Experience Dependent : Hyper Recruitment Solutions (HRS): We are currently looking for a Senior Bioinformatics Programmer to join a leading Biotechnology company based in the Cambridgeshire area. As the Senior Bioinformatics Programmer... Cambridgeshire

Funding Opportunity RFA-AG-21-005 from the NIH Guide for Grants and Contracts. The National Institute on Aging invites applications to renew an ongoing NIA-supported cooperative agreement, the National Centralized Repository for Alzheimer's Disease and Related Dementias.

Funding Opportunity RFA-AG-21-003 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) invites research to develop, characterize, and validate new, unconventional, or innovative non-rodent mammalian models of late-onset (sporadic) Alzheimer's Disease (AD). These new models are expected torecapitulate molecular, cellular, neuropathological, behavioral, and/or cognitive hallmarks and aspects of late-onset AD.Research supported under this FOA is expected to provide new investigativetools to identify the gaps in current knowledge related to molecular mechanisms of late-onset AD and identify potential therapeutic targets.

Funding Opportunity PAR-20-086 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites qualified academic institutions to apply for support to modernize existing or construct new biomedical research facilities. Applications will be accepted from public and nonprofit private institutions of higher education. Applications from both research-intensive institutions and Institutions of Emerging Excellence in biomedical research from all geographic regions in the nation are strongly encouraged. NIH recognizes the importance of all institutions of higher learning in contributing to the nations research capacity. The goal of this FOA is to upgrade or create novel biomedical research infrastructure to strengthen biomedical research programs. The proposed project must serve the applicant-defined institution-wide biomedical research needs. Each project is expected to provide long-term improvements to the institutional research infrastructure. Targeted are the modernization of core facilities and the development of other infrastructure serving an institution-wide research community on a shared basis.

Notice NOT-HS-20-006 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AG-21-011 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invitesapplications that propose basic and/or clinical studies to investigate central and peripheral control of balance in older adults and/or in relevant animal models. This FOA is driven by the need to address a major gap in our understanding of how aging impacts the vestibular system, which when impaired contributes to balance problems and an increased risk of falls in older adults. Additionally, given that balance impairment can be attributed to a number of factors (e.g. sensory, motor, cognitive, psychological,and vascular function), understanding the contribution of age-related vestibular loss, and how this interacts with these factors, is critical for informing interventions and treatments for balance problems and falls in older adults.

Notice NOT-HD-19-035 from the NIH Guide for Grants and Contracts

Notice NOT-DK-20-009 from the NIH Guide for Grants and Contracts

Notice NOT-HG-20-010 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HG-20-007 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity is to establish a consortium aimed at significantly increasing the proportion of Mendelian conditions with an identified genetic cause. A key objective of the Mendelian Genomics Research Centers is to develop and apply approaches to discover causal genes underlying Mendelian conditions for which a candidate gene was not identified using whole exome sequencing alone.

Funding Opportunity RFA-HG-20-008 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to solicit applications to develop and implement a Mendelian Genomics Data Coordination Center (MGDCC) for the Mendelian Genomics Research Consortium. The MGDCC will be responsible for managing the release of data and findings generated under the program, as well as program outreach, ensuring maximum utility for the research community. The MGDCC will also coordinate program logistics, supporting effective working groups and meetings. Finally, the MGDCC will oversee the programs Opportunity Fund, providing rapid turnaround short-term funding for functional follow-up studies to program findings.

Competitive Salary: EMBL: Bioinformatician Location: EMBL- Cambridge, Cambridgeshire, England

Notice NOT-MD-20-012 from the NIH Guide for Grants and Contracts

F. Hoffmann-La Roche AG: Data have the power to answer more than one question and enable multiple discoveries, but only if Findable, Accessible, Interoperable, and Reusable ( Switzerland (CH)

Funding Opportunity PAR-20-087 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications from qualified research institutions to seek funds to develop or improve the physical infrastructure of nonhuman primate (NHP) facilities, focusing on the needs related to the expansion of Rhesus macaque colonies. These infrastructure needs include additional space required for breeding and housing of animals as well as research facilities for carrying out HIV/AIDS-related studies linked to the expansion of the colonies. These NHP facilities must support research aligned with the NIH-established priorities for HIV/AIDS research. Any request must be justified by current and anticipated future research needs.

Funding Opportunity RFA-RM-20-009 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to invite additional applications for the Preclinical Animal Study Sites (PASS) as part of the Molecular Transducers of Physical Activity in Humans Consortium (MoTrPAC) (http://commonfund.nih.gov/MolecularTransducers). Awards made through this FOA will support preclinical mechanistic studies on a range of molecular compounds identified in the initial PASS exercise protocol (RM 15-013) which was designed to complement and substantially expand the data from the human clinical study. This FOA is expected to support up to 4-6 additional PASS as part of the MoTrPAC consortium. Phase 2 of the original PASS study sites will design and conduct detailed mechanistic studies to identify the sources, signaling pathways, physiological targets, and functions of mobilized and identified molecular transducers of physical activity; to recognize feedback and interaction effects among different pathways and tissues; and to discover specific roles of the molecules associated with specific health benefits. This RFA calls for additional proposals to explore the mechanistic links between the candidate molecular transducers of physical activity and functional effects of exercise in tissues. Overall, data from the PASS studies are anticipated to substantially increase our understanding of how different tissues and organs adapt to the exercise induced changes. The PASS will serve to confirm human data and extend the analyses of candidate transducers of physical activity from the clinical study across multiple organs and tissues that are not accessible from human participants. Applicants should propose what they think is the best strategy and approach for investigating how these mobilized compounds synergize to coordinate the overall homeostatic response to exercise. Final decisions on the actual compounds for future screening will be determined in consultation with the MoTrPAC Steering Committee.

Funding Opportunity RFA-CA-20-032 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support multidisciplinary research projects that examine the relative biological effectiveness (RBE) of high linear energy transfer (high LET) radiation on cell and tissue targets. The overall goal of the research is to establish a firm scientific basis for RBE models of high LET radiation and determine potential benefits in cancer treatment. A meritorious application is expected to be well-balanced in terms of interdisciplinary science that spans approaches in both radiation biology and radiation physics research. Priorities for this FOA are on 1) Applications with potential to enhance the understanding of mechanisms related to high LET effects in both cancer and normal tissues; and 2) Characterization of high LET effects that have potential to inform treatment strategies for cancers resistant to conventional radiation or other combined modality treatments.

Notice NOT-HG-20-013 from the NIH Guide for Grants and Contracts

£32,235 - £35,709 per annum: Animal and Plant Health Agency: The Animal and Plant Health Agency (APHA) is an executive agency of the Department for Environment, Food & Rural Affairs..... New Haw, Addlestone

Competitive Salary: EMBL: Bioinformatics Engineer Location: Germany (DE)