Funding Opportunity RFA-NS-22-070 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) invites research to develop, characterize, and rigorously validate non-rodent mammalian models of pain, associated outcome measures and/or endpoints that enable translational research for effective pain management. These models are expected to recapitulate molecular, cellular, pathological, behavioral, and/or cognitive aspects of human pain disorders and conditions. Research supported under this FOA is expected to provide well-validated models and measures that facilitate the development of non-opioid analgesic therapeutic interventions with little or no addiction liability.

Funding Opportunity RFA-NS-22-062 from the NIH Guide for Grants and Contracts. The purpose of this NINDS-led Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) initiative is to 1) develop tools, standards, and an Open-source software platform that enables a federated (multiple data repository sites with a single access portal) approach for data sharing and analysis of human digital neuropathological slides and 2) perform software testing to validate and verify that the software and tools developed can be used to perform multisite neuropathological analyses using a federated approach. The federated approach requires a single access point of digital slides from multiple geographically distinct brain banks. The resources developed are expected to also enable cross-site annotation and computational image analysis, including advanced analytic approaches. A critical feature of this FOA includes the broad sharing of neuropathological data to further advance research in this area, including the development of a digital resource for distribution and sharing of assessed neuropathological tissue. Software and tools developed under this initiative are expected to be shared using Open Science principles, and the federated digital library is expected to follow FAIR data sharing principles.

Funding Opportunity RFA-AT-23-004 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) invites applications for REsearch Across Complementary and Integrative Health Institutions (REACH) virtual resource centers. REACH virtual resource centers will foster institutional partnerships and provide resources to support research activities and research training for faculty who work at accredited complementary and integrative health clinical institutions, such as: Schools of acupuncture, chiropractic, osteopathy, naturopathy, physical therapy, and music and art therapy. The REACH virtual resource centers will provide a variety of including, but not limited to Administrative Support, Research Support, Grantsmanship, Mentoring and Training, and Team Building to support clinician scientists located at complementary and integrative health clinical institutions to form multi and interdisciplinary research teams and pursue externally funded research aligned with NCCIH Strategic Priorities for symptom management . REACH centers should focus on resources to support investigators pursuing clinical research (e.g., observational, epidemiological, mechanistic clinical research, mixed methods, feasibility studies, etc). It is expected that REACH virtual resource centers will (1) improve the quality and quantity of federal research grant applications submitted by clinician scientist faculty at complementary and integrative health clinical institutions; (2) aid the formation of multi and interdisciplinary research partnerships across partnering complementary and integrative health clinical institutions; (3) help to enhance the research environment at complementary and integrative health clinical institutions; and (4) support a pipeline for clinician scientists trained in complementary and integrative health practices to pursue research careers at clinical institutions.

Funding Opportunity PA-22-232 from the NIH Guide for Grants and Contracts. This notice of funding opportunity (NOFO) requests individual Mentored Clinical Scientist Research Career Development (K08) grant applications from applicant organizations. The overall goal of AHRQ- supported career development programs is to help ensure that a diverse pool of highly trained health services researchers is available in adequate numbers and in appropriate research areas to address the mission and priorities of AHRQ.

Funding Opportunity PAR-22-215 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to support innovative research that will inform our understanding of the mechanisms underlying the formation of structural birth defects using animal models in conjunction with human translational/clinical approaches. Applicants are encouraged to take advantage of advances in genetics, omics methods (genomics, proteomics, metabolomics, etc.), and synthetic biology, biochemical and other approaches to developmental biology research to identify specific genetic, epigenetic, environmental, or gene/environment interactions associated with the formation of, susceptibility to, and variability of structural birth defects in human populations.

Funding Opportunity PAR-22-223 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support mechanistic studies on host cell death pathways and immune responses to Mycobacterium tuberculosis (Mtb) and Mtb/HIV co-infection to identify immune targets for development of host-directed therapies.

Notice NOT-DA-22-066 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AI-22-058 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to solicit applications for the NIAID CDSMC, which will support a broad range of critical support services, including data management and processing, safety and pharmacovigilance management and processing, and sample tracking systems for NIAID-funded clinical trials, integrated studies of underlying mechanisms, clinical studies (e.g., longitudinal studies, genetic studies, etc.), and studies to identify and validate surrogates/biomarkers of immune-mediated diseases in the areas of asthma and allergic diseases, autoimmune diseases, and transplantation.

Funding Opportunity RFA-AI-22-057 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to solicit applications for a Transplantation Statistical and Clinical Coordinating Center (T-SCCC) to provide a broad range of support critical for the design, development, execution, and analysis of clinical research carried out by multiple NIAID-supported programs in transplantation. The scope is to support the study teams with statistical design and analysis, protocol development, and final analysis of study findings. In addition, the T-SCCC will support the mechanistic studies by providing biospecimen labeling, shipping, specimen tracking, and kits and/or bulk supplies for specimen collection. Finally, the T-SCCC will work collaboratively with the Clinical Data and Safety and Monitoring Center (CDSMC) that will provide data management for the Transplantation clinical trials. The type of research for which support will be provided includes clinical trials, integrated studies of underlying mechanisms, clinical studies (e.g., longitudinal studies, genetic studies, etc.), and studies to identify and validate surrogates/biomarkers.

