Funding Opportunity PAR-24-051 from the NIH Guide for Grants and Contracts. The NIDCD is committed to identifying effective interventions for the diagnosis, prevention, or treatment of communication disorders by supporting well-designed and well-executed clinical trials. This funding opportunity announcement (FOA) supports investigator initiated low risk clinical trials addressing the mission and research interests of NIDCD. Clinical trials must meet ALL the following criteria: meet the budget limits of this FOA, not require FDA oversight, are not intended to formally establish efficacy and have low risks to potentially cause physical or psychological harm.

Funding Opportunity PAR-24-050 from the NIH Guide for Grants and Contracts. he NIDCD is committed to identifying effective interventions for the treatment or prevention of communication disorders by supporting well designed and well executed clinical trials. This funding opportunity announcement (FOA) supports a cooperative agreement between an NIDCD Project Scientist and an investigator to support a clinical trial that meets ANY of the following criteria: requires FDA oversight, is intended to formally establish efficacy, or has a higher risk to potentially cause physical or psychological harm.

Funding Opportunity RFA-AG-24-040 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites U54 Cooperative Agreement applications aiming to establish multi-component Alzheimers Disease and Related Dementias Translational Centers for Microphysiological Systems (MPS) (AD/ADRD MPS Translational Centers). The overarching purpose of this Centers program is to develop 2D and 3D models of AD/ADRD as reproducible and scalable platforms that recapitulate key features of human AD/ADRD pathophysiology to be used as precision medicine research tools to investigate the complex biology of AD/ADRD and to accelerate multiple aspects of drug discovery and preclinical drug development.

Notice NOT-HL-23-117 from the NIH Guide for Grants and Contracts

Notice NOT-AG-23-066 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-NS-24-013 from the NIH Guide for Grants and Contracts. This RFA will solicit applications for a pivotal phase 3 clinical trial to determine the efficacy of FDA approved monoclonal antibody therapy compared to placebo in diverse "mixed dementia" populations with a focus on vascular contributions. Mixed dementia refers to dementia cases positive for 1) Alzheimer biomarkers, such as amyloid positron emission tomography and/or low cerebrospinal fluid amyloid beta 42 combined with elevated phosphorylated tau; and 2) evidence of vascular contributions based on imaging (white matter disease and/or subclinical infarction). Bayesian approaches with response adaptive randomization to examine specific subgroups are engouraged. Successful applications will be well-powered to determine efficacy in diverse populations representative of the effect of the disease in the United States by sex, race/ethnicity, and geographic distribution. Applications must include patient and community engagement cores that are incorporated into all stages of program development and at all levels of the organizational structure.

Notice NOT-DA-23-039 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-24-059 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support multidisciplinary and innovative intervention research to understand and address maternal morbidity and mortality in the United States, particularly but not exclusively among racial and ethnic minority, socioeconomically disadvantaged, and underserved rural populations, with a focus on understudied healthcare factors. This is a new funding opportunity to advance the goals of the NIH Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE) Initiative. IMPROVE aims to understand the biological, behavioral, environmental, sociocultural, clinical, and structural factors that affect pregnancy-related and pregnancy-associated severe morbidity and mortality and build an evidence base for improved care and outcomes. The IMPROVE initiative supports research to reduce preventable causes of maternal deaths and improve health for women before, during, and after delivery. It includes a special emphasis on health disparities and populations that are disproportionately affected, such as racial and ethnic minority persons, very young women and women of advanced maternal age, and people with disabilities.

Funding Opportunity RFA-HD-24-014 from the NIH Guide for Grants and Contracts. This limited competition Notice of Funding Opportunity (NOFO) issued by the NIH Helping to End Addiction Long-term (HEAL) Initiative and the Eunice Kennedy Shriver National Institute of Child Health and Human Development invite applications from institutions currently participating as Clinical Centers in the Outcomes of Babies with Opioid Exposure (OBOE) consortium to complete the ongoing study and follow-up of study participants.

Funding Opportunity RFA-HD-24-015 from the NIH Guide for Grants and Contracts. This limited competition Notice of Funding Opportunity (NOFO) issued by the NIH Helping to End Addiction Long-term (HEAL) Initiative and the Eunice Kennedy Shriver National Institute of Child Health and Human Development invite an application from the institution currently participating as the Data Coordinating Center in the Outcomes of Babies with Opioid Exposure (OBOE) consortium to complete the ongoing study and follow-up of study participants.

Notice NOT-OD-24-014 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-OD-24-005 from the NIH Guide for Grants and Contracts. The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) is soliciting applications for a Down Syndrome Clinical Cohort Coordinating Center (DS-4C) that will be responsible for the overall coordination and outreach for the new INCLUDE Project Down Syndrome Cohort Development Program (DS-CDP), support development of new cohorts of people with Down syndrome, and curate the metadata from the new cohorts. A companion NOFO (RFA-OD-23-052) will support the Cohort Research Sites. A related NOFO (RFA-OD-23-054) will support a Federated Biobanking Resource for the INCLUDE Project. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Funding Opportunity RFA-OD-24-004 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to establish an infrastructure to facilitate coordination, collection, management, and dissemination of biospecimen materials to advance clinical research of co-occurring conditions in individuals with Down syndrome. This effort is intended to leverage NIH's investment in the INCLUDE Project, the INCLUDE Data Coordinating Center (DCC), and support for current NIH-funded Down syndrome biospecimen repositories. The Federated Biospecimen Repository will use a cooperative agreement mechanism. In addition, this resource will be a companion to the Down Syndrome Cohort Research Sites (DS-CRS) and the Down Syndrome Clinical Cohort Coordinating Centers (DS-4C) within the Down Syndrome Cohort Development Program (DS-CDP) (for details see: RFA-OD-23-052 and RFA-OD-23-053).

Funding Opportunity RFA-OD-24-003 from the NIH Guide for Grants and Contracts. The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites applicants to participate in a new INCLUDE Project Down Syndrome Cohort Development Program (DS-CDP) as Cohort Research Sites (DS-CRS). The purpose of this program is to recruit participants with Down syndrome across the lifespan; collect biospecimens; assemble phenotypic data, images, and omics for deep phenotyping; and make the data readily available to the scientific community. Research sites will participate in all aspects of planning and conducting a common protocol, as well as interpretation and translation of results. This NOFO runs in parallel with a companion NOFO (RFA-OD-24-005) that will solicit applications for the Clinical Cohort Coordinating Center (DS-4C) to provide overall coordination of the DS-CDP. A related NOFO (RFA-OD-24-004) will support a Federated Biobanking Resource to store and distribute biospecimens collected by the Cohort Research Sites. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

Notice NOT-OD-24-012 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-010 from the NIH Guide for Grants and Contracts

Notice NOT-AI-23-074 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DK-25-003 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK. The purpose of this Centers program is to bring together basic and clinical investigators as a means to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases within the NIDDK's mission. DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner. Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission ofthe NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding.

Notice NOT-AG-23-063 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-013 from the NIH Guide for Grants and Contracts