Notice NOT-AG-24-070 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-122 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.

Notice NOT-HG-25-011 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-223 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH) participating Institutes and Centers (ICs), in collaboration with the Global Alliance for Chronic Diseases (GACD), intends to publish Funding Opportunity Announcements (FOAs) to invite applications forimplementation research on noncommunicable diseases (NCDs) in World Bank-defined low- and middle-income countries (LMICs) and American Indian/Alaskan Native (AI/AN) Tribal Nation populations in the United States.

Funding Opportunity PAR-25-213 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH) participating Institutes and Centers (ICs), in collaboration with the Global Alliance for Chronic Diseases (GACD), intends to publish Funding Opportunity Announcements (FOAs) to invite applications forimplementation research on noncommunicable diseases (NCDs) in World Bank-defined low- and middle-income countries (LMICs) and American Indian/Alaskan Native (AI/AN) Tribal Nation populations in the United States.

Notice NOT-OD-25-015 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-076 from the NIH Guide for Grants and Contracts. The Office of Research Infrastructure Programs (ORIP) encourages research project grant applications aimed at developing and implementing broadly applicable technologies, tools, and resources for validating animal models and enhancing rigor, reproducibility, and translatability of animal research. Research projects submitted under this Notice of Funding Opportunity (NOFO) should be hypothesis driven with strong preliminary data. Proposed studies, models, resources, or technologies under this NOFO must either address research interests of multiple NIH Institutes and Centers (ICs), explore multiple organ systems, or be applicable to diseases and processes that impact multiple organ systems in order to align with ORIPs NIH-wide mission and programs. Applications should aim to enhance the rigor, reproducibility, and translatability of animal research through the development and implementation of technologies, tools, and resources that have significant impact across a broad range of research areas using animal models. Applications must demonstrate how the proposed resources and technologies impact rigor and reproducibility of animal studies.

Notice NOT-DE-25-037 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-130 from the NIH Guide for Grants and Contracts. The MetNet is a collection of Research Centers that support using systems level approaches to understand the non-linear, dynamic and emergent processes in metastasis. Considering chronological progression and biological scales, the MetNet seeks to collectively derive a more comprehensive and cohesive picture of metastasis as a whole body, systems-level problem.

Notice NOT-HD-24-043 from the NIH Guide for Grants and Contracts

Notice NOT-NR-25-003 from the NIH Guide for Grants and Contracts

Notice NOT-HS-25-006 from the NIH Guide for Grants and Contracts

Notice NOT-GM-24-056 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-114 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) supports translational exploratory/developmental research that directly advances the discovery of novel treatment strategies, i.e., medical countermeasures (MCMs), that address serious morbidity and mortality after acute exposure to highly toxic chemical threats. Chemical threats are toxic compounds that could be used in a terrorist attack or accidentally released from industrial production, storage, or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pesticides, and ultra-potent synthetic (UPS) opioids. This NOFO supports translational research that includes, but is not limited to, preliminary efficacy and/or early preclinical development studies towards discovery and validation of novel molecular entities or biologics as candidate MCMs. In addition to novel agents, new treatment strategies may involve repurposing already FDA-approved products or combinations of interventions based on established mechanisms of action. Projects supported by this NOFO are expected to generate preliminary data that would facilitate the development of competitive applications for more extensive support from the NIH CounterACT Cooperative Agreement program and/or other related initiatives.

Notice NOT-AA-24-013 from the NIH Guide for Grants and Contracts

Notice NOT-AG-24-077 from the NIH Guide for Grants and Contracts

Notice NOT-DC-25-003 from the NIH Guide for Grants and Contracts

Notice NOT-PM-25-001 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-RM-24-011 from the NIH Guide for Grants and Contracts. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) has made data available through the MoTrPAC Data Hub (http://MoTrPAC-data.org). The purpose of this NOFO is to announce the availability of funding to support novel approaches for analyzing MoTrPAC data, to generate hypotheses and catalyze discoveries; for comparing the publicly released MoTrPAC data to other datasets; and for developing analytic pipelines.

Funding Opportunity RFA-MH-26-140 from the NIH Guide for Grants and Contracts. This NOFO solicits applications for next generation sensor and bioelectronic device development that will synchronize with brain recordings. The sensor and neural recording data will be used to generate new computational models of behavior in human and animal models. There has been a lack of quantitative approaches and models to understand the complexity of human and animal behavior in naturalistic settings. This NOFO focuses on the development of next generation sensors to acquire data and synchronize it with simultaneous brain recordings to build computational models.