Funding Opportunity RFA-CA-22-031 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) is soliciting applications for a Liver Cancer Consortium focused on advancing translational research in the early detection of liver cancer. Translational Research Centers (TRCs) will conduct studies to improve the surveillance of liver cancer in members of high-risk populations, increase the fraction of liver cancer detected at an early stage, and better stratify patients at risk of developing liver cancer. A major collaborative effort of the TRCs will be establishing an integrated blood and image repository with annotated clinical data from patients found to have indeterminate nodules during liver cancer surveillance. To achieve these goals, each proposed TRC should include laboratory and clinical researchers with multi-disciplinary expertise in such areas as early cancer detection, biomarkers, cancer surveillance, imaging, and biospecimen science. The Consortium will consist of several Translational Research Centers (TRCs, to be supported by this U01 FOA) and a Data Management and Coordinating Center (DMCC, to be supported a companion U24 FOA, RFA-CA-21-032). The TRCs will be expected to interact closely with the DMCC and engage in collaborative activities with other members of the Liver Cancer Consortium.

Funding Opportunity RFA-CA-22-046 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for U54 Research Centers to form the Radiation Oncology-Biology Integration Network (ROBIN). The cadre of ROBIN Centers created through this FOA will establish an agile and effective national radiation oncology network infrastructure that collectively address critical hypothesis-based translational research knowledge gaps on the biological basis of responses in cancer patients who undergo radiation treatments.

Funding Opportunity RFA-AT-23-005 from the NIH Guide for Grants and Contracts. The National Center for Complementary and Integrative Health (NCCIH) intends to solicit applications for one research resource center to build an Open-Access Repository and Database for Anatomical and Physiological Correlates of Acupoints. This FOA will support the development and maintenance of a repository and database for commonly used acupoints along with key anatomical specifications and other relevant parameters as well as integration with other databases with physiological correlates. The ultimate integrated database should be suitable for data from human subjects in an open-access and searchable format. A parallel repository and database for an appropriate animal is also desired. This FOA will utilize a cooperative agreement funding mechanism, U24, to support the development and maintenance of the repository and database to serve the research community. The repository and database should select high quality research data and aim to bring transformative values to support rigorous research on acupuncture-related interventions, which may also benefit evidence-based clinical practices and education.

Notice NOT-OH-22-005 from the NIH Guide for Grants and Contracts

Notice NOT-OH-22-004 from the NIH Guide for Grants and Contracts

Notice NOT-HG-22-030 from the NIH Guide for Grants and Contracts

Notice NOT-HG-22-031 from the NIH Guide for Grants and Contracts

Notice NOT-DE-22-015 from the NIH Guide for Grants and Contracts

Notice NOT-NS-23-016 from the NIH Guide for Grants and Contracts

Notice NOT-HD-22-041 from the NIH Guide for Grants and Contracts

Notice NOT-TR-22-034 from the NIH Guide for Grants and Contracts

Notice NOT-HD-22-039 from the NIH Guide for Grants and Contracts

Notice NOT-OD-22-166 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HG-22-019 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to establish state-of-the-art Data Analysis and Validation (DAV) Centers to join the new NHGRI program called "Molecular Phenotypes of Null Alleles in Cells (MorPhiC)". The long-term goal of MorPhiC is to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene, using in vitro multicellular systems. The catalog will be made available for broad use by the biomedical community. The program will start with a Phase 1 to optimize available methods to create null alleles and measure their phenotypic effects in a target subset of 1000 protein coding genes across the program. Phase 1 will also assess the scale limitations of such methods, develop common data formats, establish use cases for this catalog, and inform whether and how a potential second phase will be implemented. The DAV Centers will develop computational models and data analysis and visualization methods to evaluate and help ensure the utility of the MorPhiC data.

