Funding Opportunity RFA-RM-22-015 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) is part of a suite of FOAs of the NIH Common Fund Somatic Cell Genome Editing (SCGE) Phase II Program. The goal of this U19 FOA is to support team-based research Projects to accelerate further optimization and development of genome editing-based therapeutic leads towards IND-enabling studies and an IND (Investigational New Drug) application submission to the U.S. Food and Drug Administration (FDA). The proposed leads should demonstrate strong biological rationale and in vitro and/or in vivo proof of concept (POC) data generated in model system(s) each defined by the targeted cell or tissue type to establish a genome editing therapeutic approach that is potentially adaptable to target different pathogenic variants in the same cell or tissue types.

Funding Opportunity RFA-RM-22-016 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to provide support for applications that propose a novel genome editing clinical trial that includes at least two different diseases, using the same genome editor, route of administration, and delivery system.

Funding Opportunity RFA-RM-22-014 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications on the optimization and characterization of technologies and assays with the potential for utilization and adoption in regulatory submissions of genome editing therapeutics.

Notice NOT-CA-22-077 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-22-147 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites U01 cooperative agreement applications for Physical Sciences-Oncology Network (PS-ON). The goal of the PS-ON is to foster the convergence of physical sciences approaches and perspectives with cancer research to advance our understanding of cancer biology and oncology by forming transdisciplinary teams of physical scientists and cancer biologists/physician scientists. Examples of physical scientists may include engineers, physicists, mathematicians, chemists, and computer scientists. The research projects funded through this FOA, individually and as a collaborative Network along with other funded research projects, will support transdisciplinary research that: (1) drives a physical sciences perspective within the cancer research community; (2) facilitates team science and field convergence at the intersection of physical sciences and cancer research; and (3) collectively tests physical sciences-based experimental and theoretical concepts of cancer and promotes innovative solutions to address outstanding questions in cancer research.

Notice NOT-CA-22-070 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-OD-22-008 from the NIH Guide for Grants and Contracts. The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This FOA is intended to support meritorious small research projects focused on analyses of genomics other -omics, clinical and phenotypic datasets related to Down syndrome research, with an emphasis on elucidating the underlying etiologies of risk and resiliencies to co-occurring health conditions. Development of approaches, tools, or algorithms appropriate for analyzing data relevant to Down syndrome and facilitating data sharing within the research community through the INCLUDE Data Hub may also be proposed.

Notice NOT-HL-22-020 from the NIH Guide for Grants and Contracts

Notice NOT-CA-22-074 from the NIH Guide for Grants and Contracts

Notice NOT-CA-22-075 from the NIH Guide for Grants and Contracts

Notice NOT-CA-22-076 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-22-161 from the NIH Guide for Grants and Contracts. Through this funding opportunity announcement, the National Cancer Institute (NCI) solicits applications to Cancer Epidemiology Cohorts: Building the Next Generation of Research Cohorts PAR. This funding opportunity announcement seeks to support initiating and building the next generation of population-based cancer epidemiology cohorts to address specific knowledge gaps in cancer etiology and survivorship. Specifically, it will support methodological work necessary to initiate and build cancer epidemiology cohorts that can address critical scientific gaps concerning (i) new or unique exposures in relation to cancer risks and outcomes and (ii) achievement of diverse populations in cohorts with the inclusion of understudied populations (e.g., racial/ethnic groups, rural populations, and persistent poverty areas) with substantial community engagement.

Notice NOT-HG-22-016 from the NIH Guide for Grants and Contracts

Notice NOT-HG-22-017 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HS-22-008 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity Announcement (NOFO) invites applications for the development of Diagnostic Centers of Excellence (DCE). The role of a DCE is to support a component of diagnostic care in an integrated cross-disciplinary health system. Each DCE will develop expertise in one or two focus areas of diagnostic improvement. There are four areas of focus. Two of the areas of focus are aligned with frontline diagnostician support: 1) Safety-I error detection and prevention and 2) Safety-II resilience for safe practice Two additional areas of focus are aligned with improving diagnostic systems: 3) improving diagnostic precision through consensus and 4) improving truth or diagnostic reference standards.

Notice NOT-MH-22-210 from the NIH Guide for Grants and Contracts

Notice NOT-MH-22-211 from the NIH Guide for Grants and Contracts

Notice NOT-CA-22-079 from the NIH Guide for Grants and Contracts

Notice NOT-CA-22-078 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-22-156 from the NIH Guide for Grants and Contracts. The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Optional mechanism focusing on alcohol health services. This FOA will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.