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Leadership Award for Alzheimer's Disease and Related Dementias Research (R35 Clinical Trial Not Allowed)

Funding Opportunity RFA-AG-21-007 from the NIH Guide for Grants and Contracts. NIA invites applications for the Leadership Award for Alzheimer's Disease and Related Dementias Research (R35). Applicants will be supported to develop and implement innovative multidisciplinary research and mentoring programs through an interchange of ideas that enable individuals and their institutions to strengthen existing programs and the development of new research programs that are specific to the goals/milestones of the NIH Alzheimer's Disease and Alzheimer's Disease Related Dementias Summits.

Request for Information on the NICHD Vision for Multisite Clinical Trials Infrastructure

Notice NOT-HD-19-041 from the NIH Guide for Grants and Contracts

Assistant, Associate, or Professor of Medicine, Population Health Sciences - University of Central Florida - Lake Nona, FL

Indeed.com - Bioinformatics - Fri, 2019-11-08 01:38
In addition to the online application, candidates must also submit a cover letter, CV and the contact information for three professional references.
From University of Central Florida - Fri, 08 Nov 2019 06:38:27 GMT - View all Lake Nona, FL jobs
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Assistant, Associate, or Professor of Medicine, Population Health Sciences - University of Central Florida - Lake Nona, WI

Indeed.com - Bioinformatics - Fri, 2019-11-08 01:38
In addition to the online application, candidates must also submit a cover letter, CV and the contact information for three professional references.
From University of Central Florida - Fri, 08 Nov 2019 06:38:27 GMT - View all Lake Nona, WI jobs
Categories: Job Watch

Dysregulation and Proximal Risk for Suicide (R01 Clinical Trial Optional)

Funding Opportunity RFA-MH-20-327 from the NIH Guide for Grants and Contracts. A major goal of research on suicide is to improve our understanding of who is at most risk, why people transition from suicidal thoughts to action, and when to intervene ( Prioritized Research Agenda for Suicide Prevention, Short-term Objective 1.C). Risk is a dynamic process and suicide attempts are often preceded by acute stressors. While many studies of suicide risk focus on emotion dysregulation, fewer studies have examined arousal and regulation and how these domains dynamically shape emotional and cognitive functions such as response to reward, frustrative non-reward, cognitive flexibility and control, or decision-making. Very few studies in the NIMH portfolio on suicide risk have focused on proximal risk. This Funding Opportunity Announcement (FOA) will fund research that will address these gaps by providing an understanding of the mechanisms of how dysregulation interacts with cognition and negative and positive valence in order to determine time-varying risk, and then to identify modifiable targets for timely interventions during highrisk periods. A companion RFA, RFA-MH-19-326 , uses the R21 mechanism. High risk/high payoff projects that lack preliminary data or utilize existing data may be most appropriate for the R21 mechanism, while applicants with preliminary data may wish to apply to this FOA using the R01 mechanism.

Dysregulation and Proximal Risk for Suicide (R21 Clinical Trial Optional)

Funding Opportunity RFA-MH-20-326 from the NIH Guide for Grants and Contracts. A major goal of research on suicide is to improve our understanding of who is at most risk why people transition from suicidal thoughts to action, and when to intervene (Prioritized Research Agenda for Suicide Prevention, Short-term Objective 1.C). Risk is a dynamic process and suicide attempts are often preceded by acute stressors. While many studies of suicide risk focus on emotion dysregulation, fewer studies have examined arousal and regulation and how these domains dynamically shape emotional and cognitive functions such as response to reward, frustrative non-reward, cognitive flexibility and control, or decision-making. Very few studies in the NIMH portfolio on suicide risk have focused on proximal risk. This Funding Opportunity Announcement (FOA) will fund research that will address these gaps by providing an understanding of the mechanisms of how dysregulation interacts with Cognition and Negative and Positive Valence in order to determine time-varying risk, and then to identify modifiable targets for timely interventions during highrisk periods. This FOA uses the R21 mechanism. High risk/high payoff projects that lack preliminary data or utilize existing data may be most appropriate for the R21 mechanism, while applicants with preliminary data may wish to apply using the R01 mechanism, RFA-MH-19-327

NIDCR Research Grants for Analyses of Existing Genomics Data (R01 Clinical Trial Not Allowed)

Funding Opportunity PAR-20-045 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to announce support for meritorious research projects that address research questions relevant to human dental, oral, or craniofacial (DOC) conditions or traits through analyzing existing and publicly available genomics data using statistical and computational approaches. Data analysis of each project can be performed using exiting and/or novel methods to be developed in the same project, including machine learning-based methods (ML). In addition to analysis of existing data, experimental or in silico work should be proposed to validate data analysis result or validate a newly developed analytic method. Work that tackles causal mechanism of action of identified candidate causal genetic variants on onset and progression of disease is highly encouraged.

