Notice NOT-NS-23-107 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-24-023 from the NIH Guide for Grants and Contracts. To enable the development and validation of real-world remote digital endpoints from wearable devices for monitoring pain experience and progression, response to interventions, and impact on quality of life. In the context of this RFA, endpoints will include biosignatures derived from functional and physiological assessments detected from wearable devices. These biosignatures can be used to monitor the effects of therapeutics developed for the treatment of pain.

Notice NOT-EB-23-018 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NR-24-001 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to advance research that reduces firearm injury and disparities through the development and evaluation of firearm injury primary prevention interventions leveraging community healthcare settings.

Notice NOT-NS-24-012 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-MH-24-190 from the NIH Guide for Grants and Contracts. Reissue of RFA-MH-21-205 to comply with DMS Policy. This Notice of Funding Opportunity (NOFO), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several NOFOs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, BRAIN 2025: A Scientific Vision, this NOFO specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. The hope is that efforts supported under this NOFO might be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through the BRAIN Initiative.

Funding Opportunity RFA-MH-25-125 from the NIH Guide for Grants and Contracts. The purpose of this R34 NOFO is to provide resources for evaluating the feasibility, acceptability, and safety of novel approaches that are uniquely tailored to the risk profiles of these populations, that will improve outcomes and modify health risk behavior. Resources may also be used for obtaining the preliminary data needed as a prerequisite to a larger-scale (efficacy or effectiveness) services study. The goal is to support research that develops and tests broadly implementable service system interventions to rapidly identify and effectively respond to reduce suicide and suicidal behavior in various groups of at-risk youth. Specifically, the goals of this NOFO are to: 1) develop a multi-level service system intervention that coordinates suicide risk identification, evaluation, and linkage to needed treatment and services for a specifically identified at-risk youth group; 2) test the feasibility and effectiveness of the intervention in detecting and reducing suicide risk and suicidal behavior in the at-risk youth group; and 3) demonstrate the intervention's implementation and potential for future uptake in underserved, under-resourced community settings where additional at-risk youth are most likely to receive care. The ultimate goal of this NOFO is to develop and test the effectiveness of evidence-based strategies for detecting and preventing suicide and suicidal behavior among at-risk youth. It focuses on systems interventions to improve outcomes for youth and is not intended to support the development of new screening tools or assessment instruments.

Funding Opportunity RFA-MH-25-126 from the NIH Guide for Grants and Contracts. The purpose of this R01 NOFO is to provide resources for evaluating the feasibility, acceptability, and safety of novel approaches that are uniquely tailored to the risk profiles of these populations, that will improve outcomes and modify health risk behavior. Resources may also be used for obtaining the preliminary data needed as a prerequisite to a larger-scale (efficacy or effectiveness) services study. The goal of the R01 NOFO is to support research that develops and tests broadly implementable service system interventions to rapidly identify and effectively respond to reduce suicide and suicidal behavior in various groups of at-risk youth. Specifically, the goals of this NOFO are to: 1) develop a multi-level service system intervention that coordinates suicide risk identification, evaluation, and linkage to needed treatment and services for a specifically identified at-risk youth group; 2) test the feasibility and effectiveness of the intervention in detecting and reducing suicide risk and suicidal behavior in the at-risk youth group; and 3) demonstrate the intervention's implementation and potential for future uptake in underserved, under-resourced community settings where additional at-risk youth are most likely to receive care. The ultimate goal of this NOFO is to develop and test the effectiveness of evidence-based strategies for detecting and preventing suicide and suicidal behavior among at-risk youth. It focuses on systems interventions to improve outcomes for youth and is not intended to support the development of new screening tools or assessment instruments.

Notice NOT-HL-23-109 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-23-289 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity is to solicit applications for clinical sites that will provide expert diagnostic services for undiagnosed diseases across the nation. The clinical sites known as Diagnostic Centers of Excellence (DCoEs) will partner with the Undiagnosed Diseases Network (UDN) to sustain some of the key research activities currently performed by the Phase II UDN Clinical sites (see:RFA-RM-17-019) and facilitate its transition to a larger network that serves diverse undiagnosed patient populations. The DCoEs will establish collaborations and efficient processes with the Data Management and Coordinating Center (DMCC; see: RFA-NS-22-051); enroll and evaluate new participants; and foster scientific discovery. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the FOA instructions carefully and view the available PEDP guidance material.

Funding Opportunity RFA-AI-23-055 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support high risk, milestone-driven approaches for the development of robust culture techniques, and/or genetic and molecular tools to better understand the biology of select human eukaryotic pathogens including the microsporidian Enterocytozoon bieneusi; Pneumocystis jirovecii; Plasmodium vivax; and Babesia microti. This NOFO will use a milestone-driven, biphasic award mechanism. Transition to the second phase will depend on the successful completion of milestones.

Notice NOT-OD-23-169 from the NIH Guide for Grants and Contracts

Notice NOT-NS-23-109 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-23-237 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support established biomedical data resources, that have demonstrated impact and have potential for continued benefit to the mission of one or more of the NIH Institutes and Centers participating in this announcement. Each application must: (a) deliver scientific impact to the communities served; (b) employ and promote good data management practices (as outlined by the FAIR Data Principles including adherence to the NIH desirable characteristics of repositories) and efficient operations for quality and services; (c) engage with the user community and continuously address their needs; and (d) support a process for data life-cycle analysis, long-term preservation, and trustworthy governance. The evaluation of the repositories will be based on their usage, utility, impact, quality of data and services, and efficiency of operations, community needs and engagement, trustworthiness of stewardship, and governance.

Funding Opportunity PAR-23-236 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) supports the development of early-stage or new data repositories and knowledgebases as distinct and separate resources that could be valuable for the biomedical research community.

Notice NOT-CA-23-089 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-MH-25-145 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity announcement (NOFO) supports systematic and scalable approaches to profile the biological function of genes with an excess of damaging mutations in patients with neurodevelopmental and psychiatric disorders. Current understanding of the relationship between genetic and phenotypic variation is limited and one of the main bottlenecks in translating disease-associated genes to biology lies in the lack of scalable experimental platforms that can extend the unbiased nature of gene discovery to the discovery of biological mechanisms. This concept will attempt to fill that gap while also providing a bridge between existing NIMH efforts such as PsychENCODE and Convergent Neuroscience. New technologies and approaches are now making it possible to systematically implement high-throughput assays to determine how disease-linked genetic variation impacts neural function across biological levels of organization. This initiative proposes a series of NOFOs to support the large-scale implementation of high-throughput assays to interrogate the molecular, cellular and physiological function of hundreds of disease-associated genes in parallel. A combination of full-scale and pilot projects will form a consortium for broad characterization of risk genes across an array of endpoints relevant to CNS function using a variety of experimental platforms (e.g., cellular, organismal). A consortium coordination center (CCC) will serve as a central hub providing administrative coordination across projects, including data and tools harmonization, development of an open-source portal to create a unified dataset and creating a standardized set of biological resources for use by the research community.

Notice NOT-MD-23-018 from the NIH Guide for Grants and Contracts

Notice NOT-NS-24-011 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DE-24-003 from the NIH Guide for Grants and Contracts. The objective of this Notice of Funding Opportunity (NOFO) is tosupport highly integrated research teams to address challenging questions with the potential to significantly advance dental, oral and craniofacial (DOC) fields of research. Each project should have a unified and well-defined scientific goal within the NIDCR mission that requires a team with diverse perspectives and expertise in a variety of intellectual or technical areas and is beyond the experience and capabilities of one or two investigators. Collaborative program teams are expected to accomplish goals that require considerable synergy and managed team interactions.