impairment and the development of interventions targeting functional outcomes in persons living with cognitive impairment and/or quality of life outcomes in their care partners/caregivers. The goal of the FOA is to support a research network whose goals would be to review and assess the dimensions of higher cognitive abilities and functional capacities already believed to support higher order planning and decision-making, to develop valid and reliable measures of those abilities, and to provide support for pilot efforts during the instrument development and validation in a racially, ethnically, geographically, and diagnostically diverse set of participants as well as a set of enduring resources including the measurement instruments, documentation, and normative data that will enable other, future projects to incorporate the new measurements into studies.

Funding Opportunity RFA-RM-22-013 from the NIH Guide for Grants and Contracts. This funding opportunity announcement invites applications to establish the Genome Characterization Centers (GCCs) for the Somatic Mosaicism across Human Tissues (SMaHT) Network. ?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The GCCs will be responsible for generating state of the art, high throughput genomic data characterizing somatic variants in a set of 10-15 human tissues from 150+ donors. The GCCs will work closely with the SMaHT Data Analysis Center to build the framework for a comprehensive catalog of variants.

Funding Opportunity RFA-RM-22-012 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to establish the Tissue Procurement Center for the Somatic Mosaicism across Human Tissues (SMaHT) Network.?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The goal of the Tissue Procurement Center is to collect, process, store, and rapidly distribute to the Network at least 15 high quality, well characterized, human tissues recovered from a minimum of 150 individuals recruited from a diverse pool of donors.

Funding Opportunity RFA-RM-22-011 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites new applications for development of tools and technologies to enhance understanding of somatic variants as part of the Somatic Mosaicism across Human Tissues (SMaHT) Network.?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. Technology and Tools Development Projects will develop the next generation of technologies that will enhance our ability to detect and characterize somatic variants in diverse human types of tissues.

Funding Opportunity RFA-RM-22-010 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to establish the Data Analysis Center (DAC) for the Somatic Mosaicism across Human Tissues (SMaHT) Network. ?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The Data Analysis Center will be responsible for the following areas: 1. Managing all data on behalf of the Network, including ingestion, uniform processing, and standardized annotation, and archiving of data; 2. Developing new computational methods and bioinformatics tools and deploying them as part of an accessible data workbench; 3. Building a data portal for the Network, including the SMaHT Variant Catalog and variant browser, and 4. Harmonizing SMaHT resources with related programs.

Funding Opportunity RFA-RM-22-009 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to establish the Organizational Center for the Somatic Mosaicism across Human Tissues (SMaHT) Network.?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The Organizational Center will coordinate meetings, communication, outreach, and other organizational activities within the Network and be the main conduit for collaboration with related programs and the wider research community.

Notice NOT-AI-22-023 from the NIH Guide for Grants and Contracts

Notice NOT-CA-22-054 from the NIH Guide for Grants and Contracts

Notice NOT-AG-22-014 from the NIH Guide for Grants and Contracts

From £38,300, subject to skills and experience: The Francis Crick Institute: We are recruiting for a Postdoctoral Training Fellow to join the Cancer Dynamics Lab. London (Central), London (Greater) (GB)

Funding Opportunity RFA-NS-22-049 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse. Projects validating approaches using other species are also permitted if well justified. Applications may address any aspects of the data collection, analysis, and dissemination pipelines, to enable faster and more cost-effective generation and interpretation of brain-wide wiring diagrams. Projects will offer distinct capabilities and competencies aimed at developing and optimizing current technologies or entirely new and potentially risky approaches. They will be integrated into the BRAIN CONNECTS Network, consisting of other Specialized Projects from this FOA, and Comprehensive Centers from its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.

Funding Opportunity RFA-NS-22-047 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of human and non-human primate circuit connectivity. Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping region-to-region connectivity with a minimum resolution of individual cells and/or axon fibers. They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function. They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions. Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.

Funding Opportunity RFA-NS-22-048 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of mouse circuit connectivity. Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping cell-to-cell connectivity with a minimum resolution of synaptic connections. They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function. They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions. Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.