Notice NOT-AI-23-042 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AI-23-026 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to advance synthetic nucleic acid platforms for the rapid development and iterative testing of active and passive immunization strategies for HIV prevention, treatment, and cure. This funding opportunity will use a milestone-driven, biphasic award mechanism. Transition to the second phase will depend on the successful completion of milestones.

Notice NOT-AR-23-019 from the NIH Guide for Grants and Contracts

Notice NOT-AR-23-018 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-23-169 from the NIH Guide for Grants and Contracts. The purpose of this reissued Funding Opportunity Announcement (FOA) is to support high-risk, high-impact, early discovery research on vaccine approaches to prevent acquisition of or ongoing infection by HIV. In keeping with the high-risk, high-impact nature of this research, this FOA supports a Go/No-Go approach to funding high risk research, which is significantly different from most R01 projects. Continued funding for the full award duration is dependent upon achieving negotiated Go/No-Go criteria by the end of Year 2.

Notice NOT-HG-23-038 from the NIH Guide for Grants and Contracts

Notice NOT-NS-23-081 from the NIH Guide for Grants and Contracts

Notice NOT-TR-23-014 from the NIH Guide for Grants and Contracts

Notice NOT-TR-23-013 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DA-24-022 from the NIH Guide for Grants and Contracts. The goal of this initiative is to develop a patient-focused research resource center to support the work of the HIV/Justice Regional Research Hubs described in RFA-DA-24-105. The project will create a Patient Engagement Resource Center (PERC) that will partner with patients and others having lived experience with HIV, SUD, and the criminal legal system to form a research advisory/consultation model that can support the Regional Research Hub projects. In addition, the awardee will conduct original research to identify key access and utilization barriers to HIV/SUD services for individuals with criminal-legal involvement; and pilot test potential solutions. The overarching goal is to embrace user-centered design principles to inform both research and practice, in order to better engage populations involved in the criminal legal system in HIV and SUD prevention and treatment.

Funding Opportunity RFA-DA-24-023 from the NIH Guide for Grants and Contracts. This goal of this initiative is to focus on HIV prevention and treatment implementation research in justice populations with substance use disorders. The proposed initiative would focus on creating national research capacity targeted to geographic regions where there are spikes in HIV cases. Through this initiative, studies would be conducted that systematically identify individuals at most risk for acquiring or transmitting HIV as they come into contact with the justice system and connecting this population with relevant HIV and substance use prevention and treatment services.

Funding Opportunity RFA-DA-24-015 from the NIH Guide for Grants and Contracts. Under the Ending the HIV Epidemic (EHE) initiative, the National Institute on Drug Abuse (NIDA) is releasing a set of interrelated RFAs to create the HIV/Justice Research Network, a coordinated effort to study innovative strategies to promote improvements in HIV prevention and treatment services for individuals involved in the criminal legal system with substance use disorder (SUD). Separate FOAs are being issued to support three components: multiple Regional Research Hubs (RRH; RFA-DA-24-015); one Data Coordination and Dissemination Center (RFA-DA-24-023); and one Patient Engagement Resource Center (PERC; RFA-DA-24-022). It is imperative that prospective applicants read all of these related FOAs to better understand the intended purpose and structure of the HIV/Justice Research Network. This FOA seeks applications for multiple Regional Research Hubs. These phased awards will partner with the criminal legal system and HIV/SUD service providers in 3 or more communities to field pilot studies and hybrid implementation-effectiveness trials testing innovative service delivery models to better engage populations involved in the criminal legal system in HIV and SUD prevention, treatment, recovery, and harm reduction.

Funding Opportunity RFA-TR-23-011 from the NIH Guide for Grants and Contracts. NCATS is issuing this FOA in response to the declared public health emergency issued by the Secretary, HHS. Please see Determination that a Public Health Emergency Exists Nationwide as the Result of the Opioid Crisis as renewed in Renewal of the Determination that a Public Health Emergency Exists Nationwide as the Result of the Continued Consequences of the Opioid Crisis.The Helping End Addiction Long-Term (HEAL) New Innovator Award supports a postdoctoral or newly independent Early Stage Investigator of exceptional creativity who proposes novel, original and insightful research concepts with the potential to produce a major impact, test scientific paradigms, or advance key concepts on broad, important problems in biomedical research related to pain, opioid use disorder (OUD), and/or overdose (OD). Applications proposing unexpected convergence of disciplines, new scientific directions, or the use of novel methodologies are encouraged.

