Funding Opportunity RFA-AT-19-003 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to establish a National Center for Natural Product Technology Methodology and Performance Optimization (NP-TEMPO). This initiative is to improve upon and strengthen technologies and methods used in natural products research. The NP-TEMPO, supported through the U41 cooperative agreement funding mechanism, is expected to overcome existing research limitations by developing and/or adapting cutting edge, innovative approaches and technologies that will have significant impact on the chemical and biological annotation of natural products. This FOA is being released in conjunction with the National Center for Complementary and Integrative Health (NCCIH) NMR Open Access Data Exchange and the Office of Dietary Supplements (ODS) Botanical Dietary Supplement Research Centers Program. Collectively, the awards under these FOA constitute the NCCIH/ODS Centers Advancing Research on Botanical and Other Natural Products (CARBON) Program. Applicants applying under this NP-TEMPO FOA are encouraged to collaborate with the NODE, the Botanical Dietary Supplement Research Centers, and other NCCIH, ODS, and NIH supported grantees through NP-TEMPO Technology Demonstration Projects (TDPs).

Funding Opportunity RFA-OD-19-001 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the participating components invite applications to support Botanical Dietary Supplements Research Centers (BDSRC), which will constitute one component of the Consortium for Advancing Research on Botanicals and Other Natural Products (CARBON.2). The purpose of the BDSRC is to support collaborative, trans-disciplinary research that will contribute significantly to the optimal design of future clinical trials of the effects on human resilience of orally consumed, complex botanical products. The BDSRC are expected to focus on developing the most critical data to inform the optimal design of such future trials. Information acquired through achievement of the BDSRC specific aims is expected to allow for the design of optimally informative clinical trials, providing evidence for design decisions including, but not limited to, decisions about the appropriateness of the trial design (or of doing any trial with the product), as well as those regarding product formulations, doses, timing, eligibility criteria, participant characteristics to be collected, markers of proximal biological effect, outcome measures, etc. Products appropriate for applications responsive to the planned FOA will be limited to those for which there is rigorous, but not definitive, evidence supporting a clinically or public health significant, biologically and mechanistically plausible, and reproducible effect on, or relevant to, human biological or psychological resilience. Applications in which a purified phytochemical is the main focus will be considered unresponsive to the FOA. Applicants applying under this BDSRC FOA are encouraged to collaborate, as appropriate, with other CARBON.2 components, including the NMR Open Data Exchange (NODE) and the Center for Natural Product Technology, Methodology and Productivity Optimization (NP-TEMPO), as well as with other NCCIH, ODS, and NIH supported grantees.

Funding Opportunity RFA-AT-19-002 from the NIH Guide for Grants and Contracts. The National Center for Complementary and Integrative Health (NCCIH) with the Office of Dietary Supplements (ODS) solicit applications for the development of an NMR Open Data Exchange (NP-NODE) and associated efforts to accelerate coordination and data sharing among natural products researchers more broadly. The NP-NODE will create the resources necessary to facilitate the capacity to upload, download, store, search and analyze raw NMR data. This resource will comply with the principle that scientific data should be Findable, Accessible, Interoperable, and Reusable (FAIR). Ultimately, this resource will provide natural products researchers the power to mine NMR data in ways that are currently not possible. In parallel, the NP-NODE will develop an outreach plan to obtain input from diverse communities of researchers to develop consensus on the format and most critical features of the data repository. More broadly, the FOA supports and requires the coordination across the natural products research community to facilitate development of standards to accelerate sharing of data relevant to natural product chemistry and biology. Finally, the NP-NODE will serve an advisory function to assist NCCIH and ODS grantees in complying with the NCCIH Product Integrity Policy.

Notice NOT-AG-19-002 from the NIH Guide for Grants and Contracts

Notice NOT-OD-19-063 from the NIH Guide for Grants and Contracts

Notice NOT-AA-19-001 from the NIH Guide for Grants and Contracts

Notice NOT-AA-19-003 from the NIH Guide for Grants and Contracts

Notice NOT-AA-19-004 from the NIH Guide for Grants and Contracts

Notice NOT-HD-19-002 from the NIH Guide for Grants and Contracts

Notice NOT-OD-19-061 from the NIH Guide for Grants and Contracts

Notice NOT-DE-18-029 from the NIH Guide for Grants and Contracts

Funding Opportunity PA-19-166 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support research that uses evidence-based practical approaches to increase uptake of shared decision making (SDM) into routine clinical practice. To determine how to implement SDM in pragmatic settings, several areas will need to be addressed such as how to best engage patients/surrogates in the decision process; how to identify when and for whom decisions are needed; how to educate/train physicians and non-physician providers about both the importance of SDM and how to do it; how to use EHRs and other technologies to identify patients who need to make decisions, and how to capture SDM encounters and outputs; and how to incorporate SDM encounters into the clinical workflow without undue burden on staff or patients. Proposed projects will be required to consider using existing SDM evidence, knowledge, and approaches, tools, and curricula to the extent feasible. This initiative will require multi-disciplinary teams to conduct pragmatic research in clinical practice settings and other relevant settings such as community or public health clinics. Research teams should address patient, provider, contextual, and systems level factors including, but not limited to, healthcare provider education; patients with low health literacy skills; electronic healthcare record requirements to support SDM execution; clinical workflow issues that impede implementation of SDM; evaluation of SDM; and need for sustainable health care teams and models to implement SDM in real-world settings.

Notice NOT-HD-18-026 from the NIH Guide for Grants and Contracts

Notice NOT-DE-18-028 from the NIH Guide for Grants and Contracts

Notice NOT-AA-19-002 from the NIH Guide for Grants and Contracts

Notice NOT-HG-19-011 from the NIH Guide for Grants and Contracts

Notice NOT-GM-19-017 from the NIH Guide for Grants and Contracts

Notice NOT-OD-19-064 from the NIH Guide for Grants and Contracts

Notice NOT-AT-19-016 from the NIH Guide for Grants and Contracts

Notice NOT-MH-19-010 from the NIH Guide for Grants and Contracts