Notice NOT-HL-19-747 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-20-028 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit cooperative agreement applications that propose clinical trials to test the comparative effectiveness of existing pharmacological therapies or devices for prevention or management of pain while reducing risk of addiction. The studies must evaluate methods to manage specific pain conditions that are within the mission and research interests of participating NIH Institutes and Centers, and evaluate interventions including medications, biologics, medical and assistive devices or delivery system strategies in controlled trials. This FOA does not include testing behavioral interventions for management of pain. The overall goal is to inform clinicians about the effectiveness of pharmacological or device interventions or management strategies concerning use of these interventions that reduce opioid use, improve functional outcomes and reduce pain for diseases or conditions of interest. Clinical trials will be conducted within the infrastructure of the HEAL Pain Effectiveness Research Network.

Funding Opportunity RFA-DK-19-034 from the NIH Guide for Grants and Contracts. The George M. O'Brien Urology Research Centers (U54) and Exploratory Centers for Interdisciplinary Research in Benign Urology (P20) serve to advance the NIDDKs mission to support highly meritorious, innovative, interdisciplinary research in benign urologic diseases and disorders, and the training of the next generation of researchers. Critical to these broad goals is the ability to promote productive interactions between the U54 and P20 Centers, the institutional career development programs (K12), and the broader urology research and clinical communities. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for a new Urology Centers Program Interactions Core (U24). The Interactions Core will serve as focal point for establishing productive collaborations within the Urology Centers Programs and between these Programs and other NIDDK urology training and scientific efforts and the broader research and clinical communities.

Notice NOT-DE-20-007 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-TR-20-002 from the NIH Guide for Grants and Contracts. This Limited Competition Funding Opportunity Announcement (FOA) invites an application from the currently funded Microphysiological Systems (MPS) Database Center (MPS DC) which supports the NIH Tissue Chip Consortium. The overall goal of the MPS DC is to integrate the efforts of all funded components of the Tissue Chip Consortium and serve as a community-wide resource for deposition of tissue chip data, standards, protocols, and analytical tools. The MPS DC is expected to continue to be the central clearinghouse for tissue chips data management, and to incorporate novel approaches and technologies for data management, data mining and meta-analyses, and data sharing across many organs and tissues, diseases, data types, and tissue chip platforms. The MPS DC is expected to provide different levels of public and tiered access to tissue chip information for basic and clinical researchers, academic and practicing physicians, the pharmaceutical industry, NIH, FDA and other government agencies, patients, and the lay public. The MPS DC will work with IQ Consortium members to develop and make available a secure, customizable coordinated data management system for collection, storage, and analyses of diverse data types from multiple tissue chip platforms being developed and used for drug screening, safety and efficacy testing. The application must include a clear and well laid out plan to be completely independent and self-sustaining before the end of the requested NIH support.

Notice NOT-OD-20-055 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-20-097 from the NIH Guide for Grants and Contracts. This funding opportunity announcement is designed to support biomedical knowledgebases. Biomedical knowledgebases under this announcement should have the primary function to extract, accumulate, organize, annotate, and link growing bodies of information related to core datasets. Support for data curation should include efficient and effective methods of curation that scale to the needs of community and include semi-automated methods. Support for software and tool development must be limited to that which provides essential functions or significantly increases the efficiency of operation of the knowledgebase. Applications that have a significant focus on software and tool development are not appropriate for this activity.

Funding Opportunity PAR-20-089 from the NIH Guide for Grants and Contracts. This funding opportunity announcement is designed to support biomedical data repositories. Biomedical data repositories under this announcement should have the primary function to ingest, archive, preserve, manage, distribute, and make accessible the data related to a particular system or systems. Support for data curation must be limited to that which improves the efficiency and accessibility of data ingestion, management, and use and reuse by the user communities. Support for software and tool development must be limited to that which provides essential functions or significantly increases the efficiency of operation of the repository. Applications that have a significant focus on software and tool development are not appropriate for this activity.

