Funding Opportunity RFA-MH-18-250 from the NIH Guide for Grants and Contracts. This Limited Competition Funding Opportunity Announcement (FOA) invites applications to continue the activities of the National NeuroAIDS Tissue Consortium (NNTC) Clinical Sites as previously funded under RFA-MH-13-070. The NNTC Clinical Sites will function as part of the NNTC, a national resource that provides clinical data and biological specimens to NeuroAIDS investigators interested in conducting research toward a cure of Human Immunodeficiency Virus (HIV-1) infection from the central nervous system (CNS), and research on the neuropathogenesis of HIV-1 induced CNS and peripheral nervous system (PNS) dysfunction in the context of anti-retroviral therapy (ART). The NNTC Clinical Sites collect neuromedical and neuropsychiatric data from late stage, HIV-1 infected subjects who have indicated a willingness to participate in organ donation. The NNTC Clinical Sites are responsible for the following: 1) recruitment, clinical assessment and follow-up of the late-stage NNTC cohort; and 2) collection, maintenance and distribution of specimen resources. All data generated from these activities are transferred to the NNTC Data Coordinating Center (DCC). The NNTC Clinical Sites work cooperatively with the DCC to provide the clinical data and specimen resources to research investigators. A limited competition for the NNTC DCC is being sought under a separate but related companion FOA (RFA-MH-18-251).

Funding Opportunity PA-17-259 from the NIH Guide for Grants and Contracts. The NICHD Exploratory/Developmental Grant program supports exploratory and developmental research projects that fall within the NICHD mission by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Funding Opportunity RFA-RM-17-006 from the NIH Guide for Grants and Contracts. The NIH Directors New Innovator Award (DP2) supports a small number of early stage investigators of exceptional creativity who propose bold and highly innovative new research approaches that have the potential to produce a major impact on broad, important problems in biomedical and behavioral research. The NIH Director's New Innovator Award complements ongoing efforts by NIH and its Institutes and Centers to fund early stage investigators through R01 grants, which continue to be the major sources of NIH support for early stage investigators. The NIH Directors New Innovator Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund.

Notice NOT-HL-17-508 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-17-257 from the NIH Guide for Grants and Contracts. The objective of this FOA is to support research in the discovery and characterization of the full spectrum of human-specific non-coding functional genomic elements across brain regions, cell types, and developmental time periods to elucidate their role(s) in the molecular pathophysiology of mental illness. It is expected that projects under this FOA will apply unbiased genome-wide approaches, computational methods, and experimental assays to identify and characterize functional genomic elements in both healthy and diseased human brains to correlate findings with development of mental illnesses and outcomes relevant to brain function and dysfunction. Projects should work towards developing comprehensive maps of functional elements, including insulators, enhancers, promoters, silencers, transcription binding factors, non-coding RNAs (e.g., long non-coding RNAs [lncRNAs], microRNAs [miRNAs], piwi-interacting RNAs [piRNAs]), modifications to RNA, RNA spliceoforms, long-range chromatin interactions, DNA methylations, etc.

Funding Opportunity PAR-17-258 from the NIH Guide for Grants and Contracts. The objective of this FOA is to support research in the discovery and characterization of the full spectrum of human-specific non-coding functional genomic elements across brain regions, cell types, and developmental time periods to elucidate their role(s) in the molecular pathophysiology of mental illness. It is expected that projects under this FOA will apply unbiased genome-wide approaches, computational methods, and experimental assays to identify and characterize functional genomic elements in both healthy and diseased human brains to correlate findings with development of mental illnesses and outcomes relevant to brain function and dysfunction. Projects should work towards developing comprehensive maps of functional elements, including insulators, enhancers, promoters, silencers, transcription binding factors, non-coding RNAs (e.g., long non-coding RNAs [lncRNAs], microRNAs [miRNAs], piwi-interacting RNAs [piRNAs]), modifications to RNA, RNA spliceoforms, long-range chromatin interactions, DNA methylations, etc.

Notice NOT-DA-17-024 from the NIH Guide for Grants and Contracts

Notice NOT-DA-17-025 from the NIH Guide for Grants and Contracts

Notice NOT-DA-17-026 from the NIH Guide for Grants and Contracts

Notice NOT-CA-17-050 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-RM-17-008 from the NIH Guide for Grants and Contracts. The NIH Directors Early Independence Award Program supports exceptional investigators who wish to pursue independent research directly after completion of their terminal doctoral/research degree or clinical residency, thereby forgoing the traditional post-doctoral training period and accelerating their entry into an independent research career.

Notice NOT-HL-17-489 from the NIH Guide for Grants and Contracts

Notice NOT-HL-17-488 from the NIH Guide for Grants and Contracts

Notice NOT-MD-17-002 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-17-256 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks to support collaborative clinical studies, not involving treatment development, efficacy, or effectiveness trials. Primary areas of focus include mental health genetics, biomarker studies, and studies of mental illnesses (e.g., psychopathology, neurodevelopmental trajectories of psychopathology) also when associated with HIV/AIDS. Applicants should apply to this FOA when two or more sites are needed to complete the study. Accordingly, the collaborating studies share a specific protocol across the sites and are organized as such in order to increase sample size, accelerate recruitment, or increase sample diversity and representation. In studies with a large number of sites, it is expected that one site will be submitted as a coordinating R01 for data management and/or other centralized administration. For a linked set of collaborative R01s, each application has its own Program Director/Principal Investigator (PD/PI). The collaborative R01 program provides a mechanism for cross-R01 coordination, quality control, database management, statistical analysis, and reporting.

Funding Opportunity PAR-17-255 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to provide continued support for the National Swine Resource and Research Center (NSRRC). The NSRRC serves as a central resource for reagents, the creation of genetically modified swine and the procurement, preservation, and distribution of those swine and their biological materials; and as a source of information and training related to the use of these animals in biomedical research as models of human health and disease.

Notice NOT-OD-17-057 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HD-18-028 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support SBIR research projects using advanced technologies (e.g., bio-chips, microfluidics, and mobile technologies) to develop novel point-of-care (POC) devices and implement existing technologies in clinical settings with a goal to guide diagnostic and therapeutic efforts for obstetric, neonatal, pediatric critical care and reproductive disorders.

Notice NOT-AR-18-007 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HD-18-002 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to encourage the use of bioinformatics combined with analytics to identify reproductive-tract specific transcripts and proteins for potential development as non-steroidal male and female contraceptives.