Notice NOT-GM-18-008 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-18-341 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications for the Research Specialist Award (R50) in any area of NCI-funded cancer research. This FOA is specifically for laboratory-based scientists.

Funding Opportunity PAR-18-342 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites grant applications for the Research Specialist Award (R50) in any area of NCI-funded cancer research. This FOA is specifically for core/shared resource/central scientific support scientists.

Notice NOT-OH-18-003 from the NIH Guide for Grants and Contracts

Notice NOT-OH-18-002 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-18-297 from the NIH Guide for Grants and Contracts. The National Institute on Aging invites the submission of investigator-initiated program project (P01) applications. The applications should address scientific areas relevant to the NIA mission. Each application submitted to this FOA must include at least three related research projects that share a common central theme, focus, and/overall objective and an administrative core to lead the project.

Funding Opportunity PAR-18-296 from the NIH Guide for Grants and Contracts. This FOA allows for applications that propose large-scale, complex research projects with multiple highly integrated components focused on a common research question relevant to aging. Such projects will likely involve an integrated multidisciplinary team of investigators within a single institution or a consortium of institutions.

Funding Opportunity PAR-18-175 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications that propose to develop and implement Phase I or II clinical trials of promising pharmacological and non-pharmacological interventions in individuals with age-related cognitive decline and in individuals with Alzheimer's disease (AD) across the spectrum from pre-symptomatic to more severe stages of disease, as well as to stimulate studies to enhance trial design and methods.

Funding Opportunity PA-18-135 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to improve health outcomes for women, infants and children, by stimulating interdisciplinary research focused on maternal nutrition and pre-pregnancy obesity. Maternal health significantly impacts not only the mother but also the intrauterine environment, and subsequently fetal development and the health of the newborn.

Funding Opportunity PAR-18-196 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages health services research designed to increase the public health impact of Food and Drug Administration (FDA)-approved pharmacotherapies for the treatment of alcohol use disorder. Significant progress is needed in developing generalizable, scalable, cost-effective strategies to move these evidence-based interventions into the mainstream of alcohol use disorder treatment, in both general medical and specialty care settings. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) seeks applications to conduct hypothesis-driven research to identify effective methods for increasing the utilization of currently-available medications, by addressing their acceptability (to prescribers and patients), perceived effectiveness, affordability, and feasibility of use within existing care delivery systems.

Funding Opportunity PAR-18-195 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to encourage collaboration between alcohol researchers in the extramural community and those within the NIAAA intramural research program. The objective of this Funding Opportunity Announcement is to bring together the research expertise that, as a functioning collaborative unit, will address key alcohol-based research questions that would not otherwise be possible by the same individuals working towards similar goals in isolation. The goal of the research proposed by the collaborating investigators should address questions that advance the alcohol research field with respect to issues surrounding alcohol use disorders including dependence and the effects of alcohol on health. The NIH Intramural Scientist will be a tenured or tenure-track scientist from the NIAAA Intramural Research Program, with whom the PD/PI has made prior contact for the collaborative project.

Funding Opportunity PA-18-285 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support and accelerate innovative exploratory and developmental research to develop and test feasibility of effective interventions to address health disparities among U.S. immigrant populations.

Funding Opportunity PA-18-284 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support innovative research to develop and implement effective interventions to address health disparities among U.S. immigrant populations.

Funding Opportunity PA-18-191 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications from researchers with broad expertise to study the consequences of alcohol consumption on immune function with a goal toward improving the outcome of patients who abuse alcohol.

