Notice NOT-TR-22-019 from the NIH Guide for Grants and Contracts

Notice NOT-CA-22-059 from the NIH Guide for Grants and Contracts

Notice NOT-GM-22-016 from the NIH Guide for Grants and Contracts

Notice NOT-NS-22-085 from the NIH Guide for Grants and Contracts

Notice NOT-CA-22-058 from the NIH Guide for Grants and Contracts

Notice NOT-RM-22-007 from the NIH Guide for Grants and Contracts

Notice NOT-RM-22-008 from the NIH Guide for Grants and Contracts

Notice NOT-RM-22-009 from the NIH Guide for Grants and Contracts

Notice NOT-RM-22-006 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AG-23-011 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to stimulate research in noncoding ribonucleic acids (ncRNAs) to investigate the causality, directionality, mechanisms, and therapeutic potential of ncRNAs implicated in Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). This FOA will support exploratory and developmental Grant (R21) applications seeking to discover functional roles of ncRNAs and underlying mechanisms involved in the pathogenesis and progression of AD/ADRD. Proposed studies should focus on functional characterization and mechanistic investigation of previously identified ncRNAs.

Funding Opportunity RFA-AG-23-010 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to stimulate research in noncoding ribonucleic acids (ncRNAs) to investigate the causality, directionality, mechanisms, and therapeutic potential of ncRNAs in Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). This FOA will support applications seeking to discover novel mechanisms mediated by ncRNAs, elucidate molecular, and cellular functions involved in the pathogenesis and progression of AD/ADRD.

Notice NOT-TR-22-017 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DA-23-006 from the NIH Guide for Grants and Contracts. There has been a substantial increase in the number of syringe service programs (SSPs) in the US and the range of these settings has become broader, with many now located in health department or FQHCs, in addition to the more traditional CBO and AIDS Service Organization settings. There is a need to provide models for bringing sustainable integrated HIV prevention and care into SSP settings. Newer SSPs often are in settings that have limited expertise for other substance use services and may be limited in terms of HIV care. More established SSPs may provide HIV testing, but often do not directly provide other HIV prevention and care services and rely on referrals with limited follow-up. SSPs provide opportunities for regular contact with PWID and their network members (including non-injectors) which may enable greater engagement and re-engagement across the HIV continua of prevention and treatment. Newer SSPs often are in rural areas with limited capacity to provide a range of HIV services and the COVID pandemic has required restructuring of services and has led to some closures. CDC is developing infrastructure to better monitor SSP programs, survey clients, and develop technical assistance models for SSPs. A program of implementation-focused research to improve HIV prevention and care would complement this effort, as well as SAMHSAs support of these settings.

Funding Opportunity RFA-DA-23-007 from the NIH Guide for Grants and Contracts. There has been a substantial increase in the number of syringe service programs (SSPs) in the US and the range of these settings has become broader, with many now located in health department or FQHCs, in addition to the more traditional CBO and AIDS Service Organization settings. There is a need to provide models for bringing sustainable integrated HIV prevention and care into SSP settings. Newer SSPs often are in settings that have limited expertise for other substance use services and may be limited in terms of HIV care. More established SSPs may provide HIV testing, but often do not directly provide other HIV prevention and care services and rely on referrals with limited follow-up. SSPs provide opportunities for regular contact with PWID and their network members (including non-injectors) which may enable greater engagement and re-engagement across the HIV continua of prevention and treatment. Newer SSPs often are in rural areas with limited capacity to provide a range of HIV services and the COVID pandemic has required restructuring of services and has led to some closures. CDC is developing infrastructure to better monitor SSP programs, survey clients, and develop technical assistance models for SSPs. A program of implementation-focused research to improve HIV prevention and care would complement this effort, as well as SAMHSAs support of these settings.

Notice NOT-TR-22-022 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AG-23-015 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications on novel studies of the cytosolic DNA sensing mechanisms in the interactions of the aging hallmarks. The goal of this FOA is to support applications that will lead to an in-depth understanding of the molecular mechanisms that determine the effects of cytosolic DNAs on aging hallmarks in the context of aging and longevity. Research supported by this FOA should lead to new insights to address some critical mechanistic questions relevant to the role of aging hallmarks in aging and aging-related diseases. This FOA encourages innovative, mechanistic approaches to identify and characterize interactions of aging hallmarks mediated by cytosolic DNAs that ultimately modulate the regulation of healthspan and/or longevity.

Funding Opportunity RFA-AG-23-013 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits research projects with the goal of increasing our understanding of the interactions among hallmarks of aging and their regulation. Research supported by this FOA should explore the timing and possible priorities (hierarchy) among the hallmarks in various cells/tissues across the normal lifespan, and whether the interactions between the hallmarks are an adaptive response to maintain health at different stages of life. This is one of three inter-connected FOAs with an overarching focus on the interactions of aging hallmarks as a framework for innovative research in aging biology.

Funding Opportunity RFA-AG-23-012 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages innovative, mechanistic approaches to identify and characterize interactions of aging hallmarks shaped by inter-organelle communication.

Funding Opportunity PAR-22-114 from the NIH Guide for Grants and Contracts. The purpose of this trans-NCI Funding Opportunity Announcement (FOA) is to promote new cancer disparities research among investigators who do not normally conduct it and to encourage the partnership of experienced cancer research investigators with cancer disparities-focused researchers. This FOA is intended to accelerate and strengthen multi-disciplinary cancer disparities research in wide ranging areas. Cancer disparities research includes, but is not limited to basic, translational, behavioral, observational, interventional, environmental and population research studies that address the adverse differences in cancer incidence, prevalence, mortality, survivorship, burden and/or response to treatment in racial/ethnic minorities and/or underserved population groups. Proposed collaborations should focus on achieving research objectives that by necessity rely on diverse and complementary expertise, technical capabilities, and resource sets. Importantly, the supplemental request is required to be within the scope of the parent award and should expand the original aims to include a cancer disparity component and possible inclusion of international comparator cohorts. A trans NCI effort, the concept reissuance of the Collaborative Program is supported by NCIs Division of Cancer Biology (DCB), Division of Cancer Treatment and Diagnosis (DCTD), Division of Cancer Prevention (DCP), Division of Cancer Control and Population Sciences (DCCPS), Center to Reduce Cancer Health Disparities (CRCHD) and now, also included Center for Global Health.

Notice NOT-AI-22-029 from the NIH Guide for Grants and Contracts