Notice NOT-CA-23-050 from the NIH Guide for Grants and Contracts

Notice NOT-AG-23-012 from the NIH Guide for Grants and Contracts

Notice NOT-MH-23-210 from the NIH Guide for Grants and Contracts

Notice NOT-GM-23-034 from the NIH Guide for Grants and Contracts

Notice NOT-HL-23-078 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AG-24-010 from the NIH Guide for Grants and Contracts. The purpose of this limited competition FOA is to solicit an application to continue data collection, development, and dissemination of the Health and Retirement Study (HRS). The HRS is a longitudinal panel study that surveys a nationally representative sample of approximately 20,000 people aged 50 and older in the United States via mixed-mode data collection to support multidisciplinary research on life course health and aging. This renewal provides additional research opportunities to use HRS to study Alzheimers Disease and Related Dementias (AD/ADRD) formally including a companion project, the Harmonized Cognitive Assessment Protocol (HCAP), that included a neuropsychological assessment battery as well as informant reports to better characterize cognitive function. This single integrated award combining HRS and HCAP will also add important additions recommended by subject matter experts to enhance HRS/HCAP to facilitate research on AD/ADRD: additions of larger samples of Black and Hispanic populations in HCAP; contextual data to capture new elements of the exposome ranging from microscopic to macro level exposures; improving overall response/retention rates to maintain representativeness; enhanced data on occupational exposures/characteristics; expanded aging and AD/ADRD-relevant blood-based biomarkers; additional content on social factors to study racial disparities and minority health via life histories as well as the medium and long-term social impacts of the COVID-19 pandemic.

Funding Opportunity RFA-AG-24-004 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) invites U01 applications to develop national cost of illness estimates for the monetary cost of Alzheimers Disease and Alzheimers disease-related dementias (AD/ADRD) in the United States using a societal perspective. The purpose of this FOA is to support development of a national estimate of the costs of AD/ADRD using population-representative and administrative data on older Americans through a comprehensive process that uses a family and People Living With Dementia engagement panel and a Technical Monitoring Committee. Applicants must describe administrative and convening activities - including a Family and People Living With Dementia engagement panel and a Technical Monitoring Committee - to guide cost estimate development and analyses. The awardee under this FOA must establish access to appropriate dataset(s) through NIAs data linkage support contract (MedRIC.info) and analyze the data to develop estimates of costs, including direct and indirect costs. Once data have been analyzed, the awardee will lead development of products to disseminate the methods and findings of the project, through the composition of manuscripts, data briefs, infographics, and presenting the findings of the project to the scientific community. The awardee will administer pilot projects to support cost simulations assessing treatment and policy changes that would alter the cost of disease. Analytic code and products of this work will be shared with the research community.

Notice NOT-GM-23-037 from the NIH Guide for Grants and Contracts

Notice NOT-RM-23-008 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-EB-23-002 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to

Funding Opportunity RFA-NS-24-004 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

Funding Opportunity RFA-NS-24-005 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

Funding Opportunity PAR-23-140 from the NIH Guide for Grants and Contracts. This initiative is designed to promote discovery of cellular and molecular mechanisms that underlie brain blood vessels responses to passive anti-beta-amyloid immunotherapy that result in amyloid-related imaging abnormalities (ARIA). The goal is to establish an understanding of molecular mechanisms that can be targeted to protect the blood brain barrier (BBB), and thus the brain blood vessels, during therapeutic interventions that target beta-amyloid.

Funding Opportunity RFA-CA-23-031 from the NIH Guide for Grants and Contracts. The objectives of the Early Detection Research Network (EDRN; edrn.cancer.gov) are to discover, develop and validate biomarkers and imaging methods to detect early stage cancers and to translate these into clinical tests. The EDRN provides an infrastructure that is essential for this process and has successfully completed more than10 multicenter validation studies.

Funding Opportunity RFA-AG-24-009 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for the Alzheimers Disease (AD) and Alzheimers Disease-Related Dementias (ADRD) Real-World Data (RWD) Platform initiative. This Platform aims to transform the AD/ADRD research enterprise by serving as a central hub of research access that aims to: 1) improve applicability and generalizability of findings through larger datasets that include more diverse populations; 2) capture more complete information through linking a variety of data sources; 3) increase the speed at which scientific questions can be answered; and 4) improve researchers ability to answer questions that cannot be feasibly or readily answered via clinical trial.

Notice NOT-MD-23-007 from the NIH Guide for Grants and Contracts

Notice NOT-DA-23-019 from the NIH Guide for Grants and Contracts

Notice NOT-CA-23-048 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-23-127 from the NIH Guide for Grants and Contracts. The Office of Research Infrastructure Programs (ORIP) within the Division of Program Coordination, Planning, and Strategic Initiatives announces an opportunity to apply for small grant support for ORIP-supported Special Emphasis Research Career Award (SERCA) K01 recipients who have completed the first two years (24 months) of the SERCA K01 award. ORIP seeks to enhance the ability of ORIP SERCA K01 awardees to conduct research as they transition to fully independent investigator status. The R03 mechanism supports projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. The R03 is intended to support research projects that can realistically be completed in two years and that require limited levels of funding. This Funding Opportunity Announcement does not accept applications proposing clinical trial(s).

Notice NOT-HL-23-068 from the NIH Guide for Grants and Contracts