Funding Opportunity PAR-18-181 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications that focus on clarifying the relationship between delirium and Alzheimer's disease and related dementias (ADRD). Specifically sought is research focusing on understanding why persons with ADRD are at increased risk to develop delirium, often with a worse prognosis compared to those without antecedent ADRD, and why patients who experience delirium are at higher risk to develop subsequent short- and/or long-term mild cognitive impairment or ADRD, often with an accelerated rate of cognitive decline compared to those without preceding delirium. Relevant research projects may focus on, but are not limited to, those that A) provide insight into possible common, sequential, causative, contributory and/or synergistic pathways underlying both ADRD and delirium, B) elucidate mechanisms that lead to the development of delirium against the background of aging and/or neurodegeneration, with particular emphasis on use of appropriate animal models, C) identify risk factors for the onset and/or progression of delirium in those with ADRD and vice versa, D) diagnose and assess one condition in the setting of the other, E) identify putative phenotypes of patients with co-existing ADRD and delirium, or F) test pharmacologic and/or non-pharmacologic strategies to prevent, treat, or reduce the impact of delirium in patients with ADRD and vice versa. Research supported by this FOA is intended to provide mechanistic insight to improve risk assessment, diagnosis, phenotyping, prevention, and management approaches for both delirium and ADRD.

Funding Opportunity PAR-18-090 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) encourages applications that propose to develop studies that will lead to a broad understanding of the natural history of disorders that already do or could potentially benefit from early identification by newborn screening. A comprehensive understanding of the natural history of a disorder has been identified as a necessary element to facilitate appropriate interventions for infants identified by newborn screening. By defining the sequence and timing of the onset of symptoms and complications of a disorder, a valuable resource will be developed for the field.In addition, for some disorders, specific genotype-phenotype correlations may allow prediction of the clinical course, and for other disorders, identification of modifying genetic, epigenetic, or environmental factors will enhance an understanding of the clinical outcomes for an individual with such a condition. Comprehensive data on natural history will facilitate the field's ability to: 1) accurately diagnose the disorder; 2) understand the genetic and clinical heterogeneity and phenotypic expression of the disorder; 3) identify underlying mechanisms related to basic defects; 4) potentially prevent, manage, and treat symptoms and complications of the disorder; and 5) provide children and their families with needed support and predictive information about the disorder.

Funding Opportunity PAS-18-063 from the NIH Guide for Grants and Contracts. The National Institutes of Health has recently announced the HIV/AIDS research priorities for the next three to five years http://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-137.html. The goal of this Funding Opportunity Announcement (FOA) is to stimulate high priority research relevant to drug abuse and HIV/AIDS.

Funding Opportunity PAR-18-062 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing the innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of drug using behaviors (defined as alcohol, tobacco, prescription and other drug) and related disorders, prevention of drug use and HIV, and health service utilization. This FOA encourages the analyses of public use and other extant community-based or clinical datasets to their full potential in order to increase our knowledge of etiology, trajectories of drug using behaviors and their consequences including morbidity and mortality, risk and resilience in the development of psychopathology, strategies to guide the development, testing, implementation, and delivery of high quality, effective and efficient services for the prevention and treatment of drug abuse and HIV.

Funding Opportunity PA-18-057 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to encourage the application of Big Data analytics to reveal deeper or novel insights into the biological and behavioral processes associated with substance abuse and addiction.NIDA recognizes that to accelerate progress toward understanding how the human brain and behavior is altered by chronic drug use and addiction, it is vital to develop more powerful analytical methods and visualization tools that can help capture the richness of data being generated from genetic, epigenetic, molecular, proteomic, metabolomic, brain-imaging, micro-electrode, behavioral, clinical, social, services, environmental studies as well as data generated from electronic health records.Applications for this FOA should develop and/or utilize computational approaches for analyzing large, complex datasets acquired from drug addiction research.The rapid increase of technologies to acquire unprecedented amounts of neurobiological and behavioral data, and an expanding capacity to store those data, results in great opportunity to bring to bear the power of the computational methods of Big Data analytics on drug abuse and addiction.

Funding Opportunity PAR-18-042 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks to accelerate the pace and expand the breadth of scientific research on the clinical course, prevention and treatment of diseases within its mission by leveraging ongoing large, multi-center clinical research studies through ancillary studies.This Funding Opportunity Announcement (FOA) invites research project applications to conduct ancillary studies to major ongoing clinical research studies, including clinical trials and prospective observational studies. Applications submitted to this FOA must propose to collect new information and/or biological samples directly from participants of the ongoing parent study, and must address new research questions that are beyond those specified in the approved protocol of the parent study and are within the scientific mission of the NIDDK. This FOA cannot be used to extend the duration of the parent study.