Notice NOT-NS-18-014 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-ES-18-003 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications for Environmental Health Sciences Core Centers (EHS CC). As intellectual hubs for environmental health research, the EHS CC is expected to be the thought leaders for the field and advance the goals of the NIEHS Strategic Plan (http://www.niehs.nih.gov/about/strategicplan/). The Core Centers provide critical research infrastructure, shared facilities, services and/or resources, to groups of investigators conducting environmental health sciences research. An EHS CC enables researchers to conduct their independently-funded individual and/or collaborative research projects more efficiently and/or more effectively. The broad overall goal of an EHS CC is to identify and capitalize on emerging issues that advance improving the understanding of the relationships among environmental exposures, human biology, and disease. The EHS CC supports community engagement and translational research as key approaches to improving public health.

Funding Opportunity RFA-MD-18-002 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support research to determine the underlying mechanisms of how HIV related co-morbidities may influence the complexity of HIV/AIDS disease progression, quality of life and overall health outcomes among HIV positive individuals from health disparity populations.

Funding Opportunity RFA-MH-18-600 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications that will develop novel technologies and/or tools for the isolation and characterization of extracellular vesicles (EVs) of Central Nervous System (CNS) origin. The primary focus of the technology development includes robust and reproducible CNS-EV isolation methods. Specifically, there is a need to establish technologies for the isolation and purification of CNS-EVs from peripheral samples and the characterization of CNS-EV types, cargos, and origin, as well as to validate these methods for further analyses. Validation of these technologies may include the analysis of the full range of EV composition such as RNA, proteins, lipids, and metabolites.

Funding Opportunity RFA-HD-18-033 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to invite SBIR applications to stimulate new and innovative multipurpose prevention technologies (MPTs) through the development of new combinations of agents and delivery systems to prevent HIV infection and unintended pregnancy among adolescent girls and young women. HIV and unintended pregnancy are two major public health problems affecting young women globally. Combination prevention modalities may be more desirable and lead to better adherence in the end user, especially among younger populations. A viable and effective combination prevention modality would be ideal and critical for these young women who are at risk for HIV and who desire protection against pregnancy.

Funding Opportunity RFA-HD-18-034 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to invite STTR applications to stimulate new and innovative multipurpose prevention technologies (MPTs) through the development of new combinations of agents and delivery systems to prevent HIV infection and unintended pregnancy among adolescent girls and young women. HIV and unintended pregnancy are two major public health problems affecting young women globally. Combination prevention modalities may be more desirable and lead to better adherence in the end user, especially among younger populations. A viable and effective combination prevention modality would be ideal and critical for these young women who are at risk for HIV and who desire protection against pregnancy.

Funding Opportunity PAR-18-179 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for basic and translational research on caregiving for individuals with Alzheimers disease (AD), at the individual, family, community, and population level. The scope of this funding opportunity includes support for applications that propose the following: early-stage development of interventions to reduce caregiver burden and improve patient outcomes across various settings; population- and community-based research on the scope and impact of AD caregiving; improved characterization of informal and formal caregiving and the burden of caregiving across the full spectrum of the disease, including differences amongsocioeconomic, racial/ethnic and geographic sub-populations; and research addressing the unique challenges related to the provision of advanced AD care, including disparities in access to care.

Funding Opportunity PAR-18-095 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more research of all types. It is hoped that this research will inform subsequent R01 applications, and ultimately translate into improved outcomes for children with MODS, both in terms of prevention and treatment.

Funding Opportunity PAR-18-094 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to establish a program of research to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more exploratory research. The intent of this R21 funding initiative is to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of research projects addressing these topics. These studies may incur considerable research risk in efforts to make important breakthroughs in the understanding, prevention and treatment of MODS in children. Projects of limited cost or scope that use widely accepted approaches and methods within well-established fields are better suited for the R03 small grant activity code. It is hoped that the results of this exploratory research will translate into improved clinical outcomes for children with, and at risk for MODS.

