Notice NOT-OD-21-138 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-RM-21-017 from the NIH Guide for Grants and Contracts. The NIH Directors Transformative Research Award Program supports individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the research workforce. Individuals from diverse backgrounds and from the full spectrum of eligible institutions in all geographic locations are strongly encouraged to apply to this Funding Opportunity Announcement. In addition, applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Directors Transformative Research Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund.

Funding Opportunity RFA-DA-22-016 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support research project applications that are developmental and exploratory in nature to expand our knowledge on the basic neurobiology of the interrelationship between sleep and substance use disorders (SUDs). These mechanistic studies will not only offer an insight into the fundamental processes that link substance use disorders to disorders of sleep regulation and vice-versa but may also have implications for managing risk for the development of SUDs and identifying new targets for prevention and therapeutics.

Notice NOT-OD-21-130 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AA-21-009 from the NIH Guide for Grants and Contracts. This limited competition Funding Opportunity Announcement (FOA) is to support the continuation of the Data Analysis Resource for the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). Only the current NCANDA Data Analysis Resource awardee is eligible to apply in response to this FOA. The NCANDA Data Analysis Resource has responsibility for the standardization, storage, and analysis of the data acquired by the research project sites of the nation-wide consortium to study the impact of alcohol drinking on brain structure and function during adolescence and into early adulthood.

Funding Opportunity RFA-AA-21-007 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) is a limited competition to support the continuation of the Research Project Sites of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). Only the current NCANDA Research Project Site awardees are eligible to apply in response to this FOA. The NCANDA Research Project Sites have responsibility for the acquisition of data according to the standard protocol for the nation-wide consortium to study the impact of alcohol drinking on brain structure and function during adolescence and into early adulthood. RFA-AA-21 NNN (FOA link) will support continuation of the NCANDA Administrative Resource and RFA-AA-21-NNN (FOA link) will support the continuation of the Data Analysis Resource.

Funding Opportunity RFA-AA-21-008 from the NIH Guide for Grants and Contracts. This limited competition Funding Opportunity Announcement (FOA) is to support the continuation of the Administrative Resource for the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). Only the current NCANDA Administrative Resource awardee is eligible to apply in response to this FOA. The NCANDA Administrative Resource coordinates the activities of the nation-wide consortium to study the impact of alcohol drinking on brain structure and function during adolescence and into early adulthood.

Funding Opportunity RFA-HG-21-026 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to solicit applications for the Non-Human Developmental Genotype-Tissue Expression (NHP dGTEx) Research Center. The NHP dGTEx research center will perform four major functions: 1) create a tissue resource of multiple reference tissues across developmental stages in non-human primates (NHPs); 2) perform transcriptome sequencing and other genomic analysis of bulk tissues and single-cell populations; 3) perform analysis of gene expression patterns in NHPs and compare them to human gene expression patterns; and 4) make the tissue samples and data available and usable to the community.)

Funding Opportunity PAR-21-257 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH) hereby notifies the applicant community that funds may be available to provide Personal Protective Equipment (PPE) to directly support the needs of the NIH Clinical Trials and Clinical Research Activities. Only applications submitted in response to a Notice of Special Interest (NOSI) published by an IC will be allowed to apply to this FOA.

Notice NOT-HL-21-010 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DK-21-016 from the NIH Guide for Grants and Contracts. This initiative will support the development of tools and experimental platforms for the purification and characterization of Extracellular Vesicles (EV) originating from the human pancreatic islet and its broader tissue environment in healthy individuals, and individuals with T1D or at-risk of developing the disease. It will also support the exploration of the contribution of pancreatic EV biology to islet function, dysfunction and T1D disease initiation; the development of EV-based diagnostic tools for disease monitoring and classification; and the use of pancreatic EV biology to identify novel therapeutic targets.

Funding Opportunity RFA-AA-21-014 from the NIH Guide for Grants and Contracts. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) seeks applications to continue the previously funded Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD). Responsive applications are expected to address urgent and important unmet needs in the fetal alcohol spectrum disorders (FASD) field through an integrated and multidisciplinary research approach. These unmet needs include identifying FASD cases early and accurately, improving interventions to mitigate FASD outcomes; expanding basic and mechanistic understanding of alcohol teratogenesis aimed at accelerated translation, and reducing prenatal alcohol exposure and the incidence of FASD. Cooperative Agreement (UH2) applications in response to this FOA should propose exploratory/developmental projects of the CIFASD consortium.