Funding Opportunity RFA-AI-22-054 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to solicit applications for an Allergy and Asthma Statistical and Clinical Coordinating Center (AA-SCCC) to provide a broad range of support critical for design, development, execution, and analysis of clinical research in allergic diseases and asthma. The major clinical research programs to be supported by the AA-SCCC include the Atopic Dermatitis Research Network, Consortium for Food Allergy Research, Childhood Asthma in Urban Settings Clinical Research Network, and Immune Tolerance Network. The AA-SCCC also may support Investigator-Initiated Clinical Trials (IICT), and other clinical trial/study activities funded by NIAID. The types of research for which support will be provided include clinical trials, integrated studies of underlying mechanisms, clinical studies (e.g., longitudinal observational studies, genetic studies, etc.), and studies to identify and validate surrogates/biomarkers.

Notice NOT-NS-22-112 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AG-23-020 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to promote collaborative research programs to support the development of infrastructure for precision medicine approaches for minority health and health disparities in AD/ADRD. This FOA serves as a catalytic opportunity for investigators to focus on populations underrepresented in AD/ADRD research, to build resources that include neurobiological, environmental, behavioral, and social science data, and to initiate innovative, integrated, and expanded studies of individuals from these populations.

Notice NOT-OD-22-195 from the NIH Guide for Grants and Contracts

Notice NOT-OD-22-197 from the NIH Guide for Grants and Contracts

Notice NOT-HD-22-035 from the NIH Guide for Grants and Contracts

Notice NOT-OD-22-189 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AG-23-025 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications from institutions proposing to develop, or renew, a Resource Center for Minority Aging Research (RCMAR) that focuses on behavioral and social science research in a key area related to Alzheimers disease (AD) and AD-related dementias (ADRD). The goal of the AD/ADRD RCMAR program is two-fold: (1) to diversify the AD/ADRD research workforce in priority areas of social, behavioral, psychological, and economic research related to AD/ADRD by mentoring promising scientists from diverse backgrounds; and 2) to develop a research and mentoring infrastructure to foster rigorous research and lead to scientific advances in priority areas of behavioral and social science related to AD/ADRD, including, but not limited to, the following: cognitive and dementia epidemiology, behavioral and social pathways to AD/ADRD, early psychological and functional changes, AD/ADRD prevention, dementia care, caregiving/care partners, and AD/ADRD health disparities and health inequities. To achieve the goal of the AD/ADRD RCMAR program, applications should propose multipronged, collaborative approaches in a supportive environment that embraces, integrates, and strengthens diversity, equity, inclusion, and accessibility (DEIA).

Funding Opportunity RFA-AG-23-026 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to invite applications from institutions proposing to develop, or renew, a Resource Center for Minority Aging Research (RCMAR) that focuses on behavioral and social science research in a key area related to aging and/or to health disparities in older adults. Successful applications will propose the use of multipronged collaborative approaches in a supportive environment that embraces, integrates, and strengthens diversity, equity, inclusion, and accessibility (DEIA), to achieve the two-fold goal of the RCMAR program: 1) to diversify the research workforce in priority areas of social, behavioral, psychological, and economic research on aging by mentoring promising scientists from diverse backgrounds; and 2) to develop a research and mentoring infrastructure to foster rigorous behavioral and social science research on aging in a high priority research area, that can advance aging-relevant scientific discoveries, lead to the elimination of health disparities and health inequities, and improve the health and well-being of older adults who are members of NIAs Priority Populations, as specified in the NIA Health Disparities Research Framework.

Funding Opportunity RFA-AG-23-027 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to develop and maintain a coordinating center (CC) for the Resource Centers for Minority Aging Research (RCMAR) program. The RCMAR program supports behavioral and social research on aging, health disparities in older adults, and Alzheimers disease and Alzheimers disease related dementias (AD/ADRD), through the development of research infrastructure and mentorship of early career scientists from diverse backgrounds. The primary responsibilities of the RCMAR CC are to: coordinate and provide logistical support to RCMAR Centers; facilitate cooperation and collaboration across RCMAR Centers; create and maintain an interactive RCMAR CC website; identify and share research and training resources and materials; provide support, technical assistance, and resources to early career investigators; and perform program analysis and evaluation. The CC will also develop and implement strategies to enhance the visibility of the RCMAR program and behavioral and social research on aging and AD/ADRD as a whole, and to communicate the importance and value of diversity, equity, inclusion, and accessibility (DEIA) in the aging and AD/ADRD research enterprise.

Notice NOT-OD-22-142 from the NIH Guide for Grants and Contracts