NIDCR Small Research Grants for Analyses of Existing Genomics Data (R03 Clinical Trial Not Allowed)

Funding Opportunity PAR-20-046 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to provide support for meritorious research projects that address research questions relevant to human dental, oral, or craniofacial (DOC) conditions or traits through analyzing existing and publicly genomics data using statistical and computational approaches. Data analysis of each project can be performed using exiting and/or novel methods to be developed in the same project, including machine learning-based methods (ML).

Senior Biomarker Data Specialist - Seattle Genetics, Inc. - Bothell, WA

Indeed.com - Bioinformatics - Thu, 2019-11-07 19:20
The Senior Biomarker Data Specialist is responsible for managing vendor start-ups, clinical study deliverables, timelines and relationships within Clinical Data…
From Seattle Genetics, Inc. - Fri, 08 Nov 2019 00:20:01 GMT - View all Bothell, WA jobs
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Assessing the Effects of Cannabinoids on HIV-Induced Inflammation (R01 Clinical Trial Optional)

Funding Opportunity RFA-DA-20-022 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement [FOA] is to encourage basic science and preclinical research to determine the biological mechanisms underlying the effects of cannabinoids and the endocannabinoid system on HIV-associated persistent inflammation and its consequent effects on nervous system function. Projects submitted in response to this FOA must include expertise and resources in both areas of HIV/AIDS and addiction science.

NINDS Postdoctoral Mentored Career Development Award (K01 Clinical Trial Required)

Funding Opportunity PAR-20-050 from the NIH Guide for Grants and Contracts. The purpose of the NINDS Postdoctoral Mentored Career Development Award is to support the ability of outstanding, mentored postdoctoral researchers to develop a potentially impactful research project with a comprehensive career development plan that will enable them to launch an independent research program. Candidates are encouraged to apply for support from this NINDS K01 any time between the second through fourth year of cumulative mentored postdoctoral research experience, and may be supported by this NINDS K01 within the first 6 years of cumulative postdoctoral research experience. Because the completion of a strong, well-planned, thorough career development plan, in addition to development of an impactful research project, is a critical aspect of this K01, applications are strongly encouraged early in the postdoctoral eligibility window. By the end of the proposed K01 award period, the candidate should be poised to begin an independent research career with a well-developed, impactful research project and the expertise required to become a leader in the field. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development.

NINDS Postdoctoral Mentored Career Development Award (K01 No Independent Clinical Trial Allowed)

Funding Opportunity PAR-20-049 from the NIH Guide for Grants and Contracts. The purpose of the NINDS Postdoctoral Mentored Career Development Award is to support the ability of outstanding, mentored postdoctoral researchers to develop a potentially impactful research project with a comprehensive career development plan that will enable them to launch an independent research program. Candidates are encouraged to apply for support from this NINDS K01 any time between the second through fourth year of cumulative mentored postdoctoral research experience, and may be supported by this NINDS K01 within the first 6 years of cumulative postdoctoral research experience. Because the completion of a strong, well-planned, thorough career development plan, in addition to development of an impactful research project, is a critical aspect of this K01, applications are strongly encouraged early in the postdoctoral eligibility window. By the end of the proposed K01 award period, the candidate should be poised to begin an independent research career with a well-developed, impactful research project and the expertise required to become a leader in the field. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.

Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional)

Funding Opportunity RFA-ES-20-002 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement encourages applications using community-engaged research methods to investigate the potential health risks of environmental exposures of concern to the community and to implement an environmental public health action plan based on research findings. The overall goal is to inform changes and to support efforts to prevent or reduce exposure to harmful environmental exposures and improve the health of a community.

Mechanisms Underlying the Contribution of Type 1 Diabetes Disease-associated Variants (R01 Clinical Trial Not Allowed)

Funding Opportunity RFA-DK-19-020 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications from integrative teams and individual investigators for large-scale complex multi-disciplinary Functional Genomics Projects (FGPs) to determine the contributions and mechanisms underlying the contribution of associated variants for type 1 diabetes (T1D). Genome-wide association studies (GWAS) and other genomic studies of T1D have found many variants that are statistically associated with disease risk or disease protection, but they have not clearly shown which variants in genomic elements cause these effects or how they result in differences in function. Applications submitted to this RFA will systematically identify causal variants and effector transcripts associated with all known T1D risk variants, verify the role of downstream effector transcripts, build network models that explain their role(s) in T1D. These biological insights could lead to the development of reliable biomarkers and effective strategies for screening and disease prevention, rational drug design, and better tailored therapies.

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