Funding Opportunity RFA-MH-25-100 from the NIH Guide for Grants and Contracts. This BRAIN Initiative Notice of Funding Opportunity (NOFO) is to scale up efforts for viral, non-viral, transgenic, and gene regulatory element screening technologies and create reagent resources to access brain cell types. This NOFO is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. Reagent development efforts will apply gene transfer, gene regulation, genome engineering, activity sensor/effector, and atlasing technologies for use in both genetically tractable and less tractable systems, including primates and human tissue, which are relevant for future translational efforts. Reagent validation studies will provide feedback to improve scaled resources, informed by deeper understanding of neural gene transfer and regulation mechanisms. Precise targeting could ultimately aid in human disorders, for example, by providing access for gene editors to specific cell types to repair mutations.

Funding Opportunity RFA-MH-25-105 from the NIH Guide for Grants and Contracts. This BRAIN Initiative Notice of Funding Opportunity (NOFO) is to support scaled reagent production and distribution facilities involving technologies to access brain cell types. Facilities for production and distribution of these reagents by a broad and diverse set of neuroscientists will be encouraged. This NOFO is part of the BRAIN Initiative Armamentarium for Brain Cell Access transformative project. Efforts will be supported to produce and distribute gene transfer, gene regulation, and genome engineering reagents for use in both genetically tractable and less tractable systems, including primates and human tissue, which are relevant for future translational efforts. Reagents to be produced and distributed are those designed and validated under other NOFOs from the Armamentarium transformative project.

Notice NOT-AG-23-054 from the NIH Guide for Grants and Contracts

Notice NOT-RM-24-003 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-058 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-066 from the NIH Guide for Grants and Contracts

Notice NOT-HG-24-017 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-24-032 from the NIH Guide for Grants and Contracts. This NOFO would support development and validation of novel clinically- and/or pathophysiologically-relevant human cellular models of ADRD. The cellular model systems would be expected to capture the multi-faceted pathologies and multiple cell types observed in ADRDs. Validation includes internal, face, construct, and predictive (to the extent possible) validation. These models can be developed/validated with the goal of supporting therapy development or better understanding of human disease mechanisms and mechanisms that uncover predisposition to developing neurodegenerative dementias. Human cellular models need to be novel, complex, and address a gap in the currently available models. Multidisciplinary teams will be highly encouraged. Leveraging the use of and depositing new cells into existing NIH cell repository resources will also be encouraged.

Notice NOT-MH-24-186 from the NIH Guide for Grants and Contracts

Notice NOT-MH-24-176 from the NIH Guide for Grants and Contracts

Notice NOT-MH-24-185 from the NIH Guide for Grants and Contracts

Notice NOT-DK-24-013 from the NIH Guide for Grants and Contracts

Notice NOT-DK-24-010 from the NIH Guide for Grants and Contracts

Notice NOT-NS-24-066 from the NIH Guide for Grants and Contracts

Notice NOT-MH-24-195 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-MH-25-171 from the NIH Guide for Grants and Contracts. Guided by the goals established in BRAIN 2025: A Scientific Vision and reinforced by the Advisory Council to the Director Working Group on BRAIN 2.0 Neuroethics Subgroup, this Notice of Funding Opportunity (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. This NOFO encourages research project grant applications from multi-disciplinary teams focused on key ethical issues associated with BRAIN Initiative supported research areas. Efforts supported under this NOFO are intended to be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through the BRAIN Initiative.

Funding Opportunity RFA-MH-25-170 from the NIH Guide for Grants and Contracts. Guided by the goals established in BRAIN 2025: A Scientific Vision and reinforced by the Advisory Council to the Director Working Group on BRAIN 2.0 Neuroethics Subgroup, this Notice of Funding Opportunity (NOFO) from the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is intended to support efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative. This NOFO encourages research project grant applications from multi-disciplinary teams focused on key ethical issues associated with BRAIN Initiative supported research areas. Efforts supported under this NOFO are intended to be both complementary and integrative with the transformative, breakthrough neuroscience discoveries supported through the BRAIN Initiative.

Notice NOT-ES-24-002 from the NIH Guide for Grants and Contracts

Notice NOT-OH-24-007 from the NIH Guide for Grants and Contracts

Notice NOT-CA-24-031 from the NIH Guide for Grants and Contracts