Funding Opportunity RFA-CA-24-024 from the NIH Guide for Grants and Contracts. Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to provide the infrastructure for early-phase cancer prevention clinical trials through the Cancer Prevention Clinical Trials Network (CP-CTNet), DCP's main mechanism for early clinical development of cancer preventive interventions. The phase 0-2 trials performed through CP-CTNet evaluate biologic effects of interventions and determine clinically relevant correlates, with the ultimate goal of advancing their further development for cancer prevention. The research network will develop multiple cancer prevention clinical trials targeting cancers arising in various organ sites, including collaborative studies across the Network, using the UG1 cooperative agreement funding mechanisms. This NOFO relates to the performance sites that will plan and perform clinical trials.

Funding Opportunity PAR-24-260 from the NIH Guide for Grants and Contracts. The purpose of the Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) award is to support federally recognized American Indian/Alaska Native (AI/AN) Tribes, Tribal colleges and universities, Tribal health programs, or Tribal organizations(collectively, eligible Tribal entities) to establish Institutional Review Boards (IRBs) or enhance the capacity of existing Tribal IRBs.

Notice NOT-RM-24-012 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AT-24-011 from the NIH Guide for Grants and Contracts. The purpose of this NOFO is to solicit UG3/UH3 phased award research applications to conduct efficient, large-scale pragmatic clinical trial and/or implementation science Demonstration Projects within the infrastructure of the NIH-DoD-VA Pain Management Collaboratory (PMC) on non-opioid approaches to pain management and other comorbid conditions in U.S. veterans, military personnel, and their families. Additional emphasis on a whole person approach to pain management will be added as a priority for NCCIH and partnering ICOs will also add their priority areas that include pain. This NOFO will add a trial supported by the HEAL Initiative, an NIH-wide research effort aimed at addressing the opioid epidemic in part by identifying effective, non-opioid pain management solutions. The PMC established a Coordinating Center in 2017 that provides national leadership and technical expertise for all aspects of PMC research including assistance to Demonstration Project grant awardees.

Notice NOT-RM-24-011 from the NIH Guide for Grants and Contracts

Notice NOT-GM-24-046 from the NIH Guide for Grants and Contracts

Notice NOT-NS-24-075 from the NIH Guide for Grants and Contracts

Notice NOT-AR-24-019 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DK-25-024 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) seeks to support multidisciplinary research teams with complementary expertise in HIV and pathobiology, pathophysiology, and/or metabolism in organs, tissues, and/or biological systems of specific interest to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). These teams will comprehensively interrogate fundamental biological mechanisms underlying HIV-associated comorbidities, co-infections, and complications relevant to the mission of the NIDDK and advance progress toward preventing or alleviating them.

Funding Opportunity PAR-24-267 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support projects which exploit genome or epigenome editing to functionally validate and characterize genes or variants involved in substance use disorder-relevant phenotypes. It is expected that any genetic resources generated will be made broadly available to the scientific community to enable investigation of the relevant neurobiological mechanisms involved and provide critical foundational knowledge for the development of future prevention, diagnostic, and therapeutic strategies.

Notice NOT-DE-25-032 from the NIH Guide for Grants and Contracts

Notice NOT-DK-24-028 from the NIH Guide for Grants and Contracts

Notice NOT-AI-24-059 from the NIH Guide for Grants and Contracts

Notice NOT-DE-25-033 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-24-259 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites eligible academic or research institutions to apply for funding support to purchase latest scientific equipment that will enhance and modernize research-supporting operations of existing shared biomedical research facilities. Targeted are laboratory research core facilities, animal research facilities, and other similar shared-use research spaces. The goal of this NOFO is to strengthen research-auxiliary activities of biomedical research facilities and to enhance the efficiency of their operations. The NOFO does not support the purchase of scientific research instruments or their components, nor components of building-level infrastructure equipment that indirectly support research activities.

Funding Opportunity RFA-AI-24-071 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to support basic and exploratory research projects to advance our understanding of T. pallidum bacterial pathogenesis.

Notice NOT-CA-24-092 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DA-25-024 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on NIH HIV/AIDS Research Priorities: NOT-OD-20-018: UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.

Funding Opportunity RFA-AG-25-029 from the NIH Guide for Grants and Contracts. The purpose of this NOFO is to create short courses on utilizing theNIH Stage Model to develop behavioral interventions to promote healthy aging and prevent illness, improve care, foster disease management, assist with end of life decision-making and care, and support the needs of the growing older adult population. The term behavioral intervention is used broadly here, to include a variety of non-pharmacological interventions for individuals, dyads, families, groups, communities, organizations, and systems.The NIH Stage Model is a conceptual framework of behavioral intervention development composed of six stages: basic science (Stage 0), intervention generation, refinement, modification, and adaptation and pilot testing (Stage I); traditional efficacy testing (Stage II); efficacy testing with real-world providers (Stage III); effectiveness research (Stage IV) and; dissemination and implementation research (Stage V). The goal of theNIH Stage Model is to produce potent, scalable, and culturally competent behavioral interventions that are defined by their mechanism(s) of behavior change (MoBC(s), so examination of MoBC is encouraged in every stage of intervention development. The Modelcan be used for the development of single or multi-component interventions, and for interventions meant for individuals, dyads, groups, communities, organizations, or systems. This RFA supports the development, delivery, and evaluation of a short-course curriculum to equip investigators to apply theNIH Stage Model to intervention development research.

Notice NOT-GM-24-050 from the NIH Guide for Grants and Contracts