Funding Opportunity RFA-HD-23-037 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks applications for the Implementation Science Hub/Resource Center for the Maternal Health Research Centers of Excellence initiative. This FOA runs in parallel with companion FOAs that seek applications for Research Centers of Excellence (RFA-HD-23-NNN) and an Innovation and Coordinating Hub/Resource Center (RFA-HD-23-NNN). It is expected that the Implementation Science Hub will serve as a resource to Maternal Health Research Centers of Excellence, with a particular emphasis on assisting in implementing evidence-informed programs, practices and policies to improve maternal health outcomes. The Implementation Science Hub will help bridge the evidence-to-practice gap to support the development and implementation of strategies to inform integrated efforts involving policy and practice changes to improve pregnancy, perinatal, and postpartum care and advance maternal health and maternal health equity. Studies that promote equitable dissemination and implementation of evidence-based interventions among underrepresented communities are strongly encouraged.

Funding Opportunity RFA-HD-23-035 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to participate as a Research Center as part of the Maternal Health Research Centers of Excellence initiative. The purpose of this initiative is to generate innovative approaches to address preventable maternal mortality, decrease severe maternal morbidity, and promote maternal health equity in partnership with communities that are most affected (i.e., Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, sexual and gender minorities, socioeconomically disadvantaged populations, and underserved rural populations). This initiative will use an integrated multi-level approach encompassing social and biobehavioral research strategies to address the multiple contributing factors that lead to adverse maternal health outcomes and health disparities. Significant contributing factors include comorbid conditions (e.g., hypertension, diabetes, mental illness, and substance use disorders) and social determinants of health, which include structural racism and health care system factors. The goal of this initiative is for trans-disciplinary researchers to conduct multi-layered novel research approaches that will have the potential to drastically reduce pregnancy-related and pregnancy-associated maternal deaths and decrease severe maternal morbidity. Studies may be interventional (including effectiveness, comparative effectiveness, optimization, or dissemination and implementation studies), or observational (including health services studies, natural experiments, policy analyses) and may assess both short-term and long-term maternal health outcomes. The Research Centers will be uniquely poised to collaborate on studies and projects with other networks and initiatives such as the NICHD Neonatal Research Network and the NICHD Maternal and Pediatric Precision in Therapeutics (MPRINT) initiative.

Funding Opportunity RFA-HD-23-036 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks applications for the Data Innovation and Coordinating Hub/Resource Center (hereafter referred to as the Innovation and Data Hub) for the Maternal Health Research Centers of Excellence initiative. This FOA runs in parallel with companion FOAs that seek applications for Research Centers of Excellence (RFA-HD-23-NNN) and an Implementation Science Hub/Resource Center (RFA-HD-23-NNN). It is expected that the Innovation and Data Hub will provide 1) a coordination infrastructure to foster communication and collaboration for participating Research Centers and the Implementation Science Hub under the Maternal Health Centers of Excellence initiative, 2) a centralized resource to support data collection, facilitate curation, and ensure high-quality data, and 3) provide cutting edge biomedical research informatics and data science expertise to maximize data comparability and facilitate data harmonization. The Innovation and Data Hub itself will not generate new experimental data, but rather will serve as a resource, analytical platform, and portal for available analytical and data tools.

Funding Opportunity RFA-HD-23-012 from the NIH Guide for Grants and Contracts. The purpose of this FOA issued by the Eunice Kennedy ShriverNational Institute of Child Health and Human Development (NICHD), NIH is to announce the re-competition of the Reproductive Scientist Development Program (RSDP). This program constitutes a national network of mentors and scholars, in contrast to K12 programs that are based solely at a single applicant institution. The purpose of the RSDP is to provide career development support for obstetricians and gynecologists who have completed their clinical training, and who are committed to a career conducting basic science research in an academic setting. The overall goal of the Program is to strengthen the field of obstetrics and gynecology by encouraging the application of contemporary scientific advances to clinical practice and facilitating the transition to independence of physician-scientists in obstetrics and gynecology and its subspecialties.

Funding Opportunity PAR-22-221 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support studies that expand the use of existing AD/ADRD data resources to drive new discoveries that can lead to better understanding of the relationship between early life social determinants of health (SDOH), adverse childhood experiences (ACEs), AD/ADRD biomarkers, and the development of cognitive impairment and dementia, especially in populations experiencing health disparities.

Funding Opportunity PAR-22-205 from the NIH Guide for Grants and Contracts. NIAMS Clinical Trial Planning Grant (R34) - Clinical Trial Not Allowed Re-Issue