Notice NOT-ES-21-011 from the NIH Guide for Grants and Contracts

Notice NOT-AI-21-059 from the NIH Guide for Grants and Contracts

Notice NOT-AI-21-071 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-CA-21-049 from the NIH Guide for Grants and Contracts. The mission of the National Cancer Institute (NCI) Division of Cancer Biology (DCB) is to ensure continuity and stability in basic cancer research while encouraging and facilitating the emergence of new concepts, technologies, and possibilities. Towards its mission, the DCB supports multiple collaborative research programs focused on addressing important questions in basic cancer biology. To maximize the combined impact of DCB programs, this FOA aims to support a common coordinating body to facilitate collaborations, resource sharing, and outreach activities across DCB programs. DCB research programs to be coordinated by the DCB Multi-Consortia Coordinating Center (MC2 Center) include the Cancer Cell Biology Imaging Resource (CCBIR), the Cancer Systems Biology Consortium (CSBC), the Cancer Tissue Engineering Collaborative (TEC), the Metastasis Research Network (MetNet), the Patient-Derived Models of Cancer Initiative (PDMC), and the Physical Sciences-Oncology Network (PS-ON). In carrying out its roles, the MC2 Center is expected to work collaboratively with DCB research program investigators, other investigators collaborating with DCB research programs, and NCI program staff.

Funding Opportunity RFA-DK-21-018 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support pilot and feasibility trials of interventions designed to improve technology adoption in individuals from underrepresented backgrounds with type 1 diabetes mellitus (T1D). Through successful execution, these pilot and feasibility trials should provide feasibility data for larger, pragmatic trials with the overarching goal of reducing health disparity in T1D through improving technology usage in individuals from minority racial and ethnic backgrounds.

Funding Opportunity PAR-21-288 from the NIH Guide for Grants and Contracts. Reissue of RFA-20-351.The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new technologies and therapies are outside the scope of this FOA.

Funding Opportunity PAR-21-289 from the NIH Guide for Grants and Contracts. Reissue of RFA-20-350. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new technologies and therapies are outside the scope of this FOA.

Notice NOT-DA-21-067 from the NIH Guide for Grants and Contracts

Notice NOT-DK-21-026 from the NIH Guide for Grants and Contracts

Notice NOT-MD-21-025 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-CA-21-048 from the NIH Guide for Grants and Contracts. The National Cancer Institutes (NCI) Cancer Systems Biology Consortium (CSBC, https://csbconsortium.org/) supports the application of systems biology approaches to cancer research and includes U01 Research Projects and, through this FOA, U54 Research Centers. These multi-project Centers should address challenges in basic cancer biology that would benefit from a coordinated systems biology approach and should coalesce around a well-defined overarching scientific theme pursued through two or three research projects. The research projects should be driven by a specific hypothesis and incorporate iterative cycles of quantitative experimentation, analysis, modeling, and validation in a disease-relevant context. Centers will include an interdisciplinary research team including quantitative and cancer biology expertise, administrative management, optional shared resource cores, and an Outreach core that support the overall Center research theme. Each Center will make sharing interoperable datasets and community accessible tools a priority with the support of a multi-consortium U24 Coordinating Center (being solicited under RFA-CA-21-049), actively collaborate within and outside the consortium, and support a welcoming and diverse research community at the Center and Consortium level.

Funding Opportunity RFA-MH-21-237 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) intends to support a Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) that will be composed of four components to establish respectively (1) a common sequencing data processing pipeline, (2) a common imaging data processing pipeline, (3) a comprehensive brain cell knowledge base, and (4) an engaging and outreach component to coordinate the research within and beyond BICAN. The overall goals of CUBIE are to (i) enable the exploration of large-scale brain cell atlas data and knowledge, and inspire research in brain function and disorders; and (ii) ensure research rigor and data reproducibility by making the data to be findable, accessible, interoperable, and reusable, and the process transparent. An application is expected to propose only one of the above four respective components.

Funding Opportunity RFA-MH-21-236 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) intends to support a group of Specialized Collaboratories that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases in human, non-human primates, and mouse, in coordination and collaboration with other BICAN projects. In particular, the Specialized Collaboratories are expected to complement the Comprehensive Centers in BICAN with distinct capabilities, competencies, and research aims. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.