Funding Opportunity RFA-AA-21-013 from the NIH Guide for Grants and Contracts. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) seeks applications to continue the previously funded Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD). Responsive applications are expected to address urgent and important unmet needs in the fetal alcohol spectrum disorders (FASD) field through an integrated and multidisciplinary research approach. These unmet needs include identifying FASD cases early and accurately, improving interventions to mitigate FASD outcomes; expanding basic and mechanistic understanding of alcohol teratogenesis aimed at accelerated translation, and reducing prenatal alcohol exposure and the incidence of FASD. Cooperative Agreement (U24) applications in response to this FOA should propose the Data Coordination Core (U24) component of the CIFASD consortium.

Funding Opportunity RFA-AA-21-012 from the NIH Guide for Grants and Contracts. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) seeks applications to continue the previously funded Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD). Responsive applications are expected to address urgent and important unmet needs in the fetal alcohol spectrum disorders (FASD) field through an integrated and multidisciplinary research approach. These unmet needs include identifying FASD cases early and accurately, improving interventions to mitigate FASD outcomes; expanding basic and mechanistic understanding of alcohol teratogenesis aimed at accelerated translation, and reducing prenatal alcohol exposure and the incidence of FASD. Cooperative Agreement (U24) applications in response to this FOA should propose the Diagnostic-Telemedicine Core (U24) component of the CIFASD consortium.

Funding Opportunity RFA-AA-21-011 from the NIH Guide for Grants and Contracts. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) seeks applications to continue the previously funded Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD). Responsive applications are expected to address urgent and important unmet needs in the fetal alcohol spectrum disorders (FASD) field through an integrated and multidisciplinary research approach. These unmet needs include identifying FASD cases early and accurately, improving interventions to mitigate FASD outcomes; expanding basic and mechanistic understanding of alcohol teratogenesis aimed at accelerated translation, and reducing prenatal alcohol exposure and the incidence of FASD. Cooperative Agreement (U24) applications in response to this FOA should propose the Administrative Resource (U24) component of the CIFASD consortium.

Funding Opportunity RFA-AA-21-010 from the NIH Guide for Grants and Contracts. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) seeks applications to continue the previously funded Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD). Responsive applications are expected to address urgent and important unmet needs in the fetal alcohol spectrum disorders (FASD) field through an integrated and multidisciplinary research approach. These unmet needs include identifying FASD cases early and accurately, improving interventions to mitigate FASD outcomes; expanding basic and mechanistic understanding of alcohol teratogenesis aimed at accelerated translation, and reducing prenatal alcohol exposure and the incidence of FASD. Cooperative Agreement (U01) applications in response to this FOA should propose individual clinical or basic research projects.

Notice NOT-AR-22-003 from the NIH Guide for Grants and Contracts

Notice NOT-HD-21-039 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-CA-21-035 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for Biomarker Characterization Centers (BCCs), one of the three scientific units of the Early Detection Research Network (EDRN). The EDRN is a national infrastructure to discover, develop, and validate biomarkers and imaging methods for early cancer detection and risk assessment. BCCs will (1) discover, develop, characterize and test new biomarkers or refine existing biomarkers, (2) develop, refine and/or standardize biomarker assays, (3) provide resources and support for the validation of biomarkers developed by the EDRN, and (4) participate in collaborative projects with other laboratories and centers. The other two scientific units of the continuing EDRN program are the Clinical Validation Centers (CVCs), which will conduct clinical research on the validation of biomarkers and will serve as resource centers for the Network by participating in collaborative biomarker validation studies with EDRN BCCs; and the Data Management and Coordinating Center (DMCC), which will support statistical and computational analyses, informatics infrastructure, study design, coordination and management of EDRN-sponsored biomarker validation studies, and the coordination of Network-wide meetings and workshops.

Funding Opportunity RFA-CA-21-034 from the NIH Guide for Grants and Contracts. The objectives of the Early Detection Research Network (EDRN; edrn.cancer.gov) are to discover, develop and validate biomarkers and imaging methods to detect early stage cancers and to translate these into clinical tests. The EDRN provides an infrastructure that is essential for this process and has successfully completed more than10 multicenter validation studies.