Funding Opportunity PAR-21-233 from the NIH Guide for Grants and Contracts. The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies). Applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in manufacturing, scaling, pharmacokinetics, toxicology, and Phase I clinical testing. BPN-Biologics awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN-Biologics contractors (and thereby control the patent prosecution and licensing negotiations) for biotherapeutic candidates developed in this program.

Notice NOT-NS-21-060 from the NIH Guide for Grants and Contracts

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Funding Opportunity RFA-DK-20-026 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) requests applications for the Kidney Precision Medicine Project (KPMP) - Recruitment Sites (RS) to enroll participants with either acute kidney injury (AKI) and/or chronic kidney disease (CKD) into a longitudinal cohort study and perform protocol-based research kidney biopsies. The RS will collaborate with the Tissue Interrogation Sites (TIS), Kidney Tissue Atlas Coordinating Center (KTACC), and Central Hub (CH) to obtain and evaluate kidney biopsies from participants, create a Kidney Tissue Atlas, define disease subgroups, and identify critical cells, interstitial components, pathways, and targets for novel therapies.

Funding Opportunity RFA-DK-20-027 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) requests applications for the Kidney Precision Medicine Project (KPMP) - Kidney Tissue Atlas Coordinating Center (KTACC). The KTACC will collaborate with the KPMP Recruitment Sites (RS), Tissue Interrogation Sites (TIS), and Central Hub (CH) to obtain and evaluate kidney biopsies from participants with acute kidney injury (AKI) or chronic kidney disease (CKD), create a Kidney Tissue Atlas, define disease subgroups, and identify critical cells, interstitial components, pathways, and targets for novel therapies. The specific responsibilities of the KTACC will be to clean, harmonize, store, and curate all de-identified KPMP data and (1) use state-of-the-art computational approaches to carry out integrative analyses, and (2) build an interactive Kidney Tissue Atlas with FAIR principles (findable, accessible, interoperable, and reusable) to promote data retrieval, exploration, discovery, and analysis by the community.

Funding Opportunity RFA-DK-20-028 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) requests applications for the Kidney Precision Medicine Project (KPMP) - Tissue Interrogation Sites (TIS) to analyze human kidney tissue. The TIS will collaborate with the Recruitment Sites (RS), Kidney Tissue Atlas Coordinating Center (KTACC) and Central Hub (CH) to obtain and evaluate kidney biopsies from participants with acute kidney injury (AKI) or chronic kidney disease (CKD), create a Kidney Tissue Atlas, define disease subgroups, and identify critical cells, interstitial components, pathways, and targets for novel therapies.

Funding Opportunity RFA-DK-20-029 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) requests applications for the Kidney Precision Medicine Project (KPMP) - Central Hub (CH) to support the KPMP cohort, collect and de-identify all existing and new clinical data and samples, and provide scientific, infrastructure, quality control, project management, and administrative support. The CH will collaborate with the Recruitment Sites (RS), Tissue Interrogation Sites (TIS), and Kidney Tissue Atlas Coordinating Center (KTACC) to obtain and evaluate kidney biopsies from participants with acute kidney injury (AKI) or chronic kidney disease (CKD), create a Kidney Tissue Atlas, define disease subgroups, and identify critical cells, interstitial components, pathways, and targets for novel therapies.

Notice NOT-OD-21-115 from the NIH Guide for Grants and Contracts

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