Funding Opportunity PAR-18-091 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to establish a program of research to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more basic, exploratory and longitudinal research. Possible topics of study include, but are not limited, to the epidemiology, pathophysiology, monitoring, and treatment of MODS. Studies that assess specific etiologies associated with MODS including, but not limited to, sepsis, trauma, acute respiratory distress syndrome, inborn errors of metabolism, burns, cancer, transplantation and congenital heart disease are encouraged. Applications may include any appropriate study designs ranging from basic science and animal models through prospective randomized controlled trials. It is hoped that as a result of research supported through this funding opportunity, outcomes will improve both in terms of the prevention and treatment of MODS in children.

Funding Opportunity PA-18-210 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH) is committed to supporting research that will increase scientific understanding of the health status of diverse population groups and thereby improve the effectiveness of health interventions and services for individuals within those groups. Priority is placed on understudied populations with distinctive health risk profiles. This funding opportunity announcement (FOA) focuses on sexual and gender minority (SGM) populations, including lesbian, gay, bisexual, transgender, and intersex populations. Basic, social, behavioral, clinical, and services research relevant to the missions of the sponsoring Institutes and Centers may be proposed.

Funding Opportunity PA-18-198 from the NIH Guide for Grants and Contracts. The objective of this Funding Opportunity Announcement (FOA) is to encourage applications that use human laboratory paradigms and/or clinical trials to evaluate the safety and efficacy of novel or re-purposed compounds, that bind to new targets, for treatment of alcohol use disorder (AUD) or AUD with a comorbid post-traumatic stress disorder.

Funding Opportunity PA-18-197 from the NIH Guide for Grants and Contracts. The objective of this Funding Opportunity Announcement (FOA) is to encourage applications that use human laboratory paradigms and/or clinical trials to evaluate the safety and efficacy of novel or re-purposed compounds, that bind to new targets, for treatment of alcohol use disorder (AUD) or AUD with a comorbid post-traumatic stress disorder.

Funding Opportunity PA-18-158 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement is to encourage applications on biomarker discovery that utilize metabolomics approaches to advance the understanding, assessment and management of symptoms.

Funding Opportunity PA-18-155 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to foster research on the unique perspectives, needs, wishes, and decision-making processes of adolescents and young adults (AYA; defined by the World Health Organization and the Centers for Disease Control and Prevention as youth between 12 24 years of age) with serious, advanced illnesses; and research focused on specific end-of-life/palliative care (EOLPC) models that support the physical, psychological, spiritual, and social needs of AYA with serious illness, their families and caregivers.

Funding Opportunity PA-18-140 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement is to encourage applications on biomarker discovery that utilize metabolomics approaches to advance the understanding, assessment and management of symptoms.

Funding Opportunity PA-18-137 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to foster research on the unique perspectives, needs, wishes, and decision-making processes of adolescents and young adults (AYA; defined by the World Health Organization and the Centers for Disease Control and Prevention as youth between 12 24 years of age) with serious, advanced illnesses; and research focused on specific end-of-life/palliative care (EOLPC) models that support the physical, psychological, spiritual, and social needs of AYA with serious illness, their families and caregivers.

Funding Opportunity PA-18-202 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages grant applications from institutions/organizations that propose to support research on behavioral treatment for alcohol use disorders; organizational, financial, and management factors that facilitate or inhibit the delivery of services for alcohol use disorders; and phenomenon of recovery from alcohol use disorders.

Funding Opportunity PA-18-201 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages grant applications from institutions/organizations that propose to support research on behavioral treatment for alcohol use disorders; organizational, financial, and management factors that facilitate or inhibit the delivery of services for alcohol use disorders; and phenomenon of recovery from alcohol use disorders.

Funding Opportunity PA-18-200 from the NIH Guide for Grants and Contracts. The objective of this Funding Opportunity Announcement (FOA) is to encourage research on screening and brief interventions to prevent and/or reduce alcohol use and alcohol-related harms among underage and young adult populations.