Funding Opportunity PA-24-155 from the NIH Guide for Grants and Contracts. purpose of this Notice of Funding Opportunity (NOFO) is to seek health services research grant applications focused on AHRQ research priorities, including improving healthcare quality and patient safety, improving healthcare delivery and practice improvement, and enhancing whole-person healthcare delivery. AHRQ supports research in all healthcare settings, including the hospital, long-term care, ambulatory care, home healthcare, pharmacy, and care transitions between settings. Research may involve many partners and other groups, including patients, families, clinicians, non-clinical healthcare staff, policymakers, payers, healthcare organizations, providers and accreditors, local and State governments, the Federal Government, and others.

Funding Opportunity PA-24-154 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to seek health services research grant applications focused on AHRQ research priorities, including improving healthcare quality and patient safety, improving healthcare delivery and practice improvement, and enhancing whole-person healthcare delivery. AHRQ supports research in all healthcare settings, including the hospital, long-term care, ambulatory care, home healthcare, pharmacy, and care transitions between settings. Research may involve many partners and other groups, including patients, families, clinicians, non-clinical healthcare staff, policymakers, payers, healthcare organizations, providers and accreditors, local and State governments, the Federal Government, and others.

Funding Opportunity PAR-24-148 from the NIH Guide for Grants and Contracts. This FOA would support establishing deeper mechanistic insight and causal relationships between TDP-43 pathology and phenotypic outcomes, as well as mechanistic interactions between TDP-43 and other co-pathologies, such TMEM106B. Additionally, it would include comparisons (including mechanistic, molecular, structural, cellular, genetic, -omic, anatomical, neuropathological, etc.) between TDP-43 proteinopathies, including LATE, with or without AD-NC, and FTD and/or ALS.

Funding Opportunity PAR-24-147 from the NIH Guide for Grants and Contracts. This NOFO would support investigations with a minimum of two relevant co-pathologies (e.g., tau, alpha-synuclein, TDP-43, TMEM106B, vascular), with optional risk factors and co-morbidities, to identify cellular and molecular mechanisms of how/why multi-proteinopathy interactions drive worsening neurodegenerative processes and phenotypic outcomes. Studies should examine co-pathology cellular and molecular interactions across brain regions and time in proximate cell population, across various intracellular dynamics and localization, and upstream and downstream from aggregated protein states to determine what events lead to worse phenotypic outcomes.

Funding Opportunity RFA-AG-25-016 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to invite applications proposing to establish multi-scale computational models recapitulating dynamic changes associated with aging and Alzheimers disease and Alzheimers disease-related dementias (AD/ADRD). This broad scope encompasses a variety of computational approachessuch as mathematical and computational modeling, image analysis, artificial intelligence, and machine learningto better understand aging processes and AD/ADRD across molecules, cells and networks, and cognition and behavior.

Notice NOT-AI-24-015 from the NIH Guide for Grants and Contracts

Notice NOT-AR-24-012 from the NIH Guide for Grants and Contracts

Notice NOT-DA-23-064 from the NIH Guide for Grants and Contracts

Notice NOT-NS-24-055 from the NIH Guide for Grants and Contracts

Notice NOT-AT-24-027 from the NIH Guide for Grants and Contracts

Notice NOT-CA-24-029 from the NIH Guide for Grants and Contracts

Notice NOT-NS-24-056 from the NIH Guide for Grants and Contracts

Notice NOT-NS-24-057 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-059 from the NIH Guide for Grants and Contracts

Notice NOT-MH-24-170 from the NIH Guide for Grants and Contracts

Notice NOT-AT-24-033 from the NIH Guide for Grants and Contracts

Notice NOT-AI-24-007 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-24-123 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for investigator-initiated, multi-site, clinical trials (Phase III and beyond) to study the effects of natural products (i.e. botanicals, probiotics, and products marketed as dietary supplements) in NCCIH designated areas of high research priority. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Applicants should describe plans for a Clinical Coordinating Center to develop and implement the proposed multi-site clinical trial. The objective of the Clinical Coordinating Center application is to provide the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. Clinical Coordinating Center applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. Clinical Coordinating Center applications submitted under this NOFO will utilize a two-phase, milestone-driven, cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center application, submitted under PAR-20-219, proposing a data analysis and data management plan for the clinical project is required. Both a Clinical Coordinating Center application and a corresponding Data Coordinating Center (DCC) application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of the NCCIH, applicants are encouraged to consult the NCCIH website: (https://nccih.nih.gov/about/plans).

Funding Opportunity RFA-NS-24-030 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-19-011: The purpose of the NIH Blueprint and BRAIN Initiative Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award is to support a defined pathway across career stages for outstanding graduate students who are from backgrounds that are nationally underrepresented in neuroscience research. This two-phase award will facilitate completion of the doctoral dissertation and transition of talented graduate students to strong neuroscience research postdoctoral positions, and will provide career development opportunities relevant to their long-term career goal of becoming independent neuroscience researchers.

Notice NOT-NS-24-019 from the NIH Guide for Grants and Contracts