Notice NOT-AT-20-016 from the NIH Guide for Grants and Contracts

Notice NOT-OD-20-157 from the NIH Guide for Grants and Contracts

Notice NOT-GM-20-049 from the NIH Guide for Grants and Contracts

Notice NOT-NS-20-095 from the NIH Guide for Grants and Contracts

Notice NOT-DE-20-029 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HD-21-026 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to form Centers of Excellence in Therapeutics (CETs) as part of the NICHDs Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub. The MPRINT Hub will serve as a national resource for expertise in maternal and pediatric therapeutics to conduct and foster therapeutics-focused research in obstetrics, lactation, and pediatrics while enhancing inclusion of people with disabilities. By serving as a national resource, it will aggregate, present, and expand the available knowledge, tools, and expertise in maternal and pediatric therapeutics to the broader research, regulatory science, and drug development communities. The MPRINT CETs will work together and with the MPRINT Knowledge and Research Coordination Center (KRCC; RFA-HD-21-025), the central coordinating center of the MPRINT Hub, to serve as a national resource for knowledge and expertise in maternal and pediatric pharmacology and as a research center to close deficits in knowledge and technical expertise. The MPRINT CETs will conduct cutting edge clinical, translational, basic, and/or data sciences research, provide resources, and generate novel tools and approaches to advance and accelerate research and regulatory science in maternal and pediatric therapeutics. The MPRINT KRCC will serve as the primary public-facing component of the MPRINT Hub and as a conduit to the resources of the MPRINT CETs.

Funding Opportunity RFA-HD-21-025 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to form the Knowledge and Research Coordination Center (KRCC) of the NICHDs Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub. The MPRINT Hub will serve as a national resource for expertise in maternal and pediatric therapeutics to conduct and foster therapeutics-focused research in obstetrics, lactation, and pediatrics while enhancing inclusion of people with disabilities. By serving as a national resource, it will aggregate, present, and expand the available knowledge, tools, and expertise in maternal and pediatric therapeutics to the broader research, regulatory science, and drug development communities. The MPRINT KRCC will coordinate and support the operations of the entire MPRINT Hub, interface with Centers of Excellence in Therapeutics (CETs; RFA-HD-21-026), and develop a web portal to access an underlying curated knowledge base of maternal and pediatric pharmacology and therapeutics. This knowledge base will aggregate and identify knowledge deficits in the principles of maternal and pediatric therapeutics including pharmacokinetics, pharmacodynamics, genetics, proteomics, and metabolomics that inform drug development and regulatory science. The MPRINT KRCC will serve as the primary administrative component and public-facing component of the MPRINT Hub as well as a conduit to the resources in its other components such as the MPRINT CETs. Additionally, the MPRINT KRCC will oversee an Opportunity Pool of funds to address emergent needs in support of national research in maternal and pediatric therapeutics.

Notice NOT-AG-20-040 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HG-20-046 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the establishment of the Genomic Variation and Function Data and Administrative Coordinating Center (DACC). The DACC will serve as the coordinating center for the Impact of Genomic Variation on Function (IGVF) Consortium and will be responsible for establishment of a resource of consortium generated data, metadata, methods, and tools and coordination of consortium activities. The DACC will also be expected to facilitate consortium-led analyses and outreach to the broader research community. As a member of the IGVF Consortium, the DACC will work closely with all consortium components to accelerate understanding of how genomic variation impacts human health and disease through the coordination of data collection strategies and analyses.

Funding Opportunity RFA-HG-20-045 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to establish Mapping Centers that will generate single-cell, multi-omics maps of active genes and regulatory elements in the human and mouse genomes. This will be accomplished through use of high-throughput state-of-the-art methods to profile biochemical features characteristic of active genomic regions while preserving information about biological and/or spatial context. This will ultimately enable the association of active genomic regions with specific cell fates and states. Centers funded through this initiative will become part of the Impact of Genomic Variation on Function (IGVF) Consortium. As members of this consortium, Mapping Centers will be expected to work closely with one another and other Consortium components to accelerate understanding of how genomic variation impacts human health and disease through the coordination of data collection strategies and analyses.