Notice NOT-CA-20-024 from the NIH Guide for Grants and Contracts

Notice NOT-DK-20-004 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DK-19-032 from the NIH Guide for Grants and Contracts. The purpose of the Kidney, Urology or Hematology (KUH) Predoctoral to Postdoctoral Fellow Transition Awards (F99/K00) is to recruit exceptional graduate students from diverse research fields to pursue postdoctoral training focused on Kidney, Urology or Hematology (K, U, or H) research. Talented graduate students from disciplines including, but not limited to, engineering, statistics, data science, imaging, biochemistry and genetics are invited to apply to this opportunity. Graduate students who are already involved in K, U, or H research are not eligible for the F99/K00 award and are instead encouraged to apply for the Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31, PA-19-195). Prospective applicants are strongly encouraged to contact the NIDDK Program Official prior to initiating plans for application submission. This Funding Opportunity Announcement (FOA) does not allow applicants to propose to lead an independent clinical trial, but does allow applicants to propose research experience in a clinical trial led by a sponsor or co-sponsor.

Funding Opportunity RFA-NS-20-027 from the NIH Guide for Grants and Contracts. The FOA invites applications that will apply computational approaches to the integration and analysis of clinical, genomic and transcriptomic data from the Accelerating Medicine Partnership in Parkinsons disease (AMP PD) to advance the identification of algorithms, biomarkers, and disease pathways related to the diagnosis, prognosis and progression of Parkinsons disease. Development of tools and workflows for data visualization and integration across data modalities and their application to AMP PD data are also supported.

Funding Opportunity RFA-CA-20-004 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support research projects designed to solve specific problems and paradoxes in cancer research identified by the National Cancer Institute (NCI) Provocative Questions Initiative. These problems and paradoxes phrased as questions are not intended to represent the full range of NCI's priorities in cancer research. Rather, they are meant to challenge researchers to think about and elucidate specific problems in key areas of cancer research that are deemed important and have not received sufficient attention. Some of these "Provocative Questions" (PQs) stem from intriguing but older, neglected observations that have never been adequately explored. Other PQs are built on more recent findings that are perplexing or paradoxical, revealing important gaps in current knowledge. Finally, some PQs reflect problems that traditionally have been thought to be intractable but that now may be open to investigations using new strategies and recent technical advances. The current issuance of the PQ Initiative includes an updated set of 12 PQs. Each research project proposed in response to this FOA must be focused on addressing the research problems defined by a specific PQ selected from the list. Projects proposed to address PQs may use strategies that incorporate ideas and approaches from multiple disciplines, as appropriate. Transdisciplinary projects are encouraged if they serve the scientific focus of the selected PQ.

Notice NOT-HD-20-002 from the NIH Guide for Grants and Contracts

Notice NOT-NR-20-002 from the NIH Guide for Grants and Contracts

Notice NOT-HD-20-001 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-20-094 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this R25 program is to support educational activities that help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences.

Funding Opportunity PAR-20-080 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs.

Funding Opportunity RFA-CA-20-005 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support research projects designed to solve specific problems and paradoxes in cancer research identified by the National Cancer Institute (NCI) Provocative Questions Initiative. These problems and paradoxes phrased as questions are not intended to represent the full range of NCI's priorities in cancer research. Rather, they are meant to challenge researchers to think about and elucidate specific problems in key areas of cancer research that are deemed important and have not received sufficient attention. Some of these "Provocative Questions" (PQs) stem from intriguing but older, neglected observations that have never been adequately explored. Other PQs are built on more recent findings that are perplexing or paradoxical, revealing important gaps in current knowledge. Finally, some PQs reflect problems that traditionally have been thought to be intractable but that now may be open to investigations using new strategies and recent technical advances. The current issuance of the PQ Initiative includes an updated set of 12 PQs. Each research project proposed in response to this FOA must be focused on addressing the research problems defined by a specific PQ selected from the list. Projects proposed to address PQs may use strategies that incorporate ideas and approaches from multiple disciplines, as appropriate. Transdisciplinary projects are encouraged if they serve the scientific focus of the selected PQ

Funding Opportunity RFA-AI-20-001 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications to establish Combating Antibiotic-Resistant Bacteria (CARB) Interdisciplinary Research Units (CARBIRUs) focused on improving our understanding of bacterial and host factors important for antibacterial resistance and infection to inform development of new approaches to prevent, diagnose, and treat antibacterial-resistant infections.