Funding Opportunity RFA-RM-19-010 from the NIH Guide for Grants and Contracts. The purpose of this Common Fund initiative is to advance the application of cryoelectron tomography (cryoET), a powerful new method for directly visualizing macromolecular associations and organization in native cells. The two FOAs for this initiative will establish a national network of service centers that will provide these services to the community: collection of high-resolution cryoET data, cryoET specimen preparation, access for users to advanced instrumentation for cryoET, and cross-training in cryoET methods. This FOA will establish one service center that will serve as the network's central hub. The hub will serve user laboratories in the community directly and will also provide services to the four service centers that will be established by the companion FOA, RFA-RM-19-009. Those other centers will specialize in specimen preparation. The hub will perform cryoET data collection for all the user laboratories served by the whole network.

Notice NOT-RM-19-011 from the NIH Guide for Grants and Contracts

Notice NOT-HS-19-019 from the NIH Guide for Grants and Contracts

Notice NOT-NS-19-070 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-19-300 from the NIH Guide for Grants and Contracts. The goal of the Bridges to the Doctorate Research Training program is to develop a diverse pool of scientists earning a Ph.D., who have the skills to successfully transition into careers in the biomedical research workforce. This funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, evidence-based approaches to biomedical training and mentoring that will keep pace with the rapid evolution of the research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, mentoring, and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the Nation. This Funding Opportunity Announcement (FOA) does not allow appointed Trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

Notice NOT-MH-19-035 from the NIH Guide for Grants and Contracts

Notice NOT-RM-19-010 from the NIH Guide for Grants and Contracts

Notice NOT-CA-19-056 from the NIH Guide for Grants and Contracts

Notice NOT-CA-19-054 from the NIH Guide for Grants and Contracts

Notice NOT-CA-19-055 from the NIH Guide for Grants and Contracts

Notice NOT-DA-19-055 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-19-299 from the NIH Guide for Grants and Contracts. The goal of the Bridges to the Baccalaureate Research Training Program is to provide structured activities to prepare community college students to transfer to and complete a bachelor's degree in biomedical research fields. This funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, evidence-based approaches to biomedical training and mentoring that will keep pace with the rapid evolution of the research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, mentoring, and career development elements to prepare trainees to bridge from the community college and complete the bachelor's degree in biomedical fields. This program requires partnerships between two-year post-secondary educational institutions granting the associate degree with four-year colleges or universities that offer the baccalaureate degree. This FOA does not allow appointed trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

Notice NOT-MH-19-034 from the NIH Guide for Grants and Contracts

Notice NOT-MH-19-033 from the NIH Guide for Grants and Contracts

Notice NOT-DA-19-056 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-19-298 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies using non-invasive neurostimulation/neuromodulation in the treatment of Alzheimer's Disease (AD) or Alzheimer's disease-related dementias (ADRD). The goal of this FOA is to establish initial efficacy of neurostimulation/neuromodulation in the treatment of AD/ADRD or to refine these interventions for AD/ADRD patients. Multimodal or combination interventions are allowed, provided the focus and innovative component is neurostimulation.

Funding Opportunity RFA-NS-19-039 from the NIH Guide for Grants and Contracts. (Reissue of RFA-NS-16-021, PAR-18-413) Diffuse brain white matter disease is highly prevalent in the elderly, and has been clinically associated with vascular contributions to cognitive impairment and dementia (VCID) in both men and women. Diffuse white matter disease is thought to include a variety of pathologies including demyelination and/or fiber loss due to multifocal infarction and local ischemia. It is often accompanied by arteriosclerosis in deep penetrating arteries, multiple infarcts in the basal ganglia, brainstem or cerebellum. Though most commonly extending out from the periventricular surfaces, it may also occur in subcortical white matter. Diffuse white matter disease is typically detected in clinical settings as hyperintensity on magnetic resonance imaging (MRI) or signal loss on computed tomography x-ray (CT) scan; diffuse white matter disease can be detected histologically as well, for example in human pathology and in studies using animal models. Despite the prevalence and potential significance of white matter disease for cerebrovascular disease etiology and cognitive outcomes, much remains to be learned about the cellular and molecular causes, regional vulnerability, and progression over time. The physiological consequences of diffuse white matter disease on local axon and neural circuit function are almost completely unknown. The purpose of this FOA is to address some of the many gaps in knowledge of the biologic mechanisms of the commonly occurring, cerebrovascular disease and age-related diffuse white matter disease at the molecular, cellular, tissue and brain circuit level. The ultimate goal of this fundamental research is to inform future efforts to reduce the burden of illness due to age-related vascular contributions to cognitive impairment and dementia.

Notice NOT-OD-19-107 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-ES-19-010 from the NIH Guide for Grants and Contracts. The goal of this NIEHS undergraduate research education R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce in the environmental health sciences. To this end, this funding opportunity announcement (FOA) encourages the development of creative educational activities with a primary focus on research experiences for undergraduates at the junior and senior level.

Funding Opportunity RFA-AG-20-007 from the NIH Guide for Grants and Contracts. The primary aim of this Funding Opportunity Announcement (FOA) is to facilitate the characterization of the marmoset as a laboratory animal for research on aging and age-related diseases.