Notice NOT-RM-21-015 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DA-22-008 from the NIH Guide for Grants and Contracts. To support the development of innovative tools and/or technologies to monitor or manipulate BMCs in vivo and enable investigators to adopt these tools to answer outstanding questions in basic neuroscience. This research will transform our understanding of the mechanistic role of BMCs in human nervous system health and disease and may serve as the foundation for the development of novel BMC-based therapeutics.

Notice NOT-RM-21-014 from the NIH Guide for Grants and Contracts

Notice NOT-RM-21-011 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-21-106 from the NIH Guide for Grants and Contracts. The objective of the NIA Academic Leadership Career Award (K07) is to provide support for senior investigators who have the expertise and leadership skills to enhance aging and geriatric research capacity within their academic institution.

Funding Opportunity PAR-21-114 from the NIH Guide for Grants and Contracts. Some projects initiated with SBIR or STTR funding require considerable financing beyond the SBIR/STTR Phase II award to achieve commercialization. The development of medical biotechnology products is often impeded by a significant funding gap (known as the Valley of Death) between the end of the SBIR/STTR Phase II award and the commercialization stage. The goal of this FOA is to assist applicants in pursuing the next appropriate milestone(s) necessary to advance a product/technology that requires Federal regulatory approval or to bring a complex research tool to market. This opportunity aims to facilitate the transition of previously funded SBIR and STTR Phase II projects to the commercialization stage by promoting partnerships between NINDS SBIR or STTR awardees and third-party investors and/or strategic partners in the Phase IIB competing renewal. Applicants are strongly encouraged to secure independent third-party funding throughout the Phase IIB project period.

Notice NOT-TR-21-018 from the NIH Guide for Grants and Contracts

Notice NOT-GM-21-014 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-21-112 from the NIH Guide for Grants and Contracts. The specific purpose of this Funding Opportunity Announcement (FOA) is to promote the development of a diverse, interdisciplinary workforce needed to conduct translational research on Alzheimer's disease and Alzheimer's-related dementias from target discovery through clinical development. This FOA will support institutional training programs for predoctoral and postdoctoral level researchers with diverse educational backgrounds (i.e., basic biology, translational and clinical research, data science). The program invites eligible institutions to develop interdisciplinary training programs that will provide trainees with the knowledge and skills in data science, disease biology, behavioral research, and traditional and emerging drug discovery disciplines necessary to conduct rigorous and cutting-edge basic, translational, and clinical research for AD/ADRD.

Notice NOT-AT-21-002 from the NIH Guide for Grants and Contracts

Notice NOT-OD-21-053 from the NIH Guide for Grants and Contracts

Notice NOT-OD-21-050 from the NIH Guide for Grants and Contracts

Notice NOT-AI-21-014 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-RM-21-006 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to invite applications for a Research Coordinating Center (RCC) to join the Nutrition for Precision Health consortium (https://commonfund.nih.gov/nutritionforprecisionhealth). The overall goals of the RCC are to provide administrative management and general coordination across the Nutrition for Precision Health consortium; facilitate the development and implementation of dietary intervention and assessment studies across the consortium; and manage relevant data. The RCC selected will work collaboratively, as part of the Nutrition for Precision Health consortium, to develop and implement research protocols and manage data sharing workflows. The RCC must also serve as a key partner with the All of Us Research Program, since it is anticipated that all participants enrolled in the Nutrition for Precision Health dietary studies will be participants in the All of Us Research Program, and all Nutrition for Precision Health data will be shared via the All of Us Researcher Workbench. The end products of the Nutrition for Precision Health consortium will be a rich data resource for research use and algorithms to improve the precision of nutrition advice for individuals.