Funding Opportunity RFA-MH-21-235 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) intends to support a group of large-scale Comprehensive Centers that will adopt scalable technology platforms and streamlined sampling strategies and assay cascade to create comprehensive and highly granular brain cell atlases of human and non-human primates with an emphasis on human. The Centers are expected to characterize all brain cell types (neurons, glia, and other non-neuronal cells) at high-resolution. The overarching goal of the BICAN is to build reference brain cell atlases that will be widely used throughout the research community, providing a molecular and anatomical foundational framework for the study of brain function and disorders.

Funding Opportunity RFA-CA-21-050 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) will support canine clinical studies using immunotherapeutic agents and novel drug combinations together with laboratory correlative studies that seek to characterize and understand the cellular and molecular mechanisms that determine anti-tumor responses (or non-responses) in pet dogs with spontaneous tumors. The goal is to create a network of laboratories and canine clinical trial sites. The proposed clinical studies must include therapeutic modulation of the tumor microenvironment (TME) or must elicit direct immune-mediated destruction of cancer. Priority attributes include: combinations of immunotherapy/TME-modulating therapy with radiation therapy or other therapies (e.g., targeted therapies, chemotherapies or other immunotherapies); adoptive immune cell therapies such as CAR T-cell therapies or NK cell therapies; studies including longitudinal biopsy; and studies including tumor DNA sequencing and transcriptomics in pet dogs treated with immunotherapeutic agents. Within the network, awardees are expected to share therapeutic agents, specimens, and laboratory and clinical protocols in order to standardize and validate data generated. A companion funding opportunity will support a coordinating center that will aid in the development, standardization, harmonization, and conduct of the clinical and laboratory studies, as well as data management and statistical support across the funded U01 sites (see U24 award supported under companion RFA-CA-21-051).

Funding Opportunity RFA-CA-21-051 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) will support a coordinating center to facilitate coordination across the Canine Cancer Immunotherapy Network (K9CIN; see U01 awards supported under companion RFA-CA-21-050) that will conduct immunotherapy clinical trials in pet dogs with spontaneous tumors and perform laboratory correlative studies associated with the clinical trials. The network will include a representative from the NCI Comparative Oncology Program (COP) of the NCI's Center for Cancer Research as an integral component. The awardee will contribute to the administration of a steering committee of required expertise--both inside and outside the U01 network, including the PD/PIs of the U01s, representatives of the COP, and the NCI Project Collaborators --to ensure that the goals of the network are accomplished. The Coordinating Center will have several responsibilities, including, but not limited to providing administrative support to the K9CIN: development and standardization of clinical protocols and correlative assays; implementation of clinical studies in immunotherapy and combination agents including accrual to the trials; providing statistical support; facilitating sharing of agents, specimens, and data; harmonization of clinical data; and submission of clinical and correlative data to the Integrated Canine Data Commons.

Notice NOT-AR-21-027 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-21-033 from the NIH Guide for Grants and Contracts. The NINDS Materials to Enhance Training in Experimental Rigor (METER) UE5 will support curriculum development in the form of innovative educational materials that will be incorporated into a new cutting-edge online resource that aims to promote awareness, understanding, and practice of fundamental principles of rigorous biomedical research for researchers and other scientists in various career stages and learning environments. This UE5 FOA runs in parallel with a companion UC2 FOA that solicits applications for the NINDS center for Creating an Educational Nexus for Training in Experimental Rigor (CENTER), described in detail in RFA-NS-21-009.

Funding Opportunity RFA-NS-21-009 from the NIH Guide for Grants and Contracts. This is one of two Funding Opportunity Announcements (FOAs) that together aim to facilitate teaching of fundamental principles of rigorous biomedical research by developing an online educational resource for use by a broad range of researchers in an array of learning environments. The purpose of this FOA is to support the establishment of a center for Creating an Educational Nexus for Training in Experimental Rigor (CENTER), which will build, evaluate, and disseminate a user-friendly, harmonized, and openly accessible educational resource to promote awareness, understanding, and utilization of the principles of rigorous biomedical research.

Notice NOT-OD-21-153 from the NIH Guide for Grants and Contracts