Funding Opportunity RFA-HG-20-044 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to solicit applications for research projects to explore the effects of genomic variation on phenotypes at the network level. Research projects supported through this FOA will measure changes in the activity of genes and regulatory elements during biological transitions and develop generalizable analytical approaches to understand network-level relationships among genomic variation, functional elements, genes, and phenotypes related to human health and disease. Projects funded through this initiative will become part of the Impact of Genomic Variation on Function Consortium. As members of this Consortium, network projects will be expected to work with one another and other Consortium components to accelerate understanding of how genomic variation impacts human health and disease.

Funding Opportunity RFA-HG-20-043 from the NIH Guide for Grants and Contracts. FOA seeks applications to experimentally correlate variants with effects on genomic function. This will be accomplished by performing systematic perturbation; collecting data on the effects of non-coding and protein-coding genomic variation on molecular, cellular, and organismal phenotypes; generating a catalog of these variant effects; and assisting in a group predictive modeling effort using the data. Centers funded through this initiative will become part of the Impact of Genomic Variation on Function Consortium. As members of this Consortium, mapping centers will be expected to work closely with one another and other Consortium components to accelerate understanding of how genomic variation impacts human health and disease through the coordination of data collection strategies and analyses.

Funding Opportunity RFA-HG-20-047 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to solicit applications for Predictive Modeling and Analysis Projects. These projects will develop and apply innovative computational models to predict the impact of genomic variation on genome function and/or phenotype. Projects funded through this initiative will become part of the Impact of Genomic Variation on Function Consortium. As members of this Consortium, predictive modeling projects will be expected to work closely with one another and other Consortium components to accelerate understanding of how genomic variation impacts human health and disease through the coordination of data collection strategies and analyses.

Notice NOT-GM-20-048 from the NIH Guide for Grants and Contracts

Notice NOT-DA-20-069 from the NIH Guide for Grants and Contracts

Notice NOT-OD-20-155 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-HD-21-028 from the NIH Guide for Grants and Contracts. This limited competition funding opportunity announcement (FOA) issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development invites applications from institutions/organizations willing to participate with the NICHD as the Data Coordinating Center (DCC) under a cooperative agreement in an ongoing multi-center research network, the Maternal-Fetal Medicine Units (MFMU) Network, designed to perform observational and interventional clinical studies, using common protocols, to improve maternal, fetal and neonatal health.

Funding Opportunity RFA-HD-21-029 from the NIH Guide for Grants and Contracts. This limited competition funding opportunity announcement (FOA) issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development invites applications from institutions/organizations willing to participate with the NICHD as a Clinical Center under a cooperative agreement in an ongoing multi-center research network, the Maternal-Fetal Medicine Units (MFMU) Network, designed to perform observational and interventional clinical studies, using common protocols, to improve maternal, fetal and neonatal health.

Funding Opportunity RFA-HG-20-048 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support investigator-initiated research on genetic counseling processes and practices in genomic medicine. Research is needed to optimize the genetic counseling process in the context of limited resources. Grants will assess, innovate, scale, and/or research the implementation of novel genetic counseling practices to address the need for more healthcare professionals trained in genetic counseling; the uneven access to in-person genetic counseling across U.S. health care systems, and the challenges of effective and efficient communication of genomic findings to clinicians, patients, and families.

Funding Opportunity RFA-HG-20-049 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support targeted studies on genetic counseling processes and practices in genomic medicine. Research is needed to optimize the genetic counseling process in the context of limited resources. Grants will assess, innovate, scale, and/or research the implementation of novel genetic counseling practices to address the need for more healthcare professionals trained in genetic counseling; the uneven access to in-person genetic counseling across U.S. health care systems, and the challenges of effective and efficient communication of genomic findings to clinicians, patients, and families.