Funding Opportunity RFA-DK-19-022 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits U01 applications for the establishment of a clinical consortium, composed of one Data Coordinating Center (DCC) and up to 10 Clinical Centers (CC), to conduct studies on diabetes mellitus, with an emphasis on Type 1 diabetes (T1D), that occurs after or as a consequence of one or more episodes of acute pancreatitis. The Consortium will form multi-disciplinary teams composed of members from the CCs and DCC to undertake a prospective longitudinal observational study of the occurrence of diabetes that occurs during an acute pancreatitis episode or subsequently, with an emphasis on type 1 diabetes (T1D). The study will be designed to gain insight into the incidence, clinical evolution, etiology, type and pathophysiology of the T1D and other forms of diabetes that occurs during or after one or more episodes of acute pancreatitis. The teams will also undertake studies on the identification of immune and genetic risk factors and biomarkers which predict the development of T1D in a racially, ethnically, and geographically diverse population of subjects who have impaired glucose tolerance or diabetes mellitus after one or more episodes of acute pancreatitis due to various identifiable etiologies. Applications for the Data Coordinating Center (DCC) are submitted in response to a separate FOA: RFA-DK-19-023: Type 1 Diabetes in Acute Pancreatitis Consortium Data Coordinating Center (T1DAPC-DCC) (U01).

£36,737 to £44,451: Wellcome Sanger Institute: Health Informatician/Data Manager Grade: 2 Salary per annum £36,737 to £44,451 Full Time or Part Time: Full Time Contract Type: Hinxton, Cambridgeshire, England

F. Hoffmann-La Roche AG: The biomarker group within pRED Early Clinical Development Oncology is working on deciphering the complexity of human tumor- host biology by le Switzerland (CH)

Funding Opportunity RFA-AI-19-068 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Immune Tolerance Network. The major goal of this Network is to develop tolerogenic approaches for the treatment and prevention of disease in three clinical areas: asthma and allergic diseases; autoimmune diseases; and immune-mediated consequences of allotransplantation. The scope of research to be carried out includes: 1) the design and conduct of clinical trials at all phases to evaluate the safety and efficacy of investigational products and approaches for the induction and maintenance of immune tolerance in humans; 2) the design and conduct of mechanistic studies and the development of tolerance assays as integral components of the clinical trials undertaken, including establishing and directing a consortium of laboratories; and one or more biospecimen repositories, and 3) the provision of bioinformatics, data collection, validation and analysis resources. In addition, on a limited basis, the Network may support focused product development and nonclinical studies (e.g., toxicology, pharmacology, pharmacokinetics, etc.) essential for the subsequent evaluation of promising tolerance induction approaches in humans.

Notice NOT-OD-20-039 from the NIH Guide for Grants and Contracts

Notice NOT-OD-20-020 from the NIH Guide for Grants and Contracts

Notice NOT-OD-20-021 from the NIH Guide for Grants and Contracts

Notice NOT-PM-20-001 from the NIH Guide for Grants and Contracts

Notice NOT-OD-20-041 from the NIH Guide for Grants and Contracts

£36,737 to £44,451: Wellcome Sanger Institute: Health Informatician/Data Manager Grade: 2 Salary per annum £36,737 to £44,451 Full Time or Part Time: Full Time Contract Type: Hinxton, Cambridgeshire, England

Funding Opportunity RFA-AT-20-003 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications that focus on developing resources by refining and testing key concepts that will advance and further support the study of emotional well-being in the field at large. This infrastructure support will facilitate research networks through meetings, conferences, small-scale pilot research, multidisciplinary cross training (such as intensive workshops, summer institutes, or visiting scholar programs), and information dissemination to foster the growth and development of research in the following priority areas: (1) Ontology and measurement of emotional well-being; (2) Mechanistic research on the role of emotional well-being in health; (3) Biomarkers of emotional well-being; (4) Prevention research (mechanisms-focused intervention development in target populations); (5) Technology and outcome measure development for mechanistic studies; (6) Development and validation of well-being measures.

Notice NOT-DA-20-024 from the NIH Guide for Grants and Contracts

Notice NOT-DA-20-016 from the NIH Guide for Grants and Contracts

Notice NOT-RM-20-005 from the NIH Guide for Grants and Contracts

Notice NOT-RM-20-004 from the NIH Guide for Grants and Contracts

Notice NOT-RM-20-006 from the NIH Guide for Grants and Contracts

Notice NOT-OD-20-032 from the NIH Guide for Grants and Contracts

Notice NOT-EB-19-023 from the NIH Guide for Grants and Contracts

£36,737 to £44,451: Wellcome Sanger Institute: Health Informatician/Data Manager Grade: 2 Salary per annum £36,737 to £44,451 Full Time or Part Time: Full Time Contract Type: Hinxton, Cambridgeshire, England

F. Hoffmann-La Roche AG: Are you interested in working in a dynamic and evolving environment? Are you motivated by new challenges and comfortable with ambiguity? Do you Switzerland (CH)