Funding Opportunity PAR-23-170 from the NIH Guide for Grants and Contracts. The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICs) are issuing this R01 to solicit applications to address barriers and facilitators that impede use or uptake of cancer screening and preventive services in populations that experience health disparities. Interventions should include screening, preventive services, or other healthcare processes, including timely follow-up of abnormal findings, and referral to accessible care. Projects are encouraged to leverage collaborations with community partners and service providers. Interventions should address barriers and facilitators at two or more of the following levels: patient, clinician, healthcare setting, and neighborhood/community. Specific research interests of participating NIH ICs are detailed within.

Funding Opportunity PAR-23-161 from the NIH Guide for Grants and Contracts. NCATS is issuing this FOA in response to the declared public health emergency issued by the Secretary, HHS. Please see Determination that a Public Health Emergency Exists Nationwide as the Result of the Opioid Crisis as renewed in Renewal of the Determination that a Public Health Emergency Exists Nationwide as the Result of the Continued Consequences of the Opioid Crisis.This Funding Opportunity Announcement (FOA) invites applications from early and mid-career investigators (i.e. postdoctoral fellow/associates associate professor) who strive to expand their research trajectories through the acquisition of new knowledge and skills in the areas of therapeutic drug, biologic, or device development.

Funding Opportunity PAR-23-144 from the NIH Guide for Grants and Contracts. The Strengthening Research opportunities for NIH grants: STrengthening Research Opportunities for NIH Grants (STRONG): STRONG-RLI program will support research capacity needs assessments by eligible Resource Limited Institutions (RLIs). The program will also support the grantee institutions to use the results of the assessments to develop action plans for how to meet the identified needs. RLIs are defined as institutions with a mission to serve historically underrepresented populations in biomedical research that award degrees in the health professions (and in STEM fields and social and behavioral sciences) and have received an average of 0 to $25 million per year (total cost) of NIH Research Project Grant (RPG) support for the past three fiscal years.

Funding Opportunity PAR-23-267 from the NIH Guide for Grants and Contracts. This FOA provides support using the SBIR cooperative agreement mechanisms for the development of novel extracellular vesicle-based therapeutic platforms for use in regenerative medicine. Both native and engineered EVs have demonstrated the ability for specific and targeted tissue and organ repair, which can be harnessed for applications such as extracellular vesicle-based therapeutics. The main objective for this funding opportunity is to support platform-oriented technology development associated with the production, manufacturing, and use, of extracellular vesicles as therapeutics in regenerative medicine.

Funding Opportunity RFA-DA-24-038 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) encourages Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) proposing research projects directed towards commercialization for the development of novel, evidence-based, FDA-regulated medical products addressing the needs of patients suffering from opioid use disorders (OUD) and/or stimulant use disorders (StUD). Applications received under this NOFO may fall within two scientific areas, namely: (1) pharmacotherapeutics (small molecules and biologics)and (2) medical therapeutic and diagnostic devices, including software as a medical device. This NOFO strives to contribute to the effort against the national opioid and psychostimulant emergency and offer new medical products for individuals, families, and communities affected by this devastating crisis. Small business companies that developed currently marketed technologies or are developing technologies for different indications and are interested in demonstrating that their FDA-regulated product has a potential application in the OUD/StUD space are encouraged to apply.

Funding Opportunity RFA-DA-24-021 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support basic science experimental studies involving humans that expand our knowledge of theinterrelationships between sleep/circadian rhythms and substance use disorders (SUDs). These mechanistic studies will offer insights into the fundamental processes that link SUDs to disorders of sleep/circadian rhythm and vice-versa, and may also have implications for managing risks associated with developing SUDs and/or identifying new targets for prevention and therapeutics.

Funding Opportunity RFA-DA-24-020 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support basic science experimental studies that expand our knowledge of theinterrelationships between sleep/circadian rhythms and substance use disorders (SUDs). These mechanistic studies will offer insights into the fundamental processes that link SUDs to disorders of sleep/circadian rhythm and vice-versa, and may also have implications for managing risks associated with developing SUDs and/or identifying new targets for prevention and therapeutics.