Notice NOT-AI-24-075 from the NIH Guide for Grants and Contracts

Notice NOT-MD-24-022 from the NIH Guide for Grants and Contracts

Notice NOT-DE-25-039 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HS-24-005 from the NIH Guide for Grants and Contracts. This NOFO invites applications for a National Evaluation Center (NEC) to evaluate AHRQs Healthcare Extension Service: State-based Solutions to Healthcare Improvement (Healthcare Extension Service). The Healthcare Extension Service will accelerate dissemination and implementation of patient-centered outcomes research (PCOR) evidence into healthcare delivery through improvements in healthcare policy, payment, and practice and to reduce healthcare disparities especially among people who receive Medicaid, are uninsured, and other people who are medically underserved. The NEC will: 1) develop data, measures, and methods to assess the range, reach, of effectiveness healthcare extension service models implemented by state cooperative recipients; and 2) conduct a multi-method rapid-cycle formative and summative program evaluation of the Healthcare Extension Service, and the technical assistance and other services provided by the National Coordinating Center (NCC). The goal of the NEC evaluation is to provide a detailed understanding of how healthcare extension services vary across Cooperative recipients, assess the reach effectiveness, and equity of these models, identify contextual factors associated with recipient success, and document the barriers and facilitators to the delivery of healthcare extension services.

Funding Opportunity RFA-HS-24-006 from the NIH Guide for Grants and Contracts. This NOFO invites applications for a National Coordinating Center (NCC) to provide support and guidance to AHRQs Healthcare Extension Service: State-based Solutions to Healthcare Improvement (Healthcare Extension Service). The NCC will provide a wide range of services in 4 main areas: 1) technical assistance, 2) learning networks, 3) communications and dissemination, and 4) leadership and project management. The NCC recipient will work closely with AHRQ and recipients of two related NOFOs: State-based Healthcare Extension Cooperatives to Accelerate Implementation of Actionable Knowledge into Practice (U19) and the National Evaluation Center (NEC) for AHRQ's Healthcare Extension Service: State-based Healthcare Extension Cooperatives to Accelerate Implementation of Actionable Knowledge into Practice (U19).

Funding Opportunity PAR-25-051 from the NIH Guide for Grants and Contracts. The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis including under Good Manufacturing Practices (GMP), and Phase I clinical testing. Projects can enter either at the Discovery stage, to optimize promising hit compounds through medicinal chemistry to the Development stage, to advance a single development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Alternatively, projects can enter at the Development stage and progress in a shorter period to IND enabling toxicology studies and phase I clinical testing. BPN awardee Institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN contractors (and thereby control the patent prosecution and licensing negotiations) for drug candidates developed in this program.

Notice NOT-NS-24-085 from the NIH Guide for Grants and Contracts

Notice NOT-HD-24-036 from the NIH Guide for Grants and Contracts

Notice NOT-HD-24-037 from the NIH Guide for Grants and Contracts

Notice NOT-DK-24-039 from the NIH Guide for Grants and Contracts

Notice NOT-OD-25-003 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NR-25-001 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to support research that advances health equity through development, testing, and evaluation of interventions that prevent and address housing instability. Applications responding to this Notice of Funding Opportunity should develop, test, and/or evaluate the impact of a housing intervention on both health and housing outcome(s). NINR is interested in applications that focus on social determinants of health (SDOH) interventions that modify housing opportunities and/or interventions that address housing instability as a social risk by addressing individual and/or interpersonal-level housing needs.

Funding Opportunity PAR-24-300 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to encourage behavioral intervention development research to test efficacy, conduct clinical trials, examine mechanisms of behavior change, determine dose-response, treatment optimization, and/or ascertain best sequencing of behavioral, combined, sequential, or integrated behavioral and pharmacological (1) drug abuse treatment interventions, including interventions for patients with comorbidities; (2) drug abuse treatment and adherence interventions; (3) drug abuse treatment and adherence interventions that utilize technologies to boost effects and increase implementability and sustainability; (4) interventions to prevent the acquisition or transmission of HIV infection among individuals in drug abuse treatment; (5) interventions to promote adherence to drug abuse treatment, HIV and addiction medications; and (6) interventions to treat substance misuse and chronic pain. Research of interest includes but is not limited to Stage I research.

Funding Opportunity PAR-24-299 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to encourage behavioral intervention development research to test efficacy, conduct clinical trials, examine mechanisms of behavior change, determine dose-response, treatment optimization, and/or ascertain best sequencing of behavioral, combined, sequential, or integrated behavioral and pharmacological (1) drug abuse treatment interventions, including interventions for patients with comorbidities; (2) drug abuse treatment and adherence interventions; (3) drug abuse treatment and adherence interventions that utilize technologies to boost effects and increase implementability and sustainability; (4) interventions to prevent the acquisition or transmission of HIV infection among individuals in drug abuse treatment; (5) interventions to promote adherence to drug abuse treatment, HIV and addiction medications; and (6) interventions to treat substance misuse and chronic pain. Research of interest includes but is not limited to Stage II and Stage III efficacy research.

Notice NOT-DK-24-026 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-25-018 from the NIH Guide for Grants and Contracts. Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

Funding Opportunity RFA-NS-25-017 from the NIH Guide for Grants and Contracts. Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

Notice NOT-RM-24-015 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-177 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-24-301 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support the continued operation, maintenance, and dissemination of unique database bioinformatics resources that are of major importance to the research community using animal models of embryonic developmental processes. These grants will support ongoing development and enhancement of the resources, user training and services, provision of community generated data storage and curation, wide dissemination of the tools and/or resources, and expansion of interoperability with other NIH bioinformatics resources.