Notice NOT-ES-20-007 from the NIH Guide for Grants and Contracts

Notice NOT-AT-20-005 from the NIH Guide for Grants and Contracts

Notice NOT-AG-20-009 from the NIH Guide for Grants and Contracts

Notice NOT-AT-20-002 from the NIH Guide for Grants and Contracts

Notice NOT-NS-20-025 from the NIH Guide for Grants and Contracts

Notice NOT-OD-20-049 from the NIH Guide for Grants and Contracts

Notice NOT-HG-20-011 from the NIH Guide for Grants and Contracts

Notice NOT-OD-20-048 from the NIH Guide for Grants and Contracts

Notice NOT-HD-19-043 from the NIH Guide for Grants and Contracts

Notice NOT-MH-20-012 from the NIH Guide for Grants and Contracts

Notice NOT-DA-20-027 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-OD-20-007 from the NIH Guide for Grants and Contracts. The objective of this FOA is to support the development of the Data Coordinating Center for the NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) project, which consists of the following components: a Data Portal Core, a Data Management Core, and an Administrative and Outreach Core. The goal of the web-based Data Portal is to accelerate discovery of etiology and biologic pathways underlying the comorbidities of Down syndrome by facilitating access to and querying of data from cohorts of individuals with Down syndrome. The Data Portal will facilitate access to aggregated and harmonized data to empower analyses among the Down syndrome research community, as well as the broader scientific community. The Data Management Core will work with INCLUDE investigators and other data generators to facilitate data collection, processing, and harmonization. The Administrative and Outreach Core will oversee administrative activities, work closely with a Steering Committee and INCLUDE program staff, and provide outreach and education to the research community on using the Data Portal.

Funding Opportunity RFA-OD-20-006 from the NIH Guide for Grants and Contracts. The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This FOA is intended to support meritorious small research projects focused on analyses of genomic and other -omics datasets related to Down syndrome research, with an emphasis on elucidating the underlying etiologies of risk and resiliencies to co-occurring health conditions. Development of approaches, tools, or algorithms appropriate for analyzing data relevant to Down syndrome may also be proposed.

Funding Opportunity RFA-OD-20-005 from the NIH Guide for Grants and Contracts. The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project Transformative Research Award supports individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications from individuals with diverse backgrounds and in any topic relevant to Down syndrome research are welcome. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Funding Opportunity RFA-OD-20-004 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in Down syndrome. The initiative seeks applications that are intended to facilitate Down syndrome research by enabling efficient and effective movement of candidate therapeutics or diagnostics towards clinical trials for Down syndrome and its co-occurring conditions, and to increase their likelihood of success through development and testing of biomarkers and clinical outcome assessment measures, development and testing of novel trial methods and recruitment strategies, or by defining the presentation and course of the co-occurring conditions in individuals with Down syndrome to enable the design of future clinical trials.

Funding Opportunity RFA-OD-20-003 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support development of clinical trials to treat critical and co-occurring health conditions in individuals with Down syndrome. The proposed research aims should be milestone-driven. The total project period for an application submitted in response to this FOA may not exceed five years. This FOA provides support for up to two years (R61 phase) for preliminary/developmental/planning studies, followed by possible transition of up to four years of expanded clinical trial support (R33), although the total duration of the award may not exceed five years. This FOA requires measurable R61 milestones.

Notice NOT-OD-20-050 from the NIH Guide for Grants and Contracts

Notice NOT-CA-20-016 from the NIH Guide for Grants and Contracts

Notice NOT-OD-20-040 from the NIH Guide for Grants and Contracts

Notice NOT-EY-20-003 from the NIH Guide for Grants and Contracts