Funding Opportunity RFA-RM-21-005 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to invite applications for Clinical Centers (CC)s to join the Nutrition for Precision Health consortium (https://commonfund.nih.gov/nutritionforprecisionhealth). Awards made through this FOA will support CCs to recruit participants and implement complex, modular protocols for dietary interventions studies. The CCs selected will work collaboratively with each other and other participating components of the Nutrition for Precision Health consortium to develop and implement study protocols. It is anticipated that all participants enrolled by the CCs into the Nutrition for Precision Health dietary studies will be part of the All of Us Research Program, and all Nutrition for Precision Health data will be shared via the All of Us Researcher Workbench. The end products of the Nutrition for Precision Health consortium will be a rich data resource for research use and algorithms to improve the precision of nutrition advice for individuals.

Funding Opportunity RFA-RM-21-001 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to invite applications for the Artificial Intelligence for Multimodal Data Modeling and Bioinformatics (AIMDMB) Center to join the Nutrition for Precision Health consortium (https://commonfund.nih.gov/nutritionforprecisionhealth). Awards made through this FOA will generate actively learning algorithms to predict human response to different foods, nutrients, food components, and dietary patterns as well as advance understanding, from the individual and population level, of longitudinal dynamics from multimodal data with advanced computer modeling tools (e.g., with in silico human dietary response replicates or user-tailored, high-fidelity models that incorporate demographic, environmental, behavioral, multi-omic, social, cultural, clinical or other data to predict health trajectories).The Center will support the development of robust and artificially intelligent informatics platforms of multimodal, metadata-complete, human data sets data from the Nutrition for Precision Health consortium. The proposed Center projects will develop a suite of computational tools to perform data integration, harmonization, analysis and visualization of the multi-modal and multi-fidelity data as well as incorporate an adaptive design for future data incorporation. The proposed Center will be a hub in communicating state of the art for AI-ready' biomedical data to the Nutrition for Precision Health consortium. All Nutrition for Precision Health awardees must work collaboratively to plan and execute a large dietary intervention study to catalyze precision nutrition research in transforming the application of targeted dietary approaches to improve health and reduce chronic diseases. The end products of the Nutrition for Precision Health consortium will be a rich data resource for research use and algorithms to improve the precision of nutrition advice for individuals.

Funding Opportunity RFA-RM-21-004 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to invite applications for the Dietary Assessment Center to join the Nutrition for Precision Health consortium (https://commonfund.nih.gov/nutritionforprecisionhealth). The awards made through this FOA will support the side-by-side application of at least one innovative approach to assess dietary intake in addition to the Automated Self-Administered 24-hour (ASA24) Dietary Assessment Tool using free-living and controlled feeding studies with a goal of improving these methodologies through validation, evaluation, and modeling efforts. This FOA invites applications that will support a Dietary Assessment Center that will conduct innovative dietary assessment on all participants and develop innovative approaches to address dietary assessment challenges.

Funding Opportunity RFA-RM-21-003 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to invite applications for Microbiome and Metagenomics Centers (MMC) to join the Nutrition for Precision Health consortium (https://commonfund.nih.gov/nutritionforprecisionhealth). The overall goal of the Microbiome and Metagenomics Center (MMC) is to perform microbiome, metagenomics and metatranscriptomics analysis of stool specimens collected in the Nutrition for Precision Health study.

Funding Opportunity RFA-RM-21-002 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to invite applications for a Metabolomics and Clinical Assays Center (MCAC) to join the Nutrition for Precision Health Consortium (https://commonfund.nih.gov/nutritionforprecisionhealth). The focus of this center is to (1) generate targeted and non-targeted metabolite profiles and (2) perform or facilitate clinical assays from blood, urine and stool biospecimens.

Funding Opportunity PAR-21-096 from the NIH Guide for Grants and Contracts. The purpose of the NIDCD Research Career Enhancement Award for Established Investigators (K18) program is to enable established, proven investigators to augment or redirect their research programs through the acquisition of new research skills to answer questions relevant to the hearing, balance, smell, taste, voice, speech and language sciences. This Funding Opportunity Announcement is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the appropriate FOA: PAR-xx-xxxx Independent Clinical Trial Required. Applicants not planning an independent clinical trial or basic experimental study with humans, or proposing to gain research experience in a clinical trial or basic experimental study with humans led by another investigator, must apply to companion FOA PAR-xx-xxx Independent Clinical Trial Not Allowed FOA.