Funding Opportunity RFA-DK-23-004 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) welcomes applications for the Consortium on Modeling Autoimmune Diabetes (CMAD) that supports the development of in vitro and in vivo models of type 1 diabetes (T1D) to enable studies of human T1D pathophysiology and to serve as platforms for preclinical assessments of new T1D interventions. CMAD is part of the Human Islet Research Network (HIRN).

Notice NOT-AG-23-055 from the NIH Guide for Grants and Contracts

Notice NOT-OD-24-002 from the NIH Guide for Grants and Contracts

Notice NOT-HG-24-002 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-24-047 from the NIH Guide for Grants and Contracts. Through this Notice of Funding Opportunity (NOFO) is to accelerate the pace of translation of NCI-supported methods/assays/technologies (referred to as "assays") to the clinic. Specifically, the focus of this NOFO is on the adaption and clinical validation of molecular/cellular/imaging markers (referred to as "markers" r "biomarkers") for cancer detection, diagnosis, prognosis, monitoring, and prediction of response in treatment, as well as markers for cancer control and prevention. Research applications may support the acquisition of well-annotated specimens from NCI-supported or other clinical trials or observational cohorts/consortia for the purpose of clinical validation of the assay. Research projects proposed for this NOFO encourage multi-disciplinary interaction among scientific investigators, assay developers, clinicians, statisticians, and clinical laboratory staff. Clinical laboratory scientist(s) and statistical experts are highly encouraged to comprise integral parts of the application. This NOFO is not intended to support early-stage development of technology or the conduct of clinical trials, but rather the adaption and validation of assays to the point where they could be integrated into clinical trials as investigational assays/tools/devices.

Notice NOT-OD-24-008 from the NIH Guide for Grants and Contracts

Notice NOT-DC-24-004 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AI-23-057 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support research to better understand the impact of host and viral heterogeneity on pathogenesis of disease, viral persistence and immunopathology of Hepatitis B (HBV) and inform cure strategies for HBV in people living with HIV (PLWH). Applicants will establish multidisciplinary teams that span the clinical and basic/translational research arenas and establish an observational cohort to accelerate discovery and increase clinical impact.

Funding Opportunity RFA-EB-23-006 from the NIH Guide for Grants and Contracts. GL to update purpose after the NOFO is finalized. Develop plans to establish or enhance BME departments, interdisciplinary technology centers, and/or academic programs which may include: Support research and educational opportunities for trainees in bioengineering and technology development (Undergrad and/or Graduate) Plans for core technology facilities, maker space, data science centers Faculty recruitment, collaborative research programs, training, and partnerships Building curriculum and course development Innovation and entrepreneurship programs Plans for sustainability of programs

Notice NOT-CA-23-095 from the NIH Guide for Grants and Contracts

Notice NOT-EB-23-023 from the NIH Guide for Grants and Contracts

Notice NOT-HL-23-119 from the NIH Guide for Grants and Contracts

Notice NOT-GM-24-002 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-23-308 from the NIH Guide for Grants and Contracts. This funding opportunity seeks to support the Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) Program. The CPACHE Program develops and maintains comprehensive, long-term, and mutually beneficial partnerships between institutions serving underserved health disparity populations and underrepresented students (ISUPSs) and NCI-designated Cancer Centers (CCs). The program aims to achieve a stronger national cancer program and address challenges in cancer and cancer disparities research, education, and outreach, as well as cancer's impact on underserved populations. The institutions in each partnership are expected to work collaboratively to: (1) increase the cancer research and cancer research education capacity of the ISUPSs; (2) promote the diversity of the cancer research workforce; (3) improve the effectiveness of CCs in developing and sustaining research programs focused on cancer health disparities and increase the number of investigators and students conducting cancer health disparities research; and (4) develop and implement cancer-related outreach and education initiatives that benefit the surrounding underserved communities.

Notice NOT-MD-23-020 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-23-228 from the NIH Guide for Grants and Contracts. The goal of the NIGMS Predoctoral Basic Biomedical Sciences Research Training Program is to develop a diverse pool of well-trained scientists available to address the Nations biomedical research agenda. Specifically, this funding opportunity announcement provides support to eligible, domestic institutions to develop and implement effective, evidence-informed approaches to biomedical graduate training and mentoring that will keep pace with the rapid evolution of the biomedical research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the Nation.

Funding Opportunity RFA-DA-25-011 from the NIH Guide for Grants and Contracts. This broad RFA will support exploratory studies addressing mechanistic questions in HIV infection, replication, latency, and/or pathogenesis (including HAND) in the context of SUDs.

Notice NOT-AG-23-050 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DA-24-034 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to encourage clinical research that will identify and validate novel targets for non-invasive brain stimulation (NIBS) and SUD-relevant neurobiological, cognitive, and behavioral responses to NIBS that precede clinical outcomes like reduced craving or drug use. Applications are expected to be exploratory and developmental in nature. As such, these studies may involve considerable risk of failure but may lead to a breakthrough in a particular area that could have a major impact on SUD research involving NIBS. This NOFO uses a R61/R33 Phased Innovation award activity code to support applications that propose mechanistic studies designed to understand a behavior or biological process, the pathophysiology of a disease, or the mechanism of action of an intervention. In addition, applications must meet the NIH definition of a clinical trial. NIH defines a clinical trial as A research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes. (NOT-OD-15-015)

Funding Opportunity PAR-24-037 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support multi-component, multi-disciplinary projects that address scientific questions relevant to AIDS prophylactic vaccine discovery research. Extensive evaluation of vaccine concepts in non-human primate models may be included.