Notice NOT-OD-18-236 from the NIH Guide for Grants and Contracts

Notice NOT-DE-18-022 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-18-942 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to encourage applications seeking to develop the next generation of brain stimulation devices for treating mental health disorders. Applications are sought that will either 1) develop novel brain stimulation devices or 2) significantly enhance, by means of hardware/software improvements, the effectiveness of brain stimulation devices that are currently U.S. Food and Drug Administration (FDA)-approved or cleared. Novel devices should move beyond existing electrical/magnetic stimulation and develop new stimulation techniques capable of increased spatiotemporal precision as well as multi-focal, closed-loop approaches. Applications seeking to develop new capabilities should focus on significant enhancement of the spatial resolution, depth of delivery, and/or precision of the device. Incremental changes to existing devices (e.g., software updates) are not withinthe scope of this announcement.

Funding Opportunity PAR-18-941 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to encourage applications seeking to develop the next generation of brain stimulation devices for treating mental health disorders. Applications are sought that will either 1) develop novel brain stimulation devices or 2) significantly enhance, by means of hardware/software improvements, the effectiveness of brain stimulation devices that are currently U.S. Food and Drug Administration (FDA)-approved or cleared. Novel devices should move beyond existing electrical/magnetic stimulation and develop new stimulation techniques capable of increased spatiotemporal precision as well as multi-focal, closed-loop approaches. Applications seeking to develop new capabilities should focus on significant enhancement of the spatial resolution, depth of delivery, and/or precision of the device. Incremental changes to existing devices (e.g., software updates)are not within the scope of this announcement. Applications should be submitted by multi-disciplinary teams with diverse expertise including systems neuroscience, engineering, clinical, and regulatory affairs.

Funding Opportunity PA-18-937 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage epidemiological, clinical and translational research that will increase our understanding of the natural history, prevalence, biological mechanisms, psychological variables, and clinical risk factors responsible for the presence of multiple chronic pain conditions in people with pain. Recent clinical findings suggest that substantial overlap may exist between chronic pain conditions. Individuals diagnosed with one disorder often exhibit characteristics of additional chronic painful conditions or transition to other diagnostic categories. A better understanding is needed of the prevalence of overlapping pain conditions, the underlying etiologies, the progression of these conditions, the evolution of these overlaps, and the therapeutic approaches best suited for treating subjects with these conditions. The main objective of this FOA is the formation of research groups with interests bridging expertise in pain mechanisms with translational and clinical expertise to address important unresolved questions about overlapping pain conditions. Applicants are encouraged to leverage existing and develop new resources pertinent to the study of these conditions. Applicants are encouraged to include researchers with complementary expertise from outside the pain field in their research teams who will enhance the breadth of research and understanding of comorbid chronic pain conditions.

Funding Opportunity PA-18-939 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage epidemiological, clinical and translational research that will increase our understanding of the natural history, prevalence, biological mechanisms, psychological variables, and clinical risk factors responsible for the presence of multiple chronic pain conditions in people with pain. Recent clinical findings suggest that substantial overlap may exist between chronic pain conditions. Individuals diagnosed with one disorder often exhibit characteristics of additional chronic painful conditions or transition to other diagnostic categories. A better understanding is needed of the prevalence of overlapping pain conditions, the underlying etiologies, the progression of these conditions, the evolution of these overlaps, and the therapeutic approaches best suited for treating subjects with these conditions. The main objective of this FOA is the formation of research groups with interests bridging expertise in pain mechanisms with translational and clinical expertise to address important unresolved questions about overlapping pain conditions. Applicants are encouraged to leverage existing and develop new resources pertinent to the study of these conditions. Applicants are encouraged to include researchers with complementary expertise from outside the pain field in their research teams who will enhance the breadth of research and understanding of comorbid chronic pain conditions.

Funding Opportunity RFA-DA-19-008 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications from clinical investigators to participate in the National Drug Abuse Treatment Clinical Trials Network (CTN). The ongoing opioid epidemic and overdose death crisis present an urgent public health need to quickly expand the CTN to 1) increase the Networks scientific and clinical research capabilities, and 2) to better cover geographic regions across the United States and regions most impacted by the opioid overdose epidemic.

Funding Opportunity RFA-MH-19-242 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits proposals for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria matrix (or similar constructs based on comparable criteria). Some elements of the RDoC matrix have been updated since its first release, but a thorough data-driven validation that broadly explores, compares, and validates the constructs within the matrix has not been performed. This FOA seeks research that addresses the following questions: do the different domains of behavior segregate from each other? How much do they rely on distinct vs. overlapping neural circuits? What are the relationships between domains, constructs and subordinate subconstructs, both in terms of their correlational structure and their underlying neural circuitry? By answering these questions, proposals will test integrative models of functioning and identify dysregulation in psychopathology-related mechanisms that may cut across traditional diagnostic categories and may change over time. This FOA seeks to promote projects where the computational and the experimental components are well-integrated. The ultimate goal is to advance translational research that will identify novel classification approaches and/or treatment targets, and lead to more effective and timely interventions for serious mental illness.

Notice NOT-TR-19-002 from the NIH Guide for Grants and Contracts

Notice NOT-CA-18-113 from the NIH Guide for Grants and Contracts

Notice NOT-CA-18-114 from the NIH Guide for Grants and Contracts

Notice NOT-DA-18-045 from the NIH Guide for Grants and Contracts

Notice NOT-DA-18-039 from the NIH Guide for Grants and Contracts

Notice NOT-AG-18-030 from the NIH Guide for Grants and Contracts

Notice NOT-AG-18-029 from the NIH Guide for Grants and Contracts

Notice NOT-CA-18-112 from the NIH Guide for Grants and Contracts

Notice NOT-CA-18-111 from the NIH Guide for Grants and Contracts

Notice NOT-AR-19-030 from the NIH Guide for Grants and Contracts

Funding Opportunity PA-18-934 from the NIH Guide for Grants and Contracts. Through this funding opportunity announcement (FOA), the National Cancer Institute (NCI) intends to: support seven region-based hubs or networks to facilitate underrepresented investigator/trainee recruitment and career/professional development; provide enhanced capacity in the area of cancer health disparities (CHD) research; and promote CHD research-related infrastructure development and evaluation. The Geographic Management of Cancer Health Disparities Program (GMaP) is focused on creating regional linkages and connections with networks of local contacts in NCI-designated Cancer Centers (CCs), institutions serving underserved health disparity populations and underrepresented students (ISUPS), and other organizations and agencies on topics related to CHD research and improving diversity in the biomedical workforce. The goals of GMaP are to: 1) support and enhance the science of CHD; 2) promote the development of the next generation of competitive, underrepresented cancer and CHD investigators; and 3) enhance access to cancer information and research among underserved communities. The GMaP-focused administrative supplements to cancer center support (P30) grants (resulting from this FOA) are intended to leverage the significant resources and infrastructure available at the CCs, and within CRCHD flagship programs, including: Continuing Umbrella of Research Experiences (CURE), Partnerships to Advance Cancer Health Equity (PACHE), and the National Outreach Network (NON).

Notice NOT-OD-18-232 from the NIH Guide for Grants and Contracts